Reishi Polysaccharides da Colitis

Idan ba don sanarwar murabus din da Firayim Ministan Japan Shinzo Abe ya yi ba a ranar 28 ga watan Agusta, da yawancin mutane ba su lura da wannan cutar ta autoimmune da ke buƙatar magani na tsawon rai-ulcerative colitis ba.

Yawancin mutane ba za su iya jurewa kwanaki da yawa na ciwon ciki da gudawa da cututtukan ƙwayoyin cuta ke haifar da su ba, balle maƙarƙashiya da alamun bayyanar cututtuka irin su hemafecia, zazzabi, amai, bushewa, da asarar nauyi.Na farko ana iya warkar da shi ta hanyar magunguna yayin da na karshen shine kumburi da lalacewar gabobin hanji wanda ba a sani ba.Magunguna ba za su iya kawar da cutar ba kuma suna iya kawar da kumburi kawai da sauƙaƙe alamun da ke da alaƙa.

A gaskiya ma, matsalar ulcerative colitis tana cikin "ƙumburi da bai kamata ya faru ba ya daina."Lokacin da tsarin garkuwar jiki wanda ya fara mayar da martani ya kasa, amsawar kumburi ya zama kisa na lafiya kuma yana iya haifar da ciwon daji na cell.

Zhang Yongping (tsakiyar), babban manajan ofishin kamfanin dillancin labarai na Xinhua da masu kula da harkokinsu sun dauki hoton rukuni tare da tawagar GANOHERB.

Shirin Samfurin Samfuran kasa shiri ne na sadarwa na kasa da kasa wanda kamfanin dillancin labarai na Xinhua ya kirkiro don ba da hidima ga dabarun farfado da kasar Sin ta hanyar aikin samar da kayayyaki na kasa.Kamfanonin da aka zaɓa dole ne su hadu da yanayi masu tsauri daban-daban kamar koyaushe suna manne wa "mayar da hankali kan babban aiki da kuma hidima ga bukatu gabaɗaya", shiga cikin sane da yin hidima ga dabarun ci gaban ƙasa, samun fahimtar alhaki na zamantakewa, ƙwarewar masana'antu masu zaman kansu masu zaman kansu. , mafi girman ganin jama'a da suna da kyakkyawar al'adun kamfanoni, da inganta ruhin sana'a, da kiyaye mutunci da bin doka, da samun kyakkyawan ingancin da ke wakiltar masana'antun kasar Sin da ingancin kasar Sin, da kuma nuna sha'awar jin dadin jama'a, da aiwatar da aikin kasa sosai. Tsare-tsaren kawar da talauci da aka yi niyya, da matsayi a sahun gaba na masana'antu dangane da cikakken ƙarfin matsayi.

Alamar wata hanya ce mai mahimmanci ga kamfanoni don haɓaka cikakkiyar gasa.Zaɓen da aka zaɓa a cikin "Ayyukan Samar da Samfuran na Kamfanin Dillancin Labarai na Xinhua" wannan lokacin ya tabbatar da matsayin jagorar alamar GANOHERB a cikin masana'antar Reishi ta kasar Sin.Haɗin gwiwa mai ƙarfi tare da Kamfanin Dillancin Labarai na Xinhua zai ƙara haɓaka ƙima da ƙarfin tambarin "GANOHERB" da kuma nuna kyakkyawar alamar ta Sin Lingzhi.

Hoto 1 Tsarin tsari na babban hanji da hotunan endoscopic na ulcerative colitis

Babban hanji ya hada da cecum, colon, da dubura (hoton hagu): Ana haɗa cecum zuwa ƙananan hanji don hana sake fitowar abinci shiga cikin babban hanji;hanjin yana sarrafa aikin narkewar abinci da sha na babban hanji kuma yana sanya ragowar zuwa cikin najasa, wanda aka adana na ɗan lokaci a cikin dubura don fitarwa.Ulcerative colitis yana faruwa musamman a cikin kyallen jikin mucosal na hanji da dubura.Endoscopy zai nuna kumburi da ulcers a cikin mucosa na colonic.(Photo/Wikimedia Commons)

Rage kumburi yana da tasiri ne kawai yayin da tsarin rigakafi zai iya haifar da magani na dindindin.

Game da matsalar rashin lafiyar jiki, magungunan da ke da su na iya saitawa kawai game da "alamomi" da ke haifar da rashin lafiya.

"Kayyade rigakafi da ƙarfafawa da ƙarfafa juriya na jiki" shine asalin alamar alamar zinare na naman kaza na Reishi.Bisa ga wallafe-wallafen kimiyya da aka buga ya zuwa yanzu, an san cewa ko polysaccharides ko triterpenes daga Reishi naman kaza, za su iya tsara rigakafi kuma suna taka muhimmiyar rawa wajen inganta ciwon ulcerative colitis.

Reishi naman kaza polysaccharides yana rage tsananin colitis.

