ʻO Reishi Polysaccrides a me Colitis

Inā ʻaʻole no ka hoʻolaha koke ʻana i ka haʻalele ʻana e ke Kuhina Nui o Iapana ʻo Shinzo Abe i ka lā 28 ʻAukake, nui ka poʻe i ʻike ʻole i kēia maʻi autoimmune e pono ai ka mālama ʻana i ke ola lōʻihi-ulcerative colitis.

ʻAʻole hiki i ka hapa nui o ka poʻe ke ʻae i nā lā he nui o ka ʻeha o ka ʻōpū a me ka maʻi maʻi i hoʻokumu ʻia e ka maʻi bacteria, koe wale nō ka ulcerative colitis me nā hōʻailona e like me ka hemafecia, ke kuni, ka luaʻi ʻana, ka wai maloʻo, a me ka pohō kaumaha.Hiki ke ho'ōla ʻia ka mea mua e nā lāʻau lapaʻau ʻoiai ʻo ka hope ka ʻeha a me ka pōʻino o ka mucosa ʻōpū i hoʻokumu ʻia e nā kumu ʻike ʻole.ʻAʻole hiki i nā lāʻau lapaʻau ke hoʻopau i ka maʻi a hiki ke hoʻopau wale i ka mumū a hoʻomaha i nā hōʻailona pili.

ʻO ka ʻoiaʻiʻo, aia ka pilikia o ka ulcerative colitis i "ʻaʻole e pau ka ʻā ʻana ʻaʻole pono."Ke hāʻule ka ʻōnaehana pale e hoʻomaka i ka pane ʻeha, lilo ka pane ʻeha i mea pepehi olakino a hiki ke hoʻoulu i ka maʻi maʻi maʻi.

ʻO Zhang Yongping (waena), ka luna nui o ka Luna Nui Keʻena o Xinhua News Agency a me nā poʻe pili i mālama i lawe i kahi kiʻi pūʻulu me ka hui o GANOHERB

ʻO ka National Brand Project kahi papahana kamaʻilio pae ʻāina i hana ʻia e Xinhua News Agency e lawelawe i ka papahana o Reinvigorating China Through National Brands project.Pono nā hui i koho ʻia e hoʻokō i nā kūlana koʻikoʻi like ʻole e like me ka pili mau ʻana i ka "ka nānā ʻana i ka hana koʻikoʻi a me ka lawelawe ʻana i nā pono holoʻokoʻa", me ka noʻonoʻo i ke komo ʻana a me ka lawelawe ʻana i ka hoʻolālā hoʻomohala aupuni, me ka manaʻo ikaika o ke kuleana pilikanaka, alakaʻi i nā ʻoihana kūʻokoʻa kūʻokoʻa. , kiʻekiʻe ka ʻike kaiāulu a me ka inoa inoa inoa a me ka moʻomeheu hui maikaʻi, e hoʻoikaika ana i ka ʻuhane o ka hana, e kākoʻo ana i ka hoʻokele pono a me ka mālama ʻana i ke kānāwai, loaʻa kahi ʻano maikaʻi loa e hōʻike ana i ka hana ʻana o Kina a me ka maikaʻi o Kina, a me ka hoihoi i ka pono o ka lehulehu, e hoʻokō ikaika ana i ka National. Hoʻolālā ʻia ʻo Poverty Alleviation Plan, a me ka hoʻonohonoho ʻana i ke poʻo o ka ʻoihana e pili ana i nā pae ikaika piha.

He mea nui ka Brand no nā ʻoihana e hoʻomaikaʻi i kā lākou hoʻokūkū piha.Ke koho ʻia nei i loko o ka "National Brand Project of Xinhua News Agency" i kēia manawa ke hōʻoia nei i ke kūlana alakaʻi o ka brand GANOHERB i ka ʻoihana Reishi Kina.ʻO ka hui pū ʻana me Xinhua News Agency e hoʻonui i ka waiwai o ka brand a me ka ikaika o ka brand "GANOHERB" a hōʻike maikaʻi i ka nani o ka brand Lingzhi.

