Uyu munsi, abantu benshi, mugihe bahisemoGanodermaibicuruzwa, akenshi ubaze, “Ni ubuhe butumwa bwa triterpene mu bicuruzwa byawe?”Birasa nkaho hejuru ya triterpene, nibicuruzwa byiza.Ariko, ibi ntabwo aribyo rwose.

Kugeza ubu, uburyo busanzwe bukoreshwa namasosiyete yo murugo gupima ibirimoGanodermatriterpène nuburyo bwimiti.Ubu buryo bufite ibibazo bifite umwihariko namakosa manini.Kubwibyo, urwego rwibintu bya triterpene ntirushobora kwerekana neza ubwiza bwamavuta ya spore 

Mubyukuri, ubwiza bwibicuruzwa bya spore bigenwa nibintu bitandukanye.Amazi meza ya chromatografiya arashobora kumenya neza ibiri muri "Acide Ganoderic A".Niba ibicuruzwa bya peteroli ya spore bishobora kwerekana neza ibiri muri "Acide Ganoderic A", itanga garanti nziza yubwiza bwibicuruzwa.Acide Ganoderic A ni iki?Ni izihe ngaruka zidasanzwe?Ni irihe tandukaniro riri hagati yaryo na triterpène yose?Uyu munsi, reka tubimenye.

Hariho ubwoko burenga 300 bwaGanodermatriterpene.Ninde umenyereye?

Ubwa mbere, ni ngombwa kubimenyaGanodermaibice bya triterpene ntabwo ari ikintu kimwe, ahubwo bivuga ibintu muriGanodermabifite imiterere ya triterpene.Kugeza ubu, ubwoko burenga 300 bwavumbuwe, bwatanzwe muriGanodermaimibiri yera imbuto kandiGanodermaifu ya spore.

Ibi bikoresho bya triterpene birashobora kugabanywa cyane muri triterpène idafite aho ibogamiye na triterpène acide.Acide triterpène irimo ubwoko butandukanye nka Ganoderic Acide A, Ganoderic Acide B, Ganoderic Acide F, nibindi. Tutitaye ko ari Acide Ganoderic A cyangwa Acide Ganoderic B, bombi bagize umuryango wa triterpene.Buri kimwe gifite imiterere yimiti itandukanye, nkigisubizo, ifite ibikorwa bitandukanye bya physiologique.

Mu bwoko burenga 300 bwibintu bya triterpene, Acide ya Ganoderic A kuri ubu ni ubushakashatsi bwakozwe cyane kandi ni uruganda rwa triterpene rufite ingaruka nyinshi zavumbuwe.Bituruka ahaniniGanoderma lucidum, kandi ni hafi kutabaho muriGanoderma sinense.

Ibikurikira, reka tumenye ingaruka nyamukuru za Acide Ganoderic A yagaragaye cyane mubushakashatsi bwa farumasi.

Ingaruka ya Acide Ganoderic A ku Gukomeretsa Umwijima

Muri 2019, inyandiko yasohotse mu kinyamakuru cya kaminuza ya Nanjing ya Medicine gakondo y'Ubushinwa.Ubushakashatsi bwashyizeho itsinda risanzwe, itsinda ryikitegererezo, Acide ya Ganoderic Acide A (20mg / kg), hamwe na Acide ya Ganoderic Acide A (40mg / kg).Yize ku ngaruka za Acide Ganoderic A ku mbeba zatewe na D-Galactosamine (D-GaIN) na Lipopolysaccharide (LPS), n'uruhare rwayo rwo gukingira hamwe n’uburyo bujyanye no gukomeretsa umwijima byatewe na D-GaIN / LPS mu mbeba.Ubushakashatsi bwerekanye ko Acide Ganoderic ifite ingaruka zo gukingira umwijima uterwa na D-GaIN / LPS mu mbeba.Byizerwa ko izi ngaruka zishobora kuba zijyanye no kugenzura inzira ya NLRP3 / NF-KB yerekana inzira.[1]

Ingaruka zo Kurwanya Tumor Acide ya Ganoderic A.

Kubona uburyo bwiza bwo kuvura indwara mbi ya meningioma yamye ari ibyiringiro byabaganga nabarwayi.Ganodermayamye ari ingirakamaro muguhagarika ibibyimba no gukira nyuma yibibyimba.

