Reishi Polysacchrides thiab Colitis

Yog tias nws tsis yog rau qhov kev tshaj tawm tam sim ntawd los ntawm Nyij Pooj Thawj Fwm Tsav Tebchaws Shinzo Abe thaum Lub Yim Hli 28, ntau tus neeg yuav tsis tau pom tus kabmob autoimmune uas yuav tsum tau kho lub neej ntev-ulcerative colitis.

Cov neeg feem coob tsis tuaj yeem zam tau ntau hnub ntawm qhov mob plab thiab raws plab los ntawm cov kab mob kab mob, cia nyob ib leeg ulcerative colitis nrog cov tsos mob xws li hemafecia, kub taub hau, ntuav, lub cev qhuav dej, thiab poob phaus.Cov qub tuaj yeem kho tau los ntawm cov tshuaj thaum lub sijhawm tom kawg yog qhov mob thiab kev puas tsuaj ntawm cov hnyuv mucosa los ntawm cov laj thawj tsis paub.Cov tshuaj tsis tuaj yeem tshem tawm tus kab mob thiab tsuas tuaj yeem txo qhov mob thiab txo cov tsos mob.

Qhov tseeb, qhov teeb meem ntawm ulcerative colitis nyob rau hauv "qhov mob uas yuav tsum tsis txhob tshwm sim yeej tsis nres."Thaum lub cev tiv thaiv kab mob uas pib cov lus teb inflammatory ua tsis tau, cov lus teb inflammatory yuav ua rau kev noj qab haus huv killer thiab tej zaum yuav ua rau mob qog noj ntshav.

Zhang Yongping (nruab nrab), tus thawj tswj hwm ntawm General Manager Office ntawm Xinhua News Agency thiab cov neeg muaj feem cuam tshuam tau thaij duab nrog pab pawg ntawm GANOHERB

National Brand Project yog ib txoj haujlwm sib txuas lus hauv tebchaws uas tsim los ntawm Xinhua News Agency los ua haujlwm rau lub tswv yim ntawm Reinvigorating Tuam Tshoj Los Ntawm National Brands project.Cov tuam txhab raug xaiv yuav tsum ua kom tau raws li ntau yam kev nruj nruj xws li ib txwm ua raws li "kev tsom mus rau lub luag haujlwm tseem ceeb thiab ua haujlwm rau tag nrho cov txiaj ntsig", koom nrog thiab ua haujlwm rau lub teb chaws txoj kev loj hlob zoo, muaj lub siab zoo ntawm kev lav phib xaub, kev lag luam ua lag luam ywj pheej innovation muaj peev xwm. , kev pom kev zoo siab dua thiab lub npe nrov npe thiab kev coj noj coj ua zoo, txhawb lub siab ntawm kev siv tes ua haujlwm, txhawb nqa kev tswj hwm kev ncaj ncees thiab ua raws li txoj cai, muaj qhov zoo tshaj plaws uas sawv cev rau Tuam Tshoj kev tsim khoom thiab Tuam Tshoj qhov zoo, thiab txaus siab rau pej xeem kev noj qab haus huv, nquag siv lub teb chaws. Targeted Poverty Alleviation Plan, thiab ranking nyob rau hauv lub forefront ntawm kev lag luam nyob rau hauv cov nqe lus ntawm cov lus qhia txog lub zog ranks.

Hom yog ib qho tseem ceeb rau kev lag luam los txhim kho lawv txoj kev sib tw.Kev raug xaiv rau hauv "National Brand Project of Xinhua News Agency" lub sijhawm no lees paub txoj haujlwm tseem ceeb ntawm GANOHERB hom hauv Suav Reishi kev lag luam.Kev koom tes muaj zog nrog Xinhua News Agency yuav ntxiv dag zog rau cov khoom lag luam tus nqi thiab lub zog ntawm "GANOHERB" thiab ua kom pom tau zoo dua lub npe ntxim nyiam ntawm Suav Lingzhi.