Kiʻi 1 kiʻi hoʻolālā o ka ʻōpū nui a me nā kiʻi endoscopic o ka ulcerative colitis

Aia i loko o ka ʻōpū nui ka cecum, colon, a me ka rectum (kiʻi hema): pili ka cecum i ka ʻōpū liʻiliʻi e pale i ka reflux o ka meaʻai e komo i ka ʻōpū nui;ʻO ke kolonā e hoʻomalu i ka hana ʻana a me ka absorption o ka ʻōpū nui a hana i ke koena i nā feces, kahi i mālama ʻia i loko o ka rectum no ka hoʻokuʻu ʻana.Loaʻa ka ulcerative colitis ma nā ʻiʻo mucosal o ke kolonā a me ka rectum.Hōʻike ka Endoscopy i ka mumū a me nā ʻeha i loko o ka mucosa colon.(Photo/Wikimedia Commons)

ʻO ka hoʻohaʻahaʻa ʻana i ka mumū he palliative wale nō ʻoiai ke hoʻoponopono ʻana i ka pale ʻana hiki ke hoʻokō i kahi hoʻōla mau.

E pili ana i ka pilikia o nā maʻi immune, hiki i nā lāʻau lapaʻau ke hoʻonohonoho wale i nā "hōʻailona" i hana ʻia e nā maʻi immune.

ʻO "ka hoʻoponopono ʻana i ka palekana a me ka hoʻoikaika ʻana a me ka hoʻohui ʻana i ke kūʻē kino" ʻo ia ka papa kuhikuhi gula-leka o ka Reishi mushroom.Wahi a ka palapala ʻepekema i paʻi ʻia a hiki i kēia manawa, ʻike ʻia inā he polysaccharides a triterpenes paha mai Reishi mushroom, hiki iā lākou ke hoʻoponopono i ka immunity a pāʻani i kahi kuleana nui i ka hoʻomaikaʻi ʻana i ka ulcerative colitis.

Hoʻemi ka Reishi mushroom polysaccharides i ka paʻakikī o ka colitis.

ʻO ka hōʻike i paʻi ʻia e ka Department of Immunology of China Medical University ma ka Journal of Immunology Research ma 2018 a me ka hōʻike i paʻi ʻia ma ka Food & Nutrition Research e ka Department of Food Science and Engineering o Jinan University ma 2019 i hōʻoia i ka hoʻokele waha. ʻO Ganoderma lucidum polysaccharides ma kahi pānaʻi pale i ka 2 a hiki i ka 3 pule hiki ke hoʻemi nui i ka paʻakikī o ka hoʻouka ʻana o ka ulcerative colitis (Figure 2).

Kiʻi 2 Ganoderma lucidum polysaccharides e hōʻemi i nā hōʻailona o ka ulcerative colitis.

ʻO nā ʻiole i hoʻohui ʻia me Ganoderma lucidum polysaccharides (100 mg/kg i kēlā me kēia lā) no ʻelua pule ma mua ua emi ke kaumaha a me ka haʻahaʻa haʻahaʻa o ka hana maʻi (ka pohō māmā, ka diarrhea a me ka hemafecia) me ka lōʻihi o ke kolon (e hōʻike ana i ka liʻiliʻi o ka mumū a me ka pōʻino) a liʻiliʻi liʻiliʻi ka pōʻino o ka ʻiʻo (me ke ʻano o ka pōʻino o ka ʻiʻo mucosal a me ke komo ʻana o ka leukocyte) i ka wā i hoʻoulu ʻia ai ka hoʻouka ʻana o ka ulcerative colitis.(Ke Kumu/Reference 1).

No ke aha e hiki ai i Ganoderma lucidum polysaccharides ke hoʻomaikaʻi i ka ulcerative colitis?ʻElua mau hōʻike noiʻi i kālailai ʻia mai ʻelua mau hiʻohiʻona like ʻole: "regulating immune response" a "regulating intestinal ecology":

Mechanism 1: Ganoderma lucidum polysaccharides e hoʻoponopono i ka mumū a keʻakeʻa i nā pūnaewele Th17

Ua ʻike ʻia kahi noiʻi a China Medical University ʻo nā ʻiole i hoʻohui ʻia me Ganoderma lucidum polysaccharides ma mua he liʻiliʻi nā cytokines pili i ka mumū i loko o ka ʻiʻo mucosal colorectal i ka wā o ka hoʻouka ʻana o ka ulcerative colitis (Figure 3).ʻAʻole nui nā pūnae pepehi maoli a me nā pūnaewele Th17 i hoʻoikaika i ka mumū, akā ʻo nā pūnae B hiki ke hūnā iā IgA, ka antibody nui o ka ʻiʻo mucosal, ua ulu kūʻē i ke ʻano.

