I tenei ra, he maha nga taangata, ka kowhiriGanodermahua, he maha nga patai, "He aha te ihirangi triterpene o to hua?"Te ahua nei ko te teitei ake o te ihirangi triterpene, ka pai ake te hua.Heoi, kaore tenei i te tino tika.

I tenei wa, ko te tikanga e whakamahia nuitia ana e nga kamupene o roto ki te ine i nga ihirangi oGanodermatriterpenes he tikanga matū.He take motuhake tenei tikanga me nga hapa nui.Na reira, kaore e taea e te taumata o te ihirangi triterpene te whakaatu tika i te kounga o te hinu spore 

Inaa, ko te kounga o te hua hinu spore e whakatauhia ana e nga mea rereke.Ka taea e te chromatography wai mahi teitei te kite tika i te ihirangi o "Ganoderic Acid A".Mena ka taea e te hua hinu spore te whakaatu i nga korero o te "Ganoderic Acid A", ka nui ake te tohu mo te kounga o te hua.He aha te Ganoderic Acid A?He aha ona paanga motuhake?He aha te rereketanga o tera me nga triterpene katoa?I tenei ra, kia mohio tatou.

Neke atu i te 300 momo momoGanodermapūhui triterpene.Ko ēhea e mōhio ana koe?

Tuatahi, he mea nui kia mohio teraGanodermaKo nga pūhui triterpene ehara i te matū kotahi, engari me titiro ki nga matū kei rotoGanodermahe hanganga triterpene.I tenei wa, neke atu i te 300 nga momo kua kitea, kua tohatohahia ki rotoGanodermatinana hua meGanodermapaura puaa.

Ka taea te wehewehea enei puhui triterpene ki nga triterpenes koretake me nga triterpenes waikawa.Kei roto i nga triterpenes waikawa nga momo rereke penei i te Ganoderic Acid A, Ganoderic Acid B, Ganoderic Acid F, aha atu. Ahakoa he Ganoderic Acid A he Ganoderic Acid B ranei, he mema raua o te whanau triterpene.He rereke nga hanganga matū o ia tangata, na reira, he rereke nga mahi ahupūngao.

I roto i te neke atu i te 300 momo pūhui triterpene, ko te Ganoderic Acid A te mea tino rangahau i tenei wa, he puhui triterpene he maha nga paanga kua kitea.Ko te nuinga ka puta maiGanoderma lucidum, a kua tata kore i rotoGanoderma sinense.

I muri mai, me whakaatu mai nga paanga matua o te Ganoderic Acid A kua kitea whanuitia i roto i nga rangahau rongoa.

Te Painga o te Ganoderic Acid A ki runga i te mate ate ate

I te tau 2019, i whakaputaina he tuhinga ki te Journal of Nanjing University of Traditional Chinese Medicine.I whakaturia e te rangahau he roopu noa, he roopu tauira, he roopu Ganoderic Acid A iti (20mg/kg), me te roopu Ganoderic Acid A (40mg/kg).I akohia e ia nga paanga o te Ganoderic Acid A ki nga kiore i werohia ki te D-Galactosamine (D-GaIN) me te Lipopolysaccharides (LPS), me tana mahi tiaki me nga tikanga e pa ana ki te whara o te ate na te D-GaIN / LPS i roto i nga kiore.I kitea e te rangahau he painga tiaki a Ganoderic Acid A ki te whara o te ate na te D-GaIN / LPS i roto i nga kiore.E whakaponohia ana ka pa ana tenei paanga ki te whakaritenga o te huarahi tohu tohu NLRP3/NF-KB.[1]

Nga Paanga Anti-Tumor o Ganoderic Acid A

Ko te rapu maimoatanga pai mo nga maningioma kino uaua ki te rongoa ko te tumanako o nga taakuta me nga turoro.Ganodermakua whai hua tonu ki te aukati i nga pukupuku me te whakaora i muri i te pokanga pukupuku.

I te tau 2019, he purongo i whakaputaina i roto i te "Clinical and Translational Oncology" e te roopu kaupapa roro me te tumo tuakoi i te Hollings Cancer Center (he pokapū mate pukupuku i tohua e te National Cancer Institute o te United States) i tohu ko Ganoderic Acid A he Ganoderic ranei. Ka whakamahia anake te waikawa DM, ka taea e te tokorua te aukati i te tipu o te meningiomas kino me te whakaroa i te wa ora o nga kiore e mau ana i te puku.Ko te tikanga o te mahi e pa ana ki te whakaoranga o te ira NDRG2 puku suppressor.[2]

(I tangohia nga huānga whakaahua mai i te paetukutuku hautaka mana)

