I kēia lā, nui ka poʻe, ke kohoGanodermanā huahana, nīnau pinepine, "He aha ka triterpene maʻiʻo o kāu huahana?"Me he mea lā ʻoi aku ka kiʻekiʻe o ka triterpene content, ʻoi aku ka maikaʻi o ka huahana.Eia naʻe, ʻaʻole pololei loa kēia.

I kēia manawa, ʻo ke ʻano i hoʻohana mau ʻia e nā ʻoihana kūloko e ana i ka ʻike oGanodermatriterpenes he hana kemika.Loaʻa i kēia ala nā pilikia me ka kikoʻī a me nā hewa nui.No laila, ʻaʻole hiki i ka pae o ka triterpene ke hōʻike pololei i ka maikaʻi o ka aila spore 

ʻOiaʻiʻo, hoʻoholo ʻia ka maikaʻi o kahi huahana aila spore e nā kumu like ʻole.Hiki i ka chromatography wai hana kiʻekiʻe ke ʻike pololei i ka ʻike o ka "Ganoderic Acid A".Inā hiki i kahi huahana aila spore ke hōʻike maopopo i ka ʻike o "Ganoderic Acid A", hāʻawi ia i kahi hōʻoia ʻoi aku ka maikaʻi o ka huahana.He aha ka Ganoderic Acid A?He aha kona mau hopena kūikawā?He aha ka ʻokoʻa ma waena o ia me nā triterpenes?I kēia lā, e ʻike kākou.

Aia ma mua o 300 mau ʻanoGanodermapūhui triterpene.ʻO wai nā mea āu i kamaʻāina ai?

ʻO ka mea mua, he mea nui e ʻike i kēlāGanodermaʻAʻole hoʻokahi mea hoʻokahi nā pūhui triterpene, akā e pili ana i nā mea i lokoGanodermai loaʻa kahi ʻano triterpene.I kēia lā, ʻoi aku ma mua o 300 mau ʻano i ʻike ʻia, hoʻolaha ʻia maGanodermakino hua aGanodermapauda spore.

Hiki ke hoʻokaʻawale nui ʻia kēia mau pūhui triterpene i nā triterpenes neutral a me nā triterpenes acidic.ʻO nā triterpenes acidic nā ʻano like ʻole e like me Ganoderic Acid A, Ganoderic Acid B, Ganoderic Acid F, etc. ʻOiai inā he Ganoderic Acid A a i ʻole Ganoderic Acid B, he mau lālā lāua o ka ʻohana triterpene.Loaʻa i kēlā me kēia o lākou nā ʻano kemika ʻokoʻa a, ma muli o ka hopena, loaʻa iā lākou nā hana physiological like ʻole.

Ma waena o nā ʻano 300 o nā pūhui triterpene, ʻo Ganoderic Acid A ka mea i noiʻi nui ʻia a he pūhui triterpene me nā hopena he nui i ʻike ʻia.Mai ka nui maiʻO Ganoderma lucidum, a aneane loaʻa ʻole i lokoGanoderma sinense.

A laila, e hoʻolauna i nā hopena nui o Ganoderic Acid A i hōʻike nui ʻia i ka noiʻi lāʻau lapaʻau.

ʻO ka hopena o ka Ganoderic Acid A i ka ʻeha ʻeha o ke ake

Ma 2019, ua paʻi ʻia kahi ʻatikala ma ka Journal of Nanjing University of Traditional Chinese Medicine.Hoʻokumu ka haʻawina i kahi hui maʻamau, kahi hui hoʻohālike, kahi hui Ganoderic Acid A haʻahaʻa (20mg / kg), a me kahi hui Ganoderic Acid A kiʻekiʻe (40mg / kg).Ua aʻo ʻo ia i nā hopena o Ganoderic Acid A ma nā ʻiole i hoʻopaʻa ʻia me D-Galactosamine (D-GaIN) a me Lipopolysaccharides (LPS), a me kāna kuleana pale a me nā hana pili e kūʻē i ka hōʻeha ate i hoʻokomo ʻia e D-GaIN/LPS i nā ʻiole.Ua ʻike ʻia ka haʻawina he hopena pale ʻo Ganoderic Acid A i ka hōʻeha ate i hoʻokomo ʻia e D-GaIN/LPS i nā ʻiole.Manaʻoʻia e pili ana kēia hopena i ka hoʻoponopono o ke ala hōʻailona NLRP3/NF-KB.[1]

ʻO nā hopena anti-tumor o Ganoderic Acid A

ʻO ka loaʻa ʻana o kahi lāʻau lapaʻau kūpono no nā maningiomas malignant paʻakikī ka manaʻolana o nā kauka a me nā maʻi.Ganodermaua maikaʻi mau i ka pale ʻana i nā ʻōpū a me ka hoʻihoʻi hou ʻana o ka ʻoki ʻana.

