Tshuaj kho mobraug mobs lub siab thiab lub raum thaumLingzhi (tseem hu uaGanoderma lucidum los yog Reishi nceb) tiv thaiv lub siab thiab lub raum.

Ua tauGanoderma lucidum tiv thaiv lub siab thiab lub raum puas los ntawm kev siv tshuaj khomob?

Ib pab neeg tsim los ntawm xibfwb Hanan M Hassan los ntawm Kws qhia ntawv ntawm Pharmacy ntawm Delta University rau Science & Technology hauv Egypt thiab xibfwb Yasmen F Mahran los ntawm Kws Qhia Tshuaj ntawm Ain Shams University hauv tebchaws Egypt siv cisplatin, cov tshuaj siv tshuaj khomob ntau tshaj plaws, los kuaj. qhov ua tauGanoderma lucidum hauv kev tiv thaiv daim siab thiab lub raum hlwb los ntawm kev raug mob cisplatin.

Lawv cov txiaj ntsig kev tshawb fawb tau muab faib ua ob kab lus: ib qho yog tiv thaiv lub siab thaum lwm tus tiv thaiv ob lub raum.Lawv tau luam tawm hauv "Kev Tsim Tshuaj, Kev Txhim Kho thiab Kev Kho Mob" thiab "Oxidative Medicine thiab Cellular Longevity" thaum Lub Rau Hli thiab Lub Xya Hli 2020, feem.

Anti-oxidant, anti-inflammatory thiab anti-apoptotic teebmeem ntawmGanoderma lucidum tuaj yeem pom tseeb thaiv ntau yam kev puas tsuaj oxidative, inflammatory puas thiab cell apoptosis induced los ntawm cisplatin, thiab cov kev tiv thaiv no muaj feem xyuam rau lub siab hlwb los yog raum hlwb.Qhov no tsis tsuas yog qhia txog tus nqi tshuaj kho mob dualGanoderma lucidum tab sis kuj tseem muaj txoj hauv kev tiv thaiv kev tiv thaiv kab mob qog noj ntshav.

Txhawm rau kom tsis txhob ua cov kab lus no ntev dhau lawm, tus sau yuav qhia txog lub luag haujlwm ntawmGanoderma lucidum nyob rau hauv no nam nyob rau hauv ob qhov chaw nyob rau hauv kev cia siab hais tias cov scientifically raws li cov ntaub ntawv thiab cov pov thawj yuav coj kev ntseeg siab dua rau cov phooj ywg uas nrhiav kom txo tau cov kev phiv los ntawm chemotherapy.

Ntu 1Ganoderma lucidum tiv thaiv daim siab vs. cisplatin hepatotoxicity

Cov rcov neeg tshawb nrhiav piv qhov sib txawvsnruab nrab ntawm kev siv thiab tsis sivGanoderma lucidumthaum kho cisplatinnyob rau hauv rau pawg ntawm cov nas noj qab haus huv thiab qhov sib txawv ntawm kev tiv thaiv lub siab raug mob nrog sib txawvGanoderma lucidum txoj kev tswj hwm.Lawv yog:

◆Pawg tswj hwm (Cont): pab pawg uas tsis tau txais kev kho mob;

◆Ganoderma lucidumPab pawg(GL): cov pab pawg uas tsis tau txhaj tshuaj cisplatin tab sis nojGanoderma lucidum txhua hnub;

◆Cisplatin Group (CP): pab pawg uas tsuas yog txhaj tshuaj cisplatin tab sis tsis nojGanoderma lucidum;

◆Pab Pawg Txhua Hnub (Txhua Hnub): pawg kws txhaj tshuaj cyogplatinthiab nojGanoderma Lucidum txhua hnub;

◆Pawg Txhua Hnub (EOD): pawg kws txhaj tshuaj cyogplatinthiab nojGanoderma lucidum txhua hnub;

◆Intraperitoneal pab pawg (ip): pab pawg uas txhaj cyogplatinthiab txais kuvntraperitoneal mobinpe ofGanoderma lucidum.

Txhua tus neeg uas tau txais cisplatin tau txhaj tshuaj intraperitoneally nrog 12 mg / kg ntawmCisplatinthawj hnub ntawm kev sim ua kom mob siab rau lub siab;cov neeg uas tau txais kev txhaj tshuaj intraperitonealGanoderma lucidum tau txhaj ib zaug rau hnub thib ob thiab thib rau ntawm qhov kev sim.

