2018, Shirweynihii 9aad ee Caalamiga ah ee Biology-ga Mushroom iyo Alaabta Mushroom ayaa lagu qabtay Shanghai.Dr. Hua Fan oo ka socotay jaamacadda Free University of Berlin, Germany, ayaa warbixin ka jeedisay kulanka, waxaanay la wadaagtay natiijada cilmi-baadhistan ay si wada jir ah u sameeyeen shaybaadhkeeda iyo kooxda Jinsong Zhang, machadka la cuni karo ee fungi, Akademiyada Beeraha ee Shanghai.Doodda ku saabsan sida halGanoderma lucidumpolysaccharides ayaa nidaamisa difaaca iyo hababka ka hortagga kansarka iyo falanqaynta sida halGanoderma lucidumtriterpene waxay joojisaa koritaanka unugyada kansarka si ay u bixiyaan awoodda caafimaad eeGanoderma lucidumiyo rajada dawooyinka cusub.

Qoraal/ Wu Tingyao

Isagoo martigeliyay kulanka, Jinsong Zhang, oo ah agaasimaha Machadka Fungi la cuni karo, Akademiyada Sayniska Beeraha ee Shanghai, ayaa shahaado gudoonsiiyay Dr. Hua Fan.Labada xiriir ee macalin iyo arday ayaa ah darawalada muhiimka ah ee keenaya daawada dhaqameed ee Shiinaha Ganoderma galay hoolka cilmiga Yurub.(Sawirka/Wu Tingyao)

Hua Fan, oo ku dhalatay Shiinaha oo lagu beerayGanoderma lucidum1960-meeyadii iyo 70-meeyadii, waxa uu ahaa mid ka mid ah dhowr saynisyahano Shiinees ah oo aad u wanaagsan oo Jarmalka u aaday waxbarasho dibadda ah waagii hore.Horraantii 1990-meeyadii ka dib markii la aasaasay madal tijaabo ah oo difaaca jirka iyo ka hortagga burooyinka ee Jaamacadda Xorta ah ee Berlin ee Jarmalka, waxay bilowday inay la shaqeyso Machadka Fungi La Cuno, Akadeemiyada Shanghai ee Sayniska Beeraha si ay u sahamiso qaybaha bioactive eeGanoderma lucidumiyo fangaska kale ee daawada.

Ardayga qalin jabiyay ee u aaday Jarmalka isdhaafsiga isagoo ka wakiil ah Machadka Fungi la cuni karo, Shanghai Academy of Sciences Agricultural Sciences ayaa ahaa qofka ugu muhiimsan ee mas'uul ka ah Shirka Caalamiga ah ee 9th ee Biology Biology iyo Mushroom Products, Jinsong Zhang, oo ah agaasimaha Machadka Fangaska la cuni karo. ;Hua Fan waa kormeeraha dhakhtarka oo ka caawiyay Jinsong Zhang inuu shahaadada MD ka helo Jaamacadda Xorta ah ee Berlin, Jarmalka.

Kadib markii uu Jinsong Zhang ku laabtay Shiinaha, waxa uu sii waday la shaqaynta shaybaadhka Hua Fan.Polysaccharides iyo triterpenes ee ku jira warbixinta kore waxaa bixiyay kooxda Jinsong Zhang ee Machadka Fungi la cuni karo.Ku dhawaad ​​labaatankii sano ee iskaashiga labada dhinac ayaa muhiimad weyn u leh soo bandhigida Ganoderma ee hoolka Cilmi-baarista Yurub iyo kor u qaadida cilmi-baarista caalamiga ah ee Ganoderma.

Polysaccharides oo leh qaabab kala duwan ayaa leh dhaqdhaqaaqyo difaac oo kala duwan.

Kooxdu waxay go'doomiyeen oo nadiifiyeen macromolecular polysaccharide GLIS oo ka kooban 8-9% borotiinka jirka midhahaGanoderma lucidum.Tijaabooyin unug ayaa xaqiijiyay in GLIS ay ku dhaqaajin karto nidaamka difaaca jirka oo dhan iyada oo loo marayo difaaca unugga (firfircoonida macrophages) iyo difaaca humoral (dhaqdhaqaaqa lymphocytes oo ay ku jiraan unugyada B).

Dhab ahaantii, ku duritaanka GLIS ee qiyaasta 100μg ee jiir kasta oo horay loogu tallaalay unugyada S180 sarcoma waxay kordhin doontaa tirada unugyada beeryarada (oo ay ku jiraan lymphocytes) ku dhawaad ​​​​saddex-meelood meel waxayna joojinayaan koritaanka burada (heerka xakameyntu wuxuu gaaraa 60 ~ 70%).Taas macnaheedu waxa weeyeGanoderma lucidumpolysaccharide GLIS waxay leedahay awood ay ku wanaajiso habka difaaca jirka si uu ula dagaallamo burooyinka.

