Reishi Polysaccrides ndi Colitis

Pakadapanda chilengezo chadzidzidzi cha kusiya ntchito kwa Prime Minister waku Japan Shinzo Abe pa Ogasiti 28, anthu ambiri sakadazindikira matenda a autoimmune awa omwe amafunikira chithandizo chamoyo wonse-ulcerative colitis.

Anthu ambiri sangathe kupirira masiku angapo a ululu wa m'mimba ndi kutsekula m'mimba chifukwa cha matenda a bakiteriya, osasiya zilonda zam'mimba zomwe zimakhala ndi zizindikiro monga hemafecia, kutentha thupi, kusanza, kutaya madzi m'thupi, ndi kuwonda.Yoyamba ikhoza kuchiritsidwa ndi mankhwala pamene yotsirizira ndi kutupa ndi kuwonongeka kwa matumbo a m'mimba chifukwa cha zifukwa zosadziwika.Mankhwalawa sangathe kuthetsa matendawa ndipo amatha kupondereza kutupa ndikuchepetsa zizindikiro zofananira.

Ndipotu vuto la zilonda zam’mimba lagona pa “kutupa kumene sikuyenera kuchitika sikutha.”Pamene chitetezo cha mthupi chimayambitsa kuyankha kotupa chikulephera, kuyankha kotupa kumakhala kupha thanzi ndipo kungayambitsenso khansa ya m'maselo.

Zhang Yongping (wapakati), manejala wamkulu wa Ofesi Yoyang'anira Nkhani ya Xinhua ndi ena omwe anali kuyang'anira adatenga chithunzi cha gulu ndi gulu la GANOHERB

National Brand Project ndi ntchito yolumikizirana yapadziko lonse lapansi yopangidwa ndi Xinhua News Agency kuti igwiritse ntchito njira yolimbikitsanso China Kupyolera mu projekiti ya National Brands.Makampani omwe asankhidwa ayenera kukwaniritsa zovuta zosiyanasiyana monga kumamatira nthawi zonse "kuyang'ana ntchito yayikulu ndikutumikira zofuna zonse", kutenga nawo mbali ndikutumikira ndondomeko yachitukuko cha dziko, kukhala ndi malingaliro amphamvu a chikhalidwe cha anthu, luso lotsogolera makampani odziimira okha. , kuwonekera kwapamwamba pagulu ndi mbiri yamakampani ndi chikhalidwe chabwino chamakampani, kulimbikitsa mzimu waluso, kutsata kasamalidwe ka Umphumphu ndi kutsatira malamulo, kukhala ndi khalidwe labwino kwambiri lomwe limaimira kupanga kwa China ndi khalidwe la China, komanso kukhala wokondwa ndi ubwino wa anthu, kugwiritsa ntchito mwakhama National Targeted Poverty Alleviation Plan, ndikukhala patsogolo pamakampaniwo malinga ndi kuchuluka kwamphamvu.

Brand ndi njira yofunikira kuti mabizinesi apititse patsogolo mpikisano wawo.Kusankhidwa kukhala "National Brand Project ya Xinhua News Agency" nthawi ino ikutsimikizira kutsogolera kwa mtundu wa GANOHERB mumakampani aku China Reishi.Mgwirizano wamphamvu ndi Xinhua News Agency upititsa patsogolo mtengo wamtundu wa "GANOHERB" ndikuwonetsanso chithumwa cha Chinese Lingzhi.

Chithunzi 1 Chithunzi chojambula chamatumbo akulu ndi zithunzi za endoscopic za ulcerative colitis.

Utumbo waukulu umaphatikizapo cecum, colon, ndi rectum (chithunzi cha kumanzere): cecum imagwirizanitsidwa ndi matumbo aang'ono kuti ateteze kuphulika kwa chakudya kulowa m'matumbo aakulu;matumbo amawongolera kagayidwe ndi kuyamwa kwa matumbo akulu ndikupanga zotsalirazo kukhala ndowe, zomwe zimasungidwa kwakanthawi mu rectum kuti zituluke.Kutupa kwa zilonda zam'mimba kumachitika makamaka m'matumbo am'matumbo ndi rectum.Endoscopy idzawonetsa kutupa ndi zilonda zam'mimba mucosa.(Chithunzi/Wikimedia Commons)

Kuchepetsa kutupa kumangochepetsako pomwe kuwongolera chitetezo chokwanira kumatha kuchiritsa mpaka kalekale.

