Mu 2018, Msonkhano Wapadziko Lonse wa 9 pa Biology ya Bowa ndi Zinthu za Bowa udachitikira ku Shanghai.Dr. Hua Fan wochokera ku Free University of Berlin, Germany, anapereka lipoti pamsonkhanowo ndipo adagawana zotsatira za kafukufuku wopangidwa pamodzi ndi labotale yake ndi Gulu la Jinsong Zhang, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences.Kukambirana mmene singleGanoderma lucidumpolysaccharide imayang'anira njira zodzitetezera komanso zotsutsana ndi khansa komanso kuwunika momwe imodziGanoderma lucidumtriterpene imalepheretsa kukula kwa maselo a khansa kupereka mphamvu zachipatalaGanoderma lucidumndi chiyembekezo cha mankhwala atsopano.

Zolemba / Wu Tingyao

Monga mtsogoleri wa msonkhano, Jinsong Zhang, mkulu wa Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, anapereka satifiketi kwa Dr. Hua Fan.Awiriwo omwe anali ndi ubale wa aphunzitsi ndi ophunzira ndi oyendetsa ofunikira pobweretsa mankhwala achi China Ganoderma kupita ku holo ya sayansi yaku Europe.(Chithunzi / Wu Tingyao)

Hua Fan, yemwe anabadwira ku China ndikubzalaGanoderma lucidumm'zaka za m'ma 1960 ndi 70s, anali mmodzi mwa asayansi ochepa achi China omwe anapita ku Germany kukaphunzira kunja kwa masiku oyambirira.Kumayambiriro kwa zaka za m'ma 1990 pambuyo pa kukhazikitsidwa kwa immunology ndi anti-chotupa experimental nsanja pa Free University of Berlin ku Germany, anayamba kugwirizana ndi Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences kufufuza zigawo za bioactive zaGanoderma lucidumndi bowa mankhwala ena.

Wophunzira maphunziro amene anapita ku Germany kukasinthana m'malo mwa Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences anali munthu wamkulu woyang'anira 9th International Conference on Mushroom Biology ndi Bowa Products, Jinsong Zhang, mkulu wa Institute of Edible Fungi. ;Hua Fan ndiye woyang'anira udokotala yemwe adathandizira Jinsong Zhang kupeza digiri yake ya MD kuchokera ku Free University of Berlin, Germany.

Jinsong Zhang atabwerera ku China, adapitilizabe kugwirizana ndi labotale ya Hua Fan.Ma polysaccharides ndi triterpenes mu lipoti ili pamwambapa adaperekedwa ndi gulu la Jinsong Zhang ku Institute of Edible Fungi.Pafupifupi zaka makumi awiri za mgwirizano pakati pa magulu awiriwa ndizofunikira kwambiri pakuyambitsa Ganoderma ku European Research hall komanso kulimbikitsa kafukufuku wapadziko lonse pa Ganoderma.

Ma polysaccharides okhala ndi zomanga zosiyanasiyana amakhala ndi zochita zosiyanasiyana za chitetezo chamthupi.

Gululo lidapatula ndikuyeretsa macromolecular polysaccharide GLIS yokhala ndi mapuloteni 8-9% kuchokera m'matupi a zipatso.Ganoderma lucidum.Kuyesa kwa ma cell kunatsimikizira kuti GLIS imatha kuyambitsa chitetezo chamthupi chonse kudzera mu chitetezo cham'manja (kuyambitsa ma macrophages) ndi chitetezo cha humoral (kuyambitsa ma lymphocyte kuphatikiza B ma cell).

Kwenikweni, kubaya GLIS pa mlingo wa 100μg mu mbewa iliyonse yopatsidwa katemera kale ndi maselo a sarcoma a S180 kumawonjezera kuchuluka kwa maselo a ndulu (omwe ali ndi ma lymphocyte) pafupifupi gawo limodzi mwa magawo atatu ndikuletsa kukula kwa chotupa (chiwopsezo chimafika 60 ~ 70%).Izi zikutanthauza kutiGanoderma lucidumpolysaccharide GLIS imatha kupititsa patsogolo chitetezo chamthupi kulimbana ndi zotupa.

