I-Reishi Polysaccrides kunye ne-Colitis

Ukuba bekungekuko ukubhengezwa ngequbuliso kokurhoxa kweNkulumbuso yaseJapan uShinzo Abe nge-28 ka-Agasti, abantu abaninzi ngebengasiqaphelanga esi sifo esizisebenzelayo esifuna unyango oluhlala ixesha elide-isifo sokuqaqamba kwamathumbu.

Uninzi lwabantu alukwazi ukunyamezela iintsuku ezininzi zentlungu yesisu kunye nohudo olubangelwa lusulelo lwebhaktheriya, singasathethi ke i-ulcerative colitis eneempawu ezifana ne-hemafecia, umkhuhlane, ukuhlanza, ukuphelelwa ngamanzi emzimbeni, kunye nokunciphisa umzimba.Owokuqala unokunyangwa ngamayeza ngelixa umva ukuvuvukala kunye nomonakalo we-intestinal mucosa obangelwa izizathu ezingaziwayo.Amayeza akakwazi ukuphelisa isifo kwaye anokuphelisa ukudumba kunye nokuphelisa iimpawu ezinxulumeneyo.

Enyanisweni, ingxaki yokudumba kwezilonda esiswini “kukudumba okungafanele kuphele akupheli.”Xa amajoni omzimba aqala impendulo yokuvuvukala engaphumeleli, impendulo yokuvuvukala iba ngumbulali wezempilo kwaye inokubangela umhlaza weseli.

UZhang Yongping (ophakathi), umphathi jikelele woMphathi Jikelele weOfisi ye-Xinhua News Agency kunye nabantu abanxulumeneyo abaphetheyo bathathe ifoto yeqela kunye neqela le-GANOHERB

IProjekthi yophawu lweSizwe yiprojekthi yonxibelelwano ekwinqanaba lesizwe eyenziwe yi-Arhente yeeNdaba ze-Xinhua ukuze isebenze isicwangciso sokuVuselela i-China ngeprojekthi yee-Brand zeSizwe.Iinkampani ezikhethiweyo kufuneka zihlangabezane neemeko ezahlukeneyo ezingqongqo ezifana nokubambelela rhoqo "ekugxininiseni umsebenzi ongundoqo kunye nokukhonza iimfuno ngokubanzi", ukuthatha inxaxheba ngononophelo kunye nokukhonza isicwangciso sophuhliso sesizwe, ukuba nengqiqo eqinile yoxanduva lwentlalo, izakhono ezizimeleyo zokuyila ezizimeleyo ezikhokela kushishino. , ukubonakala okuphezulu kwezentlalo kunye negama lophawu kunye nenkcubeko yenkampani elungileyo, ukukhuthaza umoya wobugcisa, ukugcina ulawulo lweMfezeko kunye nokuthobela umthetho, ukuba nomgangatho obalaseleyo omele ukwenziwa kweTshayina kunye nomgangatho waseTshayina, nokuba nomdla kwintlalontle yoluntu, ukuphumeza ngenkuthalo iSizwe. IsiCwangciso sokuNcitshiswa kweNtlupheko ekuJoliswe kuso, kwaye sibekwe kwindawo ephambili kwishishini ngokwemigangatho yamandla ebanzi.

Uphawu luyindlela ebalulekileyo kumashishini ukuphucula ukhuphiswano lwawo olupheleleyo.Ukukhethwa kwi "Projekthi yeSizwe yeProjekthi ye-Arhente yeNdaba ye-Xinhua " ngeli xesha liqinisekisa indawo ehamba phambili ye-brand ye-GANOHERB kwi-industry ye-Reishi yaseTshayina.Intsebenziswano eyomeleleyo kunye ne-Arhente yeNdaba ye-Xinhua iya kwandisa ngakumbi ixabiso le-brand kunye namandla e-brand ye-"GANOHERB" kwaye ibonise ngcono i-charm ye-brand ye-Chinese Lingzhi.

