Chemotherapykuvulazas chiwindi ndi impso pameneLingzhndi (komansoGanoderma lucidum kapena bowa wa Reishi) amateteza chiwindi ndi impso.

MuthaGanoderma lucidum kupirira kuwonongeka kwa chiwindi ndi impso chifukwa cha chemotherapy?

Gulu lopangidwa ndi Pulofesa Hanan M Hassan wa Faculty of Pharmacy ya Delta University for Science & Technology ku Egypt ndi Pulofesa Yasmen F Mahran wa Faculty of Pharmacy ya Ain Shams University ku Egypt adagwiritsa ntchito cisplatin, mankhwala omwe amadziwika kwambiri a chemotherapy, kuyesa. kuthekera kwaGanoderma lucidum poteteza chiwindi ndi impso kuvulala kwa cisplatin.

Zotsatira za kafukufuku wawo zimagawidwa m'nkhani ziwiri: imodzi ikuteteza chiwindi pamene ina ikuteteza impso.Adasindikizidwa mu "Drug Design, Development and Therapy" ndi "Oxidative Medicine ndi Cellular Longevity" mu June ndi Julayi 2020, motsatana.

The anti-oxidant, odana ndi yotupa ndi odana apoptotic zotsatira zaGanoderma lucidum mwachiwonekere imatha kuletsa kuwonongeka kwa okosijeni wambiri, kuwonongeka kotupa ndi ma cell apoptosis chifukwa cha cisplatin, ndipo chitetezo chotere chimagwira ntchito pama cell a chiwindi kapena ma cell a impso.Izi sizimangowonetsa phindu lamankhwala lapawiriGanoderma lucidum komanso imapereka njira yodzitetezera yothandizira khansa ya chemotherapy.

Pofuna kupewa kuti nkhaniyi ikhale yayitali kwambiri, wolembayo afotokoze udindo waGanoderma lucidum mbali iyi m'magawo awiri ndi chiyembekezo kuti deta zozikidwa mwasayansi ndi umboni adzabweretsa chidaliro kwambiri kwa mabwenzi amene amafuna kuchepetsa zotsatira za mankhwala amphamvu.

Gawo 1Ganoderma lucidum amateteza chiwindi motsutsana ndi cisplatin hepatotoxicity

The rofufuza anayerekezera kusiyanakospakati pa kugwiritsa ntchito ndi kusagwiritsa ntchitoGanoderma lucidumpa chithandizo cha cisplatinm'magulu asanu ndi limodzi a makoswe athanzi komanso kusiyana kwa chitetezo ku kuvulala kwa chiwindi ndi zosiyanaGanoderma lucidum njira zoyendetsera.Ali:

◆Gulu Lolamulira (Cont): gulu lomwe sililandira chithandizo chilichonse;

◆Ganoderma lucidumGulu(GL): gulu lomwe silinabayidwe ndi cisplatin koma limadyaGanoderma lucidum tsiku lililonse;

◆Cisplatin Group (CP): gulu lomwe langobayidwa ndi cisplatin koma osadyaGanoderma lucidum;

◆Gulu Latsiku ndi Tsiku (Tsiku lililonse): gulu lomwe limabayidwa ndi cisplatinndi kudyaGanoderma Lucidum tsiku lililonse;

◆Gulu Latsiku Lililonse (EOD): gulu lomwe limabayidwa ndi cisplatinndi kudyaGanoderma lucidum tsiku lina lililonse;

◆Gulu la Intraperitoneal (ip): gulu lomwe labayidwa cisplatinndipo amalandira imatenda a traperitonealinjection yaGanoderma lucidum.

Onse amene analandira cisplatin anabayidwa intraperitoneally ndi 12 mg/kg waCisplatinpa tsiku loyamba la kuyesa kuyambitsa kuvulala kwakukulu kwa chiwindi;omwe adalandira jakisoni wa intraperitoneal waGanoderma lucidum anabayidwa kamodzi pa tsiku lachiwiri ndi lachisanu ndi chimodzi la kuyesa.