Chochititsa chidwi, polysaccharide ina yoyera, GLPss58, yomwe ili kutali ndiGanoderma lucidumfruiting thupi, ndi sulphated ndipo alibe zigawo za mapuloteni, osati kulimbikitsa chitetezo cha m'thupi monga GLIS komanso akhoza kuletsa kuchulukana ndi ntchito ya macrophages ndi lymphocytes, kuchepetsa kupanga cytokines yotupa, ndi kuteteza lymphocytes m'magazi kusamuka ku chotupa. minyewa… Njira zake zingapo zimachepetsa mphamvu ya chitetezo cha mthupi.Izi ndizoyenera pazosowa zachipatala za odwala omwe ali ndi kutupa kwakukulu (monga lupus erythematosus ndi matenda ena a autoimmune).

Njira yotsutsa khansa ya triterpenoids ndi yosiyana ndi ya polysaccharides.

Kuphatikiza apo, gulu la Hua Fan lidawunikiranso zochita za anticancer zamagulu asanu ndi atatu amtundu wa triterpene mu thupi lotulutsa zipatso.Ganoderma lucidum.Zotsatira zake zidawonetsa kuti awiri mwa ma triterpeneswa ali ndi zotsatira zotsutsana ndi proliferative komanso pro-apoptotic pama cell a khansa ya m'mawere, ma cell a khansa yapakhungu komanso ma cell oyipa a melanoma.

Pofufuzanso njira zomwe ma triterpenes awiriwa amathandizira kuti ma cell a khansa apitirire, ofufuzawo adapeza kuti "mwachindunji" amakakamiza maselo a khansa kuti adziwononge okha mwa "kuchepetsa kuthekera kwa nembanemba kwa mitochondria" komanso "kuwonjezera mphamvu ya okosijeni ya mitochondria" .Izi ndizosiyana kwambiri ndi udindo waGanoderma lucidumpolysaccharide GLIS yomwe "mosalunjika" imalepheretsa zotupa kudzera mu chitetezo chamthupi.

Ma polysaccharides kapena triterpenes atha kugwiritsidwa ntchito limodzi kapena kuphatikiza.

Hua Fan adatipangitsa kuti timvetsetse kudzera m'chitsanzo cholimbikira cha kafukufuku waku Germany kuti zosakaniza zosiyanasiyana zogwira ntchito zilimoGanoderma lucidumakhoza "kuphatikizidwa" kuti apange phindu la thanzi la kutalikitsa moyo kapena "kugwiritsiridwa ntchito padera" kuti apereke zotsatira zenizeni zochizira matenda omwe alipo.

Kodi ndizotheka kupanga ma polysaccharides ndi triterpenes yogwira poyeserera kukhala mankhwala azachipatala mtsogolomu?“Ndiye yang’anani mbadwo wachichepere!”Hua Fan adayang'ana mwachidwi Jinsong Zhang, yemwe anali atakhazikitsa kale gulu lolimba lofufuza.

Nkhaniyi yatengedwa kuchokeraNdi mitu yofunika iti ya Ganoderma yomwe idakambidwa pamsonkhano wofunikira kwambiri wa bowa mu 2018?-Tiye 9th International Conference on Mushroom Biology and Mushroom Products(Gawo 2).

Dr. Hua Fan wochokera ku Free University of Berlin, Germany, anapereka ndemanga pa "Kufufuza Zomwe Zingatheke Zaumoyo wa Ganoderma" pa Msonkhano Wapadziko Lonse wa 9 pa Mushroom Biology ndi Mushroom Products.(Chithunzi / Wu Tingyao)

TSIRIZA

Za wolemba/ Mayi Wu Tingyao
Wu Tingyao wakhala akunena za zomwe zikuchitikaGanoderma lucidumzambiri kuyambira 1999. Iye ndi mlembi waKuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).
 
★ Nkhaniyi yasindikizidwa ndi chilolezo cha mlembi ★ Ntchito zomwe zili pamwambazi sizingabwerezedwe, kutsanulidwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba ★ Kuphwanya mawu omwe ali pamwambawa, wolemba adzakwaniritsa udindo wake wazamalamulo ★ Zoyambirira Nkhaniyi idalembedwa m'Chitchaina ndi Wu Tingyao ndikumasuliridwa m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.