Muri 2018, i Shanghai habaye inama mpuzamahanga ya 9 ku binyabuzima n’ibihumyo.Dr. Hua Fan wo muri kaminuza y’ubuntu ya Berlin, mu Budage, yatanze raporo muri iyo nama anatangaza ibyavuye mu bushakashatsi bwakozwe na laboratoire ye hamwe n’itsinda rya Jinsong Zhang, Ikigo cya Edible Fungi, Ishuri ry’ubumenyi bw’ubuhinzi muri Shanghai.Ikiganiro cyukuntu umweGanoderma lucidumpolysaccharide igenga uburyo bwo kwirinda no kurwanya kanseri hamwe nisesengura ryuburyo bumweGanoderma lucidumtriterpene ibuza gukura kwingirangingo za kanseri zitanga ubushobozi bwubuvuzi bwaGanoderma lucidumn'icyizere cy'ibiyobyabwenge bishya.

Inyandiko / Wu Tingyao

Nk’uwakiriye iyi nama, Jinsong Zhang, umuyobozi w'ikigo cya Edible Fungi, Ishuri rikuru ry'ubumenyi mu buhinzi rya Shanghai, yahaye Dr. Hua Fan icyemezo.Babiri bari bafitanye umubano numwarimu numunyeshuri ningenzi zingenzi zo kuzana imiti gakondo yubushinwa Ganoderma muri salle yuburayi.(Ifoto / Wu Tingyao)

Hua Umufana, wavukiye mubushinwa ahingaGanoderma lucidummu myaka ya za 1960 na 70, yari umwe mu bahanga bake b'Abashinwa b'indashyikirwa bagiye mu Budage kwiga mu mahanga mu minsi ya mbere.Mu ntangiriro ya za 90 nyuma yo gushyiraho urubuga rw’ubushakashatsi bw’ubudahangarwa no kurwanya ibibyimba muri kaminuza y’ubuntu ya Berlin mu Budage, yatangiye gukorana n’Ikigo cya Edible Fungi, Ishuri ry’Ubumenyi bw’ubuhinzi rya Shanghai kugira ngo acukumbure ibice bigize bioaktike bigizeGanoderma lucidumnibindi bihumyo bivura.

Umunyeshuri wahawe impamyabumenyi wagiye mu Budage kungurana ibitekerezo mu izina rya Institute of Edible Fungi, Ishuri Rikuru ry’Ubumenyi bw’Ubuhinzi rya Shanghai ni we muntu mukuru wari ushinzwe inama mpuzamahanga ya 9 ku binyabuzima n’ibihumyo, Jinsong Zhang, umuyobozi w’ikigo cya Edible Fungi ;Hua Fan numuyobozi wa dogiteri cyane wafashije Jinsong Zhang kubona impamyabumenyi ya MD yakuye muri kaminuza yubuntu ya Berlin, mu Budage.

Jinsong Zhang amaze gusubira mu Bushinwa, yakomeje gukorana na laboratoire ya Hua Fan.Polysaccharide na triterpène muri raporo yavuzwe haruguru byatanzwe nitsinda rya Jinsong Zhang mu kigo cya Edible Fungi.Ubufatanye bumaze hafi imyaka makumyabiri hagati y’impande zombi bufite akamaro kanini mu kwinjiza Ganoderma mu cyumba cy’ubushakashatsi cy’i Burayi no guteza imbere ubushakashatsi ku isi kuri Ganoderma.

Polysaccharide ifite imiterere itandukanye ifite ibikorwa bitandukanye byo kwirinda.

Itsinda ryitandukanije kandi risukura macromolecular polysaccharide GLIS irimo proteine ​​8-9% mumibiri yimbuto zaGanoderma lucidum.Ubushakashatsi bwakorewe mu kagari bwemeje ko GLIS ishobora gukora sisitemu y’umubiri yose ikoresheje ubudahangarwa bwa selile (activation ya macrophage) hamwe n’ubudahangarwa bw’urwenya (gukora lymphocytes harimo na selile B).

Mubyukuri, gutera GLIS ku gipimo cya 100μg muri buri mbeba yabanje gukingirwa na selile ya sarcoma ya S180 bizongera umubare w'utugingo ngengabuzima (turimo lymphocytes) hafi kimwe cya gatatu kandi bibuza gukura kw'ibibyimba (igipimo cyo kubuza kugera kuri 60 ~ 70%).Ibi bivuze koGanoderma lucidumpolysaccharide GLIS ifite ubushobozi bwo kongera ubushobozi bwumubiri bwo kurwanya ibibyimba.