Dukkanin rahoton da Sashen Nazarin Immunology na Jami'ar Kiwon Lafiya ta kasar Sin ya buga a cikin Journal of Immunology Research a cikin 2018 da rahoton da aka buga a cikin Binciken Abinci & Nutrition na Sashen Kimiyyar Abinci da Injiniya na Jami'ar Jinan a cikin 2019 kwatsam ya tabbatar da cewa sarrafa baki na Ganoderma lucidum polysaccharides a kashi na rigakafi a cikin makonni 2 zuwa 3 na iya rage girman tsananin hare-haren ulcerative colitis (Hoto 2).

Hoto 2 Ganoderma lucidum polysaccharides yana rage alamun cututtuka na ulcerative colitis.

Mice da aka haɓaka tare da Ganoderma lucidum polysaccharides (100 mg / kg kowace rana) na tsawon makonni biyu a gaba yana da ƙarancin asarar nauyi da ƙananan ayyukan cututtuka (asara mai nauyi, zawo da hemafecia) tare da tsayin tsayin hanji (yana nuna ƙananan kumburi da lalacewa) da kuma ƙananan lalacewar nama (ciki har da matakin lalacewar nama na mucosal da shigar da leukocyte) lokacin da aka haifar da mummunan harin ulcerative colitis.(Madogararsa/Reference 1).

Me yasa Ganoderma lucidum polysaccharides zai iya inganta ulcerative colitis?Rahoton bincike guda biyu an bincikar su ta fuskoki biyu daban-daban: "daidaita amsawar rigakafi" da "kayyade ilimin halittu na hanji":

Mechanism 1: Ganoderma lucidum polysaccharides yana daidaita kumburi da hana ƙwayoyin Th17

Wani binciken da Jami'ar Kiwon Lafiya ta kasar Sin ta gudanar ya gano cewa berayen da aka kara su da Ganoderma lucidum polysaccharides a gaba suna da karancin cytokines da ke da alaka da kumburi a cikin nama na mucosal mai launi yayin mummunan harin ulcerative colitis (Hoto 3).Babu ƙwayoyin kisa da yawa na halitta da ƙwayoyin Th17 waɗanda ke haɓaka kumburi, amma ƙwayoyin B waɗanda zasu iya ɓoye IgA, babban rigakafin ƙwayoyin mucosal, sun girma akan yanayin.

Wadannan sauye-sauye na rigakafi ba kawai taimakawa wajen rage amsawar kumburi ba kuma suna taimakawa hanji don tsayayya da cututtuka masu yiwuwa amma kuma suna da damar da za su gyara rashin daidaituwa na kwayoyin Th17 da kwayoyin T na ka'idoji (Treg) da kuma inganta matsalar autoimmune na ulcerative colitis daga tushe.

Kowace cuta ta autoimmune tana da maɓalli mai mahimmanci wanda ke haɓaka farkonsa kuma yana ƙara lalacewa.Ga ulcerative colitis, yana daya daga cikin nau'in T-cell da ake kira Th17 sel.Cytokine mai ɓoye IL-17 (IL-17A shine mafi mahimmanci) yana iya yaƙi da cututtukan ƙwayoyin cuta da fungal iri-iri ta hanyar kumburi kuma muhimmiyar rawa ce ta shingen rigakafi na hanji.

Yawanci yana da muni kamar rashi.Kwayoyin Th17 da "kwayoyin T masu mulki" za su duba da daidaita juna, tare da ƙari a gefe ɗaya kuma ƙasa a ɗayan.Ayyukan sel T na tsari shine kiyaye juriya na autoimmune (ba don ƙaddamar da martani na rigakafi ga danginsa ba) da kuma sanya birki akan amsa mai kumburi cikin lokaci.Sabili da haka, lokacin da ƙwayoyin Th17 ke aiki sosai, ƙwayoyin T masu sarrafawa zasu zama masu rauni kuma ƙarin kumburi zai faru.

Ana ɗaukar rashin daidaituwa na waɗannan ƙungiyoyin sel guda biyu a matsayin mabuɗin fashewar ulcerative colitis.A cikin binciken da aka ambata a sama na Jami'ar Kiwon Lafiya ta kasar Sin, ko da yake tsarin kwayoyin T a cikin kyallen jikin mucosal na babban hanji ba a karu ba ta hanyar shiga tsakani na Ganoderma lucidum polysaccharides, ɓoyewar ƙwayoyin Th17 da IL-17A ya ragu sosai. Hoto 3), wanda ya kamata ya zama kyakkyawan farawa don ma'auni tsakanin kwayoyin Th17 da kwayoyin T.

Hoto 3 Ganoderma lucidum polysaccharides yana tsara rigakafi da inganta colitis.

