I-Reishi Polysaccrides kanye ne-Colitis

Ukube bekungengenxa yesimemezelo esingazelelwe sokusula kukaNdunankulu waseJapan uShinzo Abe ngo-Agasti 28, abantu abaningi bebengeke basibone lesi sifo esizimele esidinga ukwelashwa impilo yonke-i-ulcerative colitis.

Abantu abaningi abakwazi ukubekezelela izinsuku eziningi zobuhlungu besisu kanye nesifo sohudo esibangelwa izifo ezibangelwa amagciwane, ingasaphathwa eye-ulcerative colitis enezimpawu ezifana ne-hemafecia, imfiva, ukuhlanza, ukuphelelwa amanzi emzimbeni, nokuncipha kwesisindo.Owokuqala ungelapheka ngemithi kanti owokugcina uwukuvuvukala nokulimala kolwelwesi lwamathumbu okubangelwa izizathu ezingaziwa.Imithi ayikwazi ukuqeda lesi sifo futhi ingacindezela kuphela ukuvuvukala futhi ikhulule izimpawu ezihlobene.

Eqinisweni, inkinga ye-ulcerative colitis ilele “ekuvuvukeni okungafanele kuphele akupheli.Lapho amasosha omzimba aqala impendulo yokuvuvukala ehluleka, impendulo yokuvuvukala iba umbulali wezempilo futhi ingase ibangele nomdlavuza wamangqamuzana.

U-Zhang Yongping (ophakathi), imenenja-jikelele ye-General Manager Office ye-Xinhua News Agency kanye nabantu abahlobene abaphethe bathatha isithombe seqembu nethimba le-GANOHERB

I-National Brand Project iphrojekthi yezokuxhumana esezingeni likazwelonke eyakhiwe i-Xinhua News Agency ukuze inikeze isu Lokuvuselela I-China Ngephrojekthi Yemikhiqizo Kazwelonke.Izinkampani ezikhethiwe kufanele zihlangabezane nemibandela eqinile ehlukahlukene efana nokunamathela njalo “ekugxilweni komsebenzi oyinhloko nokufeza izithakazelo zizonke”, ukubamba iqhaza ngokuqaphela nasekusebenzeni isu lentuthuko likazwelonke, ukuba nomuzwa oqinile wokuzibophezela komphakathi, amakhono okuqamba azimele ahamba phambili embonini. , ukubonakala okuphezulu komphakathi kanye nesithunzi somkhiqizo kanye nesiko elihle lenkampani, ukukhuthaza umoya wobuciko, ukusekela ukuphathwa kobuqotho nokuthobela umthetho, ukuba nekhwalithi enhle kakhulu emelela ukukhiqizwa kweShayina kanye nekhwalithi yaseShayina, nokuba nomdlandla ngenhlalakahle yomphakathi, ukusebenzisa ngenkuthalo iNational National Uhlelo Oluhlosiwe Lokuqeda Ubumpofu, futhi ukleliswe phambili embonini ngokwamazinga aphelele amandla.

Ibhrendi iyindlela ebalulekile yokuthi amabhizinisi athuthukise ukuncintisana kwawo okuphelele.Ukukhethwa kokuthi "Iphrojekthi Yomkhiqizo Kazwelonke ye-Xinhua News Agency" kulokhu kuqinisekisa isikhundla esiphambili somkhiqizo we-GANOHERB embonini ye-Chinese Reishi.Ukubambisana okuqinile ne-Xinhua News Agency kuzothuthukisa inani lomkhiqizo namandla omkhiqizo we-"GANOHERB" futhi kubonise kangcono ukubukeka komkhiqizo we-Chinese Lingzhi.

