Chemotherapykuvadzas chiropa neitsvo apoLingzhini (ndinonziwoGanoderma lucidum kana Reishi mushroom) inodzivirira chiropa neitsvo.

InogonaGanoderma lucidum kutsungirira kukuvadzwa kwechiropa uye itsvo kunokonzerwa nechemotherapy?

Chikwata chakaumbwa naProfessor Hanan M Hassan kubva kuFaculty of Pharmacy yeDelta University yeScience & Technology muEgypt naMuzvinafundo Yasmen F Mahran vanobva kuFaculty of Pharmacy yeAin Shams University kuEgypt vakashandisa cisplatin, mushonga unozivikanwa wechivanhu chemotherapy, kuyedza. mukana weGanoderma lucidum mukudzivirira masero echiropa neitsvo kubva pakukuvara kwecisplatin.

Mhedzisiro yavo yekutsvagisa yakakamurwa kuita zvinyorwa zviviri: imwe iri kuchengetedza chiropa nepo imwe ichidzivirira itsvo.Vakaburitswa mu "Drug Design, Development uye Therapy" uye "Oxidative Medicine uye Cellular Longevity" munaJune naChikunguru 2020, zvichiteerana.

Iyo anti-oxidant, anti-inflammatory uye anti-apoptotic mhedzisiro yeGanoderma lucidum zvinogona kuvharisa kukuvara kwakawanda kweoxidative, kukuvara kwekuzvimba uye sero apoptosis inokonzereswa necisplatin, uye dziviriro yakadaro inoshanda kumaseru echiropa kana maseru eitsvo.Izvi hazvingoratidzi kukosha kwehuviri hwekurapa kweGanoderma lucidum asi inopawo nzira inokwanisika yekudzivirira yekenza chemotherapy.

Kuti tisaite kuti chinyorwa ichi chirebe, munyori anosuma basa reGanoderma lucidum muchikamu ichi muzvikamu zviviri mune tariro yekuti idzi data yakavakirwa nesainzi uye humbowo huchaunza kuvimba kwakawanda kune shamwari dzinotsvaga kuderedza mhedzisiro yechemotherapy.

Chikamu 1Ganoderma lucidum inodzivirira chiropa vs. cisplatin hepatotoxicity

The rvaongorori vakaenzanisa musiyanospakati pekushandisa nekusashandisaGanoderma lucidumpanguva yekurapa cisplatinmumapoka matanhatu emakonzo ane hutano uye misiyano yekudzivirira kukuvara kwechiropa neakasiyanaGanoderma lucidum nzira dzekutonga.Vari:

◆Control Group (Cont): boka risingagamuchiri chero kurapwa;

◆Ganoderma lucidumGroup(GL): boka risina kubaiwa necisplatin asi rinodyaGanoderma lucidum mazuva ese;

◆Cisplatin Group (CP): boka rinongobaiwa ne cisplatin asi risingadyiGanoderma lucidum;

◆Everyday Group (Daily): boka rinobaiwa ne cisplatinuye anodyaGanoderma Lucidum mazuva ese;

◆Rimwe nerimwe Rimwe Zuva Boka (EOD): boka rinobaiwa ne cisplatinuye anodyaGanoderma lucidum mamwe mazuva ose;

◆Intraperitoneal Group (ip): boka rinobaiwa cisplatinuye anogamuchira intraperitonealinjection ofGanoderma lucidum.

Vese vakagamuchira cisplatin vakabayiwa intraperitoneally ne 12 mg/kg yeCisplatinpazuva rekutanga rekuedza kukonzeresa kukuvara kwakanyanya kwechiropa;avo vakagamuchira intraperitoneal jekiseni reGanoderma lucidum dzakabayiwa kamwe chete pazuva rechipiri nerechitanhatu rekuedza.

TheGanoderma lucidum inoshandiswa muyedzo ine zvinhu zvinoshanda senge triterpenes, sterols, polysaccharides, polyphenols uye flavonoids.TheGanoderma lucidum yakapihwa mukuedza kwemhuka, ingave inotorwa nemuromo kana nejekiseni, inoverengerwa pachiyero chezuva nezuva che500 mg/kg.

(1)Ganoderma lucidum inoderedza kukuvara kwehepatocellular

Mushure memazuva gumi, zvinogona kuonekwa kuti cisplatin ichawedzera hepatitis index uye huwandu hwebilirubin museramu yemakonzo.Izvi zvese zviratidzo zvekukuvara kwehepatocellular.Asi kanaGanoderma lucidum inobatanidzwa panguva imwechete, kukosha kwakawedzerwa kunogona kuderedzwa zvakanyanya (Mufananidzo 1).

Data Source/Drug Des Devel Ther.2020;14:2335-2353.

Mufananidzo 1 Migumisiro ye cisplatin uyeGanoderma lucidum pane zviratidzo zvekukuvara kwechiropa

Isa chikamu chechiropa pasi pemaikorosikopu, uye iwe unogona kuona kuti cisplatin inogona kukonzera kusangana kwechiropa (ropa rinofanira kudzokera kumoyo rakavharika uye rinomira mutsinga dzehepatic), kuderera kwesero (vacuoles inooneka, inova shanduko yekutanga muropa). kukuvara kwemasero), apoptosis uye necrosis, asi mamiriro aya anogona zvakare kudzikiswa nekushandisaGanoderma lucidum.

