Ua hoʻokuʻu ʻia ka "Anti-Cancer Agents in Medicinal Chemistry" i Pepeluali 2020 i kahi hopena noiʻi o ka hui o Polofesa Li Peng mai ke Kula ʻo Pharmacy o Fujian Medical University.Ua hōʻoia ka noiʻi ma o nā hoʻokolohua cell a me nā holoholona i loaʻa mai ka triterpenes neutralʻO Ganoderma lucidumhiki ke pale nui i ka ulu ʻana o ka maʻi maʻi colorectal, a pili kona ʻano hana i ka "hoʻoikaika ʻana i ka apoptosis cell cancer."

Huina Triterpenes = Neutral Triterpenes + Acidic Triterpenes

Mai ka ʻike mua ʻana oʻO Ganoderma lucidumtriterpenes i ka makahiki 1982, ʻaʻole i hāʻawi wale nā ​​kānaka ʻepekema i nā wehewehe ʻepekema no ke ahaʻO Ganoderma lucidumʻawaʻawa loa nā kino hua" akā hāʻawi pū kekahi i nā hōʻailona ʻē aʻe ma mua o polysaccharides no ke aʻo ʻana o "No ke ahaʻO Ganoderma lucidumhe anti-tumor”.

ʻO Ganoderma lucidumtriterpenes he inoa hui, e pili ana i nā mea hana i lokoʻO Ganoderma lucidumme ka hana terpene.Wahi a ko lākou ʻano kemika, hiki ke hoʻokaʻawale ʻia lākou i ʻelua mau pūʻulu: ʻo kekahi hui he "acidic triterpenes" me nā ʻano like ʻole ganoderic acids (acidic triterpene fraction, ATF), a ʻo ka hui ʻē aʻe he "neutral triterpenes" me nā ganoderiols like ʻole ("neutral triterpene fraction. ”, NTF).Ke hui pū ʻia kēia mau pūʻulu triterpenes ʻelua, ua kapa ʻia lākou he triterpenes.

ʻOiai he nui nā hōʻike ʻepekema no ka hopena anti-tumor oʻO Ganoderma lucidumhuina triterpenes a me acidic triterpenes, he mau haʻawina e pili ana i ke kuleana oʻO Ganoderma lucidumneutral triterpenes i kēia mea.No laila, ua kālele ka hui o Polofesa Li Peng i kēia ʻāpana.

Ke hoʻohana neiʻO Ganoderma lucidumnā kino hua (i hāʻawi ʻia e Fujian Xianzhilou Biological Science and Technology Co., Ltd.) ma ke ʻano he mea hoʻokolohua, ua unuhi mua ka hui i ka huina triterpenes oʻO Ganoderma lucidummai na kino hua oʻO Ganoderma lucidumme ka ethanol, a laila hoʻokaʻawale hou i nā triterpenes kūʻokoʻa a me nā triterpenes acidic e ʻimi i kā lākou hopena pale i ka maʻi maʻi colorectal.

ʻO ka hoʻokolohua kelepona: ka hopena anti-cancer o neutral triterpenes＞ka hopena anti-cancer o acidic triterpenes

Ua hoʻokaʻawale ka poʻe noiʻiʻO Ganoderma lucidumnā triterpenes kūʻokoʻa a me nā triterpenes acidic me ʻekolu mau ʻano like ʻole o ke kanaka maʻi maʻi maʻi colorectal no 48 mau hola.Ma ka holoʻokoʻa,ʻO Ganoderma lucidumʻOi aku ka maikaʻi o ka pale ʻana o nā triterpenes kūʻokoʻa i ka ulu ʻana o nā cell cancer (proliferation) ma mua oʻO Ganoderma lucidumacidic triterpenes (Figure 1).

Hoʻokolohua holoholona:ʻO Ganoderma lucidumʻO nā triterpenes kūʻokoʻa e pale pono i ka ulu ʻana o ka tumor

Ua loiloi hou nā mea noiʻi i nā hopena anti-tumor oʻO Ganoderma lucidumneutral triterpenes in vivo ma o ka holoholona hoʻokolohua: ʻO ka mua, ua hoʻokomo ʻia ka laina cell cell cancerectal kanaka SW620 me ka lymphatic metastasis ma lalo o ka ʻili o nā ʻiole olohelohe (immune-deficient mice).Ma hope o ka puka ʻana o ke koko, 250 mg/kg a i ʻole 500 mg/kg oʻO Ganoderma lucidumHāʻawi waha ʻia nā triterpene neutral i nā ʻiole i kēlā me kēia lā.

