Masiku ano, anthu ambiri, posankhaGanodermamankhwala, nthawi zambiri amafunsa, "Kodi triterpene zili mu malonda anu?"Zikuwoneka kuti zinthu zomwe zili ndi triterpene zimakhala zabwino kwambiri.Komabe, izi sizolondola kwenikweni.

Panopa, njira ambiri ntchito ndi makampani zoweta kuyeza ziliGanodermatriterpenes ndi njira yamankhwala.Njirayi ili ndi zovuta zenizeni komanso zolakwika zazikulu.Chifukwa chake, mulingo wazinthu za triterpene sungathe kuyimira molondola mtundu wamafuta a spore 

M'malo mwake, mtundu wamafuta a spore umatsimikiziridwa ndi zinthu zosiyanasiyana.Kuchuluka kwamadzimadzi chromatography kumatha kuzindikira bwino zomwe zili mu "Ganoderic Acid A".Ngati mafuta a spore angasonyeze bwino zomwe zili mu "Ganoderic Acid A", zimapereka chitsimikizo chachikulu cha khalidwe la mankhwalawo.Kodi Ganoderic Acid A ndi chiyani?Kodi zotsatira zake zapadera ndi zotani?Kodi pali kusiyana kotani pakati pa izo ndi ma triterpenes okwana?Lero, tiyeni tidziwe.

Pali mitundu yopitilira 300 yaGanodermatriterpene mankhwala.Ndi ati omwe mumawadziwa?

Choyamba, ndikofunikira kudziwa iziGanodermamankhwala a triterpene si chinthu chimodzi, koma amatanthauza zinthu zomwe zili mkatiGanodermaomwe ali ndi mawonekedwe a triterpene.Mpaka pano, mitundu yopitilira 300 yapezeka, yogawidwa muGanodermafruiting matupi ndiGanodermaspore powder.

Ma triterpene awa amatha kugawidwa mokulira mu ma triterpenes osalowerera ndale ndi acidic triterpenes.Ma acidic triterpenes amaphatikizapo mitundu yosiyanasiyana monga Ganoderic Acid A, Ganoderic Acid B, Ganoderic Acid F, etc. Mosasamala kanthu kuti ndi Ganoderic Acid A kapena Ganoderic Acid B, onsewa ndi mamembala a banja la triterpene.Aliyense ali ndi mitundu yosiyanasiyana yamankhwala ndipo, chifukwa chake, amakhala ndi zochitika zosiyanasiyana za thupi.

Pakati pa mitundu yoposa 300 ya mankhwala a triterpene, Ganoderic Acid A ndiyomwe amafufuzidwa kwambiri ndipo ndi gulu la triterpene lomwe lili ndi zotsatira zambiri zomwe zapezeka.Iwo makamaka amachokeraGanoderma lucidum, ndipo pafupifupi kulibeGanoderma sinense.

Chotsatira, tiyeni tifotokoze zotsatira zazikulu za Ganoderic Acid A zomwe zawonetsedwa kwambiri mu kafukufuku wamankhwala.

Zotsatira za Ganoderic Acid A pa Kuvulala Kwambiri kwa Chiwindi

Mu 2019, nkhani idasindikizidwa mu Journal of Nanjing University of Traditional Chinese Medicine.Phunziroli linakhazikitsa gulu lodziwika bwino, gulu lachitsanzo, gulu laling'ono la Ganoderic Acid A (20mg / kg), ndi gulu la Ganoderic Acid A gulu (40mg / kg).Anaphunzira zotsatira za Ganoderic Acid A pa mbewa zojambulidwa ndi D-Galactosamine (D-GaIN) ndi Lipopolysaccharides (LPS), ndi ntchito yake yotetezera ndi njira zotsutsana ndi kuvulala kwa chiwindi zomwe zimayambitsidwa ndi D-GaIN / LPS mu mbewa.Kafukufukuyu adapeza kuti Ganoderic Acid A imakhala ndi chitetezo choteteza chiwindi chifukwa cha D-GaIN / LPS mu mbewa.Zimakhulupirira kuti zotsatirazi zikhoza kukhala zokhudzana ndi kayendetsedwe ka njira yowonetsera NLRP3 / NF-KB.[1]

Zotsatira za Anti-Tumor za Ganoderic Acid A

Kupeza chithandizo choyenera cha matenda a meningioma ovuta kuchiza kwakhala chiyembekezo cha madokotala ndi odwala.Ganodermawakhala akugwira ntchito poletsa zotupa komanso pochira pambuyo pa chotupa.

