Reishi Polysaccharides na Colitis

Ọ bụrụ na ọ bụghị maka ọkwa ọkwa na mberede nke Mịnịsta Ala Japan Shinzo Abe arụkwaghịm n'August 28, ọtụtụ ndị mmadụ agaraghị achọpụta ọrịa autoimmune nke chọrọ ọgwụgwọ ogologo oge-ọlcerative colitis.

Ọtụtụ ndị mmadụ enweghị ike ịnabata ọtụtụ ụbọchị mgbu afọ na afọ ọsịsa nke nje na-efe efe na-akpata, ma ya fọdụkwa naanị ulcerative colitis nwere mgbaàmà dị ka hemafecia, ahụ ọkụ, vomiting, akpịrị ịkpọ nkụ, na mbelata ibu.Enwere ike ịgwọ nke mbụ site na ọgwụ ebe nke ikpeazụ bụ mbufụt na mmebi nke mucosa eriri afọ kpatara nke amaghị ihe kpatara ya.Ọgwụ ndị ahụ enweghị ike iwepụ ọrịa ahụ ma nwee ike igbochi mbufụt ma belata mgbaàmà ndị metụtara ya.

N'ezie, nsogbu nke ulcerative colitis dabeere na "mbufụt nke na-ekwesịghị ime adịghị akwụsị."Mgbe usoro ahụ ji alụso ọrịa ọgụ nke na-amalite nzaghachi mkpali na-ada ada, nzaghachi mkpali na-aghọ onye na-egbu ahụ ike ma nwee ike ịkpata ọrịa cancer cell.

Zhang Yongping (n'etiti), onye isi njikwa nke General Manager Office nke Xinhua News Agency na ndị metụtara ya na-ahụ maka ya na ndị otu GANOHERB sere otu foto.

The National Brand Project bụ ọrụ nzikọrịta ozi ọkwa mba nke Xinhua News Agency mebere iji jee ozi atụmatụ nke ime ka China dị ike site na ọrụ ụdị ụdị mba.Ụlọ ọrụ ndị ahọpụtara ga-ezute ọnọdụ dị iche iche siri ike dị ka ịnọgide na-agbaso "ilekwasị anya na ọrụ etiti na-eje ozi n'ozuzu mmasị", na-ekere òkè na nlezianya na-eje ozi na atụmatụ mmepe mba, na-enwe mmetụta siri ike nke ọrụ mmekọrịta mmadụ na ibe ya, ụlọ ọrụ na-eduzi ikike mmepụta onwe onye. , elu na-elekọta mmadụ visibiliti na ika aha na ezi ụlọ ọrụ omenala, na-akwalite mmụọ nke nka, na-akwado iguzosi ike n'ezi management na irube isi n'iwu, na-enwe ihe magburu onwe àgwà nke na-anọchi anya China si n'ichepụta na China àgwà, na-anụ ọkụ n'obi banyere ọha ọdịmma, na-arụsi ọrụ ike mejuputa National. Atụmatụ Mbelata ịda ogbenye ezubere iche, yana ọkwa n'ihu ụlọ ọrụ n'ihe gbasara ọkwa ike zuru oke.

Brand bụ ụzọ dị mkpa maka ụlọ ọrụ iji kwalite asọmpi ha zuru oke.N'ịbụ onye ahọpụtara n'ime "National Brand Project of Xinhua News Agency" oge a na-akwado ọnọdụ isi nke ika GANOHERB na ụlọ ọrụ Reishi China.Mmekọrịta siri ike na Xinhua News Agency ga-eme ka uru ika na ike nke "GANOHERB" dịkwuo mma ma gosipụta mma nke Chinese Lingzhi.