Daim duab 1 Schematic daim duab ntawm txoj hnyuv loj thiab endoscopic dluab ntawm ulcerative colitis

Cov hnyuv loj muaj xws li cecum, txoj hnyuv, thiab lub qhov quav (sab laug daim duab): lub cecum txuas nrog cov hnyuv me kom tiv thaiv cov khoom noj nkag mus rau hauv txoj hnyuv loj;cov nyuv tswj kev zom zaub mov thiab kev nqus ntawm cov hnyuv loj thiab tsim cov khoom seem rau hauv cov quav, uas tau khaws cia rau hauv lub qhov quav rau ib ntus.Ulcerative colitis tshwm sim nyob rau hauv cov ntaub so ntswg mucosal ntawm txoj hnyuv thiab qhov quav.Endoscopy yuav qhia o thiab ulcers nyob rau hauv lub colonic mucosa.(Duab/Wikimedia Commons)

Txo qhov mob tsuas yog palliative thaum tswj kev tiv thaiv kab mob tuaj yeem ua rau muaj kev kho mob tas mus li.

Hais txog qhov teeb meem ntawm kev tiv thaiv kab mob, cov tshuaj uas twb muaj lawm tuaj yeem teeb tsa txog "cov tsos mob" tshwm sim los ntawm kev tiv thaiv kab mob.

"Kev tswj hwm kev tiv thaiv thiab kev ntxiv dag zog thiab kev sib koom ua ke ntawm lub cev tiv thaiv" yog thawj daim ntawv kos npe kub ntawm Reishi nceb.Raws li cov ntaub ntawv tshawb fawb tau tshaj tawm txog tam sim no, nws paub tias txawm nws yog polysaccharides lossis triterpenes los ntawm Reishi nceb, lawv tuaj yeem tswj kev tiv thaiv kab mob thiab ua lub luag haujlwm tseem ceeb hauv kev txhim kho cov kab mob ulcerative.

Reishi nceb polysaccharides txo qhov hnyav ntawm colitis.

Ob daim ntawv tshaj tawm luam tawm los ntawm Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv ntawm Tuam Tshoj Medical University hauv Phau Ntawv Xov Xwm ntawm Kev Tshawb Fawb Txog Kev Tshawb Fawb hauv 2018 thiab tsab ntawv tshaj tawm luam tawm hauv Food & Nutrition Research los ntawm Department of Food Science thiab Engineering ntawm Jinan University hauv 2019 coincidentally ua pov thawj tias kev tswj hwm qhov ncauj ntawm Ganoderma lucidum polysaccharides ntawm kev tiv thaiv koob tshuaj hauv 2 mus rau 3 lub lis piam tuaj yeem txo qhov hnyav ntawm cov kab mob ulcerative colitis tawm tsam (Daim duab 2).

Daim duab 2 Ganoderma lucidum polysaccharides txo cov tsos mob ntawm ulcerative colitis.

Cov nas ntxiv nrog Ganoderma lucidum polysaccharides (100 mg / kg ib hnub) rau ob lub lis piam ua ntej muaj kev poob qis thiab kev ua haujlwm ntawm cov kab mob qis (lub teeb yuag, raws plab thiab hemafecia) nrog ntev ntev ntawm txoj hnyuv (qhia tias mob tsawg dua thiab puas) thiab Kev puas tsuaj tsawg dua cov ntaub so ntswg (nrog rau cov qib ntawm cov ntaub so ntswg puas thiab leukocyte infiltration) thaum muaj mob hnyav ntawm cov kab mob ulcerative colitis raug ntxias.(Source/Reference 1).

Vim li cas Ganoderma lucidum polysaccharides tuaj yeem txhim kho ulcerative colitis?Ob qhov kev tshawb fawb qhia tau txheeb xyuas los ntawm ob qhov kev xav sib txawv: "kev tswj hwm lub cev tiv thaiv kab mob" thiab "kev tswj hwm txoj hnyuv hauv plab":

Mechanism 1: Ganoderma lucidum polysaccharides tswj o thiab inhibit Th17 hlwb

Ib txoj kev tshawb fawb los ntawm Tuam Tshoj Medical University tau pom tias cov nas uas tau ntxiv nrog Ganoderma lucidum polysaccharides ua ntej muaj tsawg dua cov kab mob cytokines nyob rau hauv cov ntaub so ntswg mucosal thaum lub sij hawm mob ulcerative colitis (Daim duab 3).Tsis muaj ntau lub hlwb tua neeg thiab Th17 hlwb uas txhawb kev mob, tab sis B hlwb uas tuaj yeem tso cov IgA, cov tshuaj tiv thaiv tseem ceeb ntawm cov ntaub so ntswg, loj hlob tawm tsam cov qauv.

