Hauv 2018, 9th International Conference on Mushroom Biology thiab Mushroom Products tau muaj nyob rau hauv Shanghai.Dr. Hua Fan los ntawm Free University of Berlin, Lub teb chaws Yelemees, tau muab tsab ntawv ceeb toom ntawm lub rooj sib tham thiab qhia txog cov txiaj ntsig ntawm kev tshawb fawb tau ua ke los ntawm nws lub chaw kuaj mob thiab Jinsong Zhang Pab Pawg, Lub Tsev Kawm Ntawv ntawm Edible Fungi, Shanghai Academy of Agricultural Sciences.Kev sib tham txog yuav ua li cas ib leegGanoderma lucidumpolysaccharide tswj lub cev tiv thaiv kab mob thiab tiv thaiv kab mob qog noj ntshav thiab kev tshuaj xyuas ntawm ib leegGanoderma lucidumtriterpene inhibits kev loj hlob ntawm cov qog nqaij hlav cancer muab cov peev xwm kho mob ntawmGanoderma lucidumthiab lub zeem muag ntawm cov tshuaj tshiab.

Text/Wu Tingyao

Raws li tus tswv tsev ntawm lub rooj sib tham, Jinsong Zhang, tus thawj coj ntawm lub koom haum ntawm Edible Fungi, Shanghai Academy of Agricultural Sciences, tau nthuav tawm daim ntawv pov thawj rau Dr. Hua Fan.Ob tus uas muaj kev sib raug zoo ntawm tus kws qhia-cov tub ntxhais kawm yog tus tsav tsheb tseem ceeb ntawm kev coj cov tshuaj suav tshuaj Ganoderma nyob rau hauv European science Hall.(Kev yees duab / Wu Tingyao)

Hua Fan, uas yug hauv Suav teb thiab cogGanoderma lucidumnyob rau xyoo 1960 thiab 70s, yog ib qho ntawm ob peb tus kws tshawb fawb suav zoo uas tau mus rau Tebchaws Yelemees mus kawm txawv teb chaws thaum ntxov.Nyob rau thaum ntxov 1990s tom qab tsim ib tug immunological thiab anti-mob sim platform ntawm lub Free University of Berlin nyob rau hauv lub teb chaws Yelemees, nws pib koom tes nrog lub koom haum ntawm Edible Fungi, Shanghai Academy ntawm Agricultural Sciences los tshawb txog cov bioactive Cheebtsam ntawmGanoderma lucidumthiab lwm yam tshuaj fungi.

Cov tub ntxhais kawm tiav uas tau mus rau lub teb chaws Yelemees rau kev sib pauv sawv cev ntawm Lub Tsev Kawm Ntawv ntawm Edible Fungi, Shanghai Academy of Agricultural Sciences yog tus thawj coj ntawm 9th International Conference on Mushroom Biology thiab Mushroom Products, Jinsong Zhang, tus thawj coj ntawm Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv. ;Hua Fan yog tus kws saib xyuas kws kho mob heev uas tau pab Jinsong Zhang tau txais nws daim MD degree los ntawm Free University of Berlin, lub teb chaws Yelemees.

Tom qab Jinsong Zhang rov qab los rau Tuam Tshoj, nws txuas ntxiv koom tes nrog Hua Fan lub chaw sim.Cov polysaccharides thiab triterpenes nyob rau hauv daim ntawv tshaj tawm saum toj no yog muab los ntawm Jinsong Zhang pab neeg ntawm lub koom haum ntawm Edible Fungi.Qhov ze li ntawm ob xyoo caum ntawm kev koom tes ntawm ob tog yog qhov tseem ceeb heev rau kev qhia txog Ganoderma rau hauv European Research Hall thiab txhawb kev tshawb fawb thoob ntiaj teb ntawm Ganoderma.

Polysaccharides nrog cov qauv sib txawv muaj ntau yam kev tiv thaiv kab mob.

Pab neeg cais tawm thiab ntxuav cov macromolecular polysaccharide GLIS uas muaj 8-9% protein los ntawm cov txiv hmab txiv ntoo lub cev.Ganoderma lucidum.Cov kev sim ntawm tes tau lees paub tias GLIS tuaj yeem ua rau tag nrho lub cev tiv thaiv kab mob los ntawm kev tiv thaiv kab mob ntawm tes (kev ua kom cov macrophages) thiab kev tiv thaiv humoral (ua kom cov lymphocytes suav nrog B hlwb).

Qhov tseeb, txhaj GLIS ntawm ib koob ntawm 100μg rau hauv txhua tus nas ua ntej txhaj tshuaj tiv thaiv nrog S180 sarcoma hlwb yuav ua rau cov hlwb spleen (muaj cov lymphocytes) ze li ib feem peb thiab inhibit qog loj hlob (inhibition tus nqi nce mus txog 60 ~ 70%).Qhov no txhais tau tiasGanoderma lucidumpolysaccharide GLIS muaj peev xwm txhim kho lub cev tiv thaiv kab mob muaj peev xwm los tua cov qog.