Umzobo 1 Umzobo weSchematic wamathumbu amakhulu kunye nemifanekiso ye-endoscopic ye-ulcerative colitis

Amathumbu amakhulu abandakanya i-cecum, ikholoni, kunye ne-rectum (umfanekiso osekhohlo): i-cecum ixhunywe emathunjini amancinci ukukhusela i-reflux yokutya ukungena emathunjini amakhulu;ikholoni ilawula ukugaya kunye nomsebenzi wokufunxa wamathumbu amakhulu kwaye yenza intsalela ibe yindle, egcinwe okwethutyana kwi-rectum ukuze ikhutshwe.I-ulcerative colitis yenzeka ikakhulu kwizicubu ze-mucosal zekholoni kunye ne-rectum.I-Endoscopy iya kubonisa ukuvuvukala kunye nezilonda kwi-colonic mucosa.(Ifoto/Wikimedia Commons)

Ukunciphisa ukudumba kukuthomalalisa kuphela ngelixa ukulawula ukhuselo lomzimba kunokunyanga unaphakade.

Ngokumalunga nengxaki yokuphazamiseka kwe-immune, amachiza akhoyo anokumisela kuphela "iimpawu" ezibangelwa ukuphazamiseka komzimba.

"Ukulawula i-immunity kunye nokomeleza kunye nokuqinisa ukuxhathisa umzimba" ekuqaleni ibhodi yophawu lwegolide ye-mushroom ye-Reishi.Ngokutsho kweencwadi zesayensi ezipapashwe ngoku, kwaziwa ukuba ingaba i-polysaccharides okanye i-triterpenes esuka kwi-mushroom ye-Reishi, inokulawula ukhuseleko kwaye idlale indima ebalulekileyo ekuphuculeni i-ulcerative colitis.

I-polysaccharides ye-mushroom ye-Reishi inciphisa ubunzima be-colitis.

Zombini ingxelo epapashwe liSebe le-Immunology yeYunivesithi yezoNyango yaseChina kwiJenali yoPhando lwe-Immunology ngo-2018 kunye nengxelo epapashwe kuPhando lokuTya kunye neSondlo liSebe leSayensi yoKutya kunye nobuNjineli beDyunivesithi yaseJinan ngo-2019 yangqina ngengozi ukuba ulawulo lomlomo. ye-Ganoderma lucidum polysaccharides kwi-dose yokukhusela kwi-2 kwiiveki ze-3 inokunciphisa kakhulu ubunzima bokuhlaselwa kwe-ulcerative colitis (Umfanekiso 2).

Umzobo we-2 i-Ganoderma lucidum polysaccharides inciphisa iimpawu ze-ulcerative colitis.

Iigundane zongezwa nge-Ganoderma lucidum polysaccharides (i-100 mg / kg ngosuku) kwiiveki ezimbini kwangaphambili zibe nokulahlekelwa kwesisindo esincinci kunye nomsebenzi ophantsi wesifo (ukulahleka kwesisindo esincinci, isifo sohudo kunye ne-hemafecia) kunye nobude obude bekholoni (ebonisa ukuvuvukala okuncinci kunye nomonakalo) kunye umonakalo omncinci omncinci wezicubu (kubandakanywa neqondo lomonakalo wezicubu ze-mucosal kunye nokungena kwe-leukocyte) xa ukuhlaselwa okukrakra kwe-ulcerative colitis kubangelwa.(Umthombo/Isalathisi 1).

Kutheni le nto iGanoderma lucidum polysaccharides inokuphucula ukudumba kwesilonda?Iingxelo ezimbini zophando ezihlalutywe kwiimbono ezimbini ezahlukeneyo: "ukulawula impendulo yokuzivikela komzimba" kunye "nokulawula i-ecology yamathumbu":

Indlela yoku-1: I-Ganoderma lucidum polysaccharides ilawula ukuvuvukala kwaye inqanda iiseli ze-Th17

Uphononongo olwenziwa yiYunivesithi yezoNyango yaseChina yafumanisa ukuba iimpuku eziye zongezwa ngeGanoderma lucidum polysaccharides kwangaphambili zineecytokines ezimbalwa ezinxulumene nokudumba kwizicubu ze-colorectal mucosal ngexesha lohlaselo oluqatha lwe-ulcerative colitis (Umfanekiso 3).Zazingekho zininzi kangako iiseli ezibulalayo zendalo kunye neeseli ze-Th17 ezikhuthaza ukudumba, kodwa iiseli ze-B ezinokukhupha i-IgA, eyona nto iphambili yokulwa nezicubu ze-mucosal, zakhula ngokuchasene nomkhwa.