Waxa xiiso leh, polysaccharide kale oo saafi ah, GLPss58, kaas oo ka go'anGanoderma lucidumjidhka miraha, waa sulfated oo aan ka koobnayn qaybaha borotiinka, ma aha oo kaliya maaha inay kor u qaadaan difaaca sida gliS, laakiin sidoo kale waxay joojin karaan bararka iyo dhaqdhaqaaqa macrophages iyo lymphocytes, waxay yareeyaan wax soo saarka cytokines bararka, iyo ka hortagga lymphocytes ee dhiiga inay u guuraan bararka. Unugyada… Hababka kala duwan ayaa yareeya xoogga jawaabta difaaca.Saamayntani waxay ku habboon tahay oo keliya baahida caafimaad ee bukaanka qaba caabuq xad-dhaaf ah oo daba-dheeraaday (sida lupus erythematosus iyo cudurrada kale ee difaaca jirka).

Habka ka hortagga kansarka ee triterpenoids wuu ka duwan yahay kan polysaccharides.

Intaa waxaa dheer, kooxda Hua Fan waxay sidoo kale qiimeeyeen waxqabadka ka hortagga kansarka ee siddeed xeryood oo triterpene ah oo ku jira jidhka midhahaGanoderma lucidum.Natiijooyinku waxay muujiyeen in laba ka mid ah triterpene-yadani ay leeyihiin saameyn liddi ku ah proliferative iyo pro-apoptotic ee unugyada kansarka naasaha bini'aadamka, unugyada kansarka mindhicirka ee bini'aadamka iyo unugyada melanoma malignant.

Falanqaynta dheeraadka ah ee hababka ay labadan triterpenes kor u qaadaan apoptosis ee unugyada kansarka, cilmi-baarayaashu waxay ogaadeen in ay "si toos ah" ugu qasbaan unugyada kansarka inay is-burburiyaan iyada oo "yaraynta awoodda xuubka mitochondria" iyo "kordhinta cadaadiska oksaydhka ee mitochondria" .Tani gabi ahaanba way ka duwan tahay doorkaGanoderma lucidumpolysaccharide GLIS oo "si dadban" u joojiya burooyinka iyada oo loo marayo habka difaaca jirka.

Polysaccharides ama triterpenes waxaa loo isticmaali karaa kali ama isku dhafan.

Hua Fan waxa ay nooga dhaadhicisay qaabka cilmi baadhista Jarmal ee adag in maaddooyinka kala duwan ee firfircooni ku jiraanGanoderma lucidumwaxaa lagu "isku dari karaa" si loo abuuro qiimaha caafimaad ee cimriga dheeraynta ama waxaa "loo codsan karaa si gooni ah" si loo bixiyo saameyn gaar ah oo daaweyn ah cudurada jira.

Suurtagal ma tahay in la sameeyo polysaccharides firfircoon iyo triterpenes firfircoon ee tijaabada ah ee daawooyinka kiliinikada mustaqbalka?"Haddaba bal eega jiilka soo koraya!"Hua Fan waxay si filayn u eegtay Jinsong Zhang, kaasoo mar hore aasaasay koox cilmi-baadhiseed xooggan.

Maqaalkan waxa laga soo qaatayMaxay yihiin mawduucyada muhiimka ah ee Ganoderma ayaa looga hadlay shirka ugu muhiimsan ee likaha la cuni karo ee 2018?- TWuxuu shirweynihii 9-aad ee caalamiga ah ee Biology-ga iyo Badeecooyinka Mushroomka(Qaybta 2aad).

Dr. Hua Fan oo ka socota Jaamacadda Bilaashka ah ee Berlin, Jarmalka, ayaa soo bandhigtay bandhig ku saabsan "Sahaminta Awoodda Daryeelka Caafimaadka ee Ganoderma" ee Shirka Caalamiga ah ee 9th ee Biyolojiga iyo Mushroomka.(Sawirka/Wu Tingyao)

DHAMAAD

Ku saabsan qoraaga/Ms. Wu Tingyao
Wu Tingyao ayaa si toos ah uga warbixinayayGanoderma lucidummacluumaadka tan iyo 1999. Iyadu waa qoraagaKu bogsashada Ganoderma(waxaa lagu daabacay Guriga Daabacaada Caafimaadka Dadweynaha Abriil 2017).
 
★ Maqaalkan waxa lagu daabacay ogolaansho gaar ah oo uu leeyahay qoraaga ★ Shaqooyinka kor ku xusan lama soo saari karo, lagana saari karo ama looma isticmaali karo siyaabo kale iyada oo aan oggolaansho laga helin qoraaga ★ ku xad-gudbida hadalka sare, qoraagu waxa uu gudan doonaa waajibaadkiisa sharci ee la xidhiidha ★ Asalka qoraalka maqaalkan waxaa ku qoray Shiinaha Wu Tingyao waxaana Ingiriis u turjumay Alfred Liu.Haddii uu jiro farqi u dhexeeya tarjumaada (Ingiriiska) iyo kan asalka ah (Shiineyska), Shiinaha asalka ah ayaa guulaysan doona.Haddii akhristayaasha ay qabaan wax su'aalo ah, fadlan la xiriir qoraaga asalka ah, Ms. Wu Tingyao.