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Chimoterapigukomeretsas umwijima nimpyiko mugiheLingzhi (nanone yitwaGanoderma lucidum cyangwa Reishi mushroom) irinda umwijima nimpyiko.

BirashobokaGanoderma lucidum kwihanganira umwijima nimpyiko byatewe na chimiotherapie?

Itsinda rigizwe na Porofeseri Hanan M Hassan wo mu ishami rya farumasi rya kaminuza ya Delta y’ubumenyi n’ikoranabuhanga muri Egiputa na Porofeseri Yasmen F Mahran wo mu ishami rya farumasi rya kaminuza ya Ain Shams muri Egiputa bakoresheje cisplatine, imiti gakondo ya chimiotherapie, mu gupima birashobokaGanoderma lucidum mukurinda umwijima nimpyiko gukomeretsa cisplatine.

Ibisubizo byabo byubushakashatsi bigabanijwemo ingingo ebyiri: kimwe kirinda umwijima mugihe ikindi kirinda impyiko.Byasohotse muri “Igishushanyo mbonera cy’ibiyobyabwenge, Iterambere n’Ubuvuzi” ​​na “Oxidative Medicine and Cellular Longevity” muri Kamena na Nyakanga 2020.

Kurwanya anti-oxyde, anti-inflammatory na anti-apoptotique yaGanoderma lucidum Birashobora kugaragara ko byangiza byinshi byangiza okiside, kwangirika kwumuriro hamwe na apoptose selile iterwa na cisplatine, kandi ubwo burinzi burakoreshwa kumasemburo yumwijima cyangwa selile.Ibi ntabwo byerekana gusa imiti ibiri yubuvuzi yaGanoderma lucidum ariko kandi itanga uburyo bushoboka bwo kurinda infashanyo ya chimiotherapie ya kanseri.

Kugirango wirinde gukora iyi ngingo ndende cyane, umwanditsi azamenyekanisha uruhare rwaGanoderma lucidum muriki gice mubice bibiri twizeye ko aya makuru ashingiye kubumenyi nibimenyetso bizazana icyizere inshuti zishaka kugabanya ingaruka ziterwa na chimiotherapie.

Igice cya 1Ganoderma lucidum irinda umwijima na cisplatin hepatotoxicity

R.abashakashatsi bagereranije itandukaniroshagati yo gukoresha no kudakoreshaGanoderma lucidummugihe cyo kuvura cisplatinemu matsinda atandatu yimbeba nzima nibitandukaniro mukurinda gukomeretsa umwijima bitandukanyeGanoderma lucidum uburyo bwo kuyobora.Ni:

Itsinda rishinzwe kugenzura (Ibirimo): itsinda ritakira imiti iyo ari yo yose;

Ganoderma lucidumItsinda(GL): itsinda ridatewe na cisplatine ariko iraryaGanoderma lucidum buri munsi;

Itsinda rya Cisplatin (CP): itsinda ryatewe gusa na cisplatine ariko ntiraryeGanoderma lucidum;

Itsinda rya buri munsi (Buri munsi): itsinda ryatewe inshinge cisplatinakaryaGanoderma Lucidum buri munsi;

Buri Yandi Matsinda Yumunsi (EOD): itsinda ryatewe inshinge cisplatinakaryaGanoderma lucidum iminsi yose;

Itsinda rya Intraperitoneal (ip): itsinda ryatewe cisplatinkandi yakira intraperitonealinjection yaGanoderma lucidum.

Abakiriye cisplatine bose batewe inshinge 12 mg / kg yaCisplatinkumunsi wambere wubushakashatsi bwo gukomeretsa umwijima ukabije;abakiriye inshinge za intraperitonealGanoderma lucidum batewe inshuro imwe kumunsi wa kabiri nuwa gatandatu wubushakashatsi.

UwitekaGanoderma lucidum ikoreshwa mubushakashatsi ikubiyemo ibintu bifatika nka triterpène, steroli, polysaccharide, polifenol na flavonoide.UwitekaGanoderma lucidum yatanzwe mubushakashatsi bwinyamaswa, bwaba bufashwe mu kanwa cyangwa no guterwa inshinge, bubarwa ku gipimo cya buri munsi cya 500 mg / kg.