Cov tshuaj tiv thaiv kab mob no tsis yog tsuas yog pab daws cov kab mob inflammatory thiab pab cov hnyuv kom tiv thaiv tau cov kab mob, tab sis kuj muaj lub sijhawm los kho qhov tsis txaus ntawm Th17 hlwb thiab tswj T hlwb (Treg) thiab txhim kho cov teeb meem autoimmune ntawm ulcerative colitis los ntawm qhov chaw.

Txhua tus kab mob autoimmune muaj qhov tseem ceeb uas txhawb nqa nws qhov pib thiab ua rau nws tsis zoo.Rau ulcerative colitis, nws yog ib qho ntawm T-cell subtypes hu ua Th17 hlwb.Lub secreted cytokine IL-17 (IL-17A yog qhov tseem ceeb tshaj plaws) tuaj yeem tawm tsam ntau yam kab mob thiab cov kab mob fungal los ntawm kev mob thiab yog lub luag haujlwm tseem ceeb ntawm cov kab mob hauv plab hnyuv.

Tshaj dhau tsuas yog phem li qhov tsis txaus.Th17 hlwb thiab "txheej txheem T hlwb" yuav xyuas thiab sib npaug sib npaug, nrog ntau dua ntawm ib sab thiab tsawg dua ntawm lwm qhov.Lub luag haujlwm ntawm kev tswj hwm T hlwb yog tswj hwm autoimmune kam rau ua (tsis txhob tso cov tshuaj tiv thaiv kab mob rau ib tus neeg hauv tsev neeg) thiab muab cov brakes rau cov lus teb rau lub sijhawm.Yog li, thaum Th17 hlwb ua haujlwm dhau lawm, kev tswj hwm T hlwb yuav ua rau tsis muaj zog thiab mob ntau dua yuav tshwm sim.

Qhov tsis sib xws ntawm ob pawg hlwb no suav tias yog tus yuam sij rau detonating ulcerative colitis.Nyob rau hauv txoj kev tshawb fawb saum toj no ntawm Tuam Tshoj Medical University, txawm hais tias kev tswj hwm T hlwb hauv cov ntaub so ntswg ntawm tus nas lub plab hnyuv loj tsis tau nce ntxiv los ntawm kev cuam tshuam ntawm Ganoderma lucidum polysaccharides, qhov tso tawm ntawm Th17 hlwb thiab IL-17A tau txo qis ( Daim duab 3), uas yuav tsum yog qhov pib zoo rau qhov sib npaug ntawm Th17 hlwb thiab tswj T hlwb.

Daim duab 3 Ganoderma lucidum polysaccharides tswj kev tiv thaiv kab mob thiab txhim kho colitis.

Rau cov nas uas tau ntxiv nrog Ganoderma lucidum polysaccharide rau ob lub lis piam (100 mg / kg ib hnub), thaum lub sij hawm mob ulcerative colitis, qhov mob ntsig txog qog necrosis (TNF-α) thiab interleukins xws li IL-1β, IL-6, IL-4, IL-17A nyob rau hauv cov ntaub so ntswg colonic mucosa txo qis, thiab theem ntawm Th17 hlwb kuj txo qis, tab sis theem ntawm kev tswj T hlwb tsis tseem ceeb (piv rau cov nas colitis uas tsis muaj. tau ntxiv nrog Ganoderma lucidum polysaccharides).(Source/Reference 1)

Mechanism 2: Ganoderma lucidum polysaccharides tswj lub plab hnyuv ecology thiab pab kho cov kev tiv thaiv tsis zoo.

Kev tshawb fawb los ntawm Jinan University pom tias Ganoderma lucidum polysaccharides tuaj yeem kho qhov sib piv ntawm cov kab mob hauv plab hnyuv ntawm cov nas sim (xws li txo cov kab mob pathogenic, ua rau cov nroj tsuag uas tiv taus qhov mob thiab zais cov kab mob luv luv fatty acid), thiab txhawb txoj hnyuv kom zais. ntau luv-chain fatty acids (Daim duab 4), uas nyob rau hauv lem tswj lub cev tiv thaiv kab mob ntawm txoj hnyuv mucosa thiab txo qhov hnyav ntawm ulcerative colitis.