Olu tshintsho lwe-immune aluncedi nje ukunciphisa impendulo yokuvuvukala kwaye luncede amathumbu ukuba axhathise ukusuleleka kwizifo ezinokuthi kodwa abe nethuba lokulungisa ukungalingani kweeseli ze-Th17 kunye neeseli ze-T ezilawulayo (i-Treg) kunye nokuphucula ingxaki ye-autoimmune ye-ulcerative colitis evela kumthombo.

Zonke izifo ezizimele zinento ephambili ekhuthaza ukuqala kwayo kwaye ikhulise ukuwohloka kwayo.Kwi-ulcerative colitis, yenye ye-T-cell subtypes ebizwa ngokuba ziiseli ze-Th17.I-cytokine efihliweyo i-IL-17 (i-IL-17A yeyona nto ibaluleke kakhulu) inokulwa nezifo ezahlukeneyo zebhaktheriya kunye ne-fungal ngokuvuvukala kwaye yindima ebalulekileyo yesithintelo somzimba wamathumbu.

Ukugqithisela kubi nje ngokusilela.Iiseli ze-Th17 kunye "neeseli ze-T ezilawulayo" ziya kujonga kwaye zilinganise omnye komnye, kunye nokunye kwicala elinye kwaye ngaphantsi kwelinye.Umsebenzi weeseli ze-T ezilawulayo kukugcina ukunyamezela kwe-autoimmune (kungekhona ukuqalisa impendulo yokuzivikela kumalungu entsapho yakhe) kunye nokubeka iibhuleki kwimpendulo yokuvuvukala ngexesha elifanelekileyo.Ngoko ke, xa iiseli ze-Th17 zisebenza kakhulu, iiseli ze-T ezilawulayo ziya kuba buthathaka kwaye ukuvuvukala kuya kwenzeka.

Ukungalingani kwala maqela mabini eeseli kuthathwa njengeyona nto iphambili ekupheliseni ukudumba kwesilonda esiswini.Kuphononongo olukhankanywe ngasentla lweYunivesithi yezoNyango yaseChina, nangona iiseli ze-T ezilawulayo kwizicubu ze-mucosal zegundane emathunjini amakhulu azizange zonyuswe ngokungenelela kwe-Ganoderma lucidum polysaccharides, ukukhutshwa kweeseli ze-Th17 kunye ne-IL-17A kuye kwancitshiswa kakhulu. Umzobo 3), okufuneka ube sisiqalo esihle sokulinganisela phakathi kweeseli ze-Th17 kunye neeseli ze-T ezilawulayo.

Umzobo we-3 i-Ganoderma lucidum polysaccharides ilawula ukhuseleko kunye nokuphucula i-colitis.

Kwiigundane eziye zongezwa ngeGanoderma lucidum polysaccharide kwiiveki ezimbini (100 mg / kg ngosuku), ngexesha lokuhlaselwa ngokukrakra kwe-ulcerative colitis, i-tumor necrosis factor ehlobene nokuvuvukala (TNF-α) kunye ne-interleukins efana ne-IL-1β, I-IL-6, i-IL-4, i-IL-17A kwi-colonic mucosa tissue iyancipha kakhulu, kwaye inqanaba leeseli ze-Th17 nalo lincitshiswe kakhulu, kodwa inqanaba leeseli ze-T ezilawulayo lalingabalulekanga ngokwezibalo (ngokuthelekisa iigundane ze-colitis ezingazange ziphumelele. yongezwa ngeGanoderma lucidum polysaccharides).(Umthombo/Isalathisi 1)

I-Mechanism 2: I-Ganoderma lucidum polysaccharides ilawula i-ecology yamathumbu kwaye inceda ukulungelelanisa ukukhuseleka kokungalingani.

