Maanta, dad badan, marka la dooranayoGanodermaAlaabooyinka, badanaa weydii, "Waa maxay waxa ku jira triterpene ee alaabtaada?"Waxay u muuqataa in heerka sare ee triterpene, ay ka sii fiican tahay alaabta.Si kastaba ha ahaatee, tani gabi ahaanba sax maaha.

Waqtigan xaadirka ah, habka caadi ahaan loo isticmaalo shirkadaha gudaha si loo cabbiro waxa ku jiraGanodermatriterpenes waa hab kiimiko.Habkani wuxuu leeyahay arrimo gaar ah iyo khaladaad waaweyn.Sidaa darteed, heerka triterpene content si sax ah uma matali karo tayada saliidda kudka 

Dhab ahaantii, tayada wax soo saarka saliid kudka waxaa lagu go'aamiyaa arrimo kala duwan.chromatography dareere-waxqabadka sarreeya ayaa si sax ah u ogaan kara waxa ku jira "Ganoderic Acid A".Haddii badeecada saliidda xabagta ay si cad u muujin karto waxa ku jira “Ganoderic Acid A”, waxay siinaysaa dammaanad weyn oo tayada badeecadda.Waa maxay Ganoderic acid A?Waa maxay saameynteeda gaarka ah?Waa maxay farqiga u dhexeeya isaga iyo wadarta triterpenes?Maanta, aan is baranno.

Waxaa jira in ka badan 300 oo noocGanodermaxeryahooda triterpene.Kuwee aad taqaan?

Marka hore, waa muhiim in taas la ogaadoGanodermaXeryahooda triterpene maaha hal walax, laakiin waxay tixraacaan walxaha ku jiraGanodermakuwaas oo leh qaab-dhismeedka triterpene.Ilaa hadda, in ka badan 300 oo nooc ayaa la helay, oo loo qaybiyayGanodermajidhka midhaha iyoGanodermabudada xabka

Xeryahooda triterpene waxaa si ballaaran loo qaybin karaa triterpenes dhexdhexaad ah iyo triterpenes acidic.Triterpenes-ka acidic waxaa ku jira noocyo kala duwan sida Ganoderic Acid A, Ganoderic Acid B, Ganoderic Acid F, iwm. Iyadoo aan loo eegin inay tahay Ganoderic Acid A ama Ganoderic Acid B, labaduba waxay ka tirsan yihiin qoyska triterpene.Mid kastaa wuxuu leeyahay qaabab kiimiko oo kala duwan, natiijaduna waxay leedahay dhaqdhaqaaqyo nafsi oo kala duwan.

Ka mid ah in ka badan noocyada 300 ee xeryahooda triterpene, Ganoderic Acid A ayaa hadda ah midka ugu cilmi-baarista badan waana unug triterpene ah oo leh saameyno badan oo la ogaaday.Waxay inta badan ka timaadaaGanoderma lucidum, oo ku dhawaad ​​aan ka jirin gudahaGanoderma sinense.

Marka xigta, aan soo bandhigno saameynta ugu weyn ee Ganoderic Acid A ee si weyn loogu muujiyay cilmi-baarista dawooyinka.

Saamaynta Ganoderic Acid A ee Dhaawaca Beerka Ba'an

2019, maqaal ayaa lagu daabacay Joornaalka Jaamacadda Nanjing ee Daawada Dhaqanka ee Shiinaha.Daraasadu waxay dejisay koox caadi ah, koox moodeel ah, koox yar oo Ganoderic Acid A (20mg/kg), iyo koox sare oo Ganoderic Acid A (40mg/kg).Waxay daraasad ku samaysay saamaynta Ganoderic Acid A ee jiirarka lagu duray D-Galactosamine (D-GaIN) iyo Lipopolysaccharides (LPS), iyo doorkeeda ilaalinta iyo hababka la xidhiidha ee ka hortagga dhaawaca beerka ee ay keento D-GaIN / LPS ee jiirarka.Daraasadu waxay ogaatay in Ganoderic Acid A ay leedahay saameyn ka hortag ah oo ka dhan ah dhaawaca beerka ee ay keentay D-GaIN/LPS ee jiirarka.Waxaa la rumeysan yahay in saameyntani ay la xiriirto nidaaminta dariiqa calaamadaynta NLRP3/NF-KB.[1]

Saamaynta Ka-hortagga Burada ee Ganoderic Acid A

Helitaanka daawaynta ugu habboon ee ay adag tahay in la daweeyo meningiomas-ka xun waxay had iyo jeer ahayd rajada dhakhaatiirta iyo bukaannada.Ganodermawaxay had iyo jeer wax ku ool u tahay joojinta burooyinka iyo soo kabashada qalliinka burada ka dib.

