The "Anti-Cancer Agents in Medicinal Chemistry" da aka fito a hukumance a watan Fabrairu 2020 buga sakamakon bincike na tawagar Farfesa Li Peng daga Makarantar Pharmacy na Fujian Medical University.Binciken ya tabbatar ta hanyar gwaje-gwajen tantanin halitta da na dabba waɗanda triterpenes tsaka tsaki dagaGanoderma lucidumna iya hana ci gaban ciwon daji na colorectal sosai, kuma tsarin aikinsa yana da alaƙa da “inganta apoptosis cell cancer.”

Jimlar Triterpenes = Triterpenes Neutral + Acidic Triterpenes

Tun farkon ganoGanoderma lucidumtriterpenes a cikin 1982, masana kimiyya ba wai kawai sun ba da bayanin kimiyya ba don “me yasaGanoderma lucidumJikin 'ya'yan itace suna da ɗaci sosai" amma kuma sun ba da alamu ban da polysaccharides don nazarin "Me yasaGanoderma lucidumanti-tumor ne".

Ganoderma lucidumtriterpenes suna ne na gamayya, wanda ke nufin abubuwan da ke aiki a cikiGanoderma lucidumtare da tsarin terpene.Dangane da tsarin sinadarai, ana iya raba su zuwa ƙungiyoyi biyu: rukuni ɗaya shine "acid triterpenes" ciki har da ganoderic acid daban-daban (acid triterpene fraction, ATF), ɗayan kuma shine "tsaka-tsaki" ciki har da ganoderiols daban-daban ("tsaka tsaki triterpene fraction). ", NTF).Lokacin da aka haɗa waɗannan ƙungiyoyi biyu na triterpenes, ana kiran su duka triterpenes.

Ko da yake akwai shaidun kimiyya da yawa game da tasirin cutar kansaGanoderma lucidumjimlar triterpenes da acidic triterpenes, akwai 'yan nazarin kan rawarGanoderma lucidumtsaka tsaki triterpenes a wannan batun.Don haka, tawagar Farfesa Li Peng ta mayar da hankali kan wannan bangare.

AmfaniGanoderma lucidum'ya'yan itace (wanda Fujian Xianzhilou Kimiyyar Halittu da Fasaha Co., Ltd ya samar) a matsayin kayan gwaji, ƙungiyar ta fara fitar da jimillar triterpenes.Ganoderma lucidumdaga fruiting jikinGanoderma lucidumtare da ethanol, sa'an nan kuma ya kara raba tsaka tsaki triterpenes da acidic triterpenes don gano tasirin hana su akan ciwon daji na colorectal.

Gwajin kwayar halitta: tasirin anti-cancer na tsaka tsaki triterpenes; tasirin anti-cancer na triterpenes acidic

Masu binciken sun yi al'ada daban-dabanGanoderma lucidumtsaka tsaki triterpenes da acidic triterpenes tare da nau'ikan nau'ikan nau'ikan nau'ikan ciwon daji na launin fata guda uku na tsawon awanni 48.Baki daya,Ganoderma lucidumtsaka tsaki triterpenes yana da tasiri mafi kyau na hanawa akan ci gaban kwayar cutar kansa (yaduwa) fiye daGanoderma lucidumtriterpenes acidic (Hoto 1).

Gwajin dabba:Ganoderma lucidumtsaka tsaki triterpenes yadda ya kamata hana ƙari girma

Masu binciken sun kara tantance illar rigakafin cutar kansaGanoderma lucidumtsaka tsaki triterpenes a cikin vivo ta hanyar gwaje-gwajen dabba: Na farko, layin kwayar cutar kansar launi na ɗan adam SW620 tare da ikon metastasis na lymphatic an dasa shi a ƙarƙashin fata na berayen tsirara (mice marasa ƙarfi).Bayan ciwon daji ya fito, 250 mg / kg ko 500 mg / kg naGanoderma lucidumAna ba da triterpenes tsaka tsaki a baki ga mice kowace rana.