Pankhani ya vuto la kusokonezeka kwa chitetezo cha mthupi, mankhwala omwe alipo amatha kukhazikitsa "zizindikiro" zomwe zimayambitsidwa ndi matenda a chitetezo cha mthupi.

"Kuwongolera chitetezo chokwanira komanso kulimbikitsa komanso kulimbikitsa kukana kwa thupi" poyambirira ndi chikwangwani chagolide cha bowa wa Reishi.Malinga ndi zolemba zasayansi zomwe zafalitsidwa mpaka pano, zimadziwika kuti ndi ma polysaccharides kapena triterpenes ochokera ku bowa wa Reishi, amatha kuwongolera chitetezo chamthupi ndikuthandiza kwambiri pakuwongolera zilonda zam'mimba.

Reishi bowa polysaccharides amachepetsa kuopsa kwa colitis.

Malipoti onse awiri omwe adasindikizidwa ndi dipatimenti ya Immunology ya China Medical University mu Journal of Immunology Research mu 2018 komanso lipoti lofalitsidwa mu Food & Nutrition Research ndi dipatimenti ya Food Science and Engineering ya Jinan University mu 2019 zinatsimikizira kuti kuyang'anira pakamwa. wa Ganoderma lucidum polysaccharides pa mlingo wodzitetezera mu 2 kwa masabata a 3 akhoza kuchepetsa kwambiri kuopsa kwa matenda a ulcerative colitis (Chithunzi 2).

Chithunzi 2 Ganoderma lucidum polysaccharides amachepetsa zizindikiro za ulcerative colitis.

Makoswe ophatikizidwa ndi Ganoderma lucidum polysaccharides (100 mg/kg patsiku) kwa milungu iwiri pasadakhale anali ndi kuchepa thupi pang'ono komanso kuchepa kwa matenda (kuchepa thupi, kutsekula m'mimba ndi hemafecia) ndi kutalika kwa m'matumbo (zomwe zikuwonetsa kutupa pang'ono ndi kuwonongeka) ndi kuwonongeka kocheperako kwa minofu (kuphatikiza kuchuluka kwa kuwonongeka kwa minofu ya mucosal ndi kulowa kwa leukocyte) pamene chiwopsezo cha ulcerative colitis chidayamba.(Magwero/Nkhani 1).

Chifukwa chiyani Ganoderma lucidum polysaccharides ingathandize kuti zilonda zam'mimba zizikhala bwino?Malipoti awiri ofufuza omwe adawunikidwa kuchokera kumitundu iwiri yosiyana: "kuwongolera kuyankha kwa chitetezo chathupi" ndi "kuwongolera zamoyo zam'mimba":

Njira 1: Ganoderma lucidum polysaccharides imayang'anira kutupa ndikuletsa ma cell a Th17

Kafukufuku wopangidwa ndi China Medical University adapeza kuti mbewa zomwe zidawonjezeredwa ndi Ganoderma lucidum polysaccharides pasadakhale zinali ndi ma cytokines ochepa okhudzana ndi kutupa m'matumbo amtundu wa colorectal mucosal kuukira koopsa kwa ulcerative colitis (Chithunzi 3).Panalibe maselo ambiri akupha achilengedwe ndi ma cell a Th17 omwe amalimbikitsa kutupa, koma maselo a B omwe amatha kutulutsa IgA, antibody yayikulu ya minofu ya mucosal, adakula motsutsana ndi izi.

Kusintha kwa chitetezo cha m'thupi kumeneku sikungothandiza kuchepetsa kuyankha kwa kutupa ndikuthandizira matumbo kukana matenda omwe angatheke komanso kukhala ndi mwayi wokonza kusamvana kwa maselo a Th17 ndi maselo a T olamulira (Treg) ndikuwongolera vuto la autoimmune la ulcerative colitis kuchokera ku gwero.