TheGanoderma lucidum Zomwe zimagwiritsidwa ntchito poyesera zimakhala ndi zinthu zogwira ntchito monga triterpenes, sterols, polysaccharides, polyphenols ndi flavonoids.TheGanoderma lucidum kuperekedwa poyesa nyama, kaya imatengedwa pakamwa kapena jekeseni, imawerengedwa pa mlingo wa tsiku ndi tsiku wa 500 mg/kg.

(1)Ganoderma lucidum amachepetsa kuwonongeka kwa hepatocellular

Pakatha masiku 10, zitha kuwoneka kuti cisplatin imachulukitsa kuchuluka kwa hepatitis ndi kuchuluka kwa bilirubin mu seramu ya makoswe.Izi ndi zizindikiro zonse za kuvulala kwa hepatocellular.Koma ngatiGanoderma lucidum ikukhudzidwa panthawi imodzimodziyo, mtengo wowonjezereka ukhoza kuchepetsedwa kwambiri (Chithunzi 1).

Gwero la Data / Mankhwala Des Devel Ther.2020;14:2335-2353.

Chithunzi 1 Zotsatira za cisplatin ndiGanoderma lucidum pa zizindikiro zovulaza chiwindi

Ikani gawo la minofu ya chiwindi pansi pa maikulosikopu, ndipo mukhoza kuona kuti cisplatin ikhoza kuyambitsa chiwindi (magazi omwe amayenera kubwerera kumtima atsekeka ndipo amasunthika m'mitsempha ya hepatic), kuwonongeka kwa maselo (ma vacuoles akuwonekera, komwe ndiko kusintha koyambirira mu kuvulala kwa ma cell), apoptosis ndi necrosis, koma izi zitha kuchepetsedwa pogwiritsa ntchitoGanoderma lucidum.

Chithunzi 2 Zotsatira za cisplatin ndiGanoderma lucidum pa hepatocytes

(2)Ganoderma lucidum kumawonjezera antioxidant mphamvu ya maselo a chiwindi

Nkhaniyi ikufaniziranso kuwonongeka kwa okosijeni komwe gulu lililonse la minyewa ya chiwindi.Pali ziwonetsero ziwiri: MDA (malondialdehyde), chinthu chomwe chimapangidwa pambuyo pa kuwonongedwa kwa ma cell ndi ma free radicals, ndi H₂O₂ (hydrogen peroxide), chinthu chapakatikati chomwe chimapangidwa pambuyo pa metabolism ya ma free radicals ndi ma enzymes a antioxidant.

Zonsezi zili ndi mphamvu ya okosijeni ya ma radicals aulere ndipo ziyenera kuthandizidwanso zisanathe kukhala "zodetsedwa", kotero kuchuluka kwake kungatiuze kuwonongeka kwa okosijeni komwe minofu ya chiwindi. “ali kuzunzika” ndi “adzamva zowawa”.

Mwachiwonekere, cisplatin idzayambitsa kuwonongeka kwakukulu kwa okosijeni ku chiwindi, koma ngatiGanoderma lucidum akuphatikizidwa Mu chithandizo nthawi yomweyo, kuwonongeka kotereku kumatha kuchepetsedwa (Chithunzi 3).

Chifukwa kusintha kwa kuchuluka kwa ma enzymes a antioxidant (SOD ndi GSH) m'chiwindi cha gulu lililonse komanso kusintha kwa zizindikiro zowonongeka kwa okosijeni kunawonetsa zosiyana kwambiri., zikhoza kuganiziridwa kutiGanoderma lucidumidzawonjezera mphamvu ya antioxidant ya minofu ya chiwindi ndikuchepetsa kuwonongeka mwa "kuwonjezera ma enzymes a antioxidant".

Chithunzi3 Zotsatira za cisplatin ndiGanoderma lucidum pa kuwonongeka kwa okosijeni kwa minofu ya chiwindi

(3)Ganoderma lucidum kumawonjezera odana ndi yotupa mphamvu ya chiwindi maselo

Cisplatin imawopseza kupulumuka kwa ma cell ndikuwononga DNA ndikupangitsa kuchuluka kwa ma radicals aulere;Ma cell omwe akupanikizika amatsegula master switch NF-kB yomwe imayang'anira kuyankhidwa kwa kutupa, kupangitsa maselo kupanga ndikutulutsa chotupa necrosis factor (TNF-α) ndi ma cytokines ena kuti ayambitse funde loyamba lazotupa ndikuwomba alamu kuti chitetezo chitetezeke.