Bayan kwanaki 13 na gwaje-gwaje, an gano cewa shiga tsakani naGanoderma lucidumtsaka tsaki triterpenes na iya sa ciwace-ciwacen ciwace-ciwace suyi girma a hankali da ƙarami, kuma tasirin hanawa yana kama da na maganin chemotherapy 5-Fu (20 mg / kg allurar intraperitoneal kowace rana), amma baya haifar da asarar nauyi kamar 5-Fu ( Hoto na 2-5).

Abubuwan da ke aiki: aƙalla nau'ikan triterpenes guda tara

Kamar yadda aka ambata a baya a cikin labarin.Ganoderma lucidumtsaka tsaki triterpenes kuma cakuda ne, wanda ya ƙunshi nau'ikan triterpenes iri-iri.Bisa ga bincike ta bincike, sama da aka ambata tsaka tsaki triterpenes naGanoderma lucidum, wanda ke da tasiri mai hanawa akan ciwon daji na launi, ya ƙunshi akalla nau'in triterpenes guda tara (Figure 6).

Hanyar aiki: don inganta apoptosis na kwayoyin cutar kansa

Idan waɗannan triterpenes guda tara an haɓaka su daban tare da layin kwayar cutar kansar launi na ɗan adam SW620 a cikin vitro, za a same su sun fi ko žasa iya kashe ƙwayoyin cutar kansa.

Masu binciken sun ci gaba da bincika mafi yawan wakilin ganoderma triterpene (ganodermanondiol) kuma sun gano cewa zai iya fara tsarin apoptosis na kwayoyin cutar ciwon daji da kuma tura kwayoyin cutar kansa daga bagade marar iyaka zuwa abyss na mutuwa.Mahimmancinsa mai mahimmanci (hanawa rabin ƙwayoyin ciwon daji) shine 11.17 μg / ml.

Wannan maida hankali ba shi da mutuwa a kan kwayoyin halitta na al'ada (layin fibroblast na linzamin kwamfuta NIH3T3), kuma dole ne a ƙara yawan maida hankali zuwa fiye da 80 μg / mL don samun tasiri mai mahimmanci (hana rayuwar rabin layin salula na linzamin kwamfuta).Wannan yana nufin cewa ganodermanondiol zai iya bambanta kwayoyin cutar kansa daga kwayoyin halitta na al'ada kuma ya ba da "magani" daban-daban, wanda ya bambanta da "dukkan kisa" sakamakon magungunan chemotherapeutic akan kwayoyin kirki da marasa kyau.

Ko wadannanGanoderma lucidumtsaka tsaki triterpenes fara tsarin apoptosis na kwayoyin cutar kansa ana samun su ta hanyar daidaita mitochondria a cikin ƙwayoyin kansa ya cancanci ƙarin bincike a cewar masu binciken.

[Magana]

Li P, et al.Sakamakon Anti-Cancer na Juzu'in Triterpene Neutral daga Ganoderma lucidum da Abubuwan da ke Aiki akan SW620 Ciwon Ciwon Ciwon Mutum.Ma'aikatan Anticancer Med Chem.2020;20 (2): 237-244.doi: 10.2174/1871520619666191015102442.

KARSHE

Game da marubucin / Ms. Wu Tingyao
Wu Tingyao ya kasance yana ba da rahoto game da Ganoderma na farko bayanai tun 1999. Ita ce marubucinWaraka tare da Ganoderma(an buga a The People's Medical Publishing House a Afrilu 2017).

★ An buga wannan labarin ne a ƙarƙashin izini na musamman na marubucin, kuma mallakin GANOHERB ne.★ Ayyukan da ke sama ba za a iya sake su ba, cire su ko amfani da su ta wasu hanyoyi ba tare da izinin GanoHerb ba.★ Idan an ba da izinin yin amfani da ayyukan, to a yi amfani da su cikin iyakar izini kuma a nuna tushen: GanoHerb.★ Duk wani keta bayanin da ke sama, GanoHerb za ta bi alhakin shari'a masu alaƙa.★ Asalin rubutun wannan labarin Wu Tingyao ne ya rubuta shi da Sinanci kuma Alfred Liu ya fassara shi zuwa Turanci.Idan akwai wani sabani tsakanin fassarar (Turanci) da na asali (China), asalin Sinanci zai yi nasara.Idan masu karatu suna da wasu tambayoyi, tuntuɓi marubuciyar asali, Ms. Wu Tingyao.