(1)Ganoderma lucidum igabanya imvune ya hepatocellular

Nyuma yiminsi 10, birashobora kugaragara ko cisplatine izongera igipimo cya hepatite hamwe na bilirubine yose muri serumu yimbeba.Ibi byose ni ibimenyetso byerekana igikomere cya hepatocellular.Ariko nibaGanoderma lucidum ni uruhare icyarimwe, agaciro kiyongereye karashobora kugabanuka cyane (Ishusho 1).

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Amakuru Inkomoko / Ibiyobyabwenge Byibikoresho.2020;14: 2335-2353.

Igishushanyo 1 Ingaruka za cisplatine naGanoderma lucidum ku bipimo byo gukomeretsa umwijima

Shira igice cyumwijima munsi ya microscope, urashobora kubona ko cisplatine ishobora gutera umwijima (amaraso agomba gusubira kumutima arahagarikwa kandi agahagarara mumitsi ya hepatike), kwangirika kwingirabuzimafatizo (vacuole igaragara, niyo mpinduka ya mbere muri gukomeretsa selile), apoptose na necrosis, ariko ibi bintu birashobora kandi kugabanuka ukoreshejeGanoderma lucidum.

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Itsinda rishinzwe kugenzura (Ibirimo)

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Itsinda rya Ganoderma lucidum (GL)

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Itsinda rya Cisplatin (CP)

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Buri Yandi Matsinda Yumunsi (EOD)

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Itsinda rya buri munsi (Buri munsi)

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Itsinda rya Intraperitoneal (ip)

CV bivuga imitsi yo hagati.Imyambi yerekana uduce twinshi twinshi cyangwa hepatocyte igabanuka.
Amakuru Inkomoko / Ibiyobyabwenge Byibikoresho.2020;14: 2335-2353.

Igishushanyo 2 Ingaruka za cisplatine naGanoderma lucidum kuri hepatocytes

(2)Ganoderma lucidum byongera ubushobozi bwa antioxydeant ya selile yumwijima

Iyi ngingo iragereranya kandi kwangiza okiside yatewe na buri tsinda ryimyanya yumwijima.Hano hari ibipimo bibiri byo kureba: MDA (malondialdehyde), igicuruzwa cyakozwe nyuma yo gusenya ingirabuzimafatizo na radicals yubuntu, na H2O2 (hydrogen peroxide), igicuruzwa giciriritse cyakozwe nyuma ya metabolism ya radicals yubusa na enzymes za antioxydeant.

Ibyo bicuruzwa byombi bifite imiterere ya okiside ya radicals yubusa kandi igomba kurushaho kuvurwa mbere yuko ishobora "kwangirika", bityo ingano yabyo irashobora kutubwira ibyangiza okiside yangiza umwijima. “Ifite yababaye ”kandi“ azababara ”.

Biragaragara, cisplatine izatera okiside ikomeye kwangiza umwijima, ariko nibaGanoderma lucidum agira uruhare Mu kuvura icyarimwe, ibyangiritse birashobora kugabanuka (Ishusho 3).

Kuberako impinduka ziterwa na enzymes za antioxydeant (SOD na GSH) mumyanya yumwijima ya buri tsinda hamwe nimpinduka zerekana ibyangiritse byangiza okiside byerekanaga inzira itandukanye rwose, birashobora kwemezwa koGanoderma lucidumbizongera ubushobozi bwa antioxydeant yumubiri wumwijima kandi bigabanye ibyangiritse "kongera imisemburo ya antioxydeant".

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Igishushanyo3 Ingaruka za cisplatine naGanoderma lucidum ku kwangiza okiside yangiza umwijima

(3)Ganoderma lucidum byongera ubushobozi bwo kurwanya inflammatory selile yumwijima

Cisplatine ibangamira ubuzima bw'utugingo ngengabuzima twangiza ADN kandi itera umubare munini wa radicals z'ubuntu;selile zotswa igitutu zizahindura kuri master switch NF-kB igenga igisubizo cyumuriro, bigatuma selile ikora kandi ikarekura ikibyimba cya nérosose (TNF-α) hamwe na cytokine kugirango ukore umurongo wambere wibisubizo byumuriro no kuvuza induru kubudahangarwa.