I te tau 2021, i whakaputaina he tuhinga ki te Chinese Journal of Clinical Pharmacology.I whakaturia e te rangahau he roopu whakamatautau ma te whakamahi i te 0.5mmol/L o te Ganoderic Acid A hei wawao i nga ruma C6 glioma kiore.I kitea ko te waahi whakawhiti o te pukupuku i roto i te roopu whakamatautau o nga kiore glioma he iti rawa atu i tera o te roopu whakahaere, a, ko te maha o nga CD31 nga waahanga whakaatu pai i tino heke ki te roopu whakahaere.Ko te whakatau ka taea e te Ganoderic Acid A te whakakore i te tipu o te kiore glioma C6 pūtau i roto i te vitro, me te wa ano, ka taea te whakakore i te tipu o te tauira glioma i roto i nga kiore ma te aukati i te hanganga o nga oko toto pukupuku.[3]

Nga Painga o te Ganoderic Acid A ki runga i te punaha Nervous

I roto i te 2015, he tuhinga matauranga i whakaputaina i roto i te Journal of Mudanjiang Medical University i kii na roto i nga whakamatautau, i kitea ko te 50μg / ml o Ganoderic Acid A ka taea te whakanui ake i te oranga o nga neurons hippocampal, te whakarei ake i te mahi SOD o nga neuron hippocampal epileptic-rite, me te whakanui ake i te kaha o te membrane mitochondrial.I whakaatuhia ka taea e te Ganoderic Acid A te tiaki i nga neuron hippocampal e tuku kino ana ma te aukati i te kino o te oxidative pūtau me te apoptosis.[4]

Ko teAukatiNga Paanga o te Ganoderic Acid A ki runga i te Renal Fibrosis me te Polycystic Kidney Disease

Ko tetahi roopu i arahihia e Ahorangi Yang Baoxue, te tumuaki o te Tari o Pharmacology i Peking University School of Basic Medical Sciences, i whakaputa i nga pepa e rua i roto i te "Acta Pharmacologica Sinica" i te mutunga o te 2019 me te timatanga o te 2020. I whakapumautia e nga pepa te aukati. pānga oGanodermai runga i te fibrosis renal me te mate whatukuhu polycystic, me te Ganoderic Acid A te waahanga whai hua nui.[5]

I tua atu, ka taea e te Ganoderic Acid A te whakakore i te tukunga o te histamine pūtau, te whakarei ake i te mahi o nga momo okana i roto i te punaha keri, me te whai hua penei i te whakaheke toto toto, te whakaheke toto, te tiaki i te ate, me te whakahaere i te mahi ate.[6]

I roto i te whānui, he tino pai ki te whai i te ihirangi tiketike oGanodermatriterpenes.Ko te taapiri i te Ganoderic Acid A, e mohiotia ana mo ona paanga tika me te kaha, ka tino whakanui i te kounga o te hinu spore.

Tohutoro:

1.Wei Hao, et al."Te painga tiaki o te Ganoderic Acid A i runga i te whara o te ate na te D-galactosamine / lipopolysaccharide i roto i nga kiore," Journal of Nanjing University of Traditional Chinese Medicine, 2019, 35 (4), p.432.

2.Wu Tingyao."Te rangahau hou: Ka whakapumautia e nga tohunga o Amerika ko te Ganoderic Acid A me te DM e whakahaere ana i te ira aukati pukupuku NDRG2, e aukati ana i te tipu o te meningiomas kino," GanoHerb Organic Ganoderma, 2020-6-12.

3.Yang Xin, Huang Qin, Pan Xiaomei."Te painga aukati o te Ganoderic Acid A mo te tipu o te glioma i roto i nga kiore," Chinese Journal of Clinical Pharmacology, 2021, 37 (8), p.997-998.

4.Wu Rongliang, Liu Junxing."Panga o te Ganoderic Acid A i runga i nga neurons hippocampal epileptic-rite rere," Journal of Mudanjiang Medical University, 2015, 36 (2), p.8.

5.Wu Tingyao."Te rangahau hou: Ko te roopu a Ahorangi Yang Baoxue i te Whare Wananga o Peking e kii ana ko Ganoderic Acid A te waahanga matua o Ganoderma triterpenes mo te tiaki whatukuhu," GanoHerb Organic Ganoderma, 2020-4-16.

6.Wei Hao, et al."Te painga tiaki o te Ganoderic Acid A i runga i te whara o te ate na te D-galactosamine / lipopolysaccharide i roto i nga kiore," Journal of Nanjing University of Traditional Chinese Medicine, 2019, 35 (4), p.433