Igishimishije, indi polysaccharide yuzuye, GLPss58, itandukanijwe naGanoderma lucidumumubiri wera imbuto, urimo sulfate kandi nta bigize poroteyine, ntabwo iteza imbere ubudahangarwa nka GLIS gusa ariko kandi irashobora kubuza ikwirakwizwa nigikorwa cya macrophage na lymphocytes, kugabanya umusaruro wa cytokine ikongora, kandi ikabuza lymphocytes mumaraso kwimukira mumuriro. tissue… Uburyo bwinshi bwayo bugabanya ubukana bwumudugudu.Izi ngaruka zirakenewe gusa mubuvuzi bukenewe nabarwayi bafite uburibwe bukabije (nka lupus erythematosus nizindi ndwara ziterwa na autoimmune).

Uburyo bwo kurwanya kanseri ya triterpenoide butandukanye nubwa polysaccharide.

Byongeye kandi, itsinda rya Hua Fan ryasuzumye kandi ibikorwa bya anticancer yibintu umunani byitwa triterpene yibintu byera imbuto.Ganoderma lucidum.Ibisubizo byerekanye ko bibiri muri ibyo triterpène bifite ingaruka zikomeye za antiproliferative na pro-apoptotique ku ngirabuzimafatizo ya kanseri y'ibere y'abantu, kanseri ya kanseri ifata abantu hamwe na selile mbi ya melanoma.

Mu gusesengura ubundi buryo uburyo izo triterpène zombi zitera apoptose ya kanseri ya kanseri, abashakashatsi basanze "mu buryo butaziguye" bahatira ingirabuzimafatizo za kanseri kwiyangiza binyuze mu "kugabanya ubushobozi bwa mitochondriya" no "kongera umuvuduko wa okiside wa mitochondriya" .Ibi bitandukanye rwose ninshingano zaGanoderma lucidumpolysaccharide GLIS "itaziguye" ibuza ibibyimba binyuze mumubiri.

Polysaccharide cyangwa triterpène irashobora gukoreshwa wenyine cyangwa muguhuza.

Hua Umufana yatwumvishije binyuze muburyo bukomeye bwubushakashatsi bwubudage ibintu bitandukanye bikora muriGanoderma lucidumIrashobora "guhuzwa" kugirango habeho agaciro k'ubuzima bwo kuramba cyangwa irashobora "gukoreshwa ukwayo" kugirango itange ingaruka zihariye zo kuvura indwara zihari.

Birashoboka gukora polysaccharide ikora na triterpène ikora mubushakashatsi ku miti ivura ejo hazaza?“Noneho reba abakiri bato!”Hua Fan yarebye ategereje Jinsong Zhang, wari umaze gushinga itsinda rikomeye ry'ubushakashatsi.

Iyi ngingo yakuwe muriNi izihe ngingo z'ingenzi za Ganoderma zaganiriweho mu nama y'ingenzi y'ibiribwa biribwa muri 2018?- T.we Inama mpuzamahanga ya 9 ku binyabuzima n’ibihumyo(Igice cya 2).

Dr. Hua Fan wo muri kaminuza yigenga ya Berlin, mu Budage, yatanze ikiganiro kuri “Gucukumbura Ubushobozi bwo Kwita ku Buzima bwa Ganoderma” mu nama mpuzamahanga ya 9 yerekeye ibinyabuzima by’ibihumyo n’ibicuruzwa by’ibihumyo.(Ifoto / Wu Tingyao)

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao
Wu Tingyao yagiye atanga raporo imbonankuboneGanoderma lucidumamakuru kuva 1999. Niwe mwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).
 
★ Iyi ngingo yasohowe ku ruhushya rwihariye rw’umwanditsi works Ibikorwa byavuzwe haruguru ntibishobora gusubirwamo, gucibwa cyangwa gukoreshwa mu bundi buryo utabiherewe uburenganzira n’umwanditsi ★ Kurenga ku magambo yavuzwe haruguru, umwanditsi azakomeza inshingano zijyanye n’amategeko ★ Umwimerere inyandiko yiyi ngingo yanditswe mu gishinwa na Wu Tingyao ihindurwa mu Cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.