Mufananidzo 2 Migumisiro ye cisplatin uyeGanoderma lucidum pane hepatocytes

(2)Ganoderma lucidum inowedzera antioxidant simba remasero echiropa

Ichi chinyorwa chinowedzera kufananidza kukuvadzwa kweiyo oxidative inobatwa neboka rega rega rechiropa tishu.Pane zviratidzo zviviri zvekucherechedza: MDA (malondialdehyde), chigadzirwa chakaumbwa mushure mekuparadzwa kwesero membranes nemahara radicals, uye H₂O₂ (hydrogen peroxide), chigadzirwa chepakati chakaumbwa mushure memetabolism yemahara radicals ne antioxidant enzymes.

Zvese zviri zviviri zvigadzirwa zvine oxidative zvimiro zvemahara radicals uye zvinofanirwa kurapwa zvakare zvisati zvanyatso "detoxified", saka huwandu hwazvo hunogona kutiudza kukuvadzwa kweoxidative iyo chiropa tishu. “ane akatambura” uye “achatambura”.

Zviripachena, cisplatin ichakonzera kukuvara kukuru kweoxidative kune chiropa tishu, asi kanaGanoderma lucidum inobatanidzwa Mukurapa panguva imwechete, kukanganisa kwakadaro kunogona kuderedzwa (Mufananidzo 3).

Nekuti shanduko mukusangana kweantioxidant enzymes (SOD neGSH) mumatishu echiropa eboka rega rega uye shanduko yeoxidative kukuvara zviratidzo zvakaratidza zvinopesana zvachose., zvinogona kutaurwa kutiGanoderma lucidumichawedzera iyo antioxidant kugona kwechiropa tishu uye kuderedza kukuvadzwa ne "kuwedzera antioxidant enzymes".

Mufananidzo3 Migumisiro ye cisplatin uyeGanoderma lucidum pane oxidative kukuvara kwechiropa tishu

(3)Ganoderma lucidum inowedzera simba rinopesana nekuputika kwemasero echiropa

Cisplatin inotyisidzira kupona kwemasero nekukuvadza DNA uye kukwezva nhamba huru yemahara radicals;maseru ari pasi pekumanikidzwa anovhura master switch NF-kB inodzora kuzvimba kupindura, zvichiita kuti masero agadzire uye abudise tumor necrosis factor (TNF-α) uye mamwe ma cytokines kuti avhure iyo yekutanga wave yekuzvimba maitiro uye kuridza alarm yekudzivirira.

Pakarepo mushure mezvo, masero aya anourayiwa nekukuvara kweoxidative kana kuzvimba anoburitsa imwe cytokine, HMGB-1, kuti iite kuti mamwe masero edziviriro ashande, zvichikonzera mafungu ekuzvimba.

Kuenderera mberi kwekuzvimba hakuzongowedzera kukuvadzwa kweoxidative asiwo kutyaira mamwe maseru kufa, uye kukonzeresa kuti chiropa chiite fibrosis zvishoma nezvishoma panguva yekudzokorora kuzvimba nekugadzirisa.

Sezvineiwo, sezvakangoitaGanoderma lucidum inogona kuderedza kukuvadzwa kweoxidative kunokonzerwa necisplatin, kuyedza kwemhuka kwakasimbisawo kuti kushandiswa kwakasanganiswa kwecisplatin uye.Ganoderma lucidum inogona kurambidza kushandiswa kwekushandura NF-kB, kuderedza kupisa-kukurudzira TNF-αuye HMGB-1, uye kuwedzeraiyo inopesana nekuputika cytokine IL-10muzvikamu zvechiropa panguva imwe chete (Mufananidzo 4).

Kutorwa pamwechete, izvi zvinokonzeresa hazvingodzivise kuzvimba asiwo zvinoderedza collagen deposition uye kudzivirira kufambira mberi kwechiropa fibrosis (Mufananidzo 5).

Data Source/Drug Des Devel Ther.2020;14: 2335-2353.

Mufananidzo 4 Migumisiro ye cisplatin uyeGanoderma lucidum pakuzvimba kwechiropa tishu

Data Source/Drug Des Devel Ther.2020;14: 2335-2353.

Mufananidzo 5 Mhedzisiro yecisplatin uye Ganoderma lucidum pachiropa fibrosis

(4)Ganoderma lucidum inowedzera anti-apoptotic kugona kwemasero echiropa

Kunyangwe kuburikidza nekukuvara kweoxidative kana kukuvara kwekuzvimba, cisplatin inozopedzisira yaita "apoptosis" mashandiro uye kumanikidza masero echiropa kufa.

Mune mamwe mazwi, kana masero echiropa achigona kubata mutsara wekupedzisira wekudzivirira, vanova nemikana yakawanda yekurarama uye kuderedza kuoma kwekukuvara kwechiropa.