Mwamsanga pambuyo pake, maselo omwe amaphedwa ndi kuwonongeka kwa okosijeni kapena kutupa adzatulutsa cytokine ina, HMGB-1, kuti ayambe kuyambitsa maselo ambiri a chitetezo cha mthupi, kuyambitsa mafunde a kutupa.

Kutupa kosalekeza sikungowonjezera kuwonongeka kwa okosijeni komanso kuyendetsa maselo ambiri ku imfa, komanso kuchititsa kuti minofu ya chiwindi ikhale ndi fibrosis pang'onopang'ono panthawi ya kutupa ndi kukonzanso mobwerezabwereza.

Mwamwayi, mongaGanoderma lucidum amatha kuchepetsa kuwonongeka kwa okosijeni komwe kumachitika chifukwa cha cisplatin, kuyesa kwa nyama kunatsimikiziranso kuti kugwiritsa ntchito cisplatin ndiGanoderma lucidum ikhoza kuletsa kuyambitsa kwa NF-kB, kuchepetsa kutupa-kulimbikitsa TNF-Andi HMGB-1, ndikuwonjezeraanti-inflammatory cytokine IL-10m'matumbo a chiwindi nthawi yomweyo (Chithunzi 4).

Kutengedwa palimodzi, zotsatirazi sizimangoletsa kutupa komanso zimachepetsa kuyika kwa collagen ndikuletsa kukula kwa chiwindi fibrosis (Chithunzi 5).

Gwero la Data / Mankhwala Des Devel Ther.2020;14: 2335-2353.

Chithunzi 4 Zotsatira za cisplatin ndiGanoderma lucidum pa kutupa kwa chiwindi minofu

Gwero la Data / Mankhwala Des Devel Ther.2020;14: 2335-2353.

Chithunzi 5 Zotsatira za cisplatin ndi Ganoderma lucidum pa chiwindi fibrosis

(4)Ganoderma lucidum kumawonjezera mphamvu ya anti-apoptotic ya maselo a chiwindi

Kaya chifukwa cha kuwonongeka kwa okosijeni kapena kuwonongeka kwa kutupa, cisplatin pamapeto pake idzayambitsa makina a "apoptosis" ndikukakamiza maselo a chiwindi kufa.

Mwa kuyankhula kwina, ngati maselo a chiwindi akhoza kugwira mzere wotsiriza wa chitetezo, adzakhala ndi mwayi wochuluka wopulumuka ndikuchepetsa kuopsa kwa kuwonongeka kwa chiwindi.

Pali mamolekyu ambiri a protein omwe amawongolera apoptosis.Pakati pawo, omwe amaimira kwambiri ndi awa: p53, yomwe imatha kulimbikitsa apoptosis, Bcl-2, yomwe ingalepheretse apoptosis, ndi caspase-3, yomwe imayambitsa apoptosis pamphindi yomaliza.

Malinga ndi ofufuza'kusanthula kwa minyewa ya chiwindi ya nyama zoyesera pagulu lililonse,Ganoderma lucidum sizingangolimbikitsa kufotokozera kwa Bcl-2 komanso kulepheretsa mawu a p53 ndi caspase-3, omwe angapereke mphamvu zamphamvu zotsutsana ndi apoptotic kwa maselo a chiwindi.

(5) Ma asidi a Ganoderic amagwira ntchito yofunika kwambiri yolimbana ndi kutupa

Kuchokera ku anti-oxidation, anti-inflammation, anti-apoptosis kupita ku ntchito yeniyeni yochepetsera kuwonongeka kwa chiwindi, ochita kafukufuku apanga njira yaGanoderma lucidum poletsa cisplatin hepatotoxicity mu chithunzi chotsatirachi kuti mufotokozere.

Gwero la Data / Mankhwala Des Devel Ther.2020;14: 2335-2353.