Ib feem loj ntawm cov khoom absorbed los ntawm txoj hnyuv loj yog tsim los ntawm cov kab mob nyob hauv cov hnyuv loj.Thaum cov polysaccharides uas tsis tuaj yeem zom tau los ntawm txoj hnyuv me (xws li cov khoom noj muaj fiber ntau, Ganoderma lucidum polysaccharides) nkag mus rau hauv cov hnyuv loj, lawv yuav raug tawg ua ntau yam kab mob luv luv fatty acids los ntawm ib pawg kab mob uas nyob ntawm lawv rau kev ua neej nyob. .Cov acetic acids, propionic acids thiab butyric acids tsis yog tsuas yog txhawb cov hnyuv, tab sis kuj tiv thaiv cov mucosal barrier thiab tswj lub cev tiv thaiv kab mob.Piv nrog rau cov kab mob zoo li no, qee cov kab mob hauv plab yog cov txhawb kev mob.Thaum qhov kev faib ua feem ntawm ib leeg tsis sib npaug, feem ntau yog qhov pib ntawm kev mob.

Cov kev tshawb fawb tau lees paub tias qhov tsis sib xws ntawm cov kab mob plab hnyuv thiab tsis txaus tso tawm ntawm cov kab mob luv luv fatty acids tuaj yeem ua rau muaj kev tiv thaiv kab mob thiab ua rau cov kab mob ulcerative colitis.Ganoderma lucidum polysaccharides tuaj yeem thim rov qab qhov xwm txheej, tswj kev tiv thaiv kab mob los ntawm kev tswj cov hnyuv ecology, thiab ntxiv txhim kho cov kab mob ulcerative.Tsis yog nws txias?(Yuav tsum tau txuas ntxiv-Ganoderma triterpenes)

Daim duab 4 Ganoderma lucidum polysaccharides tswj txoj hnyuv ecology thiab txhim kho colitis

Cov nas tau noj nrog Ganoderma lucidum polysaccharides rau 3 lub lis piam (393.75 mg / kg ib hnub) thiab tom qab ntawd raug mob hnyav ntawm cov kab mob ulcerative colitis.Lawv cov hnyuv feem ntau muaj qhov tshwm sim ntawm cov kab mob Proteobacteria ntau ntxiv, txo cov Firmicutes flora, thiab txo qis cov kab mob fatty acid secretion.Txawm li cas los xij, nyob rau hauv txoj hnyuv loj uas tiv thaiv los ntawm Ganoderma lucidum polysaccharides, ob lub paj loj tau ntsib kev loj hlob thiab poob qis, thiab cov ntsiab lus ntawm cov saw luv fatty acids kuj tau nce sharply.(Source/Reference 2)

【References】

Wei B, et al.Kev Txhaum Cai ntawm Th17 Cell Teb hauv Kev Txom Nyem ntawm Dextran Sulfate Sodium-Induced Colitis los ntawm Ganoderma lucidum Polysaccharides.JImmunolRes.Peb Hlis 20, 2018: 2906494.doi: 10.1155/2018/2906494 PAB.eCollection 2018.2.Xie J, et al.Ganoderma lucidum polysaccharide txhim kho nas DSS-induced colitis los ntawm altering cecalmicrobiota thiab noob qhia ntawm colonic epithelial hlwb.Food Nutr Res.2019 Peb 12; 63.doi: 10.29219/fnr.v63.1559 ib.eCollection 2019.

Hais txog tus sau/ Ms. Wu Tingyao
Wu Tingyao tau tshaj tawm cov ntaub ntawv Ganoderma lucidum thawj zaug txij li xyoo 1999. Nws yog tus sau "Ganoderma lucidum: Ingenious Beyond Description" (tshaj tawm hauv Lub Tsev Kho Mob Cov Neeg Kho Mob thaum Lub Plaub Hlis 2017).

★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau, thiab cov tswv cuab yog GANOHERB ★ Cov haujlwm saum toj no tsis tuaj yeem luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis tau tso cai ntawm GanoHerb ★ Yog tias cov haujlwm tau tso cai siv, lawv yuav tsum tau siv nyob rau hauv lub Scope ntawm kev tso cai thiab qhia lub hauv paus: GanoHerb ★ Ua txhaum ntawm cov lus saum toj no, GanoHerb yuav ua raws li nws cov luag hauj lwm raws li txoj cai

Dhau ntawm Millennia Health Culture
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