"Ndị na-ahụ maka mgbochi ọrịa cancer na ọgwụ ọgwụ" ewepụtara na February 2020 bipụtara nsonaazụ nyocha nke otu Prọfesọ Li Peng sitere na oflọ Akwụkwọ Ọgwụ nke Mahadum Ahụike Fujian.The nnyocha kwadoro site cell na anụmanụ nnwale na-anọpụ iche triterpenes siGanoderma lucidumnwere ike igbochi uto nke ọrịa cancer colorectal nke ọma, usoro ya na-emetụtakwa "ịkwalite apoptosis cell cancer."

Mkpokọta Triterpenes = Triterpenes nọpụrụ iche + Acidic Triterpenes

Ebe ọ bụ na nchọpụta mbụ nkeGanoderma lucidumtriterpenes na 1982, ndị ọkà mmụta sayensị enyebeghị nkọwa sayensị maka “ihe kpatara yaGanoderma lucidumAhụ ndị na-amị mkpụrụ dị oke ilu mana nyekwara nkọwa ndị ọzọ karịa polysaccharides maka ọmụmụ nke "Gịnị kpataraGanoderma lucidumbụ mgbochi tumor".

Ganoderma lucidumtriterpenes bụ aha mkpokọta, nke na-ezo aka na ihe ndị na-arụ ọrụ n'imeGanoderma lucidumna usoro terpene.Dị ka usoro kemịkal ha si dị, enwere ike kewaa ha ụzọ abụọ: otu otu bụ "acid triterpenes" gụnyere ụdị ganoderic acid dị iche iche (acid triterpene fraction, ATF), na otu nke ọzọ bụ "triterpenes na-anọpụ iche" gụnyere iche iche ganoderiols ("neutral triterpene fraction). ", NTF).Mgbe a na-ejikọta ìgwè abụọ a nke triterpenes, a na-akpọ ha ngụkọta triterpenes.

Ọ bụ ezie na enwere ọtụtụ ihe akaebe sayensị maka mmetụta mgbochi tumor nkeGanoderma lucidumngụkọta triterpenes na acidic triterpenes, e nwere ole na ole ọmụmụ banyere ọrụ nkeGanoderma lucidumtriterpenes na-anọpụ iche na nke a.Ya mere, ndị otu Prọfesọ Li Peng lekwasịrị anya na akụkụ a.

IjiGanoderma lucidumozu ndị na-amị mkpụrụ (nke Fujian Xianzhilou Biological Science and Technology Co., Ltd nyere) dị ka ihe nnwale, ndị otu ahụ bu ụzọ wepụta mkpokọta triterpenes nkeGanoderma lucidumsi fruiting ozu nkeGanoderma lucidumna ethanol, wee kewaa triterpenes na-anọpụ iche na triterpenes acidic iji chọpụta mmetụta mgbochi ha na ọrịa cancer colorectal.

Nnwale cell: mmetụta mgbochi ọrịa kansa nke triterpenes na-anọpụ iche; mmetụta mgbochi kansa nke triterpenes acidic.

Ndị ọrụ nyocha ahụ zụlitere iche icheGanoderma lucidumtriterpenes na-anọpụ iche na triterpenes acidic nwere ụdị atọ dị iche iche nke mkpụrụ ndụ kansa colorectal mmadụ maka awa 48.Na mkpokọta,Ganoderma lucidumtriterpenes na-anọpụ iche nwere mmetụta mgbochi dị mma nke ukwuu na uto mkpụrụ ndụ kansa (mmebawanye) karịaGanoderma lucidumtriterpenes acidic (ọgụgụ 1).

Nnwale anụmanụ:Ganoderma lucidumtriterpenes na-anọpụ iche na-egbochi uto tumor nke ọma

Ndị nyocha ahụ nyochara nsonaazụ mgbochi tumor nkeGanoderma lucidumtriterpenes na-anọpụ iche na vivo site na nnwale anụmanụ: Nke mbụ, eriri mkpụrụ ndụ cancer colorectal mmadụ SW620 nwere ikike metastasis lymphatic ka etinyere n'okpuru akpụkpọ ụmụ oke ịgba ọtọ (oke ụmụ oke na-enweghị ihe mgbochi).Mgbe etuto ahụ pụtachara, 250 mg / kg ma ọ bụ 500 mg / kgGanoderma lucidumA na-enye ụmụ oke ọnụ triterpenes na-anọpụ iche kwa ụbọchị.

Mgbe ụbọchị 13 nke nnwale, a chọpụtara na ntinye aka nkeGanoderma lucidumtriterpenes na-anọpụ iche nwere ike ime ka etuto ahụ na-eto nwayọọ nwayọọ ma dị ntakịrị, yana mmetụta mgbochi ya dị ka nke ọgwụ chemotherapy 5-Fu (20 mg / kg intraperitoneal injection kwa ụbọchị), ma ọ naghị akpata oke ibu dị arọ dị ka 5-Fu ( Ọgụgụ 2-5).