Ma hope o 13 mau lā o nā hoʻokolohua, ua ʻike ʻia ke komo ʻana oʻO Ganoderma lucidumHiki i nā triterpenes kūʻokoʻa ke hoʻolōʻihi a liʻiliʻi i nā maʻi koko, a ua hoʻohālikelike ʻia kona hopena inhibitory me ka lāʻau lapaʻau chemotherapy 5-Fu (20 mg/kg intraperitoneal injection i kēlā me kēia lā), akā ʻaʻole ia e hoʻemi i ke kaumaha nui e like me 5-Fu ( Helu 2-5).

Nā mea hoʻoikaika kino: ʻeiwa mau ʻano triterpenes

E like me ka mea i ʻōlelo mua ʻia ma ka ʻatikala,ʻO Ganoderma lucidumHe hui pū nā neutral triterpenes, aia nā ʻano triterpenes like ʻole.Wahi a ka mea noiʻi noiʻi, nā triterpenes kūʻokoʻa i ʻōlelo ʻia ma luna oʻO Ganoderma lucidum, nona ka hopena pale i ka ma'i 'a'ai colorectal, aia ma kahi o eiwa mau 'ano triterpenes (Figure 6).

Mechanism o ka hana: e hoʻoikaika i ka apoptosis o nā maʻi kanesa

Inā hoʻokaʻawale ʻia kēia mau triterpenes ʻeiwa me ka laina cell cell cancerectal human SW620 in vitro, e ʻike ʻia lākou e hiki ke pepehi i nā maʻi maʻi maʻi.

Ua ʻimi hou ka poʻe noiʻi i ka ganoderma triterpene (ganodermanondiol) nui loa a ʻike ʻia hiki iā ia ke hoʻomaka i ke ʻano apoptosis o nā maʻi maʻi maʻi a hoʻokuʻu i nā maʻi kanesa mai ke kuahu pau ʻole a hiki i ka hohonu o ka make.ʻO kona manaʻo maikaʻi (ka hoʻopaʻa ʻana i ka hapalua o nā maʻi kanesa) he 11.17 μg/mL.

ʻAʻohe lethality o kēia manaʻo ma nā pūnaewele maʻamau (mouse embryonic fibroblast cell line NIH3T3), a pono e hoʻonui ʻia ka ʻike i ʻoi aku ma mua o 80 μg/mL e loaʻa ai kahi hopena koʻikoʻi (e kāohi i ke ola o ka hapalua o nā laina cell embryonic mouse).ʻO kēia keʻano o ka ganodermanondiol hiki ke hoʻokaʻawale i nā maʻi kanesa mai nā pūnaewele maʻamau a hāʻawi i nā "lawelawe" likeʻole, heʻokoʻa loa ia mai ka hopena "pepehi a pau" o nā lāʻau chemotherapeutic ma nā pūnaewele maikaʻi a maikaʻiʻole.

ʻO kēia pahaʻO Ganoderma lucidumHoʻomaka ka neutral triterpenes i ka hana apoptosis o nā maʻi maʻi maʻi i loaʻa i ka hoʻoponopono ʻana i ka mitochondria i loko o nā maʻi maʻi maʻi e pono e noiʻi hou e like me ka poʻe noiʻi.

[Nā kuhikuhi]

Li P, et al.Nā hopena anti-cancer o kahi haʻihaʻi triterpene neutral mai Ganoderma lucidum a me kāna mau mea hana ma luna o SW620 nā pūnaewele maʻi maʻi ʻaʻai kanaka.Nā Agena Anticancer Med Chem.2020;20(2): 237-244.doi: 10.2174/1871520619666191015102442.

HOPE

No ka mea kākau/ Ms. Wu Tingyao
Ua hōʻike ʻo Wu Tingyao i ka Ganoderma lima mua ʻike mai ka makahiki 1999. ʻO ia ke kumu oHoola me Ganoderma(i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).

★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau, a no GANOHERB ka mea nona.★ ʻAʻole hiki ke hana hou ʻia nā hana ma luna aʻe, ʻokiʻoki a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka ʻae ʻia e GanoHerb.★ Inā ua ʻae ʻia nā hana e hoʻohana ʻia, pono e hoʻohana ʻia i loko o ke ʻano o ka mana a hōʻike i ke kumu: GanoHerb.★ No ka uhaki ʻana i ka ʻōlelo ma luna, e ʻimi ʻo GanoHerb i nā kuleana pili kānāwai.★ Ua kākau ʻia ka kikokikona kumu o kēia ʻatikala ma ka ʻōlelo Pākē e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.