"Anti-Cancer Agents in Medicinal Chemistry" yomwe idatulutsidwa mu February 2020 idafalitsa zotsatira za kafukufuku wa gulu la Pulofesa Li Peng waku School of Pharmacy of Fujian Medical University.Kafukufukuyu adatsimikizira kudzera mu kuyesa kwa ma cell ndi nyama komwe ma triterpenes osalowerera ndale adachokeraGanoderma lucidumikhoza kulepheretsa kukula kwa khansa ya m'mimba, ndipo kachitidwe kake kamagwirizana ndi "kulimbikitsa apoptosis ya khansa."

Total Triterpenes = Neutral Triterpenes + Acidic Triterpenes

Chiyambireni kupezeka koyamba kwaGanoderma lucidumtriterpenes mu 1982, asayansi sanangopereka mafotokozedwe asayansi a “chifukwa chiyaniGanoderma lucidummatupi obala zipatso ndi owawa kwambiri" komanso amaperekanso zowunikira zina kupatula ma polysaccharides pophunzira "Chifukwa chiyaniGanoderma lucidumndi anti-chotupa. "

Ganoderma lucidumtriterpenes ndi dzina lophatikizana, lomwe limatanthawuza zomwe zimagwira ntchito muGanoderma lucidumndi terpene kapangidwe.Malinga ndi kapangidwe kawo ka mankhwala, amatha kugawidwa m'magulu awiri: gulu limodzi ndi "acidic triterpenes" kuphatikiza ma ganoderic acid (gawo la acidic triterpene, ATF), gulu lina ndi "neutral triterpenes" kuphatikiza ma ganoderiols osiyanasiyana ("neutral triterpene fraction" ", NTF).Pamene magulu awiriwa a triterpenes aphatikizidwa, amatchedwa ma triterpenes okwana.

Ngakhale pali umboni wambiri wa sayansi wotsutsa-chotupa zotsatira zaGanoderma lucidumokwana triterpenes ndi acidic triterpenes, pali maphunziro ochepa pa udindo waGanoderma lucidumndale triterpenes pankhaniyi.Chifukwa chake, gulu la Pulofesa Li Peng lidayang'ana gawo ili.

KugwiritsaGanoderma lucidummatupi a fruiting (operekedwa ndi Fujian Xianzhilou Biological Science and Technology Co., Ltd.) monga zinthu zoyesera, gululo linatulutsa koyamba ma triterpenes okwana.Ganoderma lucidumkuchokera ku matupi obala zipatso aGanoderma lucidumndi ethanol, kenako analekanitsa ndale triterpenes ndi acidic triterpenes kufufuza awo chopinga zotsatira pa colorectal khansa.

Kuyesera kwa ma cell: anti-cancer effect of neutral triterpenes＞the anti-cancer effect of acidic triterpenes

Ofufuza payokha chikhalidweGanoderma lucidumma triterpenes osalowerera ndale ndi ma triterpenes a acidic okhala ndi mitundu itatu yosiyanasiyana ya ma cell a khansa ya colorectal kwa maola 48.Kuwombetsa mkota,Ganoderma lucidumma triterpenes osalowerera ndale anali ndi zotsatira zabwinoko zoletsa kukula kwa maselo a khansa (kuchuluka) kuposaGanoderma lucidumacidic triterpenes (Chithunzi 1).

Kuyesera kwa Zinyama:Ganoderma lucidumneutral triterpenes amalepheretsa kukula kwa chotupa

Ofufuzawo adawunikanso zotsatira za anti-chotupa zaGanoderma lucidumma triterpenes osalowerera mu vivo kudzera pakuyesa nyama: Choyamba, cell cell ya khansa yamtundu wa SW620 yokhala ndi mphamvu ya lymphatic metastasis idayikidwa pansi pa khungu la mbewa zamaliseche (mbewa zopanda chitetezo chamthupi).Pambuyo chotupa chatulukira, 250 mg/kg kapena 500 mg/kg waGanoderma lucidumma triterpenes osalowerera ndale amaperekedwa pakamwa kwa mbewa tsiku lililonse.