Kune akawanda mapuroteni mamorekuru anogadzirisa apoptosis.Pakati pavo, iyo inomiririra yakawanda ndeye: p53, iyo inogona kukurudzira apoptosis, Bcl-2, iyo inogona kudzivisa apoptosis, uye caspase-3, iyo inouraya apoptosis paminiti yekupedzisira.

Maererano nevatsvakurudzi'kuongororwa kwechiropa chemhuka dzekuedza muboka rimwe nerimwe,Ganoderma lucidum haigoni kungokurudzira kutaura kweBcl-2 asiwo inhibisa kutaura kwep53 uye caspase-3, iyo inogona kupa simba rinopesana neapoptotic simba remasero eropa.

(5) Ganoderic acids inoita basa rinokosha rinopesana nekuputika

Kubva ku-anti-oxidation, anti-inflammation, anti-apoptosis kusvika pakuita chaiko kwekuderedza kukuvadzwa kwechiropa, vatsvakurudzi vakanyora nzira yeGanoderma lucidum mukuvharisa cisplatin hepatotoxicity mudhiyagiramu inotevera yereferensi yako.

Data Source/Drug Des Devel Ther.2020;14: 2335-2353.

Mufananidzo 6 Iyo nzira yeGanoderma lucidum mukudzivisa chiropa chehutu hwe cisplatin.

Mukupera kwechidzidzo ichi, ongororo ye“molecular docking simulation system”akawana kuti angangoita gumi nemana ganoderic acids mune triterpenes yeGanoderma lucidum (sezvinoratidzwa mutafura iri pasi apa) inogona kusungira zvakananga uye zvinobudirira kukiyi cytokine HMGB-1, nokudaro kumisa basa re-pro-inflammatory reHMGB-1.

Sezvo anti-kuzvimba ndeimwe yenzira dzakakosha dzeGanoderma lucidum kuderedza Cisplatin-induced hepatotoxicity,“hupfumi muGanoderic acid”chave chiratidzo chechikamu cheGanoderma lucidum kudzivirira chiropa.

ChirudziiGanoderma lucidum ingredients inogona kuva neGanoder yakawanda kudaroic acids?Zvinoenderana netsvagiridzo yapfuura, zvinozivikanwa kuti ivo varipo zvakanyanya mu "Ganoderma lucidum mucheroing body alcohol extract”.

Zvakakodzera kutaura kuti makonzo ari muGanoderma lucidum boka raingodya cheteGanoderma lucidum anenge akafanana nemakonzo ari mucontrol boka mune zvambotaurwa pamusoro pekuedza, zvichiratidza izvozvoGanoderma lucidum yakachengeteka zvakanyanya kudyiwa.

Mukuwedzera, nzira yekushandisaGanoderma lucidum kunokoshawo zvikuru.Kana iwe uchida review chati inoratidzwa munyaya ino, hazvina kuoma kuwana kuti “EzvikuruDay Group” ine simba rakanakisisa.

Saizvozvo, EzvikuruDay Group has the best effect mukuderedza chiropauye renal toxicity ye cisplatin mukuedza kwemhuka,zvinova siyanat kubva zvimweGanoderma lucidum mapoka.

Ndedzipi kuratidzwa kwakananga kwemigumisiro yakanaka yataurwa pamusoro apa?Gara wakamirira "Chikamu 2Ganoderma lucidum inodzivirira itsvo vs. Cisplatin nephrotoxicity”.

[Data Kwakabva]

1.Hanan M Hassan, nevamwe.Kudzvinyirirwa kweCisplatin-Induced Hepatic Injury mumakonzo Kuburikidza neAlarmin High-Mobility Group Box-1 Pathway by.Ganoderma lucidum: Theoretical uye Kuedza Kudzidza.Zvinodhaka Devel Ther.2020;14: 2335-2353.

2.Yasmen F Mahran, nevamwe.Ganoderma lucidumInodzivirira Cisplatin-Induced Nephrotoxicity kuburikidza neInhibition yeEpidermal Growth Factor Receptor Signaling uye Autophagy-Mediated Apoptosis.Oxid Med Cell Longev.2020. doi: 10.1155/2020/4932587.

END

Nezve munyori/ Ms. Wu Tingyao

Wu Tingyao anga achitaura nezvekutanga-ruokoGanoderma lucidumruzivo kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★ Chinyorwa ichi chakaburitswa pasi pemvumo yakasarudzika yemunyori, uye muridzi ndeweGANOHERB ★ Mabasa ari pamusoro haagone kudhindwa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yeGanoHerb ★ Kana mabasa acho akatenderwa kushandiswa, iwo inofanira kushandiswa mukati mechikamu chemvumo uye kuratidza kwakabva: GanoHerb ★ Kutyorwa kwechirevo chiri pamusoro, GanoHerb ichaita mabasa ayo ane chekuita nemutemo ★ Zvinyorwa zvepakutanga zvechinyorwa ichi chakanyorwa muchiChinese naWu Tingyao uye chakashandurirwa muchiChirungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.

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