Nhasi, vanhu vazhinji, pakusarudzaGanodermazvigadzirwa, kazhinji vanobvunza, "Ndeipi triterpene yemukati yechigadzirwa chako?"Zvinoita sekuti iyo yakakwira iyo triterpene yemukati, inova nani chigadzirwa.Zvisinei, izvi hazvisi chokwadi zvachose.

Parizvino, nzira inowanzoshandiswa nemakambani epamba kuyera zvirimoGanodermatriterpenes ikemikari nzira.Iyi nzira ine nyaya dzine hutsanana uye zvikanganiso zvakakura.Naizvozvo, iyo nhanho yezvinyorwa zve triterpene haigone kunyatso miririra kunaka kwemafuta e spore 

Muchokwadi, kunaka kwechigadzirwa chemafuta e spore kunotemerwa nezvinhu zvakasiyana.High-performance liquid chromatography inogona kunyatsoona zviri mu "Ganoderic Acid A".Kana chigadzirwa chemafuta che spore chichigona kuratidza zvakajeka zvirimo zve "Ganoderic Acid A", inopa vimbiso yakakura yemhando yechigadzirwa.Chii chinonzi Ganoderic Acid A?Ndezvipi zvakakosha zvazvinoita?Ndeupi musiyano uripo pakati payo uye yakazara triterpenes?Nhasi, ngatizvizivei.

Kune marudzi anopfuura mazana matatu eGanodermatriterpene mishonga.Ndedzipi dzaunoziva?

Chekutanga, zvakakosha kuziva izvozvoGanodermatriterpene makomisheni haisi chinhu chimwe chete, asi zvinoreva zvinhu zviri mukatiGanodermaiyo ine triterpene chimiro.Parizvino, marudzi anopfuura mazana matatu akawanikwa, akagoverwa mukatiGanodermamichero miviri uyeGanodermaspore powder.

Aya ma triterpene makomisheni anogona kupatsanurwa zvakakamurwa kuita neutral triterpenes uye acidic triterpenes.I-acidic triterpenes inosanganisira marudzi akasiyana-siyana akadai seGanoderic Acid A, Ganoderic Acid B, Ganoderic Acid F, etc. Pasinei nokuti iGanoderic Acid A kana Ganoderic Acid B, vose vari nhengo dzemhuri ye triterpene.Mumwe nemumwe ane zvimiro zvakasiyana zvemakemikari uye, semhedzisiro, ane akasiyana physiological zviitiko.

Pakati pemhando dzinopfuura mazana matatu emhando dzetriterpene, Ganoderic Acid A ndiyo inonyanya kutsvagirwa uye iri musanganiswa wetriterpene une zvakawanda zvakawanikwa.Inonyanya kubvaGanoderma lucidum, uye inenge isipo mukatiGanoderma sinense.

Tevere, ngatiunzei mibairo mikuru yeGanoderic Acid A yakaratidzirwa zvakanyanya mukutsvaga kwemishonga.

Mhedzisiro yeGanoderic Acid A pane Acute Chiropa Kukuvara

Muna 2019, chinyorwa chakaburitswa muChinyorwa cheNanjing University yeChinyakare Chinese Medicine.Chidzidzo chacho chakagadzira boka remazuva ose, boka remuenzaniso, boka rakaderera reGanoderic Acid A (20mg / kg), uye yepamusoro-dose Ganoderic Acid A boka (40mg / kg).Yakadzidza zvinokonzerwa neGanoderic Acid A pamakonzo akaiswa neD-Galactosamine (D-GaIN) uye Lipopolysaccharides (LPS), uye basa rayo rekudzivirira uye nzira dzakabatana dzinorwisana nekukuvara kwechiropa kunokonzerwa neD-GaIN / LPS mumakonzo.Chidzidzo chacho chakawana kuti Ganoderic Acid A ine simba rekudzivirira kurwisana nechiropa chinokonzerwa neD-GaIN / LPS mumakonzo.Zvinotendwa kuti mhedzisiro iyi inogona kunge yakabatana nehurongwa hweNLRP3/NF-KB yekusaina nzira.[1]

Iyo Anti-Tumor Migumisiro yeGanoderic Acid A

Kuwana kurapwa kwakakodzera kune yakaoma-kurapa meningiomas yagara iri tariro yevanachiremba nevarwere.Ganodermayakagara ichishanda mukudzivisa mapundu uye mukuvhiya kwepashure-bundu kupora.

