Muna 2018, Musangano wechipfumbamwe weInternational Mushroom Biology uye Mushroom Zvigadzirwa wakaitwa muShanghai.Dr. Hua Fan vanobva kuFree University yeBerlin, Germany, vakapa mushumo pamusangano uye vakagovera mugumisiro wetsvakurudzo yakaitwa pamwe chete nerabhoritari yake uye Jinsong Zhang's Team, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences.Hurukuro yekuti sei singleGanoderma lucidumpolysaccharide inogadzirisa immune uye anti-cancer maitiro uye ongororo yekuti imwe cheteGanoderma lucidumtriterpene inhibisa kukura kwekenza maseru inopa mukana wekurapa weGanoderma lucidumuye tarisiro yemishonga mitsva.

Chinyorwa/ Wu Tingyao

Semukuru wemusangano, Jinsong Zhang, mutungamiriri weInstitute of Edible Fungi, Shanghai Academy of Agricultural Sciences, akapa chitupa kuna Dr. Hua Fan.Vaviri vaive nehukama hwemudzidzisi-mudzidzi ndivo vatyairi vakakosha kuunza mushonga wechiChinese weGanoderma kupinda muhoro yesainzi yeEurope.(Mufananidzo/Wu Tingyao)

Hua Fan, akaberekerwa kuChina uye akadyaraGanoderma lucidummu1960s uye 70s, aive mumwe wevashoma vakatanhamara vesainzi veChinese vakaenda kuGermany kunodzidza kunze kwenyika mumazuva ekutanga.Mukutanga kwema1990 mushure mekugadzwa kweiyo immunological uye anti-bundu yekuyedza chikuva paFree University yeBerlin kuGermany, akatanga kushanda pamwe neInstitute of Edible Fungi, Shanghai Academy yeAgricultural Sayenzi kuti vaongorore bioactive zvikamu zve.Ganoderma lucidumnemamwe fungi yemishonga.

Mudzidzi akapedza kudzidza akaenda kuGermany kunochinjana akamirira Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences ndiye aitungamirira Musangano wechipfumbamwe weMusangano weMushroom Biology uye Mushroom Products, Jinsong Zhang, mutungamiriri weInstitute of Edible Fungi. ;Hua Fan ndiye mutariri ane chiremba akabatsira Jinsong Zhang kuwana dhigirii rake reMD kubva kuFree University yeBerlin, Germany.

Mushure mekunge Jinsong Zhang adzokera kuChina, akaramba achibatirana nerabhoritari yeHua Fan.Mapolysaccharides nematriterpenes ari pamusoro apa akapihwa nechikwata chaJinsong Zhang paInstitute of Edible Fungi.Makore anoda kusvika makumi maviri ekubatana pakati pemapato maviri aya akakosha zvikuru pakupinzwa kweGanoderma muEuropean Research hall uye kusimudzirwa kwetsvakiridzo yepasi rose yeGanoderma.

Polysaccharides ane zvimiro zvakasiyana ane maitiro akasiyana ekudzivirira.

Chikwata chakazviparadzanisa nekuchenesa macromolecular polysaccharide GLIS ine 8-9% mapuroteni kubva kumitumbi inobereka michero.Ganoderma lucidum.Kuedza kwesero kwakasimbisa kuti GLIS inogona kumisa immune system yese kuburikidza neserura immunity (activation of macrophages) uye humoral immunity (activation ye lymphocytes kusanganisira B masero).

Chaizvoizvo, kubaya GLIS pamushonga we100μg mumbeva yega yega pre-yakabaiwa neS180 sarcoma masero kuchawedzera huwandu hwemasero espleen (ane lymphocytes) neinoda kusvika pachikamu chimwe chete pazvitatu uye kudzivirira bundu kukura (inhibition rate inosvika 60~ 70%).Izvi zvinoreva kutiGanoderma lucidumpolysaccharide GLIS ine kugona kukwidziridza kugona kwe immune system kurwisa mamota.

