Iyo "Anti-Cancer Agents muMedicinal Chemistry" yakaburitswa zviri pamutemo muna Kukadzi 2020 yakaburitsa tsvakiridzo yechikwata chaProfessor Li Peng kubva kuChikoro cheFarmacy cheFujian Medical University.Tsvagiridzo yakasimbisa kuburikidza nesero uye mhuka kuyedza iyo yaakarerekera triterpenes kubvaGanoderma luciduminogona kumisa zvakanyanya kukura kwegomarara remukati, uye maitiro ayo ekuita ane hukama ne "kusimudzira cancer cell apoptosis."

Total Triterpenes = Neutral Triterpenes + Acidic Triterpenes

Kubva pakatanga kuwanikwa kweGanoderma lucidumtriterpenes muna 1982, masayendisiti haana kungopa tsananguro dzesainzi dze "neiGanoderma lucidumMitumbi inobereka michero inovava” asi yakapawo zvimwe zviratidzo kunze kwepolysaccharides yekudzidza kwe "NeiGanoderma lucidumane anti-tumor".

Ganoderma lucidumtriterpenes izita remubatanidzwa, iro rinoreva zvinhu zvinoshanda mukatiGanoderma lucidumine terpene chimiro.Zvinoenderana nechimiro chavo chemakemikari, vanogona kukamurwa kuita mapoka maviri: rimwe boka "acidic triterpenes" kusanganisira akasiyana ganoderic acids (acidic triterpene chikamu, ATF), uye rimwe boka "neutral triterpenes" kusanganisira akasiyana ganoderiols ("neutral triterpene chikamu ”, NTF).Kana mapoka maviri aya etriterpenes asanganiswa, anodaidzwa kunzi total triterpenes.

Kunyangwe paine humbowo hwakawanda hwesainzi hweiyo anti-tumor mhedzisiro yeGanoderma lucidumyakazara triterpenes uye acidic triterpenes, pane zvishoma zvidzidzo pamusoro pebasa reGanoderma lucidumneutral triterpenes panyaya iyi.Naizvozvo, timu yaProfessor Li Peng yakatarisana nechikamu ichi.

KushandisaGanoderma lucidumMiviri inobereka michero (yakapihwa naFujian Xianzhilou Biological Science and Technology Co., Ltd.) sechinhu chekuyedza, timu yakatanga kuburitsa iyo yakazara triterpenesGanoderma lucidumkubva kumitumbi inobereka michero yeGanoderma lucidumne ethanol, uyezve ndokuparadzanisa ma neutral triterpenes uye acidic triterpenes kuti vaongorore maitiro avo ekudzivisa pagomarara reruvara.

Kuedza kwesero: iyo inopesana nekenza mhedzisiro yekusarerekera triterpenes＞iyo inopesana nekenza mhedzisiro ye acidic triterpenes.

Vatsvakurudzi vakasiyana tsikaGanoderma lucidumneutral triterpenes uye acidic triterpenes ine matatu akasiyana marudzi emunhu colorectal cancer maseru kwemaawa makumi mana nemasere.Pamusoro pazvo,Ganoderma lucidumneutral triterpenes yaive yakanyanya nani inhibitory mhedzisiro pagomarara cell kukura (kuwanda) kupfuuraGanoderma lucidumacidic triterpenes (Mufananidzo 1).

Kuedza kwemhuka:Ganoderma lucidumneutral triterpenes zvinobudirira inhibit bundu kukura

Vatsvakurudzi vakaongorora zvakare anti-tumor migumisiro yeGanoderma lucidumneutral triterpenes in vivo kuburikidza nekuedza kwemhuka: Chekutanga, munhu colorectal cancer cell line SW620 ine lymphatic metastasis kugona yakaiswa pasi peganda re nude mbeva (immune-define mbeva).Mushure mekunge bundu rabuda, 250 mg/kg kana 500 mg/kg yeGanoderma lucidumma-neutral triterpenes anopihwa nemuromo kumakonzo mazuva ese.

Mushure memazuva gumi nematatu ekuedzwa, zvakaonekwa kuti kupindira kweGanoderma lucidumneutral triterpenes inogona kuita kuti mabundu akure zvishoma uye zvishoma, uye inhibitory maitiro anofananidzwa neayo echemotherapy drug 5-Fu (20 mg/kg intraperitoneal jekiseni pazuva), asi hazvikonzere kurasikirwa kwakakomba se5-Fu ( Mufananidzo 2-5).

Active ingredients: angangoita mapfumbamwe emhando dze triterpenes

Sezvambotaurwa munyaya yacho,Ganoderma lucidumneutral triterpenes zvakare musanganiswa, uyo une dzakasiyana siyana dzakasiyana triterpenes.Maererano nekuongorora kwemuongorori, zvakataurwa pamusoro apa zvakarerekera kune triterpenes yeGanoderma lucidum, iyo ine inhibitory mhedzisiro pane colorectal cancer, ine angangoita mapfumbamwe emhando dze triterpenes (Mufananidzo 6).

Mechanism yekuita: kukurudzira apoptosis yekenza maseru

Kana idzi pfumbamwe triterpenes dzakasimwa zvakasiyana neyemunhu colorectal cancer cell line SW620 in vitro, vanozowanikwa vachigona kana kushoma kuuraya maseru egomarara.

Vatsvakurudzi vakaongorora zvakare inomiririra ganoderma triterpene (ganodermanondiol) uye vakaona kuti inogona kutanga nzira yeapoptosis yemasero egomarara uye kusunda maseru egomarara kubva paatari isingaperi kuenda kugomba rerufu.Kubata kwayo kunoshanda (kuvharirwa kwehafu yekenza maseru) ndeye 11.17 μg/mL.

Uku kusungirirwa hakuna hutsinye pamasero akajairwa (mouse embryonic fibroblast cell line NIH3T3), uye kusungirirwa kunofanirwa kuwedzerwa kusvika kupfuura 80 μg/mL kuti kuve nemhedzisiro yakakosha (kudzivisa kupona kwehafu yembeva embryonic cell lines).Izvi zvinoreva kuti ganodermanondiol inogona kusiyanisa masero emukenza kubva kumasero akajairwa uye kupa "kurapa" kwakasiyana, kwakasiyana zvachose ne "zvose zvinouraya" zvinokonzerwa nemakemikari echemotherapeutic pamasero akanaka uye akaipa.

Kana avaGanoderma lucidumneutral triterpenes inotanga iyo apoptosis mashandiro ekenza maseru inowanikwa nekudzora mitochondria mumaseru egomarara inokodzera kuenderera mberi nekuferefetwa maererano nevaongorori.

[References]

Li P, nevamwe.Anti-Cancer Mhedzisiro yeNeutral Triterpene Fraction kubva kuGanoderma lucidum neAyo Active Constituents paSW620 Human Colorectal Cancer Cells.Anticancer Agents Med Chem.2020;20(2): 237-244.doi: 10.2174/1871520619666191015102442.

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Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achitaura nezvekutanga-ruoko Ganoderma ruzivo kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★ Chinyorwa ichi chakaburitswa pasi pemvumo yakasarudzika yemunyori, uye muridzi ndeweGANOHERB.★ Mabasa ari pamusoro haagone kudhindwa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yeGanoHerb.★ Kana mabasa akabvumirwa kushandiswa, anofanirwa kushandiswa mukati mechikamu chemvumo uye kuratidza kwakabva: GanoHerb.★ Pakutyorwa kwechirevo chiri pamusoro, GanoHerb ichatevera mabasa anoenderana nemutemo.★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.