Cov "Anti-Cancer Agents in Medicinal Chemistry" tau tshaj tawm thaum Lub Ob Hlis 2020 tau tshaj tawm cov kev tshawb fawb los ntawm pab pawg xibfwb Li Peng los ntawm Tsev Kawm Ntawv Pharmacy ntawm Fujian Medical University.Kev tshawb fawb tau lees paub los ntawm kev sim ntawm tes thiab tsiaj txhu uas tsis muaj triterpenes los ntawmGanoderma lucidumtuaj yeem cuam tshuam kev loj hlob ntawm cov qog nqaij hlav hauv plab, thiab nws cov txheej txheem ntawm kev ua haujlwm cuam tshuam rau "txhim kho mob qog noj ntshav ntawm tes apoptosis."

Tag nrho Triterpenes = Neutral Triterpenes + Acid Triterpenes

Txij li thaum thawj discovery ntawmGanoderma lucidumtriterpenes hauv xyoo 1982, cov kws tshawb fawb tsis tau tsuas yog muab cov lus piav qhia txog "vim li casGanoderma lucidumTxiv hmab txiv ntoo lub cev yog iab heev” tab sis kuj muab cov ntsiab lus uas tsis yog polysaccharides rau kev kawm ntawm “Vim li casGanoderma lucidumyog anti-tumor."

Ganoderma lucidumtriterpenes yog lub npe sib sau ua ke, uas yog hais txog cov khoom xyaw nquag hauvGanoderma lucidumnrog terpene qauv.Raws li lawv cov qauv tshuaj, lawv tuaj yeem muab faib ua ob pawg: ib pawg yog "acidic triterpenes" suav nrog ntau yam ganoderic acids (acidic triterpene feem, ATF), thiab lwm pab pawg yog "tsis muaj triterpenes" nrog rau ntau yam ganoderiols ("nruab nrab triterpene feem. ", NTF).Thaum ob pawg ntawm triterpenes ua ke, lawv hu ua tag nrho triterpenes.

Txawm hais tias muaj ntau yam pov thawj scientific rau kev tiv thaiv qog nqaij hlav ntawmGanoderma lucidumtag nrho triterpenes thiab acidic triterpenes, muaj ob peb kev tshawb fawb txog lub luag hauj lwm ntawmGanoderma lucidumnruab nrab triterpenes nyob rau hauv no hais txog.Yog li ntawd, Xib Fwb Li Peng pab neeg tau tsom mus rau qhov no.

SivGanoderma lucidumTxiv hmab txiv ntoo lub cev (muab los ntawm Fujian Xianzhilou Biological Science thiab Technology Co., Ltd.) raws li cov khoom siv sim, pab pawg thawj zaug tau rho tawm tag nrho cov triterpenes ntawmGanoderma lucidumlos ntawm fruiting lub cev ntawmGanoderma lucidumnrog ethanol, thiab tom qab ntawd ntxiv cais cov nruab nrab triterpenes thiab acidic triterpenes los tshawb txog lawv cov nyhuv inhibitory ntawm mob qog noj ntshav.

Kev sim ntawm tes: kev tiv thaiv kab mob qog noj ntshav ntawm nruab nrab triterpenes ＞ cov tshuaj tiv thaiv qog noj ntshav ntawm acidic triterpenes

Cov kws tshawb fawb cais kab lis kev caiGanoderma lucidumnruab nrab triterpenes thiab acidic triterpenes nrog peb hom sib txawv ntawm tib neeg cov qog nqaij hlav hauv plab rau 48 teev.Ntawm tag nrho,Ganoderma lucidumnruab nrab triterpenes muaj qhov cuam tshuam zoo inhibitory ntawm cov qog nqaij hlav qog noj ntshav (proliferation) dua liGanoderma lucidumacidic triterpenes (Daim duab 1).

Tsiaj kev sim:Ganoderma lucidumnruab nrab triterpenes zoo inhibit qog loj hlob

Cov kws tshawb fawb tau soj ntsuam ntxiv txog kev tiv thaiv qog nqaij hlav ntawmGanoderma lucidumnruab nrab triterpenes hauv vivo los ntawm kev sim tsiaj: Ua ntej, tib neeg kab mob qog noj ntshav hauv lub cev SW620 nrog lymphatic metastasis muaj peev xwm tau cog rau hauv qab ntawm daim tawv nqaij ntawm cov nas liab qab (cov nas tsis muaj zog tiv thaiv kab mob).Tom qab cov qog tau tshwm sim, 250 mg / kg lossis 500 mg / kg ntawmGanoderma lucidumnruab nrab triterpenes tau muab qhov ncauj rau cov nas txhua hnub.

