Namuhla, abantu abaningi, lapho ukhethaI-Ganodermaimikhiqizo, ivame ukubuza, "Yini okuqukethwe kwe-triterpene yomkhiqizo wakho?"Kubonakala sengathi ukuphakama kwe-triterpene, umkhiqizo ungcono.Nokho, lokhu akulungile ngokuphelele.

Njengamanje, indlela evame ukusetshenziswa izinkampani zasekhaya ukukala okuqukethweI-GanodermaI-triterpenes iyindlela yamakhemikhali.Le ndlela inezinkinga zokucaciswa kanye namaphutha amakhulu.Ngakho-ke, izinga lokuqukethwe kwe-triterpene alikwazi ukumela ngokunembile ikhwalithi yamafutha e-spore 

Eqinisweni, ikhwalithi yomkhiqizo kawoyela we-spore inqunywa izici ezihlukahlukene.I-chromatography yoketshezi esebenza kahle kakhulu ingathola ngokunembile okuqukethwe kwe-“Ganoderic Acid A”.Uma umkhiqizo kawoyela we-spore ungakhombisa ngokucacile okuqukethwe kwe-"Ganoderic Acid A", unikeza isiqinisekiso esikhulu sekhwalithi yomkhiqizo.Iyini i-Ganoderic Acid A?Iyini imiphumela yayo ekhethekile?Uyini umehluko phakathi kwayo nama-triterpenes aphelele?Namuhla, ake sikwazi.

Kunezinhlobo ezingaphezu kuka-300 zeI-Ganodermaama-triterpene compounds.Yiziphi ozaziyo?

Okokuqala, kubalulekile ukwazi lokhoI-GanodermaI-triterpene compounds ayiyona into eyodwa, kodwa kunalokho ibhekisela ezintweni ezikuyoI-Ganodermaanesakhiwo se-triterpene.Kuze kube manje, zingaphezu kuka-300 izinhlobo ezitholakele, ezisatshalaliswe ngaphakathiI-Ganodermaimizimba yezithelo kanyeI-Ganodermai-spore powder.

Lezi zinhlanganisela ze-triterpene zingahlukaniswa ngokubanzi zibe yi-neutral triterpenes kanye ne-acidic triterpenes.I-acidic triterpenes ihlanganisa izinhlobo ezahlukene ezifana ne-Ganoderic Acid A, i-Ganoderic Acid B, i-Ganoderic Acid F, njll. Kungakhathaliseki ukuthi i-Ganoderic Acid A noma i-Ganoderic Acid B, bobabili bangamalungu omndeni we-triterpene.Ngayinye inezakhiwo zamakhemikhali ezihlukene futhi, ngenxa yalokho, inemisebenzi ehlukene yomzimba.

Phakathi kwezinhlobo ezingaphezu kuka-300 zenhlanganisela ye-triterpene, i-Ganoderic Acid A okwamanje iyona ecwaningwe kakhulu futhi iyinhlanganisela ye-triterpene enemiphumela eminingi etholakele.Ikakhulukazi ivelaI-Ganoderma lucidum, futhi cishe ayikho phakathiI-Ganoderma sinense.

Okulandelayo, ake sethule imiphumela eyinhloko ye-Ganoderic Acid A eboniswe kabanzi ocwaningweni lwemithi.

Umthelela we-Ganoderic Acid A Ekulimaleni Okubi Kwesibindi

Ngo-2019, kwashicilelwa indatshana kuJournal of Nanjing University of Traditional Chinese Medicine.Ucwaningo lwamisa iqembu elivamile, iqembu lemodeli, iqembu le-Ganoderic Acid A eliphansi (20mg/kg), kanye neqembu eliphezulu le-Ganoderic Acid A (40mg/kg).Ifunde imiphumela ye-Ganoderic Acid A kumagundane ajovwe nge-D-Galactosamine (D-GaIN) kanye ne-Lipopolysaccharides (LPS), kanye nendima yayo yokuvikela kanye nezindlela ezihlobene nokulimala kwesibindi okubangelwa i-D-GaIN/LPS kumagundane.Ucwaningo luthole ukuthi i-Ganoderic Acid A inomphumela wokuvikela ekulimaleni kwesibindi okubangelwa i-D-GaIN/LPS kumagundane.Kukholakala ukuthi lo mphumela ungase uhlobane nokulawulwa kwendlela yokusayina ye-NLRP3/NF-KB.[1]

I-Anti-Tumor Effects ye-Ganoderic Acid A

Ukuthola ukwelashwa okufanele kwe-meningioma eyingozi okunzima ukuyelapha bekulokhu kuyithemba lodokotela neziguli.I-Ganodermabekulokhu kusebenza ngempumelelo ekuvimbeleni izimila kanye nokululama kokuhlinzwa kwangemva kwesimila.