CovGanoderma lucidum siv hauv kev sim muaj cov khoom xyaw nquag xws li triterpenes, sterols, polysaccharides, polyphenols thiab flavonoids.CovGanoderma lucidum muab rau hauv kev sim tsiaj, txawm tias nws tau noj los ntawm qhov ncauj lossis los ntawm kev txhaj tshuaj, suav nrog ntawm ib koob tshuaj 500 mg / kg ib hnub.

(1)Ganoderma lucidum txo qhov mob hepatocellular

Tom qab 10 hnub, nws tuaj yeem pom tau tias cisplatin yuav ua rau cov kab mob siab ua kom nce siab thiab tag nrho cov qib bilirubin hauv cov nas cov ntshav.Cov no yog tag nrho cov cim qhia ntawm kev raug mob hepatocellular.Tab sis yog tiasGanoderma lucidum koom nrog tib lub sijhawm, tus nqi nce tuaj yeem txo tau ntau heev (Daim duab 1).

Cov ntaub ntawv Source/Drug Des Devel Ther.2020;14: 2335-2353.

Daim duab 1 Cov teebmeem ntawm cisplatin thiabGanoderma lucidum ntawm daim siab mob qhov taw qhia

Muab cov ntaub so ntswg ntawm daim siab tso rau hauv lub tshuab ntsuas, thiab koj tuaj yeem pom tias cisplatin tuaj yeem ua rau daim siab mob plab (cov ntshav uas yuav tsum rov qab mus rau lub plawv yog thaiv thiab stagnates hauv cov hlab ntsha hauv siab), cell degeneration (vacuoles tshwm sim, uas yog qhov hloov pauv ntxov tshaj plaws hauv cov hlab ntsha. cellular raug mob), apoptosis thiab necrosis, tab sis cov kev mob no kuj yuav txo tau los ntawm kev sivGanoderma lucidum.

Daim duab 2 Cov teebmeem ntawm cisplatin thiabGanoderma lucidum ntawm hepatocytes

(2)Ganoderma lucidum txhim khu lub peev xwm antioxidant ntawm daim siab hlwb

Kab lus no ntxiv piv rau kev puas tsuaj oxidative raug kev txom nyem los ntawm txhua pab pawg neeg ntawm daim siab.Muaj ob qhov ntsuas ntsuas: MDA (malondialdehyde), ib yam khoom tsim tom qab kev puas tsuaj ntawm cell membranes los ntawm cov dawb radicals, thiab H₂O₂ (hydrogen peroxide), ib qho khoom nruab nrab tsim tom qab cov metabolism ntawm cov dawb radicals los ntawm cov enzymes antioxidant.

Ob qho ntawm cov khoom no muaj cov khoom oxidative ntawm cov dawb radicals thiab yuav tsum tau kho ntxiv ua ntej lawv tuaj yeem "detoxified", yog li tus nqi ntawm lawv tuaj yeem qhia peb txog kev puas tsuaj oxidative uas lub siab cov ntaub so ntswg. “muaj kev txom nyem" thiab "yuav raug kev txom nyem".

Pom tseeb, cisplatin yuav ua rau oxidative puas tsuaj rau daim siab, tab sis yogGanoderma lucidum koom nrog hauv kev kho mob tib lub sijhawm, xws li kev puas tsuaj tuaj yeem raug txo qis (Daim duab 3).

Vim tias qhov kev hloov pauv hauv cov ntsiab lus ntawm cov enzymes antioxidant (SOD thiab GSH) hauv daim siab cov ntaub so ntswg ntawm txhua pab pawg thiab cov kev hloov pauv hauv oxidative kev puas tsuaj qhia tau pom qhov sib txawv kiag li., nws tuaj yeem suav tau tiasGanoderma lucidumyuav ua rau kom muaj peev xwm antioxidant ntawm daim siab cov ntaub so ntswg thiab txo qhov kev puas tsuaj los ntawm "nce antioxidant enzymes".