Uphando oluvela kwiDyunivesithi yaseJinan lufumanise ukuba iGanoderma lucidum polysaccharides inokulungelelanisa umlinganiselo wezityalo zamathumbu eempuku zokulinga (ezifana nokunciphisa i-pathogenic flora, ukwandisa isityalo esichasayo ukudumba kunye nokufihla i-fatty chain short-chain), kwaye ikhuthaze amathumbu ukuba akhuphe. ngakumbi i-fatty chain-chain fatty acids (Umfanekiso 4), olawula impendulo yokuzivikela kwi-intestinal mucosa kunye nokunciphisa ubunzima be-ulcerative colitis.

Inxalenye enkulu yezinto ezifunxwa ngamathumbu amakhulu ziveliswa yibhaktheriya ehlala emathunjini amakhulu.Xa ezo polysaccharides zingenako ukugaywa ngamathumbu amancinci (ezifana nefayibha yokutya, iGanoderma lucidum polysaccharides) zingena ethunjini elikhulu, ziya kutyunyuzwa zibe zii-acids ezahlukeneyo ze-short-chain fatty acids liqela lebhaktheriya ezixhomekeke kuzo ukuze ziphile. .Ezi zi-acetic acids, i-propionic acids kunye ne-butyric acids azigcini nje ukondla iiseli zamathumbu kodwa zikhusela umqobo we-mucosal kunye nokulawula ukuphendula komzimba.Xa kuthelekiswa nolu hlobo lweebhaktheriya ezinobuhlobo, ezinye iibhaktheriya zamathumbu zikhuthaza ukudumba.Xa umlinganiselo omnye komnye ungalungelelananga, kudla ngokuba sisiqalo sesigulo.

Uphononongo luye lwaqinisekisa ukuba ukungalingani komlinganiselo wezityalo zamathumbu kunye nokungonelanga kwe-secretion ye-short-chain fatty acids kunokubangela ukuphazamiseka kwe-immune kwaye kubangele i-ulcerative colitis.I-Ganoderma lucidum polysaccharides inokuguqula imeko, ilawule ukhuseleko ngokulawula i-ecology yamathumbu, kwaye iphucule ngakumbi i-ulcerative colitis.Ngaba akupholile?(Iza kuqhubeka-Ganoderma triterpenes)

Umzobo 4 I-Ganoderma lucidum polysaccharides ilawula i-ecology yamathumbu kunye nokuphucula ukubola

Iigundane zondliwa nge-Ganoderma lucidum polysaccharides kwiiveki ze-3 (393.75 mg / kg ngosuku) kwaye emva koko zenzelwa ukuhlaselwa okubukhali kwe-ulcerative colitis.Amathumbu abo adumbileyo adla ngokuba nesenzeko sokwanda kweProteobacteria flora, ukunciphisa iiflora zeFirmicutes, kunye nokuncipha kwe-short-chain fatty secretion.Nangona kunjalo, emathunjini amakhulu akhuselwe yi-Ganoderma lucidum polysaccharides, iiflora ezimbini ezinkulu ziye zafumana ukukhula okuphawulekayo kunye nokuncipha, kunye nomxholo we-short-chain fatty acids nawo unyuke ngokukhawuleza.(Umthombo/Isalathisi 2)

【Iimbekiselo】

Wei B, kunye nabanye.Ukunyanzeliswa kweMpendulo yeSeli ye-Th17 ekunciphiseni i-Dextran Sulfate ye-Sodium-Induced Colitis yi-Ganoderma lucidum Polysaccharides.JImmunolRes.2018 Meyi 20;2018:2906494.doi: 10.1155/2018/2906494.I-eCollection 2018.2.Xie J, kunye nabanye.I-Ganoderma lucidum polysaccharide iphucula i-rat DSS-induced colitis ngokuguqula i-cecalmicrobiota kunye ne-gene expression yeeseli ze-colonic epithelial.Ukutya Nutr Res.2019 Feb 12;63.doi: 10.29219/fnr.v63.1559.I-eCollection ka-2019.

Malunga nombhali/ Nksz. Wu Tingyao
UWu Tingyao uye wabika malunga nolwazi lokuqala lwe-Ganoderma lucidum ukususela kwi-1999. Ungumbhali we "Ganoderma lucidum: I-Ingenious Beyond Description" (epapashwe kwi-People's Medical Publishing House ngo-Ephreli 2017).

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