Pambuyo pa masiku 13 akuyesa, adapeza kuti kulowererapo kwaGanoderma lucidumma triterpenes osalowerera ndale amatha kupangitsa kuti zotupa zizikula pang'onopang'ono komanso zing'onozing'ono, ndipo zotsatira zake zolepheretsa zimafanana ndi mankhwala a chemotherapy 5-Fu (20 mg/kg intraperitoneal jekeseni patsiku), koma sizimayambitsa kuwonda kwambiri ngati 5-Fu. Chithunzi 2-5).

Zomwe zimagwira ntchito: mitundu yosachepera isanu ndi inayi ya ma triterpenes

Monga tanenera poyamba paja,Ganoderma lucidumma triterpenes osalowerera nawonso ndi osakaniza, omwe amakhala ndi ma triterpenes osiyanasiyana.Malinga ndi kusanthula kwa ofufuza, zomwe tatchulazi za ndale triterpenes zaGanoderma lucidum, yomwe imalepheretsa khansa yapakhungu, imakhala ndi mitundu isanu ndi inayi ya triterpenes (Chithunzi 6).

Njira zochita: kulimbikitsa apoptosis ya maselo a khansa

Ngati ma triterpenes asanu ndi anayiwa atakulitsidwa padera ndi mzere wa khansa ya colorectal cell SW620 mu vitro, apezeka kuti amatha kupha ma cell a khansa.

Ofufuzawo adafufuzanso ganoderma triterpene (ganodermanondiol) yoyimilira kwambiri ndipo adapeza kuti imatha kuyambitsa njira ya apoptosis yama cell a khansa ndikukankhira ma cell a khansa kuchokera paguwa losatha kupita kuphompho la imfa.Kukhazikika kwake kothandiza (kuletsa theka la maselo a khansa) ndi 11.17 μg/mL.

Kuphatikizikaku kulibe kupha pama cell abwinobwino (mouse embryonic fibroblast cell line NIH3T3), ndipo ndendeyi iyenera kukulitsidwa kupitilira 80 μg/mL kuti ikhale ndi zotsatira zazikulu (kuletsa kupulumuka kwa theka la mizere yama cell embryonic mbewa).Izi zikutanthauza kuti ganodermanondiol imatha kusiyanitsa maselo a khansa kuchokera ku maselo abwinobwino ndikupereka "mankhwala" osiyanasiyana, omwe ndi osiyana kwambiri ndi "kupha zonse" zotsatira za mankhwala a chemotherapeutic pa maselo abwino ndi oipa.

Kaya iziGanoderma lucidumndale triterpenes kuyambitsa njira ya apoptosis ya maselo a khansa imatheka powongolera mitochondria m'maselo a khansa ndiyoyenera kufufuzidwa mopitilira malinga ndi ofufuza.

[Maumboni]

Li P, ndi al.Anti-Cancer Effects of Neutral Triterpene Fraction from Ganoderma lucidum and its Active Constituents on SW620 Human Colorectal Cancer Cells.Anticancer Agents Med Chem.2020;20 (2): 237-244.doi: 10.2174/1871520619666191015102442.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao
Wu Tingyao wakhala akunena za Ganoderma woyamba zambiri kuyambira 1999. Iye ndi mlembi waKuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).

★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba, ndipo umwini ndi wa GANOHERB.★ Ntchito zomwe zili pamwambazi sizingapangidwenso, kuchotsedwa kapena kugwiritsidwa ntchito m'njira zina popanda chilolezo cha GanoHerb.★ Ngati ntchitozo zaloledwa kugwiritsidwa ntchito, ziyenera kugwiritsidwa ntchito molingana ndi chilolezo ndikuwonetsa gwero: GanoHerb.★ Pakuphwanya kulikonse kwa mawu omwe ali pamwambapa, GanoHerb idzatsata maudindo okhudzana ndi zamalamulo.★ Zolemba zoyambirira za nkhaniyi zidalembedwa m'Chitchaina ndi Wu Tingyao ndikumasulira m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.