Ihe na-arụ ọrụ: opekata mpe ụdị triterpenes itoolu

Dị ka e kwuru na mbụ n'isiokwu ahụ,Ganoderma lucidumtriterpenes na-anọpụ iche bụkwa ngwakọta, nke nwere ụdị triterpenes dị iche iche.Dị ka onye na-eme nchọpụta si analysis, n'elu-e kwuru na-anọpụ iche triterpenes nkeGanoderma lucidum, nke nwere mmetụta na-egbochi ọrịa cancer colorectal, nwere ma ọ dịkarịa ala ụdị triterpenes itoolu (Fig 6).

Usoro nke ime ihe: iji kwalite apoptosis nke mkpụrụ ndụ kansa

Ọ bụrụ na emebere triterpene itoolu ndị a iche iche site na eriri cell cell cancer colorectal SW620 in vitro, a ga-achọpụta na ha nwere ike igbu mkpụrụ ndụ kansa ma ọ bụ karịa.

Ndị nchọpụta ahụ gara n'ihu nyochara ganoderma triterpene (ganodermanondiol) nke kachasị nnọchiteanya ma chọpụta na ọ nwere ike ịmalite usoro apoptosis nke mkpụrụ ndụ cancer na ịkwanye mkpụrụ ndụ cancer site na ebe ịchụàjà na-adịghị agwụ agwụ na abyss nke ọnwụ.Ntinye ya dị irè (mgbochi nke ọkara nke mkpụrụ ndụ kansa) bụ 11.17 μg / ml.

Ntinye uche a enweghị ihe na-egbu egbu na mkpụrụ ndụ nkịtị (mouse embryonic fibroblast cell line NIH3T3), na ntinye uche ga-abawanye karịa 80 μg / ml iji nwee mmetụta dị ịrịba ama (na-egbochi ndụ nke ọkara nke ahịrị sel embrayo nke òké).Nke a pụtara na ganodermanondiol nwere ike ịmata ọdịiche dị na mkpụrụ ndụ kansa site na sel nkịtị ma nye "ọgwụgwọ" dị iche iche, nke dị nnọọ iche na mmetụta "igbu niile" nke ọgwụ chemotherapeutic na mkpụrụ ndụ dị mma na nke ọjọọ.

Ma ndị aGanoderma lucidumtriterpenes na-anọpụ iche na-ebido usoro apoptosis nke mkpụrụ ndụ kansa na-enweta site na ịhazi mitochondria na mkpụrụ ndụ kansa kwesịrị nyocha ọzọ dịka ndị nyocha si kwuo.

[Ntụaka]

Li P, et al.Mmetụta mgbochi ọrịa kansa nke akụkụ Triterpene nọpụrụ iche sitere na Ganoderma lucidum na ihe mejupụtara ya na-arụ ọrụ na SW620 Human Colorectal Cancer Cells.Ndị na-ahụ maka mgbochi ọrịa cancer Med Chem.2020;20 (2): 237-244 .doi: 10.2174/1871520619666191015102442.

N'ikpeazụ

Banyere onye odee/ Oriakụ Wu Tingyao
Wu Tingyao na-akọ akụkọ banyere Ganoderma nke mbụ ozi kemgbe 1999. O bu odeeỌgwụgwọ na Ganoderma(nke e bipụtara na The People's Medical Publishing House na Eprel 2017).

★ A na-ebipụta akụkọ a n'okpuru ikike nke onye edemede, na ikike ya bụ GANOHERB.★ A pụghị imepụtagharị ọrụ ndị a dị n'elu, wepụ ma ọ bụ jiri ya mee ihe n'ụzọ ndị ọzọ na-enweghị ikike nke GanoHerb.★ Ọ bụrụ na enyerela ikike iji ọrụ ndị ahụ, ekwesịrị iji ha n'ime oke ikike wee gosi isi mmalite: GanoHerb.★ Maka mmebi ọ bụla nke nkwupụta dị n'elu, GanoHerb ga-agbaso ọrụ iwu metụtara ya.★ Wu Tingyao dere ederede izizi nke akụkọ a n'asụsụ Chinese wee sụgharịa ya n'asụsụ Bekee site n'aka Alfred Liu.Ọ bụrụ na enwere nghọtahie n'etiti ntụgharị asụsụ (Bekee) na nke izizi (Chinese), Chinese izizi ga-emeri.Ọ bụrụ na ndị na-agụ akwụkwọ nwere ajụjụ ọ bụla, biko kpọtụrụ onye edemede mbụ bụ Oriakụ Wu Tingyao.