Ako kanya, izo selile zishwe no kwangirika kwa okiside cyangwa gutwika zizarekura indi cytokine, HMGB-1, kugirango ikore ingirabuzimafatizo nyinshi, itera imiraba yumuriro.

Gukomeza gutwikwa ntibizongera gusa kwangirika kwa okiside ahubwo bizanatera selile nyinshi gupfa, ndetse binatera ingirangingo zumwijima gukura buhoro buhoro fibrosis mugihe cyo gutwikwa no gusana.

Kubwamahirwe, kimweGanoderma lucidum irashobora kugabanya kwangiza okiside iterwa na cisplatine, ubushakashatsi bwinyamaswa nabwo bwemeje ko ikoreshwa rya cisplatine hamweGanoderma lucidum Irashobora guhagarika ibikorwa bya inflammation switch NF-kB, kugabanya TNF itera umurirona HMGB-1, no kwiyongeraanti-inflammatory cytokine IL-10mu ngingo z'umwijima icyarimwe (Ishusho 4).

Ufatiye hamwe, izi ngaruka ntizibuza gusa gucana ahubwo zigabanya no kwanduza kolagen no gukumira fibrosis yumwijima (Ishusho 5).

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Amakuru Inkomoko / Ibiyobyabwenge Byibikoresho.2020;14: 2335-2353.

Igicapo 4 Ingaruka za cisplatine naGanoderma lucidum ku gutwika umwijima

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Itsinda rishinzwe kugenzura (Ibirimo)

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Ganoderma lucidumItsinda(GL)

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Itsinda rya Cisplatin (CP)

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Buri Yandi Matsinda Yumunsi (EOD)

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Itsinda rya buri munsi (Buri munsi)

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Itsinda rya Intraperitoneal (ip)

Imyambi yerekana uduce twa kolagen.

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Amakuru Inkomoko / Ibiyobyabwenge Byibikoresho.2020;14: 2335-2353.

Igicapo 5 Ingaruka za cisplatine na Ganoderma lucidum kuri fiboside yumwijima

(4)Ganoderma lucidum byongera ubushobozi bwo kurwanya apoptotique ya selile yumwijima

Haba binyuze mu kwangiza okiside cyangwa kwangirika kwinshi, cisplatine amaherezo izakora uburyo bwa "apoptose" kandi ihatira selile umwijima gupfa.

Muyandi magambo, niba selile yumwijima ishobora gufata umurongo wanyuma wo kwirwanaho, bazagira amahirwe menshi yo kubaho no kugabanya ubukana bwangirika bwumwijima.

Hariho molekile nyinshi za poroteyine zigenga apoptose.Muri bo, abahagarariye cyane ni: p53, ishobora guteza apoptose, Bcl-2, ishobora kubuza apoptose, na caspase-3, ikora apoptose kumunota wanyuma.

Abashakashatsi bavuga'isesengura ry'umwijima w'inyamaswa zigerageza muri buri tsinda,Ganoderma lucidum ntishobora guteza imbere imvugo ya Bcl-2 gusa ahubwo inabuza imvugo ya p53 na caspase-3, ishobora gutanga ingufu zikomeye zo kurwanya apoptotique kumasemburo yumwijima.

(5) Acide ya Ganoderic igira uruhare runini rwo kurwanya inflammatory

Kuva anti-okiside, anti-inflammation, anti-apoptose kugeza kumikorere nyayo yo kugabanya kwangirika kwumwijima, abashakashatsi bakoze uburyo bwaGanoderma lucidum muguhagarika cisplatine hepatotoxicity mubishushanyo bikurikira kugirango ubone.

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Amakuru Inkomoko / Ibiyobyabwenge Byibikoresho.2020;14: 2335-2353.