Sezvineiwo, imwe yakachena polysaccharide, GLPss58, iyo yakaparadzaniswa kubvaGanoderma lucidumfruiting body, ine sulfated uye haina maprotein components, kwete chete haikurudziri kudzivirirwa senge GLIS asiwo inogona kutadzisa kuwanda uye kuita kwe macrophages uye lymphocytes, kuderedza kugadzirwa kwe inflammatory cytokines, uye kudzivirira lymphocytes muropa kubva kutamira kune yakatsva. matissue… Maitiro ayo akawanda anoderedza kusimba kwemhinduro ye immune.Izvi zvinongoenderana nezvinodiwa zvekurapa zvevarwere vane chisingaperi kuzvimba (senge lupus erythematosus uye zvimwe zvirwere zve autoimmune).

Iyo anti-cancer mechanism ye triterpenoids yakasiyana neye polysaccharides.

Pamusoro pezvo, timu yaHua Fan yakaongororawo chiitiko cheanticancer chesere single triterpene makomisheni mumuviri unobereka michero.Ganoderma lucidum.Mhedzisiro yacho yakaratidza kuti maviri ematriterpenes aya ane akakosha antiproliferative uye pro-apoptotic mhedzisiro pamasero egomarara rezamu remunhu, masero egomarara remunhu uye masero akaipa emelanoma.

Mukuenderera mberi nekuongorora maitiro ayo maviri matatu matatu anosimudzira apoptosis yekenza maseru, vaongorori vakawana kuti "zvakananga" vanomanikidza maseru egomarara kuti azviparadze kuburikidza ne "kuderedza mukana we membrane we mitochondria" uye "kuwedzera oxidative pressure ye mitochondria" .Izvi zvakasiyana zvachose nebasa reGanoderma lucidumpolysaccharide GLIS iyo "zvisina kunanga" inovharira mapundu kuburikidza ne immune system.

Polysaccharides kana triterpenes inogona kushandiswa imwe chete kana musanganiswa.

Hua Fan akaita kuti tinzwisise kuburikidza neyakaomesesa yekuGerman yekutsvagisa modhi iyo dzakasiyana siyana dzinoshanda zvinhu mukatiGanoderma luciduminogona "kusanganiswa" kugadzira kukosha kwehutano hwekuwedzera hupenyu kana inogona "kushandiswa zvakasiyana" kuti ipe chaiyo yekurapa mhedzisiro yezvirwere zviripo.

Zvinoita here kuita mapolysaccharides anoshanda uye anoshanda triterpenes mukuyedza kuita mishonga yekiriniki mune ramangwana?“Ipapo tarira chizvarwa chiduku!”Hua Fan akatarisa Jinsong Zhang, uyo akanga atotanga boka rakasimba rekutsvagisa.

Chinyorwa ichi chakatorwa kubvaNdedzipi nyaya dzakakosha dzeGanoderma dzakakurukurwa mumusangano wakanyanya kukosha wehowa muna 2018?- Tiye 9th International Musangano paMushroom Biology uye Mushroom Zvigadzirwa(Chikamu 2).

Dr. Hua Fan vanobva kuFree University yeBerlin, Germany, vakapa mharidzo pamusoro pe "Kuongorora Hutano Hwehutano Hunogona Kuitwa Ganoderma" pa9th International Conference pamusoro peMushroom Biology uye Mushroom Products.(Mufananidzo/Wu Tingyao)

END

Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achitaura nezvekutanga-ruokoGanoderma lucidumruzivo kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).
 
★Chinyorwa ichi chakatsikiswa pasi pemvumo yemunyori chete ★ Mabasa ari pamusoro haagone kutsikiswa, kudonhedzwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori ★ Kutyora chirevo chiri pamusoro, munyori achaita mabasa anoenderana nemutemo ★ Iwo ekutanga. chinyorwa chechinyorwa ichi chakanyorwa neChinese naWu Tingyao uye chakashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.