I ka makahiki 2019, kahi hōʻike i paʻi ʻia ma ka "Clinical and Translational Oncology" e ka lolo a me ka spinal tumor programme team ma ka Hollings Cancer Center (kahi maʻi maʻi maʻi i koho ʻia e ka National Cancer Institute o ʻAmelika Hui Pū ʻIa) i kuhikuhi ʻia inā ʻo Ganoderic Acid A a i ʻole Ganoderic. Hoʻohana wale ʻia ka Acid DM, hiki i nā mea ʻelua ke pale pono i ka ulu ʻana o nā maningiomas malignant a hoʻolōʻihi i ka manawa ola o nā ʻiole e lawe ana i ka tumo.ʻO ke ʻano o ka hana e pili ana i ka hoʻihoʻi hou ʻana o ke ʻano suppressor tumor NDRG2.[2]

(Ua lawe ʻia nā mea kiʻi mai ka punaewele puke pai)

Ma 2021, ua paʻi ʻia kahi ʻatikala ma ka Chinese Journal of Clinical Pharmacology.Ua hoʻokumu ke aʻo ʻana i kahi hui hoʻokolohua me ka hoʻohana ʻana i ka 0.5mmol/L o Ganoderic Acid A e komo i loko o nā pūnaewele glioma C6.Uaʻikeʻia heʻoi aku ka liʻiliʻi o ka'āpana'āpana o ka'ōpū i loko o ka hui hoʻokolohua o nāʻiole glioma ma mua o ka pūʻulu hoʻomalu, a ua hoʻemi nuiʻia ka helu o nā pūnaewele hōʻike maikaʻi CD31 i ka hoʻohālikelikeʻana i ka pūʻulu hoʻomalu.Ua huki ʻia ka hopena e hiki i ka Ganoderic Acid A ke kāohi i ka hoʻonui ʻana o ka glioma C6 cell in vitro, a i ka manawa like, hiki iā ia ke pale i ka ulu ʻana o ke kumu hoʻohālike glioma i nā ʻiole ma ke kāohi ʻana i ke kūkulu ʻana i nā kīʻaha koko koko.[3]

Nā hopena o ka Ganoderic Acid A ma ka Pūnaehana Nervous

Ma 2015, he ʻatikala hoʻonaʻauao i paʻi ʻia ma ka Journal of Mudanjiang Medical University i hōʻike ʻia ma o nā hoʻokolohua, ua ʻike ʻia ʻo 50μg/ml o Ganoderic Acid A hiki ke hoʻonui i ke ola o nā neurons hippocampal, hoʻonui i ka hana SOD o nā neurons hippocampal epileptic-like, a hoʻonui i ka hiki o ka membrane mitochondrial.Ua hōʻike ʻia e hiki i ka Ganoderic Acid A ke pale aku i ka hoʻokuʻu ʻana i nā neurons hippocampal ma ke kāohi ʻana i ka pōʻino oxidative cell a me ka apoptosis.[4]

ʻO kaKāohiʻO nā hopena o ka Ganoderic Acid A ma ka Renal Fibrosis a me ka Polycystic Kidney Disease

ʻO kahi hui i alakaʻi ʻia e Professor Yang Baoxue, ke poʻo o ke Keʻena ʻOihana Pharmacology ma ke Kula Nui ʻo Peking University of Basic Medical Science, i paʻi i ʻelua mau pepa ma ka "Acta Pharmacologica Sinica" ma ka hopena o 2019 a me ka hoʻomaka ʻana o 2020. hopena oGanodermama ka renal fibrosis a me ka polycystic kidney maʻi, me Ganoderic Acid A ʻo ia ka mea pono nui.[5]

Eia kekahi, hiki i ka Ganoderic Acid A ke kāohi i ka hoʻokuʻu ʻana o ka histamine cellular, hoʻonui i ka hana o nā ʻano ʻano like ʻole i ka ʻōnaehana digestive, a loaʻa nā hopena e like me ka hoʻohaʻahaʻa ʻana i nā lipids koko, hoʻemi i ke koko, pale i ke ake, a me ka hoʻoponopono ʻana i ka hana ate.[6]

Ma keʻano laulā, he mea maikaʻi loa ka loaʻa ʻana o kahi maʻiʻo kiʻekiʻe oGanodermatriterpenes.ʻO ka hoʻohui ʻana i ka Ganoderic Acid A, i ʻike ʻia no kāna mau hopena pololei a ikaika, e hoʻomaikaʻi nui i ka maikaʻi o ka aila spore.

Kuhikuhi:

1.Wei Hao, et al."Ka hopena pale o Ganoderic Acid A ma ka hōʻeha ate i hoʻokomo ʻia e D-galactosamine / lipopolysaccharide i nā ʻiole," Journal of Nanjing University of Traditional Chinese Medicine, 2019, 35(4), p.432.

2.Wu Tingyao."Nā noiʻi hou: Ua hōʻoia ka poʻe ʻepekema ʻAmelika e hoʻoponopono ʻo Ganoderic Acid A a me DM i ka tumor suppressor gene NDRG2, e kāohi ana i ka ulu ʻana o nā meningiomas malignant," GanoHerb Organic Ganoderma, 2020-6-12.

3.Yang Xin, Huang Qin, Pan Xiaomei."Ka hopena inhibitory o Ganoderic Acid A i ka uluʻana o ka glioma i nāʻiole," Chinese Journal of Clinical Pharmacology, 2021, 37 (8), p.997-998.

4.Wu Rongliang, Liu Junxing."Ka hopena o Ganoderic Acid A ma ka epileptic-like discharge hippocampal neurons," Journal of Mudanjiang Medical University, 2015, 36 (2), p.8.

5.Wu Tingyao."Nā noiʻi hou: Ua hōʻoia ka hui ʻo Profesor Yang Baoxue ma ke Kulanui ʻo Peking ʻo Ganoderic Acid A ʻo ia ka mea nui o Ganoderma triterpenes no ka pale ʻana i ka ʻōpū," GanoHerb Organic Ganoderma, 2020-4-16.

6.Wei Hao, et al."Ka hopena pale o Ganoderic Acid A ma ka ʻeha ate i hoʻokomo ʻia e D-galactosamine / lipopolysaccharide i nā ʻiole," Journal of Nanjing University of Traditional Chinese Medicine, 2019, 35(4), p.433