Don mice da aka ƙara tare da Ganoderma lucidum polysaccharide na tsawon makonni biyu (100 mg / kg kowace rana), a lokacin mummunan harin ulcerative colitis, ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta (TNF-α) da kuma interleukins irin su IL-1β, IL-6, IL-4, IL-17A a cikin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar kuma kuma ta rage yawan matakan Th17 sel kuma ya ragu sosai, amma matakin ƙwayoyin T na tsarin ba su da mahimmanci (idan aka kwatanta da ƙananan ƙwayoyin colitis da ba su da shi. Ganoderma lucidum polysaccharides.(Madogara/Nazari na 1)

Mechanism 2: Ganoderma lucidum polysaccharides yana daidaita yanayin yanayin hanji kuma yana taimakawa daidaita rashin daidaituwar rigakafi.

Bincike daga Jami'ar Jinan ya gano cewa Ganoderma lucidum polysaccharides na iya daidaita rabon flora na hanji na berayen gwaji (kamar rage ƙwayar cuta, ƙara flora da ke tsayayya da kumburi da asirin gajeriyar sarkar fatty acid), da inganta tsarin hanji don ɓoyewa. karin gajeriyar sarka mai fatty acid (Hoto na 4), wanda hakan ke daidaita martanin rigakafi na mucosa na hanji kuma yana rage tsananin ciwon ulcer.

Babban sashi na kayan da babban hanji ke sha yana samuwa ne daga kwayoyin da ke zaune a cikin babban hanji.Lokacin da waɗannan polysaccharides waɗanda ƙananan hanji ba za su iya narkar da su ba (irin su fiber na abinci, Ganoderma lucidum polysaccharides) suka shiga babban hanji, ƙungiyar ƙwayoyin cuta waɗanda ke dogara gare su don rayuwa za su rushe su zuwa cikin gajeriyar sarƙaƙƙiya iri-iri. .Wadannan acetic acid, propionic acid da butyric acid ba wai kawai suna ciyar da sel na hanji ba amma kuma suna kare shingen mucosal da daidaita amsawar rigakafi.Idan aka kwatanta da irin wannan nau'in ƙwayoyin cuta na abokantaka, wasu ƙwayoyin cuta na hanji sune masu haɓaka kumburi.Lokacin da rabon juna ya ɓace, sau da yawa shine farkon rashin lafiya.

Bincike ya tabbatar da cewa rashin daidaituwar flora na hanji da rashin isassun fatty acids na gajeriyar sarkar na iya haifar da rashin lafiya da kuma haifar da ulcerative colitis.Ganoderma lucidum polysaccharides na iya jujjuya halin da ake ciki, daidaita rigakafi ta hanyar daidaita yanayin yanayin hanji, da kuma kara inganta cututtukan ulcerative colitis.Ba dadi?(Za a ci gaba - Ganoderma triterpenes)

Hoto na 4 Ganoderma lucidum polysaccharides yana daidaita ilimin halittu na hanji da inganta colitis

An ciyar da berayen tare da Ganoderma lucidum polysaccharides na makonni 3 (393.75 mg / kg kowace rana) sannan kuma an haifar da mummunan harin ulcerative colitis.Hanjin su masu kumburi yawanci suna da al'amarin na ƙãra Proteobacteria flora, rage Firmicutes flora, da kuma rage gajeren sarkar fatty acid.Duk da haka, a cikin babban hanji da Ganoderma lucidum polysaccharides ke karewa, manyan furanni biyu sun sami ci gaba da raguwa sosai, kuma abun ciki na ɗan gajeren sarkar fatty acid shima ya tashi sosai.(Madogara/Nazari na 2)

【Reference】

Wei B, et al.Damuwa da Amsar Kwayoyin Halitta na Th17 a cikin Ragewar Dextran Sulfate Sodium-Induced Colitis ta Ganoderma lucidum Polysaccharides.JImmunolRes.2018 Mayu 20; 2018: 2906494.doi: 10.1155/2018/2906494.eCollection 2018.2.Xie J, et al.Ganoderma lucidum polysaccharide yana inganta bera da DSS ke haifar da colitis ta hanyar canza cecalmicrobiota da maganganun kwayoyin halitta na sel epithelial colonic.Abincin Nutr Res.2019 Fabrairu 12; 63.doi: 10.29219/fnr.v63.1559.eCollection 2019.

Game da marubucin / Ms. Wu Tingyao
Wu Tingyao tana ba da rahoto kan bayanan Ganoderma lucidum na farko tun 1999. Ita ce marubucin "Ganoderma lucidum: Ingenious Beyond Description" (an buga shi a cikin Gidan Buga Likitan Jama'a a cikin Afrilu 2017).

★ Wannan labarin an buga shi ne a ƙarƙashin izini na musamman na marubucin, kuma mallakin GANOHERB ne ★ Wadannan ayyukan da ke sama ba za a iya sake su ba, cire su ko amfani da su ta wasu hanyoyi ba tare da izinin GanoHerb ba ★ Idan ayyukan sun sami izini a yi amfani da su. ya kamata a yi amfani da shi a cikin iyakar izini kuma a nuna tushen: GanoHerb ★ keta bayanin da ke sama, GanoHerb za ta bi alhakinta na shari'a.

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