Onyonyo 1 Eserese atụmatụ nke nnukwu eriri afọ na ihe oyiyi endoscopic nke ulcerative colitis

Nnukwu eriri afọ na-agụnye cecum, colon, na rectum (foto aka ekpe): a na-ejikọta cecum na obere eriri afọ iji gbochie reflux nke nri na-abanye n'ime eriri afọ ukwu;eriri afọ na-achịkwa ọrụ mgbari na mgbari nke eriri afọ buru ibu ma na-emepụta ihe fọdụrụ n'ime nsị, nke a na-echekwa nwa oge n'ime ikensi maka ịgbapụ.Ulcerative colitis na-apụtakarị na anụ ahụ mucosal nke eriri afọ na ikensi.Endoscopy ga-egosi mbufụt na ọnya na mucosa colonic.(Foto/Wikimedia Commons)

Mbelata mbufụt bụ naanị ihe na-ebelata ebe ịchịkwa ihe mgbochi nwere ike imetụta ọgwụgwọ na-adịgide adịgide.

Banyere nsogbu nke ọrịa na-alụso ọrịa ọgụ, ọgwụ ndị dị ugbu a nwere ike ịtọ maka "mgbaàmà" nke ọrịa na-alụso ọrịa ọgụ kpatara.

"Ịchịkwa ihe mgbochi na iwusi ike na ime ka nguzogide anụ ahụ sie ike" bụ ihe nrịbama nke nwere mkpụrụedemede ọla edo nke ero Reishi.Dị ka akwụkwọ ndị ọkà mmụta sayensị bipụtara ugbu a, a maara na ma ọ bụ polysaccharides ma ọ bụ triterpenes sitere na ero Reishi, ha nwere ike ịhazi ihe mgbochi ma rụọ ọrụ dị mkpa n'ịkwalite ọrịa ulcerative colitis.

Reishi ero polysaccharides na-ebelata oke colitis.

Ma akụkọ ahụ nke Ngalaba Immunology nke Mahadum Ahụike China bipụtara na Journal of Immunology Research na 2018 na akụkọ ahụ bipụtara na Nchọpụta Nri & Nutrition nke Ngalaba Nri Sayensị na Injinia nke Mahadum Jinan na 2019 gosipụtara n'otu ntabi anya na nchịkwa ọnụ. nke Ganoderma lucidum polysaccharides na mgbochi mgbochi n'ime izu 2 ruo 3 nwere ike belata oke ọgụ nke ulcerative colitis (Figure 2).

Ihe osise 2 Ganoderma lucidum polysaccharides na-ebelata ihe mgbaàmà nke ulcerative colitis.

Ụmụ oke agbakwunyere na Ganoderma lucidum polysaccharides (100 mg / kg kwa ụbọchị) maka izu abụọ tupu oge eruo nwere obere ibu ibu na ọrịa ọrịa dị ala (mbelata dị arọ, afọ ọsịsa na hemafecia) na ogologo ogologo nke colon (na-egosi obere mbufụt na mmebi) na mmebi anụ ahụ dị obere (gụnyere ogo mmebi anụ ahụ mucosal na ntinye leukocyte) mgbe a kpalitere nnukwu ọgụ nke ulcerative colitis.(Isi mmalite/Ntụaka 1).

Kedu ihe kpatara Ganoderma lucidum polysaccharides nwere ike imezi ọnyá afọ ọnya?Akuko nyocha abuo nyochara site n'echiche abuo di iche iche: "nhazi nzaghachi nke mgbochi" na "ikwazi ihe ndi ozo nke intestinal":

Mechanism 1: Ganoderma lucidum polysaccharides na-achịkwa mbufụt ma na-egbochi sel Th17

Nnyocha nke Mahadum Ahụike China chọpụtara na ụmụ oke agbakwunyere na Ganoderma lucidum polysaccharides tupu oge eruo nwere obere cytokines metụtara mbufụt na anụ ahụ mucosal colorectal n'oge nnukwu ọgụ nke ulcerative colitis (Nyocha 3).Enweghị ọtụtụ mkpụrụ ndụ na-egbu egbu na sel Th17 na-akwalite mbufụt, mana mkpụrụ ndụ B nke nwere ike izobe IgA, bụ isi mgbochi nke anụ ahụ mucosal, toro megide omume ahụ.

Mgbanwe ndị a na-alụso ọrịa ọgụ ọ bụghị nanị na-enyere aka ibelata mmeghachi omume mkpali na-enyere eriri afọ aka iguzogide ọrịa ndị nwere ike ime ma nwee ohere iji dozie ahaghị nhata nke mkpụrụ ndụ Th17 na sel T na-achịkwa (Treg) ma melite nsogbu autoimmune nke ulcerative colitis site na isi iyi.