Umfanekiso 1 Umdwebo we-Schematic wamathumbu amakhulu kanye nezithombe ze-endoscopic ze-ulcerative colitis

Amathumbu amakhulu ahlanganisa i-cecum, i-colon, ne-rectum (isithombe esingakwesokunxele): i-cecum ixhunywe emathunjini amancane ukuze kuvinjwe i-reflux yokudla engena emathunjini amakhulu;ikholoni lilawula ukugayeka kokudla kanye nomsebenzi wokumunca wethumbu elikhulu futhi lenze izinsalela zibe indle, egcinwa okwesikhashana ku-rectum ukuze ikhishwe.I-ulcerative colitis yenzeka ikakhulukazi ezicutshini ze-colon kanye ne-rectum.I-Endoscopy izobonisa ukuvuvukala nezilonda ku-colonic mucosa.(Isithombe/Wikimedia Commons)

Ukunciphisa ukuvuvukala kuyadambisa kuphela kuyilapho ukulawula ukungatheleleki kungase kubangele ukwelapha unomphela.

Ngokuphathelene nenkinga yokuphazamiseka komzimba, izidakamizwa ezikhona zingabeka kuphela "izimpawu" ezibangelwa ukuphazamiseka komzimba.

"Ukulawula ukungatheleleki nokuqinisa futhi kuqiniswe ukumelana komzimba" ekuqaleni kuyibhodi lezimpawu ezisagolide zekhowe likaReishi.Ngokusho kwezincwadi zesayensi ezishicilelwe kuze kube manje, kuyaziwa ukuthi kungakhathaliseki ukuthi i-polysaccharides noma i-triterpenes evela ku-Reishi mushroom, ingalawula ukungatheleleki futhi idlale indima ebalulekile ekuthuthukiseni i-ulcerative colitis.

I-Reishi mushroom polysaccharides inciphisa ubulukhuni be-colitis.

Yomibili imibiko eshicilelwe nguMnyango Wezempilo waseChina Medical University ku-Journal of Immunology Research ngo-2018 kanye nombiko oshicilelwe ku-Food & Nutrition Research nguMnyango Wesayensi Yokudla Nobunjiniyela baseJinan University ngo-2019 kwafakazela ngephutha ukuthi ukuphathwa ngomlomo. we-Ganoderma lucidum polysaccharides kumthamo wokuvimbela emasontweni angu-2 kuya kwangu-3 anganciphisa kakhulu ukuqina kokuhlaselwa kwe-ulcerative colitis (Umfanekiso 2).

Umfanekiso 2 I-Ganoderma lucidum polysaccharides inciphisa izimpawu ze-ulcerative colitis.

Amagundane ahlanganiswe ne-Ganoderma lucidum polysaccharides (100 mg/kg ngosuku) amasonto amabili kusengaphambili ayenokuncipha okuncane kwesisindo kanye nomsebenzi wezifo ophansi (ukuncipha kwesisindo esincane, isifo sohudo kanye ne-hemafecia) enobude obude bekholoni (ebonisa ukuvuvukala nokulimala okuncane) kanye ukulimala okuncane kakhulu kwezicubu (okuhlanganisa izinga lokulimala kwezicubu ze-mucosal kanye nokungena kwe-leukocyte) lapho ukuhlaselwa okunamandla kwe-ulcerative colitis kwenziwa.(Umthombo/Inkomba 1).

Kungani i-Ganoderma lucidum polysaccharides ingathuthukisa i-ulcerative colitis?Imibiko emibili yocwaningo ehlaziywe ngemibono emibili ehlukene: "ukulawula ukuphendula kwamasosha omzimba" kanye "nokulawula imvelo yamathumbu":

Indlela 1: I-Ganoderma lucidum polysaccharides ilawula ukuvuvukala futhi ivimbele amaseli e-Th17

Ucwaningo olwenziwa yi-China Medical University lwathola ukuthi amagundane ayengezwe nge-Ganoderma lucidum polysaccharides kusengaphambili ayenama-cytokines ambalwa ahlobene nokuvuvukala kuzicubu ze-colorectal mucosal ngesikhathi sokuhlasela okunamandla kwe-ulcerative colitis (Umfanekiso 3).Ayengekho amangqamuzana abulalayo emvelo amaningi kanye namaseli e-Th17 akhuthaza ukuvuvukala, kodwa amaseli e-B akwazi ukukhiqiza i-IgA, i-antibody eyinhloko yezicubu ze-mucosal, akhule ngokumelene nalo mkhuba.