Ngo-2019, umbiko oshicilelwe ku- "Clinical and Translational Oncology" yithimba lohlelo lwengqondo nomgogodla eHollings Cancer Center (isikhungo somdlavuza esiqokwe yiNational Cancer Institute yase-United States) waveza ukuthi noma ngabe iGanoderic Acid A noma iGanoderic I-Acid DM isetshenziswa iyodwa, zombili zingavimbela ngempumelelo ukukhula kwama-meningiomas ayingozi futhi zandise isikhathi sokusinda samagundane aphethe isimila.Indlela yesenzo ihlobene nokuphinda kusebenze isakhi sofuzo sokucindezela isimila NDRG2.[2]

(Izinto zesithombe zithathwe kuwebhusayithi yejenali esemthethweni)

Ngo-2021, kwashicilelwa indatshana ku-Chinese Journal of Clinical Pharmacology.Ucwaningo lusungule iqembu lokuhlola lisebenzisa u-0.5mmol/L we-Ganoderic Acid A ukuze lingenelele kumaseli egundane e-glioma C6.Kutholwe ukuthi indawo yesiphambano se-tumor eqenjini lokuhlola lamagundane e-glioma yayincane kakhulu kuneqembu lokulawula, futhi inani lamaseli e-CD31 abonisa kahle lancipha kakhulu uma kuqhathaniswa neqembu lokulawula.Isiphetho safinyelelwa ukuthi i-Ganoderic Acid A ingavimbela ukwanda kwamaseli e-rat glioma C6 ku-vitro, futhi ngesikhathi esifanayo, ingavimbela ukukhula kwemodeli ye-glioma kumagundane ngokuvimbela ukwakheka kwemithambo yegazi yesimila.[3]

Imithelela Ye-Ganoderic Acid A Kusistimu Yezinzwa

Ngo-2015, i-athikili yezemfundo eyanyatheliswa ku-Journal of Mudanjiang Medical University yabika ukuthi ngokuhlolwa, kwatholakala ukuthi i-50μg/ml ye-Ganoderic Acid A ingakhuphula izinga lokusinda kwama-hippocampal neurons, ithuthukise umsebenzi we-SOD wama-neurons e-hippocampal afana nesithuthwane, futhi kwandise amandla olwelwesi lwe-mitochondrial.Kwaboniswa ukuthi i-Ganoderic Acid A ingavikela ukukhipha ngokungavamile ama-hippocampal neurons ngokuvimbela ukulimala kwe-cell oxidative kanye ne-apoptosis.[4]

IVimbaImiphumela ye-Ganoderic Acid A ku-Renal Fibrosis kanye ne-Polycystic Kidney Disease

Ithimba eliholwa uSolwazi Yang Baoxue, inhloko yoMnyango Wezemithi e-Peking University School of Basic Medical Science, lishicilele amaphepha amabili alandelana ku-“Acta Pharmacologica Sinica” ekupheleni kuka-2019 nasekuqaleni kuka-2020. Amaphepha aqinisekisa ukuthi imiphumela yeI-Ganodermaku-renal fibrosis kanye nesifo sezinso se-polycystic, i-Ganoderic Acid A iyisakhi esiyinhloko esisebenzayo.[5]

Ngaphezu kwalokho, i-Ganoderic Acid A ingavimbela ukukhululwa kwe-histamine yeselula, ithuthukise ukusebenza kwezitho ezihlukahlukene ohlelweni lokugaya ukudla, futhi ibe nemiphumela efana nokwehlisa i-lipids yegazi, ukunciphisa umfutho wegazi, ukuvikela isibindi, nokulawula ukusebenza kwesibindi.[6]

Ngokuvamile, kuhle ukuba nokuqukethwe okuphezulu kwakhoI-Ganodermaama-triterpenes.Ukwengeza i-Ganoderic Acid A, eyaziwa ngemiphumela yayo enembayo nenamandla, kungathuthukisa kakhulu izinga likawoyela we-spore.

Izithenjwa:

1.Wei Hao, et al."Umphumela ovikelayo we-Ganoderic Acid A ekulimaleni kwesibindi okubangelwa i-D-galactosamine/lipopolysaccharide kumagundane," Ijenali yaseNanjing University of Traditional Chinese Medicine, 2019, 35(4), p.432.

2.Wu Tingyao."Ucwaningo olusha: Izazi zaseMelika ziqinisekisa ukuthi i-Ganoderic Acid A kanye ne-DM ilawula i-tumor suppressor gene NDRG2, ivimbela ukukhula kwama-malignant meningiomas," i-GanoHerb Organic Ganoderma, 2020-6-12.

3.Yang Xin, Huang Qin, Pan Xiaomei."Umphumela ovimbelayo we-Ganoderic Acid A ekukhuleni kwe-glioma kumagundane," I-Chinese Journal of Clinical Pharmacology, 2021, 37(8), p.997-998.

4.Wu Rongliang, Liu Junxing."Umthelela we-Ganoderic Acid A kuma-hippocampal neurons akhishwa yisifo sokuwa," Ijenali ye-Mudanjiang Medical University, 2015, 36 (2), p.8.

5.Wu Tingyao."Ucwaningo olusha: Ithimba likaSolwazi Yang Baoxue e-Peking University liyaqinisekisa ukuthi i-Ganoderic Acid A iyingxenye eyinhloko ye-Ganoderma triterpenes yokuvikela izinso," i-GanoHerb Organic Ganoderma, 2020-4-16.

6.Wei Hao, et al."Umphumela wokuvikela we-Ganoderic Acid A ekulimaleni kwesibindi okubangelwa i-D-galactosamine/lipopolysaccharide kumagundane," Ijenali yaseNanjing University of Traditional Chinese Medicine, 2019, 35(4), p.433