Reishi Polysacchrides na Colitis

Iyo hataba itangazwa ritunguranye ryatanzwe na Minisitiri w’intebe w’Ubuyapani Shinzo Abe ku ya 28 Kanama, abantu benshi ntibari kubona iyi ndwara ya autoimmune isaba kwivuza ubuzima-bwa kolite.

Abantu benshi ntibashobora kwihanganira iminsi myinshi yububabare bwo munda hamwe nimpiswi ziterwa nubwandu bwa bagiteri, tutibagiwe na colitis ibisebe bifite ibimenyetso nka hemafecia, umuriro, kuruka, kubura umwuma, no kugabanya ibiro.Iyambere irashobora gukira imiti mugihe iyanyuma ari ugutwika no kwangirika kwa mucosa yo munda yatewe nimpamvu zitazwi.Imiti ntishobora gukuraho indwara kandi irashobora guhagarika gusa umuriro no kugabanya ibimenyetso bifitanye isano.

Mubyukuri, ikibazo cya kolite y ibisebe kiri mu "gutwika bitagomba kubaho ntibihagarara."Iyo sisitemu yumubiri itangiza igisubizo cyananiranye, igisubizo cyo gutwika gihinduka umwicanyi wubuzima ndetse gishobora no gutera kanseri ya selile.

Zhang Yongping (hagati), umuyobozi mukuru wibiro bikuru bishinzwe ibiro ntaramakuru bya Xinhua hamwe n’abandi bafitanye isano bafashe ifoto yitsinda hamwe nitsinda rya GANOHERB

Umushinga w’ibikorwa by’igihugu ni umushinga w’itumanaho ku rwego rw’igihugu washyizweho n’ikigo cy’amakuru cya Xinhua kugira ngo ukore ingamba zo kongera ingufu mu Bushinwa binyuze mu mushinga w’igihugu.Ibigo byatoranijwe bigomba kuba byujuje ibisabwa bitandukanye nko guhora byubahiriza "kwibanda ku gikorwa nyamukuru no guharanira inyungu rusange", kugira uruhare no gukorera ingamba z’iterambere ry’igihugu, bifite imyumvire ikomeye y’inshingano z’imibereho, ubushobozi bw’inganda zigenga udushya twigenga. , imibereho myiza igaragara no kumenyekana no kumenyekanisha umuco hamwe n’umuco mwiza w’ibigo, guteza imbere umwuka w’ubukorikori, kubahiriza imiyoborere y’ubunyangamugayo no kubahiriza amategeko, kugira ireme ryiza ryerekana inganda z’Ubushinwa n’ubuziranenge bw’Ubushinwa, kandi ushishikajwe n’imibereho myiza y’abaturage, ushyira mu bikorwa igihugu Intego igamije kurwanya ubukene, no gushyira ku mwanya wa mbere mu nganda ukurikije imbaraga zuzuye.

Ikirango nuburyo bwingenzi kubigo bitezimbere ubushobozi bwabo bwo guhangana.Gutoranywa muri "National Brand Project of Xinhua News Agency" iki gihe cyemeza umwanya wambere wikirango cya GANOHERB munganda zubushinwa Reishi.Ubufatanye bukomeye n’ikigo cy’amakuru cya Xinhua kizarushaho kuzamura agaciro n’ikirango cya “GANOHERB” no kwerekana neza igikundiro cy’umushinwa Lingzhi.

Igishushanyo 1 Igishushanyo mbonera cy'amara manini n'amashusho ya endoskopique ya colitis ibisebe

Amara manini arimo cecum, colon, na rectum (ifoto y'ibumoso): cecum ihujwe n'amara mato kugirango birinde ko ibiryo byinjira mu mara manini;ururondogoro rugenzura igogorwa ryimikorere no kwinjiza amara manini kandi rugakora ibisigara mu mwanda, bibikwa by'agateganyo mu muyoboro kugira ngo bisohoke.Indwara ya colitis iboneka cyane cyane mumitsi ya mucosal ya colon na rectum.Endoscopi izerekana uburibwe n'ibisebe muri mucosa.(Ifoto / Wikimedia Commons)

Kugabanya gucana ni palliative gusa mugihe kugenzura ubudahangarwa bishobora gukiza burundu.

Kubyerekeye ikibazo cyubudahangarwa bw'umubiri, imiti iriho irashobora gushiraho gusa "ibimenyetso" biterwa nuburwayi.

"Kugenga ubudahangarwa no gushimangira no gushimangira kurwanya umubiri" mubyukuri icyapa cyanditseho zahabu cy ibihumyo bya Reishi.Dukurikije ibitabo bya siyansi byatangajwe kugeza ubu, birazwi ko yaba polysaccharide cyangwa triterpène ziva mu gihumyo cya Reishi, zishobora kugenga ubudahangarwa kandi zikagira uruhare runini mu kuzamura kolite y’ibisebe.

