Ngo-2018, iNkomfa ye-9 yeZizwe ngeZizwe kwiBhayoloji yeMushroom kunye neeMveliso zeMushroom yabanjwa eShanghai.UGqr Hua Fan ovela kwiYunivesithi yamahhala yaseBerlin, eJamani, wanikela ingxelo kwintlanganiso waza wabelana ngesiphumo sophando olwenziwa ngokubambisana nebhubhoratri yakhe kunye neQela likaJinsong Zhang, i-Institute of Edible Fungi, i-Shanghai Academy yeSayensi yezoLimo.Ingxoxo ngendlela enyeI-Ganoderma lucidumi-polysaccharide ilawula iindlela zokuzivikela kunye nokuchasana nomhlaza kunye nohlalutyo lwendlela enyeI-Ganoderma lucidumi-triterpene inqanda ukukhula kweeseli zomhlaza zibonelela ngesakhono sonyangoI-Ganoderma lucidumkunye nethemba lamachiza amatsha.

Umbhalo/ Wu Tingyao

Njengomququzeleli wentlanganiso, uJinsong Zhang, umlawuli weZiko leFungi elidliwayo, i-Shanghai Academy yeSayensi yezoLimo, unike isatifikethi kuGqr Hua Fan.Aba babini babenobudlelwane bukatitshala-umfundi ngabaqhubi ababalulekileyo bokuzisa iyeza lemveli laseTshayina iGanoderma kwiholo yesayensi yaseYurophu.(Ifoto/Wu Tingyao)

U-Hua Fan, owazalelwa e-China kwaye watyalaI-Ganoderma lucidumngeminyaka yoo-1960 no-70, wayengomnye wezazinzulu ezimbalwa ezibalaseleyo zaseTshayina eziye eJamani ukuya kufunda kumazwe aphesheya ngeentsuku zokuqala.Ekuqaleni kweminyaka yoo-1990 emva kokusekwa kweqonga lovavanyo lokugonyela kunye ne-anti-tumor kwiYunivesithi yaseBerlin yaseJamani, waqala ukusebenzisana neZiko leFungi elidliwayo, iShanghai Academy yeSayensi yezoLimo ukuhlola amacandelo e-bioactiveI-Ganoderma lucidumkunye nezinye iifungi zonyango.

Umfundi ophumeleleyo owaya eJamani ukutshintshiselana egameni leZiko leFungi elidliwayo, iShanghai Academy yeSayensi yezoLimo yayingumntu oyintloko ophethe iNkomfa ye-9 yeHlabathi yeBhayoloji yeMushroom kunye neeMveliso zeMushroom, uJinsong Zhang, umlawuli weZiko leFungi ezidliwayo. ;U-Hua Fan ngoyena mphathi wogqirha owanceda uJinsong Zhang wafumana isidanga sakhe se-MD kwiYunivesithi yaseBerlin, eJamani.

Emva kokuba uJinsong Zhang ebuyele eChina, waqhubeka esebenzisana nebhubhoratri yeHua Fan.I-polysaccharides kunye ne-triterpenes kule ngxelo ingentla yanikezelwa liqela likaJinsong Zhang kwi-Institute of Edible Fungi.Phantse iminyaka engamashumi amabini yentsebenziswano phakathi kwamaqela amabini ibaluleke kakhulu ekungenisweni kweGanoderma kwiholo yoPhando lwaseYurophu kunye nokukhuthazwa kophando lwehlabathi kwiGanoderma.

I-Polysaccharides enezakhiwo ezahlukeneyo zinemisebenzi eyahlukeneyo yokuzivikela.

Iqela lakhetha kwaye lahlambulula i-macromolecular polysaccharide GLIS equlethe i-8-9% yeprotheyini evela kwimizimba yeziqhamo.I-Ganoderma lucidum.Uvavanyo lweeseli luqinisekisile ukuba i-GLIS inokuvula amajoni omzimba wonke ngokusebenzisa i-immunity yeselula (ukusebenza kwe-macrophages) kunye ne-humoral immunity (ukusebenza kwe-lymphocytes kuquka iiseli ze-B).

Ngokwenyani, ukutofa i-GLIS ngedosi ye-100μg kwimpuku nganye egonywe ngaphambili nge-S180 yeeseli ze-sarcoma kuya kwandisa inani leeseli ze-spleen (eziqulethe i-lymphocytes) malunga nesinye kwisithathu kunye nokuthintela ukukhula kwethumba (izinga lokuthintela lifikelela kuma-60 ~ 70%).Oku kuthetha ukubaI-Ganoderma lucidumI-polysaccharide GLIS inamandla okuphucula amandla omzimba wokulwa namathumba.