2019, warbixin lagu daabacay "Clinical and Translational Oncology" oo ay sameeyeen kooxda barnaamijka burooyinka maskaxda iyo laf dhabarta ee Xarunta Kansarka ee Hollings (xarun kansar oo uu u qoondeeyay Machadka Kansarka Qaranka ee Mareykanka) ayaa tilmaantay in Ganoderic Acid A ama Ganoderic Acid DM keligiis ayaa la isticmaalaa, labaduba waxay si wax ku ool ah u joojin karaan koritaanka meningiomas-ka xun waxayna sii dheerayn karaan muddada badbaadada ee jiirarka buro-sida.Habka ficilku wuxuu la xiriiraa dib-u-kicinta hidda-wadaha xakameynaya burada NDRG2.[2]

(Waxyaabaha sawirka waxaa laga soo qaatay bogga rasmiga ah ee joornaalka)

2021, maqaal ayaa lagu daabacay joornaalka Shiinaha ee dawooyinka kiliinikada.Daraasadu waxay dejisay koox tijaabo ah iyadoo la adeegsanayo 0.5mmol/L ee Ganoderic Acid A si ay u farageliso unugyada glioma C6 ee jiirka.Waxaa la ogaaday in qaybta isku-dhafka ah ee buro ee kooxda tijaabada ah ee jiirka glioma ay si aad ah uga yar tahay kooxda kantaroolka, iyo tirada CD31 unugyada muujinta wanaagsan ayaa si weyn hoos ugu dhacay marka la barbardhigo kooxda kantaroolka.Gabagabadii waxaa la soo saaray in Ganoderic Acid A ay joojin karto faafitaanka unugyada glioma C6 ee unugyada vitro, isla markaana, waxay joojin kartaa korriinka qaabka glioma ee jiirka iyadoo xannibaysa samaynta xididdada dhiigga ee buro.[3]

Saamaynta Ganoderic Acid A ee Nidaamka Dareenka

2015, maqaal tacliimeed oo lagu daabacay joornaalka Mudanjiang Medical University ayaa sheegay in tijaabooyinka, lagu ogaaday in 50μg / ml ee Ganoderic Acid A ay kordhin karto heerka badbaadada ee neerfayaasha hippocampal, kor u qaadida dhaqdhaqaaqa SOD ee neurons-sida hippocampal neurons, iyo kordhinta awoodda xuubka mitochondrial.Waxaa la muujiyay in Ganoderic Acid A ay ilaalin karto si aan caadi ahayn oo sii daaya neerfayaasha hippocampal iyadoo la joojinayo dhaawaca unugyada oksaydhiyaha iyo apoptosis.[4]

Thehor istaagSaamaynta Ganoderic Acid A ee Fibrosis Kelyaha iyo Cudurka Kelyaha ee Polycystic

Koox uu hoggaaminayo Professor Yang Baoxue, oo madax ka ah Waaxda Farmashiga ee Jaamacadda Peking ee Sayniska Caafimaadka Aasaasiga ah, ayaa daabacday laba waraaqood oo isku xigta "Acta Pharmacologica Sinica" dhammaadka 2019 iyo bilawga 2020. Waraaqaha ayaa xaqiijiyay carqaladaynta saamayntaGanodermaon fibrosis kelyaha iyo cudurka kelyaha polycystic, oo leh Ganoderic Acid A oo ah qaybta ugu waxtarka badan.[5]

Intaa waxaa dheer, Ganoderic Acid A waxay joojin kartaa sii deynta histamine-ka gacanta, waxay wanaajisaa shaqada xubnaha kala duwan ee habka dheef-shiidka, waxayna leedahay saameyn ay ka mid yihiin hoos u dhigista dufanka dhiigga, yareynta cadaadiska dhiigga, ilaalinta beerka, iyo nidaaminta shaqada beerka.[6]

Guud ahaan, waxaa hubaal ah in ay wanaagsan tahay in aad ka kooban tahayGanodermatriterpenes.Ku darida Ganoderic Acid A, oo loo yaqaan saameynteeda saxda ah ee xoogga leh, waxay si weyn u kordhin doontaa tayada saliidda kudka.

Tixraacyo:

1.Wei Hao, iyo al."Saamaynta ilaalinta ee Ganoderic Acid A ee dhaawaca beerka ee ay keentay D-galactosamine / lipopolysaccharide ee jiirarka," Joornaalka Jaamacadda Nanjing ee Daawada Dhaqanka ee Shiinaha, 2019, 35 (4), p.432.

2.Wu Tingyao."Cilmi-baaris cusub: Aqoonyahannada Maraykanku waxay xaqiijinayaan in Ganoderic Acid A iyo DM ay nidaamiyaan hidda-wadaha xakameynaya burooyinka NDRG2, oo xakameynaya koritaanka meningiomas malignant," GanoHerb Organic Ganoderma, 2020-6-12.

3.Yang Xin, Huang Qin, Pan Xiaomei."Saamaynta xannibaadda ee Ganoderic Acid A ee koritaanka glioma ee jiirka," Joornaalka Shiinaha ee Farmashiistaha Clinical, 2021, 37 (8), p.997-998.

4.Wu Rongliang, Liu Junxing."Saamaynta Ganoderic Acid A on suuxdin-sida dheecaan hippocampal neurons," Journal of Mudanjiang Medical University, 2015, 36 (2), p.8.

5.Wu Tingyao."Cilmi-baaris cusub: Kooxda Professor Yang Baoxue ee Jaamacadda Peking waxay xaqiijisay in Ganoderic Acid A ay tahay qaybta ugu muhiimsan ee Ganoderma triterpenes ee ilaalinta kelyaha," GanoHerb Organic Ganoderma, 2020-4-16.

6.Wei Hao, iyo al."Saameynta ilaalinta Ganoderic Acid A ee dhaawaca beerka ee ay keentay D-galactosamine / lipopolysaccharide ee jiirarka," Joornaalka Jaamacadda Nanjing ee Daawada Dhaqanka ee Shiinaha, 2019, 35 (4), p.433