“Anti-Cancer Agents in Medicine Chemistry” yasohotse ku mugaragaro muri Gashyantare 2020 yashyize ahagaragara ibyavuye mu bushakashatsi bwakozwe n'itsinda rya Porofeseri Li Peng wo mu Ishuri rya Farumasi rya kaminuza y’ubuvuzi ya Fujian.Ubushakashatsi bwemeje binyuze mu bushakashatsi bwakagari n’inyamaswa ko triterpène idafite aho ibogamiyeGanoderma lucidumirashobora kubuza cyane gukura kwa kanseri yu mura, kandi uburyo bwayo bwo gukora bujyanye no "guteza imbere kanseri ya apoptose."

Triterpène Yose = Triterpène idafite aho ibogamiye + Acide Triterpène

Kuva ivumburwa rya mbere ryaGanoderma lucidumtriterpène mu 1982, abahanga ntabwo batanze ibisobanuro bya siyansi gusa "kukiGanoderma lucidumimibiri yera imbuto irakaze cyane "ariko inatanga ibimenyetso bitari polysaccharide yo kwiga" KukiGanoderma lucidumni kurwanya ibibyimba ”.

Ganoderma lucidumtriterpene ni izina rusange, ryerekeza kubintu bikora muriGanoderma lucidumhamwe na terpene.Ukurikije imiterere yimiti yabo, barashobora kugabanywamo amatsinda abiri: itsinda rimwe ni "acide triterpene" harimo acide zitandukanye za ganoderic (agace ka acide triterpene, ATF), naho irindi tsinda ni "triterpène itabogamye" harimo na ganoderiol zitandukanye ("agace kitagira aho kibogamiye. ”, NTF).Iyo ayo matsinda yombi ya triterpène ahujwe, yitwa triterpène yose.

Nubwo hari ibimenyetso byinshi bya siyansi byerekana ingaruka zo kurwanya ibibyimba byaGanoderma lucidumtriterpène yose hamwe na triterpène acide, hariho ubushakashatsi buke kuruhare rwaGanoderma lucidumkutabogama triterpène muriki kibazo.Kubwibyo, itsinda rya Porofeseri Li Peng ryibanze kuri iki gice.

GukoreshaGanoderma lucidumimibiri yera imbuto (yatanzwe na Fujian Xianzhilou Biologiya Science and Technology Co., Ltd.) nkibikoresho byubushakashatsi, itsinda ryabanje gukuramo triterpène zose zaGanoderma lucidumKuva ku mibiri yera imbuto yaGanoderma lucidumhamwe na Ethanol, hanyuma irusheho gutandukanya triterpène idafite aho ibogamiye na triterpène acide kugira ngo isuzume ingaruka zibuza kanseri yibara.

Ubushakashatsi bwakagari: ingaruka zo kurwanya kanseri ya triterpène idafite aho ibogamiye effect ingaruka zo kurwanya kanseri ya triterpène acide

Abashakashatsi bafite imico itandukanyeGanoderma lucidumkutabogama kwa triterpène na acide triterpène hamwe nubwoko butatu butandukanye bwa kanseri yibasira abantu mumasaha 48.Muri rusange,Ganoderma lucidumkutabogama kwa triterpène byagize ingaruka nziza cyane zo guhagarika imikurire ya kanseri (gukwirakwizwa) kurutaGanoderma lucidumacide triterpène (Ishusho 1).

Ubushakashatsi ku nyamaswa:Ganoderma lucidumkutabogama kwa triterpène bibuza neza gukura kwikibyimba

Abashakashatsi bakomeje gusuzuma ingaruka zo kurwanya ibibyimba byaGanoderma lucidumkutabogama kwa triterpène muri vivo binyuze mubushakashatsi bwinyamaswa: Ubwa mbere, umurongo wa kanseri yibara ya kanseri yumuntu SW620 hamwe nubushobozi bwa lymphatic metastasis yatewe munsi yuruhu rwimbeba zambaye ubusa (imbeba zidafite ubudahangarwa).Ikibyimba kimaze kugaragara, 250 mg / kg cyangwa 500 mg / kg yaGanoderma lucidumkutabogama kwa triterpene bihabwa umunwa imbeba burimunsi.