Lezi zinguquko zokuzivikela komzimba azigcini nje ukusiza ukunciphisa impendulo yokuvuvukala futhi zisize amathumbu ukuba amelane nezifo ezingenzeka kodwa futhi abe nethuba lokulungisa ukungalingani kwamangqamuzana e-Th17 kanye namaseli e-T alawulayo (i-Treg) nokuthuthukisa inkinga ye-autoimmune ye-ulcerative colitis emthonjeni.

Sonke isifo esizimele sinesici esibalulekile esikhuthaza ukuqala kwaso futhi sikhulise ukuwohloka kwaso.Nge-ulcerative colitis, ingenye ye-T-cell subtypes ebizwa ngokuthi amaseli e-Th17.I-cytokine eyimfihlo i-IL-17 (i-IL-17A iyona ebaluleke kakhulu) ingalwa nezifo ezihlukahlukene ze-bacterial and fungal ngokusebenzisa ukuvuvukala futhi iyindima ebalulekile yesithiyo sokuzivikela emathunjini.

Ukweqisa kubi njengokushoda.Amaseli e-Th17 kanye "namaseli e-T alawulayo" azohlola futhi alinganise omunye nomunye, ngokuningi ngakolunye uhlangothi nangaphansi kolunye.Umsebenzi wamaseli e-T alawulayo ukugcina ukubekezelelana kwe-autoimmune (hhayi ukwethula impendulo yokuzivikela komzimba kumalungu omndeni womuntu siqu) nokubeka amabhuleki ekuphenduleni kokuvuvukala ngesikhathi esifanele.Ngakho-ke, lapho amaseli e-Th17 esebenza kakhulu, amaseli e-T alawulayo azoba buthakathaka futhi ukuvuvukala okungaphezulu kuzokwenzeka.

Ukungalingani kwala maqembu amabili amangqamuzana kuthathwa njengokhiye wokuqhumisa i-ulcerative colitis.Kulolu cwaningo olubalulwe ngenhla lwe-China Medical University, nakuba amaseli e-T alawulayo ezicutshini ze-mucosal yegundane lamathumbu amakhulu awazange akhuliswe ukungenelela kwe-Ganoderma lucidum polysaccharides, ukukhishwa kwamaseli e-Th17 kanye ne-IL-17A kuye kwancishiswa kakhulu ( Umfanekiso 3), okufanele kube isiqalo esihle sebhalansi phakathi kwamaseli e-Th17 namaseli T alawulayo.

Umfanekiso 3 I-Ganoderma lucidum polysaccharides ilawula ukungatheleleki futhi ithuthukise ukuqunjelwa.

Ngamagundane ayesengezwe nge-Ganoderma lucidum polysaccharide amasonto amabili (100 mg / kg ngosuku), ngesikhathi sokuhlasela okukhulu kwe-ulcerative colitis, i-tumor necrosis factor ehlobene nokuvuvukala (TNF-α) kanye nama-interleukins afana ne-IL-1β, I-IL-6, IL-4, IL-17A ku-colonic mucosa tissue yehla kakhulu, futhi izinga lamaseli e-Th17 nalo lehla kakhulu, kodwa izinga lamaseli e-T alawulayo lalingabalulekile ngokwezibalo (uma kuqhathaniswa namagundane e-colitis ayengazange yengezwe ngeGanoderma lucidum polysaccharides).(Umthombo/Inkomba 1)

Indlela 2: I-Ganoderma lucidum polysaccharides ilawula i-ecology yamathumbu futhi isize ukulungisa ukungatheleleki okungalingani.