ʻO kēia mau hoʻololi immune ʻaʻole wale e kōkua i ka hoʻohaʻahaʻa ʻana i ka pane inflammatory a kōkua i ka ʻōpū e pale aku i nā maʻi hiki ke loaʻa i ka manawa kūpono e hoʻoponopono ai i ka imbalance o nā cell Th17 a me nā ʻāpana T regulatory (Treg) a hoʻomaikaʻi i ka pilikia autoimmune o ulcerative colitis mai ke kumu.

Loaʻa i kēlā me kēia maʻi autoimmune kahi kumu nui e hoʻoikaika ai i kona hoʻomaka ʻana a hoʻonui i kona deterioration.No ka ulcerative colitis, ʻo ia kekahi o nā subtypes T-cell i kapa ʻia ʻo Th17 cell.ʻO ka cytokine IL-17 huna (IL-17A ka mea nui loa) hiki ke hakakā i nā maʻi bacterial a me nā maʻi fungal ma o ka mumū a he hana koʻikoʻi ia o ka pale pale pale.

Ua like ka hewa me ka hemahema.ʻO nā pūnaewele Th17 a me nā "pūnaewele T hoʻoponopono" e nānā a kaulike kekahi i kekahi, me ka nui ma kekahiʻaoʻao a emi iho ma kekahiʻaoʻao.ʻO ka hana o nā pūnaewele T regulatory ʻo ia ka mālama ʻana i ka hoʻomanawanui autoimmune (ʻaʻole e hoʻomaka i kahi pane kūlohelohe i nā lālā o ka ʻohana ponoʻī) a kau i nā kaʻa i ka pane ʻeha i ka manawa kūpono.No laila, i ka wā e ʻeleu ai nā pūnaewele Th17, e nāwaliwali nā pūnaewele T hoʻoponopono a nui aʻe ka mumū.

ʻO ke kaulike ʻole o kēia mau pūʻulu ʻelua i manaʻo ʻia ʻo ia ke kī i ka detonating ulcerative colitis.Ma ka haʻawina i ʻōlelo ʻia ma luna o China Medical University, ʻoiai ʻaʻole i hoʻonui ʻia nā cell T regulatory i loko o nā ʻiʻo mucosal o ka ʻōpū nui o ka ʻiole e ka hana ʻana o Ganoderma lucidum polysaccharides, ua hoʻemi nui ʻia ka huna ʻana o nā cell Th17 a me IL-17A ( Kiʻi 3), ʻo ia ka hoʻomaka maikaʻi no ke kaulike ma waena o nā cell Th17 a me nā cell T regulatory.

Hōʻike 3 Ganoderma lucidum polysaccharides e hoʻoponopono i ka palekana a hoʻomaikaʻi i ka colitis.

No nā ʻiole i hoʻohui ʻia me ka Ganoderma lucidum polysaccharide no ʻelua pule (100 mg/kg i kēlā me kēia lā), i ka wā o ka hoʻouka ʻana o ka ulcerative colitis, ka mea pili i ka maʻi maʻi necrosis factor (TNF-α) a me nā interleukins e like me IL-1β, IL-6, IL-4, IL-17A i loko o ka colonic mucosa kikoo loa hoemi, a me ka pae o Th17 pūnaewele no hoi i emi loa, akā, i ka pae o regulatory T keena ka mea, aole i helu helu (i ka hoohalike ana me ka colitis iole i ole. ua hoʻohui ʻia me Ganoderma lucidum polysaccharides).(Ke kumu/Nānā 1)

Mechanism 2: Hoʻoponopono ʻo Ganoderma lucidum polysaccharides i ka ecology intestinal a kōkua i ka hoʻoponopono ʻana i ka pale ʻole.

Ua ʻike ʻia ka noiʻi mai ke Kulanui ʻo Jinan e hiki i ka Ganoderma lucidum polysaccharides ke hoʻoponopono i ka ratio o ka pua o ka ʻōpū o nā ʻiole hoʻokolohua (e like me ka hōʻemi ʻana i ka flora pathogenic, ka hoʻonui ʻana i ka pua e kūʻē i ka mumū a me nā mea huna pōkole-chain fatty acid), a hoʻoikaika i ka ʻāpana ʻōpū e huna. ʻoi aku ka nui o nā ʻakika momona pōkole (Figure 4), ʻo ia ka mea e hoʻoponopono ai i ka pane kūlohelohe o ka mucosa intestinal a hoʻemi i ka paʻakikī o ka ulcerative colitis.