Nyuma yiminsi 13 yubushakashatsi, byagaragaye ko intervention yaGanoderma lucidumkutabogama kwa triterpène birashobora gutuma ibibyimba bikura buhoro kandi bito, kandi ingaruka zabyo zo kubuza kugereranywa nu muti wa chimiotherapie 5-Fu (inshinge 20 mg / kg inshinge za intraperitoneal kumunsi), ariko ntibitera kugabanuka cyane nka 5-Fu ( Igicapo 2-5).

Ibikoresho bifatika: byibura ubwoko icyenda bwa triterpene

Nkuko byavuzwe haruguru mu ngingo,Ganoderma lucidumkutabogama kwa triterpène nabyo ni imvange, irimo triterpene zitandukanye.Dukurikije isesengura ry’umushakashatsi, triterpène yavuzwe haruguru idafite aho ibogamiyeGanoderma lucidum, igira ingaruka mbi kuri kanseri yibara, irimo byibura ubwoko icyenda bwa triterpène (Ishusho 6).

Uburyo bwibikorwa: guteza imbere apoptose ya selile kanseri

Niba iyi triterpène icyenda itezimbere itandukanye hamwe numurongo wa kanseri ya kanseri yumuntu SW620 muri vitro, bazasanga bafite ubushobozi buke cyangwa buke bwo kwica selile.

Abashakashatsi bakomeje gukora ubushakashatsi kuri ganoderma triterpene ihagarariwe cyane (ganodermanondiol) basanga ishobora gutangiza uburyo bwa apoptose ya selile kanseri kandi igatera kanseri ya kanseri kuva ku gicaniro kitagira iherezo ikagera ikuzimu.Kwibanda kwayo neza (kubuza igice cya selile kanseri) ni 11.17 μg / mL.

Uku kwibandaho ntiguhitana ingirabuzimafatizo zisanzwe (imbeba ya embryonic fibroblast selile umurongo NIH3T3), kandi kwibumbira hamwe bigomba kwiyongera kugera kuri 80 μg / mL kugirango bigire ingaruka zikomeye (kubuza kubaho igice cya kabiri cyimirongo ya selile yimbeba).Ibi bivuze ko ganodermanondiol ishobora gutandukanya ingirabuzimafatizo za kanseri n'uturemangingo dusanzwe kandi igatanga “imiti” itandukanye, itandukanye rwose n'ingaruka za “kwica zose” z'imiti ya chimiotherapeutique ku ngirabuzimafatizo nziza kandi mbi.

Niba aribyoGanoderma lucidumkutabogama kwa triterpène bitangiza uburyo bwa apoptose ya selile kanseri igerwaho muguhuza mitochondriya mungirangingo za kanseri ikwiye gukorwaho iperereza nkuko abashakashatsi babitangaza.

[Reba]

Li P, n'abandi.Ingaruka zo Kurwanya Kanseri Zigice cya Triterpene Zidafite aho zibogamiye ziva muri Ganoderma lucidum hamwe n’ibiyigize bikora kuri SW620 ya kanseri y’umuntu.Anticancer Agents Med Chem.2020;20 (2): 237-244.doi: 10.2174 / 1871520619666191015102442.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao
Wu Tingyao yagiye atanga raporo kuri Ganoderma amakuru kuva 1999. Niwe mwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).

★ Iyi ngingo yasohowe uruhushya rwihariye rwumwanditsi, kandi nyirubwite ni GANOHERB.Work Ibikorwa byavuzwe haruguru ntibishobora kubyara, gucibwa cyangwa gukoreshwa mubundi buryo utabiherewe uburenganzira na GanoHerb.★ Niba imirimo yemerewe gukoreshwa, igomba gukoreshwa murwego rwo gutanga uburenganzira no kwerekana inkomoko: GanoHerb.★ Ku kurenga ku magambo yavuzwe haruguru, GanoHerb azakomeza inshingano zijyanye n'amategeko.Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.