Reishi mushroom polysaccharide igabanya ubukana bwa colitis.

Raporo yombi yasohowe n’ishami ry’ubudahangarwa muri kaminuza y’ubuvuzi y’Ubushinwa mu kinyamakuru cy’ubushakashatsi bw’ubudahangarwa mu mwaka wa 2018 na raporo yasohotse mu bushakashatsi bw’ibiribwa n’imirire n’ishami ry’ubumenyi bw’ibiribwa n’ubuhanga muri kaminuza ya Jinan muri 2019 byahuriranye n’ubuyobozi bw’akanwa. ya Ganoderma lucidum polysaccharide ku kigero cyo kwirinda mu byumweru 2 kugeza kuri 3 birashobora kugabanya cyane ubukana bwibitero bya kolitisite (Ishusho 2).

Igishushanyo 2 Ganoderma lucidum polysaccharide igabanya ibimenyetso bya kolite y ibisebe.

Imbeba zongerewe na Ganoderma lucidum polysaccharide (100 mg / kg kumunsi) muminsi ibyumweru bibiri mbere yabanje kugabanya ibiro hamwe nibikorwa byindwara nkeya (gutakaza ibiro byoroheje, diarrhea na hemafecia) hamwe nuburebure bwa colon (byerekana umuriro muke no kwangirika) kandi kwangirika gukabije kwinyama (harimo urugero rwo kwangirika kwimitsi ya mucosal no kwinjira kwa leukocyte) mugihe habaye igitero gikaze cya colitis ulcerative colitis.(Inkomoko / Reba 1).

Kuki Ganoderma lucidum polysaccharide ishobora kunoza colitis?Raporo ebyiri z’ubushakashatsi zasesenguwe mu buryo bubiri butandukanye: “kugenzura ubudahangarwa bw'umubiri” no “kugenzura ibidukikije byo mu mara”:

Uburyo bwa 1: Ganoderma lucidum polysaccharide igenga umuriro kandi ikabuza selile Th17

Ubushakashatsi bwakozwe na kaminuza y’ubuvuzi y’Ubushinwa bwerekanye ko imbeba zari zongerewe na Ganoderma lucidum polysaccharide hakiri kare zifite cytokine nkeya ziterwa n’umuriro mu ngingo zifata umwijima mu gihe cy’igitero gikaze cya kolite y’ibisebe (Ishusho 3).Ntabwo ingirabuzimafatizo nyinshi zica hamwe na selile Th17 zateje umuriro, ariko selile B zishobora gusohora IgA, antibody nyamukuru yumubiri wa mucosal, yakuze irwanya iyo nzira.

Izi mpinduka z’ubudahangarwa ntizifasha gusa kugabanya igisubizo cy’umuriro no gufasha amara kurwanya indwara zishobora kubaho ariko kandi zifite amahirwe yo gukosora ubusumbane bw’utugingo ngengabuzima Th17 hamwe n’utugingo ngengabuzima T (Treg) no kunoza ikibazo cya autoimmune ya kolite y’ibisebe bituruka ku isoko.

Indwara zose ziterwa na autoimmune zifite ikintu cyingenzi gitera itangira kandi cyongera ububi bwacyo.Kuri colitis ibisebe, ni bumwe mu bwoko bwa T-selile bwitwa Th17 selile.Cytokine isohoka IL-17 (IL-17A niyo ikomeye cyane) irashobora kurwanya indwara zitandukanye ziterwa na bagiteri na fungal binyuze mu gucana kandi ni uruhare runini rwinzitizi zo mu nda.

Ibirenze ni bibi kimwe no kubura.Th17 selile na "kugenzura T selile" bizagenzura kandi bingane, hamwe nibindi byinshi kuruhande rumwe na bike kurundi.Imikorere ya selile T igenga ni ugukomeza kwihanganira autoimmune (kudatangiza ubudahangarwa bw'umuryango wawe) no gushyira feri kubisubizo byaka mugihe gikwiye.Kubwibyo, iyo selile ya Th17 ikora cyane, T igenga T selile izacika intege kandi hazabaho umuriro mwinshi.

Ubusumbane bwaya matsinda yombi yingirabuzimafatizo bifatwa nkurufunguzo rwo guturika ibisebe bya kolite.Mu bushakashatsi bwavuzwe haruguru muri kaminuza y’ubuvuzi y’Ubushinwa, n’ubwo ingirabuzimafatizo za T zigenga ingirabuzimafatizo zo mu nda nini zitigeze ziyongera bitewe no gutabara kwa Ganoderma lucidum polysaccharide, imisemburo ya selile Th17 na IL-17A yagabanutse cyane ( Igishushanyo 3), bigomba kuba intangiriro nziza kuburinganire hagati ya selile Th17 na selile T igenga.

Igicapo 3 Ganoderma lucidum polysaccharide igenga ubudahangarwa no kunoza kolite.