Tom qab 13 hnub ntawm kev sim, nws tau pom tias qhov kev cuam tshuam ntawmGanoderma lucidumnruab nrab triterpenes tuaj yeem ua rau cov qog loj hlob qeeb thiab me me, thiab nws cov nyhuv inhibitory yog piv rau cov tshuaj kho mob 5-Fu (20 mg / kg intraperitoneal txhaj ib hnub), tab sis nws tsis ua rau hnyav hnyav li 5-Fu ( Daim duab 2-5).

Cov khoom xyaw nquag: tsawg kawg yog cuaj hom triterpenes

Raws li tau hais ua ntej hauv kab lus,Ganoderma lucidumnruab nrab triterpenes kuj yog ib qho sib tov, uas muaj ntau yam sib txawv triterpenes.Raws li tus kws tshawb fawb soj ntsuam, cov saum toj no-hais txog nruab nrab triterpenes ntawmGanoderma lucidum, uas muaj kev cuam tshuam rau kev mob qog noj ntshav hauv plab, muaj tsawg kawg yog cuaj hom triterpenes (Daim duab 6).

Mechanism ntawm kev txiav txim: los txhawb apoptosis ntawm cov qog nqaij hlav cancer

Yog hais tias cuaj triterpenes no yog kab lis kev cai sib cais nrog tib neeg kab mob qog noj ntshav hauv lub cev SW620 hauv vitro, lawv yuav pom tias muaj peev xwm tua cov qog nqaij hlav cancer ntau dua.

Cov kws tshawb fawb tau tshawb nrhiav ntau tus neeg sawv cev ntawm ganoderma triterpene (ganodermanondiol) thiab pom tias nws tuaj yeem pib lub tshuab apoptosis ntawm cov qog nqaij hlav cancer thiab thawb cov qog nqaij hlav cancer los ntawm lub thaj tsis kawg mus rau qhov tob tob ntawm kev tuag.Nws cov concentration zoo (inhibition ntawm ib nrab ntawm cov qog nqaij hlav cancer) yog 11.17 μg / mL.

Qhov concentration no tsis muaj kev tuag ntawm cov hlwb ib txwm (mos embryonic fibroblast cell kab NIH3T3), thiab cov concentration yuav tsum tau nce mus rau ntau tshaj 80 μg / mL kom muaj txiaj ntsig zoo (txhim kho txoj sia ntawm ib nrab ntawm nas embryonic cell kab).Qhov no txhais tau hais tias ganodermanondiol tuaj yeem paub qhov txawv ntawm cov qog nqaij hlav qog nqaij hlav los ntawm cov hlwb ib txwm muaj thiab muab "kev kho mob", uas txawv kiag li ntawm "txhua yam tua" cov tshuaj chemotherapeutic ntawm cov hlwb zoo thiab phem.

Seb cov noGanoderma lucidumnruab nrab triterpenes pib lub apoptosis mechanism ntawm cov qog nqaij hlav cancer yog ua tiav los ntawm kev tswj cov mitochondria hauv cov qog nqaij hlav cancer yog tsim nyog rau kev tshawb nrhiav ntxiv raws li cov kws tshawb fawb.

[Cov ntaub ntawv]

Li P, et al.Anti-Cancer Effects of a Neutral Triterpene Fraction from Ganoderma lucidum and its Active Constituents on SW620 Human Colorectal Cancer Cells.Anticancer Agents Med Chem.2020;20(2): 237-244.doi: 10.2174/1871520619666191015102442 ib.

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Hais txog tus sau/ Ms. Wu Tingyao
Wu Tingyao tau tshaj tawm ntawm thawj txhais tes Ganoderma cov ntaub ntawv txij thaum 1999. Nws yog tus sau ntawmKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).

★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau, thiab cov tswv cuab yog GANOHERB.★ Cov haujlwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis muaj kev tso cai ntawm GanoHerb.★ Yog tias cov haujlwm tau tso cai siv, lawv yuav tsum tau siv nyob rau hauv qhov kev tso cai thiab qhia qhov chaw: GanoHerb.★ Rau ib qho kev ua txhaum cai ntawm cov lus hais saum toj no, GanoHerb yuav ua raws li cov luag haujlwm raug cai.★ Cov ntawv qub ntawm kab lus no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.