Chithunzi 6 Njira ya Ganoderma lucidum poletsa chiwopsezo cha chiwindi cha cisplatin

Pamapeto pa phunziroli, kusanthula kwa“molecular docking kayeseleledwe kachitidwe”anapeza kuti osachepera 14 ganoderic zidulo mu triterpenes waGanoderma lucidum (monga momwe tawonetsera mu tebulo ili m'munsimu) akhoza kumangirira mwachindunji ndi mogwira mtima ku cytokine yaikulu HMGB-1, motero kulepheretsa ntchito yotsutsa-kutupa ya HMGB-1.

Popeza odana ndi kutupa ndi imodzi mwa njira zofunika zaGanoderma lucidum kuchepetsa kuopsa kwa hepatotoxicity ya Cisplatin,“chuma mu Ganoderic asidi”chakhala chizindikiro chigawo chaGanoderma lucidum kuteteza chiwindi.

Ndi mtundu wanjiGanoderma lucidum chopangiras ikhoza kukhala ndi Ganoder yochulukaic asidis?Malinga ndi kafukufuku wakale, zimadziwika kuti amapezeka makamaka mu "Ganoderma lucidum zipatsondi kutulutsa mowa kwa thupi”.

Ndikoyenera kutchula kuti makoswe muGanoderma lucidum gulu limene linangodyaGanoderma lucidum pafupifupi ofanana ndi makoswe mukulamulira gulu muzotsatira zoyesera zomwe tatchulazi, kusonyeza kutiGanoderma lucidum ndizotetezeka kwambiri kuti zitha kudyedwa.

Komanso, njira yogwiritsira ntchitoGanoderma lucidum ndi zofunikanso kwambiri.Ngati mukulolera revuwu tchati chomwe chawonetsedwa m'nkhaniyi, sizovuta kupeza kuti "EkwambiriDay Gulu” imakhala ndi zotsatira zabwino kwambiri.

Pamenepo, EkwambiriDay Gulu has zotsatira zabwino mu kuchepetsa chiwindindi kuopsa kwa aimpso kwa cisplatin pakuyesa nyama,chomwe chiri zosiyanat ku zinaGanoderma lucidum magulu.

Kodi zotsatira zabwino zomwe tazitchulazi ndi ziti?Yang'anirani "Gawo 2Ganoderma lucidum amateteza impso vs. Cisplatin nephrotoxicity”.

[Magwero a Data]

1.Hanan M Hassan, et al.Kuponderezedwa kwa Cisplatin-Induced Hepatic Kuvulala mu Makoswe Kupyolera mu Alarmin High-Mobility Group Box-1 Pathway ndiGanoderma lucidum: Maphunziro a Theoretical and Experimental.Mankhwala Devel Ther.2020; 14: 2335-2353.

2.Yasmen F Mahran, et al.Ganoderma lucidumImateteza Nephrotoxicity Yopangidwa ndi Cisplatin Kupyolera mu Kuletsa Epidermal Growth Factor Receptor Signaling ndi Autophagy-Mediated Apoptosis.Oxid Med Cell Longev.2020. doi: 10.1155/2020/4932587.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao

Wu Tingyao wakhala akunena za zomwe zikuchitikaGanoderma lucidumzambiri kuyambira 1999. Iye ndi mlembi waKuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).

★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba, ndipo umwini ndi wa GANOHERB ★ Ntchito zomwe zili pamwambazi sizingapangidwenso, kuchotsedwa kapena kugwiritsidwa ntchito m'njira zina popanda chilolezo cha GanoHerb ★ Ngati ntchitozo zaloledwa kugwiritsidwa ntchito, iwo ziyenera kugwiritsidwa ntchito mkati mwa chilolezo ndikuwonetsa gwero: GanoHerb ★ Kuphwanya mawu omwe ali pamwambawa, GanoHerb idzakwaniritsa udindo wake wokhudzana ndi malamulo ★ Zolemba zoyambirira za nkhaniyi zinalembedwa m'Chitchaina ndi Wu Tingyao ndikumasuliridwa ku Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.

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