Ucwaningo oluvela eNyuvesi yaseJinan luthole ukuthi i-Ganoderma lucidum polysaccharides ingakwazi ukulungisa isilinganiso sezitshalo zamathumbu zamagundane okuhlola (njengokunciphisa i-pathogenic flora, ukwandisa isitshalo esimelana nokuvuvukala kanye nezimfihlo ze-short chain fatty acid), futhi ikhuthaze umgudu wamathumbu ukuthi ukhiphe. ama-fatty acids amaningi ama-short-chain (Umfanekiso wesi-4), nawo alawula impendulo yokuzivikela ye-mucosa yamathumbu futhi anciphise ukuqina kwe-ulcerative colitis.

Ingxenye enkulu yezinto ezimuncwa ithumbu elikhulu ikhiqizwa amagciwane ahlala emathunjini amakhulu.Lapho lawo ma-polysaccharides angakwazi ukugaywa amathumbu amancane (njenge-fiber yokudla, i-Ganoderma lucidum polysaccharides) engena ethunjini elikhulu, azohlukaniswa abe ama-fatty chain ahlukahlukene ahlukahlukene yiqembu lamabhaktheriya athembele kuwo ukuze aziphilise. .Lawa ma-acetic acid, ama-propionic acid nama-asidi e-butyric awagcini nje ukondla amangqamuzana amathumbu kodwa futhi avikela umgoqo we-mucosal futhi alawule ukuphendula kwamasosha omzimba.Uma kuqhathaniswa nalolu hlobo lwamabhaktheriya anobungane, amanye amagciwane amathumbu angabagqugquzeli bokuvuvukala.Lapho isilinganiso somunye nomunye singalingani, ngokuvamile kuba yisiqalo sokugula.

Ucwaningo luye lwaqinisekisa ukuthi ukungalingani kwesilinganiso sezitshalo zamathumbu kanye nokungakhiqizi okwanele kwamafutha e-short chain kungabangela ukuphazamiseka kwamasosha omzimba futhi kubangele i-ulcerative colitis.I-Ganoderma lucidum polysaccharides ingahlehlisa isimo, ilawule ukungatheleleki ngokulawula imvelo yamathumbu, futhi ithuthukise i-ulcerative colitis.Akupholile?(Izoqhubeka-Ganoderma triterpenes)

Umfanekiso 4 I-Ganoderma lucidum polysaccharides ilawula imvelo yamathumbu futhi ithuthukise ukuqunjelwa

Amagundane adliswa nge-Ganoderma lucidum polysaccharides amasonto angu-3 (393.75 mg/kg ngosuku) futhi abe esengeniswa ukuhlaselwa okunamandla kwe-ulcerative colitis.Amathumbu abo avuvukele ngokuvamile anesimo sokwanda kwezitshalo ze-Proteobacteria, ukuncipha kwezitshalo ze-Firmicutes, kanye nokuncipha kokuphuma kwe-fatty chain secretion.Kodwa-ke, emathunjini amakhulu avikelwe i-Ganoderma lucidum polysaccharides, izimbali ezimbili ezinkulu ziye zabhekana nokukhula okuphawulekayo nokwehla, futhi okuqukethwe kwamafutha e-short-chain fatty acids nakho kukhuphuke kakhulu.(Umthombo/Inkomba 2)

【Izithenjwa】

Wei B, et al.Ukucindezelwa kwe-Th17 Cell Response Ekuqedeni I-Dextran Sulfate Sodium-Induced Colitis nge-Ganoderma lucidum Polysaccharides.I-JImmunolRes.2018 May 20;2018:2906494.doi: 10.1155/2018/2906494.I-eCollection 2018.2.Xie J, et al.I-Ganoderma lucidum polysaccharide ithuthukisa i-rat DSS-induced colitis ngokushintsha i-cecalmicrobiota kanye ne-gene expression of colonic epithelial cells.Ukudla Nutr Res.2019 Feb 12;63.doi: 10.29219/fnr.v63.1559.I-eCollection 2019.

Mayelana nombhali/ Nks. Wu Tingyao
U-Wu Tingyao ubelokhu ebika ngolwazi lokuqala lwe-Ganoderma lucidum kusukela ngo-1999. Ungumbhali we-“Ganoderma lucidum: Ingenious Beyond Description” (eshicilelwe ku-People's Medical Publishing House ngo-April 2017).

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