Muna 2019, mushumo wakaburitswa mu "Clinical and Translational Oncology" nehuropi uye spinal tumor chirongwa timu kuHollings Cancer Center (nzvimbo yegomarara yakasarudzwa neNational Cancer Institute yeUnited States) yakaratidza kuti ingave Ganoderic Acid A kana Ganoderic. Acid DM inoshandiswa yoga, zvose zvinogona kudzivisa kukura kweanouraya meningiomas uye kuwedzera nguva yekurarama kwemakonzo anotakura bundu.Iyo nzira yekuita inobatana nekudzoreredzwa kwebundu suppressor gene NDRG2.[2]

(Zvinhu zvemifananidzo zvinotorwa kubva kune yepamutemo jenari webhusaiti)

Muna 2021, chinyorwa chakabudiswa muChinese Journal of Clinical Pharmacology.Chidzidzo ichi chakamisa boka rekuyedza rinoshandisa 0.5mmol/L yeGanoderic Acid A kupindira mumakonzo glioma C6 masero.Zvakaonekwa kuti nzvimbo yepamuchinjikwa yebundu muboka rekuedza reglioma rats yakanga iri duku kudarika iyo yeboka rinodzora, uye nhamba yeCD31 yakanaka kutaura masero yakaderedzwa zvikuru kana ichienzaniswa neboka rinodzora.Mhedziso yakaitwa kuti Ganoderic Acid A inogona kutadzisa kuwanda kwegonzo glioma C6 masero mu vitro, uye panguva imwecheteyo, inogona kutadzisa kukura kweiyo glioma modhi mumakonzo nekuvhara kuumbwa kwebundu tsinga dzeropa.[3]

Mhedzisiro yeGanoderic Acid A paNervous System

Muna 2015, chinyorwa chezvidzidzo chakabudiswa mu Journal of Mudanjiang Medical University chakashuma kuti kuburikidza nekuedza, zvakaonekwa kuti 50μg/ml yeGanoderic Acid A inogona kuwedzera mararamiro ehuppocampal neurons, kuwedzera basa reSOD rehuppocampal neurons, uye kuwedzera mitochondrial membrane inogona.Zvakaratidzwa kuti Ganoderic Acid A inogona kudzivirira kuburitsa zvisina kujairika hippocampal neurons nekudzivisa sero oxidative kukuvara uye apoptosis.[4]

TheHinderMhedzisiro yeGanoderic Acid A paRenal Fibrosis uye Polycystic Kidney Chirwere

Chikwata chinotungamirwa naProfessor Yang Baoxue, mukuru weDhipatimendi rePharmacology paPeking University Chikoro cheBasic Medical Sayenzi, chakaburitsa mapepa maviri akateedzana mu "Acta Pharmacologica Sinica" mukupera kwa2019 uye kutanga kwa2020. Mapepa akasimbisa kuvhiringidza. migumisiro yeGanodermaparenal fibrosis uye chirwere cheitsvo chepolycystic, neGanoderic Acid A iri iyo inonyanya kushanda chikamu.[5]

Mukuwedzera, Ganoderic Acid A inogona kudzivisa kusunungurwa kwe cellular histamine, kuwedzera kushanda kwezvikamu zvakasiyana-siyana muhutano hwekudya, uye ine migumisiro yakadai sekuderedza lipids yeropa, kuderedza ropa, kuchengetedza chiropa, nekugadzirisa kushanda kwechiropa.[6]

Kazhinji, zvakanaka kuti uve nehuwandu hwepamusoroGanodermatriterpenes.Kuwedzera Ganoderic Acid A, inozivikanwa nekunyatso uye ine simba mhedzisiro, kwaizowedzera zvakanyanya kunaka kweiyo spore oiri.

References:

1.Wei Hao, nevamwe."Kudzivirira maitiro eGanoderic Acid A pakukuvara kwechiropa kunokonzerwa neD-galactosamine / lipopolysaccharide mumakonzo," Journal yeNanjing University yeTraditional Chinese Medicine, 2019, 35 (4), p.432.

2.Wu Tingyao."Kutsvagisa kutsva: Nyanzvi dzeAmerica dzinosimbisa kuti Ganoderic Acid A uye DM inodzora bundu suppressor gene NDRG2, ichitadzisa kukura kweanouraya meningiomas," GanoHerb Organic Ganoderma, 2020-6-12.

3.Yang Xin, Huang Qin, Pan Xiaomei."Inhibitory effect yeGanoderic Acid A pakukura kweglioma mumakonzo," Chinese Journal of Clinical Pharmacology, 2021, 37 (8), p.997-998.

4.Wu Rongliang, Liu Junxing."Mugumisiro weGanoderic Acid A pane epileptic-like discharge hippocampal neurons," Journal of Mudanjiang Medical University, 2015, 36 (2), p.8.

5.Wu Tingyao."Kutsvagisa kutsva: Chikwata chaPurofesa Yang Baoxue kuPeking University chinosimbisa kuti Ganoderic Acid A ndiyo chikamu chikuru cheGanoderma triterpenes yekudzivirira itsvo," GanoHerb Organic Ganoderma, 2020-4-16.

6.Wei Hao, nevamwe."Kudzivirira maitiro eGanoderic Acid A pakukuvara kwechiropa kunokonzerwa neD-galactosamine / lipopolysaccharide mumakonzo," Journal yeNanjing University yeTraditional Chinese Medicine, 2019, 35 (4), p.433