Ọrịa autoimmune ọ bụla nwere isi ihe na-akwalite mmalite ya ma mee ka ọ daa njọ.Maka ulcerative colitis, ọ bụ otu n'ime ụdị T-cell a na-akpọ sel Th17.Cytokine zoro ezo IL-17 (IL-17A bụ nke kachasị mkpa) nwere ike ịlụso nje bacteria na fungal dị iche iche ọgụ site na mbufụt ma bụrụ ọrụ dị mkpa nke mgbochi eriri afọ.

Ngafe dị njọ dị ka ụkọ.Mkpụrụ ndụ Th17 na "sel T na-achịkwa" ga-enyocha ma dozie ibe ha, na-enwekwu ihe n'otu akụkụ na obere n'akụkụ nke ọzọ.Ọrụ nke mkpụrụ ndụ T na-achịkwa bụ ịnọgide na-enwe ndidi nke autoimmune (ọ bụghị ịmalite mmeghachi omume mgbochi nye ndị òtù ezinụlọ nke onwe ya) na itinye breeki na nzaghachi mkpali n'oge.Ya mere, mgbe mkpụrụ ndụ Th17 na-arụsi ọrụ ike, mkpụrụ ndụ T na-achịkwa ga-esiwanye ike ma na-enwekwu mbufụt ga-eme.

A na-ahụtaghị ahaghị nhata nke otu mkpụrụ ndụ abụọ a dị ka isi ihe na-agbawa ọnya afọ.N'ime ọmụmụ ihe a kpọtụrụ aha n'elu nke Mahadum Medical China, ọ bụ ezie na sel T na-achịkwa na mucosal anụ ahụ nke oke eriri afọ adịghị abawanye site na ntinye aka nke Ganoderma lucidum polysaccharides, secretion nke sel Th17 na IL-17A belatara nke ukwuu ( Ọgụgụ 3), nke kwesịrị ịbụ mmalite dị mma maka nguzozi n'etiti sel Th17 na sel T na-achịkwa.

Ọgụgụ 3 Ganoderma lucidum polysaccharides na-achịkwa mgbochi ma melite colitis.

Maka ụmụ oke agbakwunyere na Ganoderma lucidum polysaccharide maka izu abụọ (100 mg / kg kwa ụbọchị), n'oge nnukwu ọgụ nke ulcerative colitis, ihe na-akpata ọrịa tumor necrosis (TNF-α) na interleukins dị ka IL-1β, IL-6, IL-4, IL-17A na colonic mucosa anụ ahụ belatara nke ukwuu, na ọkwa nke sel Th17 belatara nke ukwuu, mana ọkwa nke mkpụrụ ndụ T nke na-achịkwa abụghị ihe dị ịrịba ama (ma e jiri ya tụnyere ụmụ oke colitis nke na-enweghị. A na-agbakwunye ya na Ganoderma lucidum polysaccharides).(Isi mmalite/Ntụaka 1)

Mechanism 2: Ganoderma lucidum polysaccharides na-achịkwa ihe ọmụmụ nke eriri afọ ma nyere aka dozie ihe mgbochi na-adịghị mma.

Nnyocha sitere na Mahadum Jinan chọpụtara na Ganoderma lucidum polysaccharides nwere ike ịhazigharị oke nke ahịhịa eriri afọ nke oke nnwale (dịka ibelata ahịhịa ndụ pathogenic, ịba ụba ahịhịa nke na-egbochi mbufụt na nzuzo acid fatty dị mkpụmkpụ), ma kwalite traktị eriri afọ iji zoo. Acids fatty nke dị mkpụmkpụ karịa (Njirimara 4), nke n'aka nke ya na-achịkwa nzaghachi mgbochi nke mucosa intestinal ma na-ebelata ogo nke ulcerative colitis.