ʻO kahi hapa nui o ka mea i hoʻomoʻa ʻia e ka ʻōpū nui e hana ʻia e ka bacteria e noho ana i loko o ka ʻōpū nui.Ke komo kēlā mau polysaccharides i hiki ʻole ke hoʻoheheʻe ʻia e ka ʻōpū liʻiliʻi (e like me ka fiber dietary, Ganoderma lucidum polysaccharides) i loko o ka ʻōpū nui, e wāwahi ʻia lākou i loko o nā ʻakika momona pōkole e kahi hui bacteria e hilinaʻi nei iā lākou no ke ola. .ʻO kēia mau acetic acids, propionic acids a me butyric acids ʻaʻole ia e hānai wale i nā ʻōpū o ka ʻōpū akā pale pū kekahi i ka pale mucosal a hoʻoponopono i ka pane immune.Ke hoʻohālikelike ʻia me kēia ʻano bacteria hoa aloha, ʻo kekahi mau bacteria ʻōpū ka mea e hoʻolalelale ai i ka mumū.Inā ʻaʻole kaulike ka hapa o kekahi i kekahi, ʻo ia ka hoʻomaka ʻana o kahi maʻi.

Ua hōʻoia ʻia nā haʻawina ʻo ke kaulike ʻole o ka ratio flora intestinal a me ka lawa ʻole o ka huna ʻana o nā ʻakika momona pōkole hiki ke hoʻoulu i nā maʻi kūlohelohe a hoʻoulu i ka ulcerative colitis.Hiki i ka Ganoderma lucidum polysaccharides ke hoʻololi i ke kūlana, hoʻoponopono i ka palekana ma o ka hoʻoponopono ʻana i ka ecology intestinal, a hoʻomaikaʻi hou i ka ulcerative colitis.ʻAʻole maikaʻi?(E hoʻomau ʻia-Ganoderma triterpenes)

Kiʻi 4 Ganoderma lucidum polysaccharides e hoʻoponopono i ka ecology o ka ʻōpū a hoʻomaikaʻi i ka colitis

Ua hānai ʻia nā ʻiole me Ganoderma lucidum polysaccharides no nā pule he 3 (393.75 mg/kg i kēlā me kēia lā) a laila ua hoʻoulu ʻia i kahi hōʻeha koʻikoʻi o ka ulcerative colitis.ʻO ko lākou ʻōpū ʻeha ka mea maʻamau i ka hoʻonui ʻia o ka pua Proteobacteria, hoʻemi i ka flora Firmicutes, a hoʻemi i ka huna ʻana o ka momona momona.Eia nō naʻe, i loko o ka ʻōpū nui i pale ʻia e Ganoderma lucidum polysaccharides, ua ʻike nā pua nui ʻelua i ka ulu nui a me ka emi ʻana, a ua piʻi nui hoʻi ka ʻike o nā waikawa momona pōkole.(Ke kumu/Nānā 2)

【References】

Wei B, et al.Hoʻopau i ka Th17 Cell pane i ka hoʻohaʻahaʻa ʻana i ka Dextran Sulfate Sodium-Induced Colitis e Ganoderma lucidum Polysaccharides.JImmunolRes.2018 Mei 20;2018:2906494.doi: 10.1155/2018/2906494.eCollection 2018.2.Xie J, et al.Hoʻomaikaʻi ʻo Ganoderma lucidum polysaccharide i ka ʻiole DSS-induced colitis ma o ka hoʻololi ʻana i ka cecalmicrobiota a me ka hōʻike ʻana o nā cell epithelial colonic.Meaʻai Nutr Res.2019 Feb 12;63.doi: 10.29219/fnr.v63.1559.eCollection 2019.

No ka mea kākau/ Ms. Wu Tingyao
Ke hōʻike nei ʻo Wu Tingyao i ka ʻike mua Ganoderma lucidum mai 1999. ʻO ia ka mea kākau o "Ganoderma lucidum: Ingenious Beyond Description" (i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).

★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau, a no GANOHERB ka mea nona ★ ʻAʻole hiki ke hana hou ʻia nā hana ma luna aʻe, ʻoki ʻia a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka GanoHerb ★ Inā ua ʻae ʻia nā hana e hoʻohana ʻia, Pono e hoʻohana ʻia i loko o ke ʻano o ka ʻae ʻia a hōʻike i ke kumu: GanoHerb ★ ʻAʻe i ka ʻōlelo i luna, e ʻimi ʻo GanoHerb i kāna mau kuleana pili kānāwai.

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