Matenda aliwonse a autoimmune ali ndi chinthu chofunikira kwambiri chomwe chimalimbikitsa kuyambika kwake ndikuwonjezera kuwonongeka kwake.Kwa ulcerative colitis, ndi amodzi mwa T-cell subtypes yotchedwa Th17 cell.Cytokine yobisika ya IL-17 (IL-17A ndiyo yofunika kwambiri) imatha kulimbana ndi matenda osiyanasiyana a bakiteriya ndi mafangasi kupyolera mu kutupa ndipo ndi gawo lofunika kwambiri la chitetezo cha m'mimba.

Kuchulukirachulukira kulinso koyipa monga kuperewera.Maselo a Th17 ndi "maselo a T olamulira" adzayang'ana ndi kulinganiza wina ndi mzake, ndi zambiri mbali imodzi ndi zochepa kumbali inayo.Ntchito ya maselo a T owongolera ndikusunga kulolerana kwa autoimmune (osati kuyambitsa kuyankha kwa chitetezo chamthupi kwa achibale anu) ndikuyika mabuleki pakuyankha kotupa munthawi yake.Choncho, pamene maselo a Th17 akugwira ntchito kwambiri, maselo a T olamulira adzakhala ofooka ndipo kutupa kudzachitika.

Kusagwirizana kwa magulu awiriwa a maselo amaonedwa kuti ndi chinsinsi chothetsera matenda a ulcerative colitis.Mu kafukufuku tatchulawa wa China Medical University, ngakhale kuti zowongolera maselo T mu mucosal zimakhala za mbewa matumbo aakulu sanawonjezeke ndi kulowererapo kwa Ganoderma lucidum polysaccharides, katulutsidwe wa maselo Th17 ndi IL-17A wakhala kwambiri yafupika. Chithunzi 3), chomwe chiyenera kukhala chiyambi chabwino chapakati pa maselo a Th17 ndi maselo a T olamulira.

Chithunzi 3 Ganoderma lucidum polysaccharides imayang'anira chitetezo chamthupi ndikuwongolera colitis.

Kwa mbewa zomwe zidawonjezeredwa ndi Ganoderma lucidum polysaccharide kwa milungu iwiri (100 mg / kg patsiku), panthawi yachiwopsezo cha ulcerative colitis, chotupa chokhudzana ndi kutupa kwa necrosis factor (TNF-α) ndi interleukins monga IL-1β, IL-6, IL-4, IL-17A mu colonic mucosa minofu yafupika kwambiri, ndipo msinkhu wa maselo a Th17 nawonso unachepetsedwa kwambiri, koma mlingo wa maselo olamulira T sunali wofunikira kwambiri (poyerekeza ndi mbewa za colitis zomwe sizinalipo. kuwonjezeredwa ndi Ganoderma lucidum polysaccharides).(Magwero/Nkhani 1)

Njira 2: Ganoderma lucidum polysaccharides imayang'anira zamoyo zam'mimba ndikuthandizira kusintha chitetezo chokwanira.

Kafukufuku wochokera ku yunivesite ya Jinan adapeza kuti Ganoderma lucidum polysaccharides amatha kusintha chiŵerengero cha zomera za m'mimba za makoswe oyesera (monga kuchepetsa zomera zowonongeka, kuonjezera zomera zomwe zimalimbana ndi kutupa komanso zinsinsi za mafuta afupiafupi), ndikulimbikitsa matumbo kuti atuluke. mafuta afupiafupi amafuta acids (Chithunzi 4), omwe amawongolera chitetezo cham'matumbo am'mimba ndikuchepetsa kuopsa kwa zilonda zam'mimba.