A na-emepụta akụkụ buru ibu nke ihe nke eriri afọ buru ibu na-amịpụta site na nje bacteria bi na nnukwu eriri afọ.Mgbe polysaccharides ndị ahụ nke obere eriri afọ enweghị ike ịgbari (dị ka eriri nri, Ganoderma lucidum polysaccharides) na-abanye n'ime eriri afọ buru ibu, otu nje bacteria na-adabere na ha maka ndụ ha ga-agbaji n'ime acid fatty dị mkpụmkpụ dị iche iche. .Acid acetic a, propionic acid na butyric acid ọ bụghị naanị na-azụ mkpụrụ ndụ eriri afọ kamakwa na-echekwa ihe mgbochi mucosal ma na-ahazi nzaghachi mgbochi.E jiri ya tụnyere ụdị nje bacteria enyi na enyi a, ụfọdụ nje bacteria na-akpata eriri afọ bụ ndị na-akwalite mbufụt.Mgbe ọnụ ọgụgụ nke ibe ha na-adịghị mma, ọ na-abụkarị mmalite nke ọrịa.

Nnyocha e mere egosila na enweghị ahaghị nhata nke flora intestinal na ezughị oke nke fatty acids dị mkpụmkpụ nwere ike ịkpata ọrịa mgbochi ma kpalite ulcerative colitis.Ganoderma lucidum polysaccharides nwere ike gbanwee ọnọdụ ahụ, na-achịkwa ihe mgbochi site n'ịchịkwa ihe ndị dị ndụ n'ime eriri afọ, ma na-emeziwanye ulcerative colitis.Ọ bụghị mma?A ga-aga n'ihu - Ganoderma triterpenes.

Ọgụgụ 4 Ganoderma lucidum polysaccharides na-achịkwa ihe ọmụmụ nke eriri afọ ma melite colitis.

A na-enye ụmụ oke ahụ na Ganoderma lucidum polysaccharides maka izu 3 (393.75 mg / kg kwa ụbọchị) wee bute ya nnukwu ọgụ nke ulcerative colitis.eriri afọ ha na-ere ọkụ na-enwekarị ihe omume nke ịba ụba Proteobacteria flora, mbelata osisi Firmicutes, na mbelata nzuzo acid fatty dị mkpụmkpụ.Otú ọ dị, n'ime eriri afọ buru ibu nke Ganoderma lucidum polysaccharides na-echebe, nnukwu floras abụọ ahụ enwewo ọganihu dị ukwuu na mbelata, na ọdịnaya nke fatty acids dị mkpụmkpụ ebiliwokwa nke ọma.(Isi mmalite/Ntụaka 2)

【Ntụaka】

Wei B, et al.Mwepu nke nzaghachi cell Th17 na Mbelata nke Dextran Sulfate Sodium Induced Colitis site na Ganoderma lucidum Polysaccharides.JImmunolRes.2018 Mee 20;2018:2906494 .doi: 10.1155/2018/2906494.eCollection 2018.2.Xie J, et al.Ganoderma lucidum polysaccharide na-eme ka oke DSS kpatara colitis site n'ịgbanwe cecalmicrobiota na mkpụrụ ndụ mkpụrụ ndụ nke mkpụrụ ndụ epithelial colonic.Nri Nutr Res.2019 Febụwarị 12;63.doi: 10.29219/fnr.v63.1559.eCollection 2019.

Banyere onye odee/ Oriakụ Wu Tingyao
Wu Tingyao na-akọ banyere ozi Ganoderma lucidum nke mbụ kemgbe 1999. Ọ bụ onye edemede nke "Ganoderma lucidum: Ingenious Beyond Description" (nke e bipụtara na Ụlọ Nbipụta Ahụike Ndị Mmadụ na April 2017).

★ A na-ebipụta akụkọ a n'okpuru ikike nke onye edemede, na onye nwe ya bụ GANOHERB ★ Ọrụ ndị dị n'elu enweghị ike ịmegharị, wepụ ma ọ bụ jiri ya mee ihe n'ụzọ ndị ọzọ na-enweghị ikike nke GanoHerb ★ Ọ bụrụ na enyere ikike iji ọrụ ndị ahụ, ha ekwesịrị iji ya mee ihe n'ime oke ikike wee gosi isi mmalite: GanoHerb ★ Mmebi okwu a dị n'elu, GanoHerb ga-agbaso ọrụ iwu metụtara ya.

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