Ku mbeba zari zujujwe na Ganoderma lucidum polysaccharide mu byumweru bibiri (100 mg / kg kumunsi), mugihe cy'igitero gikaze cya colitis ulcerative, indwara yibibyimba biterwa no gutwika indwara (TNF-α) na interleukine nka IL-1β, IL-6, IL-4, IL-17A mu nyama zo mu nda ya mucosa yagabanutse ku buryo bugaragara, kandi urwego rwa selile Th17 narwo rwaragabanutse ku buryo bugaragara, ariko urwego rw’utugingo ngengabuzima T ntirwari rufite imibare (ugereranije n'imbeba za colitis zitari zifite) hiyongereyeho Ganoderma lucidum polysaccharide).(Inkomoko / Reba 1)

Mechanism 2: Ganoderma lucidum polysaccharide igenga ibidukikije byo munda kandi igafasha guhindura ubudahangarwa bw'umubiri.

Ubushakashatsi bwakorewe muri kaminuza ya Jinan bwerekanye ko Ganoderma lucidum polysaccharide ishobora guhindura igipimo cy’ibimera byo mu mara by’imbeba zigerageza (nko kugabanya ibimera bitera indwara, kongera ibimera birwanya umuriro no guhisha aside irike y’urunigi), kandi bigatera imbere mu mara gusohora. andi mavuta acide aciriritse (Isanamu 4), nayo agenga ubudahangarwa bw'umubiri wa mucosa wo munda kandi bikagabanya ubukana bwa kolite y ibisebe.

Igice kinini cyibintu byinjijwe n amara manini bikorwa na bagiteri ziba mu mara manini.Iyo izo polysaccharide zidashobora gutogorwa n amara mato (nka fibre yibiryo, Ganoderma lucidum polysaccharide) zinjiye mu mara manini, zizacika mo ibice bitandukanye byamavuta acide aciriritse nitsinda rya bagiteri biterwa nabo kugirango babeho. .Acide acetike, acide protionic na acide butyric ntabwo igaburira ingirabuzimafatizo zo munda gusa ahubwo inarinda inzitizi ya mucosal kandi igenga ubudahangarwa bw'umubiri.Ugereranije nubu bwoko bwa bagiteri yinshuti, bagiteri zimwe zo munda nizo zitera umuriro.Iyo igipimo cya buriwese kitaringaniye, akenshi ni intangiriro yuburwayi.

Ubushakashatsi bwemeje ko ubusumbane bw’imiterere y’ibimera byo mu mara hamwe n’isohoka ridahagije rya aside irike ya aside irike bishobora gutera indwara z’umubiri kandi bigatera kolite ibisebe.Ganoderma lucidum polysaccharide irashobora guhindura ibintu, igenga ubudahangarwa igenga ibidukikije byo munda, kandi ikarushaho kunoza kolite y ibisebe.Ntabwo ari byiza?(Gukomeza-Ganoderma triterpène)

Igicapo 4 Ganoderma lucidum polysaccharide igenga ibidukikije byo munda no kunoza kolite

Imbeba zagaburiwe na Ganoderma lucidum polysaccharide mu byumweru 3 (393,75 mg / kg kumunsi) hanyuma zitera igitero gikaze cya kolite y ibisebe.Amara yabo yaka ubusanzwe afite ikibazo cyo kwiyongera kwa flora ya Proteobacteria, kugabanuka kwa flora ya Firmicutes, no kugabanuka kwa acide ya fatty acide.Nyamara, mu mara manini arinzwe na Ganoderma lucidum polysaccharide, ibimera bibiri byingenzi byagiye bikura kandi bigabanuka, kandi ibirimo aside irike ngufi na byo byazamutse cyane.(Inkomoko / Reba 2)

Reba】

Wei B, n'abandi.Kurwanya Th17 Ibisubizo Byakagari muguhashya Dextran Sulfate Sodium Yatewe na Colitis na Ganoderma lucidum Polysaccharide.JImmunolRes.2018 Gicurasi 20; 2018: 2906494.doi: 10.1155 / 2018/2906494.gutoranya 2018.2.Xie J, n'abandi.Ganoderma lucidum polysaccharide itezimbere imbeba DSS iterwa na colitis ihindura cecalmicrobiota hamwe na gene imvugo ya selile epithelial selile.Ibiryo Nutr Res.2019 Gashyantare 12; 63.doi: 10.29219 / fnr.v63.1559.eCollection 2019.

Ibyerekeye umwanditsi / Madamu Wu Tingyao
Wu Tingyao yagiye atanga amakuru ku makuru ya Ganoderma lucidum kuva mu 1999. Ni umwanditsi wa “Ganoderma lucidum: Ingenious Beyond Description” (yasohotse mu gitabo cy’ubuvuzi cy’ubuvuzi muri Mata 2017).

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