Mu mwaka wa 2019, raporo yasohotse muri “Clinical and Translational Oncology” yakozwe n'itsinda rya gahunda y'ibibyimba byo mu bwonko no mu ruti rw'umugongo mu kigo cya kanseri cya Hollings (ikigo cya kanseri cyagenwe n'ikigo cy'igihugu gishinzwe kanseri muri Amerika) cyerekanye ko niba Acide Ganoderic A cyangwa Ganoderic Acide DM ikoreshwa yonyine, byombi birashobora kubuza gukura kwa meningioma mbi kandi bikongerera igihe cyo kubaho kwimbeba zifite ibibyimba.Uburyo bwibikorwa bujyanye no kongera gukora gene suppressor gene NDRG2.[2]

(Ibintu by'amashusho byakuwe kurubuga rwibinyamakuru byemewe)

Mu 2021, ingingo yasohotse mu kinyamakuru cyo mu Bushinwa cya Pharmacology Clinical.Ubushakashatsi bwashyizeho itsinda ryubushakashatsi ukoresheje 0.5mmol / L ya Acide ya Ganoderic A kugirango yivange muri selile glioma C6.Byagaragaye ko agace kambukiranya ikibyimba mu itsinda ry’igeragezwa ry’imbeba za glioma cyari gito cyane ugereranije n’itsinda rishinzwe kugenzura, kandi umubare w’ingirabuzimafatizo za CD31 wagabanutse cyane ugereranije n’itsinda rishinzwe kugenzura.Umwanzuro wafashwe ko Acide Ganoderic A ishobora kubuza ikwirakwizwa ryimbeba ya glioma C6 muri vitro, kandi mugihe kimwe, irashobora kubuza imikurire ya glioma yimbeba mu guhagarika imitsi yamaraso yibibyimba.[3]

Ingaruka za Acide ya Ganoderic A kuri sisitemu ya Nervous

Mu mwaka wa 2015, ingingo y’inyigisho yasohotse mu kinyamakuru cya kaminuza y’ubuvuzi ya Mudanjiang yatangaje ko binyuze mu bushakashatsi bwakozwe, byagaragaye ko 50μg / ml ya Acide ya Ganoderic A ishobora kongera ubuzima bwa neurone ya hippocampal, ikazamura ibikorwa bya SOD bya epileptic imeze nka hippocampal neuron, no kongera ubushobozi bwa mitochondrial membrane.Hagaragajwe ko Acide A ya Ganoderic ishobora kurinda neurone isohora bidasanzwe mu bwonko bwa okiside yangiza na apoptose.[4]

UwitekaInzitiziing Ingaruka za Acide Ganoderic A kuri Fibrosis yimpyiko nindwara yimpyiko ya Polycystic

Itsinda riyobowe na Porofeseri Yang Baoxue, ukuriye ishami rya Farumasi mu Ishuri Rikuru ry’Ubuvuzi bw’ibanze rya Peking, ryasohoye impapuro ebyiri zikurikiranye muri “Acta Pharmacologica Sinica” mu mpera za 2019 no mu ntangiriro za 2020. Impapuro zemeje ko zibangamira. Ingaruka zaGanodermakuri fibrosis yimpyiko nindwara yimpyiko polycystic, hamwe na Acide ya Ganoderic A nikintu cyingenzi cyingenzi.[5]

Byongeye kandi, Acide Ganoderic A irashobora kubuza irekurwa rya histamine selile, kongera imikorere yingingo zitandukanye muri sisitemu yumubiri, kandi ikagira ingaruka nko kugabanya lipide yamaraso, kugabanya umuvuduko wamaraso, kurinda umwijima, no kugenzura imikorere yumwijima.[6]

Muri rusange, rwose nibyiza kugira ibintu byinshi byoGanodermatriterpenes.Ongeramo Acide Ganoderic A, izwiho ingaruka zayo kandi zikomeye, byazamura cyane ubwiza bwamavuta ya spore.

Reba:

1.Wei Hao, n'abandi.Ikinyamakuru cyo muri kaminuza ya Nanjing y’ubuvuzi gakondo bw’Abashinwa, 2019, 35 (4), p.432, “Ingaruka zo gukingira Acide Ganoderic A ku gukomeretsa umwijima guterwa na D-galactosamine / lipopolysaccharide mu mbeba.”

2.Wu Tingyao.GanoHerb Organic Ganoderma, 2020-6-12, GanoHerb Organic Ganoderma, 2020-6-12.

3.Yang Xin, Huang Qin, Pan Xiaomei.Ikinyamakuru cyo mu Bushinwa cyitwa Clinical Pharmacology, 2021, 37 (8), p.997-998, “Ingaruka mbi ya Acide Ganoderic A ku mikurire ya glioma mu mbeba.”

4.Wu Rongliang, Liu Junxing.Ikinyamakuru cya kaminuza y’ubuvuzi ya Mudanjiang, 2015, 36 (2), p.8.

5.Wu Tingyao.GanoHerb Organic Ganoderma, 2020-4-16, “Ubushakashatsi bushya: Itsinda rya Porofeseri Yang Baoxue muri kaminuza ya Peking ryemeje ko Acide Ganoderic Acide A ari cyo kintu cy'ingenzi kigize triterpène ya Ganoderma mu kurinda impyiko.”

6.Wei Hao, n'abandi.Ikinyamakuru cyo muri kaminuza ya Nanjing y’ubuvuzi gakondo bw’Abashinwa, 2019, 35 (4), p.433