Daim duab3 Cov teebmeem ntawm cisplatin thiabGanoderma lucidum ntawm oxidative puas ntawm daim siab cov ntaub so ntswg

(3)Ganoderma lucidum txhim kho lub peev xwm tiv thaiv kab mob ntawm daim siab hlwb

Cisplatin hem kom ciaj sia ntawm cov hlwb los ntawm kev puas tsuaj DNA thiab inducing ib tug loj tus naj npawb ntawm dawb radicals;cov hlwb nyob rau hauv siab yuav tig rau tus tswv hloov NF-kB uas tswj cov kab mob o, ua rau cov hlwb los ua ke thiab tso cov qog necrosis (TNF-α) thiab lwm yam cytokines los qhib thawj nthwv dej ntawm cov tshuaj tiv thaiv kab mob thiab suab lub tswb rau kev tiv thaiv.

Tam sim ntawd tom qab ntawd, cov hlwb raug tua los ntawm kev puas tsuaj oxidative lossis o yuav tso tawm lwm cov cytokine, HMGB-1, txhawm rau ua kom lub cev tiv thaiv kab mob ntau dua, ua rau muaj kev mob tshwm sim.

Kev mob tsis tu ncua yuav tsis tsuas yog, dhau los, ua kom oxidative puas tsuaj, tab sis kuj ua rau cov hlwb ntau dua kom tuag, thiab tseem ua rau daim siab cov ntaub so ntswg maj mam tsim fibrosis thaum lub sij hawm rov ua mob thiab kho.

Hmoov zoo, ib yam liGanoderma lucidum tuaj yeem txo qhov kev puas tsuaj oxidative los ntawm cisplatin, kev sim tsiaj kuj tau lees paub tias kev siv cisplatin ua ke thiabGanoderma lucidum tuaj yeem cuam tshuam qhov ua rau ntawm tus mob hloov NF-kB, txo qhov mob-txhim kho TNF-athiab HMGB-1, thiab nceAnti-inflammatory cytokine IL-10nyob rau hauv cov ntaub so ntswg ntawm daim siab tib lub sij hawm (Daim duab 4).

Noj ua ke, cov teebmeem no tsis yog tsuas yog inhibit qhov mob tab sis kuj txo cov collagen deposition thiab tiv thaiv kev loj hlob ntawm daim siab fibrosis (Daim duab 5).

Cov ntaub ntawv Source/Drug Des Devel Ther.2020;14: 2335-2353.

Daim duab 4 Cov teebmeem ntawm cisplatin thiabGanoderma lucidum ntawm o ntawm daim siab cov ntaub so ntswg

Cov ntaub ntawv Source/Drug Des Devel Ther.2020;14: 2335-2353.

Daim duab 5 Cov teebmeem ntawm cisplatin thiab Ganoderma lucidum ntawm daim siab fibrosis

(4)Ganoderma lucidum txhim kho lub peev xwm los tiv thaiv apoptotic ntawm daim siab hlwb

Txawm hais tias los ntawm kev puas tsuaj oxidative los yog kev puas tsuaj, cisplatin thaum kawg yuav ua rau "apoptosis" mechanism thiab yuam cov hlwb kom tuag.

Hauv lwm lo lus, yog tias daim siab lub hlwb tuaj yeem tuav txoj kab kawg ntawm kev tiv thaiv, lawv yuav muaj feem ntau muaj sia nyob thiab txo qhov mob siab ntawm daim siab.

Muaj ntau cov protein molecules uas tswj apoptosis.Ntawm lawv, cov neeg sawv cev tshaj plaws yog: p53, uas tuaj yeem txhawb nqa apoptosis, Bcl-2, uas tuaj yeem cuam tshuam apoptosis, thiab caspase-3, uas ua rau apoptosis ntawm feeb kawg.

Raws li cov kws tshawb fawb'kev soj ntsuam ntawm daim siab nqaij ntawm cov tsiaj sim hauv txhua pab pawg,Ganoderma lucidum tuaj yeem tsis tsuas yog txhawb nqa kev qhia ntawm Bcl-2 tab sis kuj inhibit qhov kev qhia ntawm p53 thiab caspase-3, uas tuaj yeem muab lub zog tiv thaiv apoptotic rau lub siab.

(5) Ganoderic acids ua lub luag haujlwm tseem ceeb los tiv thaiv kev mob

Los ntawm kev tiv thaiv oxidation, tiv thaiv kab mob, tiv thaiv apoptosis mus rau qhov ua tau zoo ntawm kev txo lub siab puas tsuaj, cov kws tshawb fawb tau sau cov txheej txheem ntawmGanoderma lucidum hauv inhibiting cisplatin hepatotoxicity rau hauv daim duab hauv qab no rau koj siv.