Okubangel 'umdla kukuba, enye i-polysaccharide ecocekileyo, i-GLPss58, eyodwaI-Ganoderma lucidumumzimba ovelisa iziqhamo, i-sulfated kwaye ayinazo iiprotheyini, ayikhuthazi nje ukukhuseleka njenge-GLIS kodwa inokuthintela ukwanda kunye nomsebenzi we-macrophages kunye ne-lymphocytes, ukunciphisa ukuveliswa kwee-cytokines ezivuthayo, kunye nokuthintela i-lymphocytes egazini ukuba ifudukele kwindawo evuthayo. iithishu… Iindlela ezininzi zehlisa amandla empendulo yokhuselo lomzimba.Esi siphumo sifanelekile kwiimfuno zonyango zezigulane ezinokuvuvukala okungapheliyo (ezifana ne-lupus erythematosus kunye nezinye izifo ezizimele).

I-anti-cancer mechanism ye-triterpenoids ihluke kwi-polysaccharides.

Ukongeza, iqela lika-Hua Fan likwavavanye umsebenzi we-anticancer yeekhompawundi ezisibhozo ze-triterpene eyodwa kumzimba ovelisa iziqhamo.I-Ganoderma lucidum.Iziphumo zabonisa ukuba ezimbini kwezi triterpenes zineziphumo ezibalulekileyo zokuchasa kunye ne-pro-apoptotic kwiiseli zomhlaza wamabele womntu, iiseli zomhlaza webala lomntu kunye neeseli ezinobungozi zemelanoma.

Kuhlalutyo olongezelelweyo lweendlela ezithi zimbini ze-triterpenes zikhuthaze i-apoptosis yeeseli zomhlaza, abaphandi bafumanise ukuba "ngokuthe ngqo" banyanzela iiseli zomhlaza ukuba zizitshabalalise "ngokunciphisa amandla enwebu ye-mitochondria" kunye "nokunyusa uxinzelelo lwe-oxidative ye-mitochondria" .Oku kwahluke ngokupheleleyo kwindima yeI-Ganoderma lucidumi-polysaccharide GLIS ethi "ngokungathanga ngqo" inqanda amathumba ngokusebenzisa amajoni omzimba.

I-Polysaccharides okanye i-triterpenes ingasetyenziswa yodwa okanye ngokudibeneyo.

U-Hua Fan usenze saqonda ngemodeli yophando yaseJamani engqongqo ukuba izithako ezahlukeneyo ezisebenzayoI-Ganoderma lucidum"inokudibaniswa" ukudala ixabiso lempilo lokwandisa ubomi okanye "inokusetyenziswa ngokwahlukileyo" ukubonelela ngemiphumo ethile yokunyanga izifo ezikhoyo.

Ngaba kunokwenzeka ukwenza iipolysaccharides ezisebenzayo kunye ne-triterpenes esebenzayo kuvavanyo lwamachiza eklinikhi kwixesha elizayo?“Uze ujonge isizukulwana esitsha!”U-Hua Fan wajonga ngokulindelekileyo kuJinsong Zhang, owayesele eseke iqela elinamandla lophando.

Eli nqaku licatshulwe kwiZiziphi izihloko ezibalulekileyo zeGanoderma ezixutyushwa kwinkomfa ye-mushroom ebaluleke kakhulu edliwayo kwi-2018?-Tyena iNkomfa ye-9 yeZizwe ngezizwe kwiBiology yeMushroom kunye neeMveliso zamaMushroom(Icandelo 2).

UDkt. Hua Fan ovela kwiYunivesithi yamahhala yaseBerlin, eJamani, wanikela intetho malunga "UkuHlola iMpilo yokuNakekela iGanoderma" kwiNkomfa ye-9 yeZizwe ngezizwe kwi-Mushroom Biology kunye neeMveliso zeMushroom.(Ifoto/Wu Tingyao)

ISIPHELO

Malunga nombhali/ Nksz. Wu Tingyao
UWu Tingyao unike ingxelo okokuqalaI-Ganoderma lucidumulwazi ukususela ngo-1999. Ungumbhali weUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).
 
★ Eli nqaku lipapashwa phantsi kogunyaziso olukhethekileyo lombhali ★ Le misebenzi ingentla ayinakuphinda kuveliswe, icatshulwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa ngumbhali ★ Ukwaphulwa kwale nkcazo ingasentla, umbhali uya kuqhuba uxanduva lwakhe lomthetho olunxulumeneyo ★ Eyokuqala umbhalo weli nqaku ubhalwe ngesiTshayina nguWu Tingyao kwaye waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.