Ngo-2018, iNgqungquthela Yesi-9 Yamazwe Ngamazwe Yebhayoloji Yamakhowe Nemikhiqizo Yamakhowe yayibanjelwe eShanghai.UDkt. Hua Fan wase-Free University of Berlin, eJalimane, unikeze umbiko emhlanganweni futhi wabelana ngomphumela wocwaningo olwenziwa ngokuhlanganyela yilabhorethri yakhe kanye neThimba likaJinsong Zhang, i-Institute of Edible Fungi, i-Shanghai Academy of Agricultural Sciences.Ingxoxo ngendlela eyodwaI-Ganoderma lucidumi-polysaccharide ilawula izindlela zokuzivikela kanye nezokulwa nomdlavuza kanye nokuhlaziywa kokuthi eyodwaI-Ganoderma lucidumi-triterpene ivimbela ukukhula kwamangqamuzana omdlavuza ukunikeza amandla ezokwelaphaI-Ganoderma lucidumkanye nethemba lemithi emisha.

Umbhalo/ Wu Tingyao

Njengomphathi womhlangano, uJinsong Zhang, umqondisi we-Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, wethule isitifiketi kuDkt. Hua Fan.Laba ababili ababenobudlelwano bukathisha nomfundi bangabashayeli ababalulekile bokuletha umuthi wendabuko wamaShayina iGanoderma ehholo lesayensi laseYurophu.(Izithombe/Wu Tingyao)

U-Hua Fan, owazalelwa e-China futhi watshalaI-Ganoderma lucidumngeminyaka yawo-1960 no-70s, wayengomunye wososayensi abambalwa baseShayina abavelele abaya eJalimane ukuyofunda phesheya ezinsukwini zokuqala.Ekuqaleni kwawo-1990 ngemva kokusungulwa kwenkundla yokuhlola amasosha omzimba kanye ne-anti-tumor e-Free University of Berlin eJalimane, waqala ukubambisana ne-Institute of Edible Fungi, i-Shanghai Academy of Agricultural Sciences ukuhlola izingxenye ze-bioactiveI-Ganoderma lucidumnezinye isikhunta zokwelapha.

Umfundi oneziqu owaya eJalimane ukuyohwebelana egameni le-Institute of Edible Fungi, iShanghai Academy of Agricultural Sciences wayengumuntu oyinhloko owayephethe iNgqungquthela Yesi-9 Yamazwe Ngamazwe Yebhayoloji Yamakhowe Nemikhiqizo Yamakhowe, uJinsong Zhang, umqondisi we-Institute of Edible Fungi. ;U-Hua Fan uyena kanye umphathi wobudokotela osize u-Jinsong Zhang ukuthi athole iziqu zakhe ze-MD e-Free University of Berlin, eJalimane.

Ngemva kokuba uJinsong Zhang ebuyele eChina, waqhubeka nokubambisana nelabhorethri kaHua Fan.Ama-polysaccharides nama-triterpenes embikweni ongenhla anikezwe ithimba lika-Jinsong Zhang e-Institute of Edible Fungi.Cishe iminyaka engamashumi amabili yokubambisana phakathi kwala maqembu amabili ibaluleke kakhulu ekwethulweni kwe-Ganoderma ehholo Lokucwaninga LaseYurophu kanye nokukhuthazwa kocwaningo lomhlaba wonke nge-Ganoderma.

Ama-Polysaccharides anezakhiwo ezahlukene anemisebenzi ehlukene yokuzivikela komzimba.

Iqembu lahlukanisa futhi lahlanza i-macromolecular polysaccharide GLIS equkethe amaprotheni angama-8-9% emizimbeni ethela izithelo.I-Ganoderma lucidum.Ukuhlolwa kwamaseli kuqinisekisile ukuthi i-GLIS ingakwazi ukwenza wonke amasosha omzimba asebenze ngokuvikeleka kwamangqamuzana (ukwenza kusebenze ama-macrophage) kanye nokuvikeleka kwe-humoral (ukwenziwa kusebenze kwama-lymphocyte okuhlanganisa namaseli B).

Empeleni, ukujova i-GLIS ngethamo elingu-100μg kwigundane ngalinye eligonywe kusengaphambili ngamaseli e-S180 sarcoma kuzokhuphula inani lamaseli ubende (aqukethe i-lymphocyte) cishe ngengxenye eyodwa kwezintathu futhi kuvimbele ukukhula kwesimila (izinga lokuvimbela lifinyelela ku-60~ 70%).Lokhu kusho ukuthiI-Ganoderma lucidumi-polysaccharide GLIS inamandla okuthuthukisa amandla amasosha omzimba okulwa nezimila.