Interestingly, lwm ntshiab polysaccharide, GLPss58, uas yog cais los ntawmGanoderma lucidumTxiv hmab txiv ntoo lub cev, yog sulfated thiab tsis muaj protein ntau Cheebtsam, tsis tsuas yog tsis txhawb kev tiv thaiv zoo li GLIS, tab sis kuj yuav inhibit qhov kev loj hlob thiab kev ua ntawm macrophages thiab lymphocytes, txo cov zus tau tej cov inflammatory cytokines, thiab tiv thaiv lymphocytes nyob rau hauv cov ntshav los ntawm migrating mus rau tus mob. cov ntaub so ntswg… Nws ntau yam mechanisms txo qhov kev siv ntawm lub cev tiv thaiv kab mob.Cov nyhuv no tsuas yog tsim nyog rau cov kev xav tau ntawm kev kho mob ntawm cov neeg mob uas mob ntev heev (xws li lupus erythematosus thiab lwm yam kab mob autoimmune).

Cov tshuaj tiv thaiv kab mob qog noj ntshav ntawm triterpenoids txawv ntawm polysaccharides.

Tsis tas li ntawd, Pab Pawg Hua Fan kuj tau soj ntsuam cov kev ua haujlwm ntawm cov tshuaj tiv thaiv kab mob ntawm yim ib leeg triterpene tebchaw hauv cov txiv hmab txiv ntoo ntawm lub cev.Ganoderma lucidum.Cov txiaj ntsig tau pom tias ob qho ntawm cov triterpenes no muaj cov tshuaj tiv thaiv kab mob tseem ceeb thiab cov txiaj ntsig pro-apoptotic rau tib neeg cov qog nqaij hlav qog noj ntshav, tib neeg cov qog nqaij hlav hauv plab thiab cov qog nqaij hlav malignant melanoma.

Hauv kev tsom xam ntxiv ntawm cov txheej txheem uas ob lub triterpenes no txhawb nqa apoptosis ntawm cov qog nqaij hlav cancer, cov kws tshawb fawb pom tias lawv "qhib" yuam cov qog nqaij hlav cancer rau tus kheej los ntawm "txo lub peev xwm ntawm mitochondria" thiab "nce oxidative siab ntawm mitochondria" .Qhov no yog txawv kiag li ntawm lub luag hauj lwm ntawmGanoderma lucidumpolysaccharide GLIS uas "indirectly" inhibits qog los ntawm lub cev tsis muaj zog.

Polysaccharides los yog triterpenes tuaj yeem siv ib leeg lossis ua ke.

Hua Fan ua rau peb nkag siab los ntawm cov qauv kev tshawb fawb German nruj uas muaj ntau yam khoom xyaw hauvGanoderma lucidumtuaj yeem "sib koom ua ke" los tsim kom muaj txiaj ntsig kev noj qab haus huv ntawm lub neej ntev lossis tuaj yeem "siv cais" los muab cov teebmeem tshwj xeeb rau cov kab mob uas twb muaj lawm.

Puas yog nws muaj peev xwm ua kom cov active polysaccharides thiab active triterpenes nyob rau hauv qhov kev sim rau cov tshuaj kho mob yav tom ntej?“Cia li saib cov tub ntxhais hluas!”Hua Fan ntsia ntsoov ntawm Jinsong Zhang, uas twb tau tsim ib pab neeg tshawb fawb muaj zog.

Kab lus no yog excerpted los ntawmDab tsi tseem ceeb Ganoderma cov ntsiab lus tau tham hauv lub rooj sib tham tseem ceeb tshaj plaws ntawm cov nceb nceb hauv 2018?- Tnws 9th International Conference on Mushroom Biology thiab Mushroom Products(Part 2).

Dr. Hua Fan los ntawm Free University of Berlin, Lub teb chaws Yelemees, tau nthuav tawm "Kev Tshawb Fawb Txog Kev Kho Mob Muaj Peev Xwm ntawm Ganoderma" ntawm 9th International Conference on Mushroom Biology thiab Mushroom Products.(Kev yees duab / Wu Tingyao)

END

Hais txog tus sau/ Ms. Wu Tingyao
Wu Tingyao tau tshaj tawm thawj zaugGanoderma lucidumcov ntaub ntawv txij thaum 1999. Nws yog tus sau ntawmKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).
 
★ Kab lus no yog luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau ★ Cov hauj lwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis tau txais kev tso cai los ntawm tus sau ★ Kev ua txhaum ntawm cov lus saum toj no, tus sau yuav ua raws li nws cov luag haujlwm raws cai ★ Thawj Cov ntawv ntawm tsab xov xwm no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.