Mbali yaikulu ya zinthu zomwe zimatengedwa ndi matumbo akuluakulu amapangidwa ndi mabakiteriya omwe amakhala m'matumbo akuluakulu.Pamene ma polysaccharides omwe sangathe kugayidwa ndi matumbo aang'ono (monga zakudya zopangira zakudya, Ganoderma lucidum polysaccharides) amalowa m'matumbo akuluakulu, amagawidwa kukhala mafuta afupiafupi osiyanasiyana ndi gulu la mabakiteriya omwe amadalira iwo kuti akhale ndi moyo. .Ma acetic acids, ma propionic acid ndi ma butyric acid samangodyetsa ma cell a m'mimba komanso amateteza chotchinga cha mucosal ndikuwongolera chitetezo chamthupi.Poyerekeza ndi mtundu uwu wa mabakiteriya ochezeka, mabakiteriya ena am'mimba ndi omwe amalimbikitsa kutupa.Pamene chiŵerengero cha wina ndi mzake chikasokonekera, nthawi zambiri chimakhala chiyambi cha matenda.

Kafukufuku watsimikizira kuti kusalinganika kwa chiŵerengero cha zomera za m'mimba ndi kuchepa kwa mafuta afupiafupi a mafuta acids kungayambitse matenda a chitetezo cha mthupi ndi kuyambitsa zilonda zam'mimba.Ma Ganoderma lucidum polysaccharides amatha kusintha mkhalidwewo, kuwongolera chitetezo chamthupi mwa kuwongolera zamoyo zam'matumbo, ndikuwonjezera kukulitsa matenda am'matumbo.Si zabwino?(Kupitilira-Ganoderma triterpenes)

Chithunzi 4 Ganoderma lucidum polysaccharides imayang'anira zachilengedwe zam'matumbo ndikuwongolera colitis

Makoswe adadyetsedwa ndi Ganoderma lucidum polysaccharides kwa milungu itatu (393.75 mg/kg patsiku) ndipo kenako adayambitsa matenda a ulcerative colitis.Matumbo awo otupa amakhala ndi chodabwitsa cha kuchuluka kwa zomera za Proteobacteria, kuchepa kwa zomera za Firmicutes, ndi kuchepa kwa katulutsidwe kakang'ono ka mafuta acid.Komabe, m'matumbo akuluakulu otetezedwa ndi Ganoderma lucidum polysaccharides, zomera ziwiri zazikuluzikulu zakhala zikukula kwambiri ndi kuchepa, ndipo zomwe zili mumtundu wafupipafupi wamafuta acids zakweranso kwambiri.(Magwero/Nkhumbo 2)

【Zowonjezera】

Wei B, ndi al.Kuponderezedwa kwa Th17 Cell Response mu Kuchepetsa Dextran Sulfate Sodium-Induced Colitis ndi Ganoderma lucidum Polysaccharides.JImmunolRes.2018 May 20;2018:2906494.doi: 10.1155/2018/2906494.eCollection 2018.2.Xie J, ndi al.Ganoderma lucidum polysaccharide imathandizira makoswe a DSS-induced colitis posintha cecalmicrobiota ndi mawonekedwe a jini a cell epithelial cell.Zakudya za Nutr Res.2019 Feb 12; 63.doi: 10.29219/fnr.v63.1559.eCollection 2019.

Za wolemba/ Mayi Wu Tingyao
Wu Tingyao wakhala akufotokoza za chidziwitso choyamba cha Ganoderma lucidum kuyambira 1999. Iye ndi mlembi wa "Ganoderma lucidum: Ingenious Beyond Description" (yofalitsidwa mu The People's Medical Publishing House mu April 2017).

★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba, ndipo umwini ndi wa GANOHERB ★ Ntchito zomwe zili pamwambazi sizingapangidwenso, kuchotsedwa kapena kugwiritsidwa ntchito m'njira zina popanda chilolezo cha GanoHerb ★ Ngati ntchitozo zaloledwa kugwiritsidwa ntchito, iwo ziyenera kugwiritsidwa ntchito mkati mwachilolezo ndikuwonetsa gwero: GanoHerb ★ Kuphwanya mawu omwe ali pamwambawa, GanoHerb idzatsatira maudindo ake okhudzana ndi malamulo

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