Kuyathakazelisa ukuthi enye i-polysaccharide ehlanzekile, i-GLPss58, ehlukanisiwe nayoI-Ganoderma lucidumi-fruiting body, i-sulfated futhi ayinazo izingxenye zamaprotheni, ayigcini nje ngokukhuthaza ukungatheleleki njenge-GLIS kodwa futhi ingavimbela ukwanda nokusebenza kwama-macrophages nama-lymphocyte, inciphise ukukhiqizwa kwama-cytokines avuthayo, futhi ivimbele ama-lymphocyte egazini ukuthi afudukele ku-inflamed. izicubu… Izinqubo zayo eziningi zehlisa ukushuba kokusabela kwamasosha omzimba.Lo mphumela ulungele izidingo zezokwelapha zeziguli ezinokuvuvukala okungapheli okungapheli (njenge-lupus erythematosus nezinye izifo ezizimele).

Indlela yokulwa nomdlavuza ye-triterpenoids ihlukile kuleyo yama-polysaccharides.

Ngaphezu kwalokho, ithimba lika-Hua Fan liphinde lahlola umsebenzi wokulwa nomdlavuza wezinhlanganisela eziyisishiyagalombili ze-triterpene eyodwa emzimbeni othela izithelo.I-Ganoderma lucidum.Imiphumela yabonisa ukuthi amabili kulawa ma-triterpenes anemiphumela ebalulekile yokulwa nokuvuvukala kanye ne-pro-apoptotic kumaseli omdlavuza webele womuntu, amangqamuzana omdlavuza we-colorectal womuntu kanye namaseli e-melanoma ayingozi.

Ekuhlaziyeni okwengeziwe kwezinqubo lawa ma-triterpenes amabili akhuthaza ngawo i-apoptosis yamangqamuzana omdlavuza, abacwaningi bathola ukuthi “ngokuqondile” baphoqa amangqamuzana omdlavuza ukuthi azibhubhise “ngokunciphisa amandla olwelwesi lwe-mitochondria” kanye “nokwandisa ingcindezi ye-oxidative ye-mitochondria” .Lokhu kuhluke ngokuphelele endimeni yeI-Ganoderma lucidumi-polysaccharide GLIS “ngokungaqondile” evimbela izimila ngohlelo lokuzivikela komzimba.

I-Polysaccharides noma i-triterpenes ingasetshenziswa yodwa noma ihlanganiswe.

U-Hua Fan usenze saqonda ngemodeli yocwaningo yaseJalimane eqinile ukuthi izithako ezihlukahlukene ezisebenzayo zikhonaI-Ganoderma lucidum"ingahlanganiswa" ukuze idale inani lezempilo lokwelula impilo noma "ingasetshenziswa ngokuhlukana" ukuze inikeze imiphumela ethile yokwelapha ezifweni ezikhona.

Kungenzeka yini ukwenza ama-polysaccharides asebenzayo nama-triterpenes asebenzayo ekuhlolweni abe yimithi yomtholampilo esikhathini esizayo?“Khona-ke bheka isizukulwane esisha!”U-Hua Fan wabheka uJinsong Zhang, owayesesungule ithimba eliqinile labacwaningi.

Lesi sihloko sicashuniweYiziphi izihloko ezibalulekile ze-Ganoderma okuxoxwe ngazo engqungqutheleni ebaluleke kakhulu yamakhowe adliwayo ngo-2018?-TInkomfa Yesi-9 Yamazwe Ngamazwe Yebhayoloji Yamakhowe kanye Nemikhiqizo Yamakhowe(Ingxenye 2).

UDkt. Hua Fan waseYunivesithi Yamahhala yaseBerlin, eJalimane, wenze isethulo esithi “Ukuhlola Amandla Okunakekelwa Kwezempilo kwe-Ganoderma” eNgqungqutheleni Yezizwe Eziyisi-9 Yebhayoloji Yamakhowe kanye Nemikhiqizo Yamakhowe.(Izithombe/Wu Tingyao)

PHELA

Mayelana nombhali/ Nks. Wu Tingyao
U-Wu Tingyao ubelokhu ebika mathuphaI-Ganoderma lucidumulwazi kusukela ngo-1999. Ungumbhali weUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).
 
★ Lesi sihloko sishicilelwe ngaphansi kwegunya elikhethekile lombhali ★ Le misebenzi engenhla ayikwazi ukuphinda ikhiqizwe, icashunwe noma isetshenziswe ngezinye izindlela ngaphandle kwemvume yombhali ★ Ukwephulwa kwesitatimende esingenhla, umbhali uzoqhuba izibopho zayo zomthetho ezihlobene ★ Eyokuqala umbhalo walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.