Cov ntaub ntawv Source/Drug Des Devel Ther.2020;14: 2335-2353.

Daim duab 6 Lub tshuab ntawm Ganoderma lucidum hauv inhibiting siab toxicity ntawm cisplatin

Thaum kawg ntawm txoj kev tshawb no, kev tsom xam ntawm cov“molecular docking simulation system”pom tias tsawg kawg 14 ganoderic acids hauv triterpenes ntawmGanoderma lucidum (raws li qhia hauv cov lus hauv qab no) tuaj yeem ncaj qha thiab zoo khi rau tus yuam sij cytokine HMGB-1, yog li inactivating pro-inflammatory kev ua ntawm HMGB-1.

Txij li thaum anti-o yog ib qho tseem ceeb mechanisms ntawmGanoderma lucidum txo Cisplatin-induced hepatotoxicity,“nplua nuj nyob rau hauv Ganoderic kua qaub”tau dhau los ua qhov ntsuas qhov ntsuas ntawmGanoderma lucidum tiv thaiv lub siab.

Yam twgGanoderma lucidum cov khoom xyaws tuaj yeem muaj xws li Ganoder ntauic kua qaubs?Raws li kev tshawb fawb yav dhau los, nws paub tias lawv feem ntau muaj nyob hauv "Ganoderma lucidum txiv hmab txiv ntoohauv lub cev cawv extract."

Nws yog tsim nyog hais tias cov nas nyob rau hauv lubGanoderma lucidum pab pawg uas tsuas nojGanoderma lucidum yuav luag tib yam li cov nas nyob hauv lubtswj pab pawg nyob rau hauv cov kev sim saum toj no-hais txog cov txiaj ntsig, qhia tiasGanoderma lucidum muaj kev nyab xeeb heev rau kev noj.

Tsis tas li ntawd, txoj kev sivGanoderma lucidum kuj tseem ceeb heev.Yog koj txaus siab rau review ua daim ntawv qhia nyob rau hauv tsab xov xwm no, nws tsis yog nyuaj rau nrhiav tau tias "EheevDay Pab pawg” muaj cov txiaj ntsig zoo tshaj plaws.

Qhov tseeb, EheevDay Pab pawg has qhov zoo tshaj plaws hauv kev txo cov kab mob siabthiab raum toxicity ntawm cisplatin hauv cov tsiaj sim,uas yog txawvt los ntawm lwm yamGmob anoderma lucidum pab pawg.

Dab tsi yog qhov tshwj xeeb tshwm sim ntawm cov txiaj ntsig zoo saum toj no?Nyob twj ywm rau "Part 2Ganoderma lucidum tiv thaiv lub raum vs. Cisplatin nephrotoxicity ".

[Cov ntaub ntawv Source]

1.Hanan M Hassan, et al.Kev Tiv Thaiv Cisplatin-Induced Hepatic Injury hauv nas Los ntawm Alarmin High-Mobility Group Box-1 Txoj Kev los ntawmGanoderma lucidum: Theoretical and Experimental Study.Drug Des Devel Ther.2020; 14: 2335-2353.

2.Yasmen F Mahran, et al.Ganoderma lucidumTiv thaiv Cisplatin-Induced Nephrotoxicity los ntawm Inhibition ntawm Epidermal Growth Factor Receptor Signaling thiab Autophagy-Mediated Apoptosis.Oxid Med Cell Longev.Xyoo 2020. doi: 10.1155/2020/4932587.

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Hais txog tus sau/ Ms. Wu Tingyao

Wu Tingyao tau tshaj tawm thawj zaugGanoderma lucidumcov ntaub ntawv txij thaum 1999. Nws yog tus sau ntawmKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).

★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau, thiab cov tswv cuab yog GANOHERB ★ Cov haujlwm saum toj no tsis tuaj yeem luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis tau tso cai ntawm GanoHerb ★ Yog tias cov haujlwm tau tso cai siv, lawv yuav tsum tau siv nyob rau hauv lub Scope ntawm kev tso cai thiab qhia lub hauv paus: GanoHerb ★ Kev ua txhaum ntawm cov lus saum toj no, GanoHerb yuav caum nws cov luag hauj lwm raws li txoj cai ★ Thawj cov ntawv nyeem ntawm tsab xov xwm no yog sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.

Dhau ntawm Millennia Health Culture

Pab txhawb rau Kev Noj Qab Haus Huv rau Txhua Tus