Mu 2019, lipoti lofalitsidwa mu "Clinical and Translational Oncology" ndi gulu laubongo ndi chotupa chamsana ku Hollings Cancer Center (malo a khansa omwe adasankhidwa ndi National Cancer Institute ku United States) adawonetsa kuti ngakhale Ganoderic Acid A kapena Ganoderic. Acid DM imagwiritsidwa ntchito yokha, onse amatha kulepheretsa kukula kwa meningiomas owopsa ndikutalikitsa nthawi yakukhala ndi mbewa zokhala ndi chotupa.Limagwirira ntchito zikugwirizana ndi reactivation wa chotupa suppressor jini NDRG2.[2]

(Zithunzi zazithunzi zatengedwa patsamba lovomerezeka lamagazini)

Mu 2021, nkhani idasindikizidwa mu Chinese Journal of Clinical Pharmacology.Kafukufukuyu adakhazikitsa gulu loyesera pogwiritsa ntchito 0.5mmol / L ya Ganoderic Acid A kuti alowerere mu rat glioma C6 maselo.Zinapezeka kuti gawo lamtundu wa chotupa mu gulu loyesera la makoswe a glioma linali laling'ono kwambiri kusiyana ndi gulu lolamulira, ndipo chiwerengero cha CD31 maselo owonetserako chinachepetsedwa kwambiri poyerekeza ndi gulu lolamulira.Mapeto ake adanenedwa kuti Ganoderic Acid A imatha kuletsa kuchuluka kwa rat glioma C6 maselo mu vitro, ndipo nthawi yomweyo, imatha kuletsa kukula kwa mtundu wa glioma mu makoswe poletsa mapangidwe a mitsempha yamagazi.[3]

Zotsatira za Ganoderic Acid A pa Nervous System

Mu 2015, nkhani yamaphunziro yomwe idasindikizidwa mu Journal of Mudanjiang Medical University inanena kuti kudzera muzoyeserera, zidapezeka kuti 50μg/ml ya Ganoderic Acid A imatha kukulitsa kupulumuka kwa ma hippocampal neurons, kupititsa patsogolo ntchito ya SOD ya khunyu ngati hippocampal neurons, ndikuwonjezera kuthekera kwa nembanemba ya mitochondrial.Zinawonetsedwa kuti Ganoderic Acid A imatha kuteteza kutulutsa kwa hippocampal neurons mwa kuletsa kuwonongeka kwa cell oxidative ndi apoptosis.[4]

TheKulepheretsaZotsatira za Ganoderic Acid A pa Renal Fibrosis ndi Polycystic Impso Matenda

Gulu lotsogozedwa ndi Pulofesa Yang Baoxue, wamkulu wa dipatimenti ya zamankhwala ku Peking University School of Basic Medical Science, adasindikiza mapepala awiri motsatizana mu "Acta Pharmacologica Sinica" kumapeto kwa 2019 ndi kumayambiriro kwa 2020. Mapepalawa adatsimikizira cholepheretsa. zotsatira zaGanodermapa aimpso fibrosis ndi polycystic matenda a impso, ndi Ganoderic Acid A kukhala gawo lothandiza kwambiri.[5]

Kuphatikiza apo, Ganoderic Acid A imatha kuletsa kutulutsidwa kwa histamine yama cell, kukulitsa ntchito ya ziwalo zosiyanasiyana m'matumbo am'mimba, ndipo imakhala ndi zotsatirapo monga kutsitsa lipids m'magazi, kuchepetsa kuthamanga kwa magazi, kuteteza chiwindi, ndikuwongolera magwiridwe antchito a chiwindi.[6]

Nthawi zambiri, ndikwabwino kukhala ndi zinthu zambiriGanodermatriterpenes.Kuonjezera Ganoderic Acid A, yomwe imadziwika ndi zotsatira zake zenizeni komanso zamphamvu, kungapangitse kuti mafuta a spore akhale abwino kwambiri.

Zolozera:

1.Wei Hao, ndi al."Kuteteza kwa Ganoderic Acid A pa kuvulala kwachiwindi komwe kumachitika ndi D-galactosamine/lipopolysaccharide mu mbewa," Journal of Nanjing University of Traditional Chinese Medicine, 2019, 35(4), p.432.

2.Wu Tingyao."Kafukufuku watsopano: Akatswiri aku America amatsimikizira kuti Ganoderic Acid A ndi DM imayang'anira chotupa chopondereza jini NDRG2, kuletsa kukula kwa meningiomas oyipa," GanoHerb Organic Ganoderma, 2020-6-12.

3.Yang Xin, Huang Qin, Pan Xiaomei."Zolepheretsa za Ganoderic Acid A pakukula kwa glioma mu makoswe," Chinese Journal of Clinical Pharmacology, 2021, 37 (8), p.997-998.

4.Wu Rongliang, Liu Junxing."Zotsatira za Ganoderic Acid A pa khunyu-ngati discharge hippocampal neurons," Journal of Mudanjiang Medical University, 2015, 36 (2), p.8.

5.Wu Tingyao."Kafukufuku watsopano: Gulu la Pulofesa Yang Baoxue ku Peking University likutsimikizira kuti Ganoderic Acid A ndiye gawo lalikulu la Ganoderma triterpenes poteteza impso," GanoHerb Organic Ganoderma, 2020-4-16.

6.Wei Hao, et al."Kuteteza kwa Ganoderic Acid A pa kuvulala kwa chiwindi komwe kumayambitsa D-galactosamine/lipopolysaccharide mu mbewa," Journal of Nanjing University of Traditional Chinese Medicine, 2019, 35(4), p.433