Igicapo 6 Uburyo bwa Ganoderma lucidum muguhagarika uburozi bwumwijima bwa cisplatine

Mu gusoza ubu bushakashatsi, isesengura ryasisitemu yo kwiganawasanze byibuze acide 14 za ganoderic muri triterpène yaGanoderma lucidum (nkuko bigaragara mu mbonerahamwe ikurikira) irashobora guhuza mu buryo butaziguye kandi neza na cytokine HMGB-1, bityo igakora ibikorwa byo gutwika HMGB-1.

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Kubera ko anti-inflammation ari bumwe muburyo bwingenzi bwaGanoderma lucidum kugabanya Cisplatine iterwa na hepatotoxicity,ubukire muri Ganoderic asideyahindutse icyerekezo cyaGanoderma lucidum kurinda umwijima.

Ubwoko kiGanoderma lucidum ingirakamaros irashobora kubamo Ganoder nyinshiic asides?Nk’ubushakashatsi bwashize, birazwi ko ahanini bahari muri “Ganoderma lucidum imbutoing ibinyobwa bisindisha umubiri ”.

Birakwiye kuvuga ko imbeba ziri muriGanoderma lucidum itsinda ryariye gusaGanoderma lucidum ni Nka Nka Imbeba murikugenzura itsinda mubisubizo byubushakashatsi byavuzwe haruguru, byerekana koGanoderma lucidum ni umutekano cyane kubikoresha.

Byongeye, uburyo bwo gukoreshaGanoderma lucidum ni na ngombwa cyane.Niba ufite ubushake bwo kuvugururaiew imbonerahamwe yerekanwe muri iyi ngingo, ntabwo bigoye kubona ko “EcyaneDay Itsinda”Ifite ingaruka nziza.

Mubyukuri, EcyaneDay Itsinda has Ingaruka nziza mu kugabanya umwijimana uburozi bwimpyiko bwa cisplatine mubushakashatsi bwinyamaswa,aribyo bitandukanyet kuva ikindiGanoderma lucidum amatsinda.

Ni ubuhe buryo bwihariye bugaragaza ingaruka nziza zavuzwe haruguru?Komeza ukurikirane “Igice cya 2Ganoderma lucidum irinda impyiko na Cisplatin nephrotoxicity ”.

[Inkomoko y'amakuru]

1.Hanan M Hassan, n'abandi.Kurwanya Cisplatine Yatewe no Gukomeretsa Hepatike mu mbeba Binyuze muri Alarmin Yihuta-Itsinda rya Boxe-1 Inzira yaGanoderma lucidum: Inyigisho nubushakashatsi.Ibiyobyabwenge.2020; 14: 2335-2353.

2.Yasmen F Mahran, n'abandi.Ganoderma lucidumIrinda Cisplatine iterwa na Neprotoxicity binyuze mu kubuza Epidermal Growth Factor Receptor Ibimenyetso na Autophagy-Mediated Apoptose.Oxid Med Cell Longev.2020. doi: 10.1155 / 2020/4932587.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao

Wu Tingyao yagiye atanga raporo imbonankuboneGanoderma lucidumamakuru kuva 1999. Niwe mwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).

★ Iyi ngingo yasohowe uruhushya rwihariye rwumwanditsi, kandi nyirubwite ni iya GANOHERB works Ibikorwa byavuzwe haruguru ntibishobora kubyara, gucibwa cyangwa gukoreshwa mubundi buryo butabiherewe uburenganzira na GanoHerb ★ Niba imirimo yemerewe gukoreshwa, barayikoresheje bigomba gukoreshwa mu rwego rwo gutanga uburenganzira no kwerekana inkomoko: GanoHerb ★ Kurenga ku magambo yavuzwe haruguru, GanoHerb azakomeza inshingano zijyanye n'amategeko ★ Umwandiko w’umwimerere w’iki kiganiro wanditswe mu Gishinwa na Wu Tingyao uhindurwa mu Cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.

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Igihe cyo kohereza: Gicurasi-08-2021

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