Namhlanje, abantu abaninzi, xa ukhethaI-Ganodermaiimveliso, zihlala zibuza, "Yintoni umxholo we-triterpene kwimveliso yakho?"Kubonakala ngathi uphezulu umxholo we-triterpene, ngcono imveliso.Nangona kunjalo, oku akuchanekanga ngokupheleleyo.

Okwangoku, indlela esetyenziswa ngokuqhelekileyo ziinkampani zasekhaya ukulinganisa umxholoI-Ganodermai-triterpenes yindlela yekhemikhali.Le ndlela inemiba ethile kunye neempazamo ezinkulu.Ngoko ke, inqanaba lomxholo we-triterpene alikwazi ukumela ngokuchanekileyo umgangatho weoli ye-spore 

Ngapha koko, umgangatho wemveliso yeoli ye-spore umiselwa zizinto ezahlukeneyo.I-chromatography yolwelo oluphezulu olusebenzayo luyakwazi ukubona ngokuchanekileyo umxholo we "Ganoderic Acid A".Ukuba imveliso yeoli ye-spore ingabonisa ngokucacileyo umxholo we "Ganoderic Acid A", inika isiqinisekiso esikhulu somgangatho wemveliso.Yintoni iGanoderic Acid A?Iyintoni imiphumo yayo ekhethekileyo?Uthini umahluko phakathi kwayo kunye ne-triterpenes epheleleyo?Namhlanje, makhe siyazi.

Kukho iintlobo ezingaphezu kwama-300 zeI-Ganodermaiikhompawundi triterpene.Zeziphi oqhelene nazo?

Okokuqala, kubalulekile ukwazi okoI-GanodermaIikhompawundi ze-triterpene aziyonto enye, kodwa zibhekisa kwizinto ezikuyoI-Ganodermaezinesakhiwo se-triterpene.Ukuza kuthi ga ngoku, zingaphezu kwama-300 iintlobo ezifunyenweyo, ezisasazwe kuyoI-Ganodermaimizimba yeziqhamo kunyeI-Ganodermaumgubo wesipore.

Ezi khompawundi ze-triterpene zinokuhlulwa ngokubanzi zibe zii-triterpenes ezingathathi hlangothi kunye ne-acidic triterpenes.I-acidic triterpenes iquka iintlobo ezahlukeneyo ezifana ne-Ganoderic Acid A, i-Ganoderic Acid B, i-Ganoderic Acid F, njl. Kungakhathaliseki ukuba i-Ganoderic Acid A okanye i-Ganoderic Acid B, bobabini bangamalungu entsapho ye-triterpene.Ngamnye unezakhiwo ezahlukeneyo zeekhemikhali kwaye, ngenxa yoko, zinemisebenzi eyahlukeneyo yomzimba.

Phakathi kweendidi ezingaphezu kwe-300 ze-triterpene compounds, i-Ganoderic Acid A ngoku iyona uphando kwaye i-triterpene ikhompawundi eneziphumo ezininzi ezifunyenweyo.Ubukhulu becala ivelaI-Ganoderma lucidum, kwaye iphantse yangabikho kuyoGanoderma sinense.

Okulandelayo, makhe sazise iziphumo eziphambili zeGanoderic Acid A eziye zabonakaliswa ngokubanzi kuphando lwe-pharmacological.

Isiphumo se-Ganoderic Acid A kwi-Acute Injury yesibindi

Ngo-2019, inqaku lapapashwa kwiJenali yeYunivesithi yaseNanjing yeSintu saseTshayina.Uphononongo lusethe iqela eliqhelekileyo, iqela lomzekelo, iqela eliphantsi le-Ganoderic Acid A (20mg / kg), kunye neqela eliphezulu le-Ganoderic Acid A (40mg / kg).Ifunde imiphumo ye-Ganoderic Acid A kwiigundane ezifakwe kwi-D-Galactosamine (D-GaIN) kunye ne-Lipopolysaccharides (LPS), kunye nendima yayo yokukhusela kunye neendlela ezinxulumene nokulimala kwesibindi okwenziwa yi-D-GaIN / LPS kwiigundane.Uphononongo lufumene ukuba i-Ganoderic Acid A inefuthe lokukhusela ekulimazeni kwesibindi okubangelwa yi-D-GaIN / LPS kwiigundane.Kukholelwa ukuba esi siphumo sinokunxulumana nokulawulwa kwendlela yokubonisa i-NLRP3/NF-KB.[1]

Iimpembelelo ze-Anti-Tumor ye-Ganoderic Acid A

Ukufumana unyango olufanelekileyo kwi-meningiomas enobungozi enzima ukunyanga bekusoloko kulithemba koogqirha kunye nezigulane.I-Ganodermaibisoloko isebenza ngempumelelo ekunqandeni amathumba kunye nasekubuyiseni utyando lwasemva kwethumba.

Ngo-2019, ingxelo epapashwe kwi "Clinical and Translational Oncology" yingqondo kunye neqela lenkqubo ye-spinal tumor kwiZiko loMhlaza laseHollings (iziko lomhlaza elonyulwe liZiko lomhlaza leSizwe laseMelika) yachaza ukuba ingaba yiGanoderic Acid A okanye iGanoderic. I-Acid DM isetyenziswe yodwa, zombini inokuthintela ngokufanelekileyo ukukhula kwe-meningiomas enobungozi kunye nokwandisa ixesha lokusinda kweegundane ezithwala i-tumor.Indlela yokusebenza ihambelana nokuphinda kusebenze i-tumor suppressor gene NDRG2.[2]

(Izinto zomfanekiso zithathwe kwiwebhusayithi yejenali esemthethweni)

Ngo-2021, inqaku lapapashwa kwi-Chinese Journal of Clinical Pharmacology.Uphononongo lusethe iqela lokulinga usebenzisa i-0.5mmol / L ye-Ganoderic Acid A ukungenelela kwiiseli ze-rat glioma C6.Kwafunyaniswa ukuba indawo ye-cross-sectional ye-tumor kwiqela lokulinga lamagundane e-glioma yayincinci kakhulu kuneqela lokulawula, kwaye inani leeseli ze-CD31 zokubonisa ezintle zancitshiswa kakhulu xa kuthelekiswa neqela lokulawula.Isigqibo sathathwa ukuba i-Ganoderic Acid A inokuthintela ukwanda kweeseli ze-rat glioma C6 kwi-vitro, kwaye kwangaxeshanye, inokuthintela ukukhula kwemodeli ye-glioma kwiigundane ngokuthintela ukubunjwa kwemithambo yegazi ye-tumor.[3]

Iimpembelelo zeGanoderic Acid A kwiNkqubo yeNervous

Kwi-2015, inqaku lezemfundo elipapashwe kwi-Journal ye-Mudanjiang Medical University yabika ukuba ngokusebenzisa iimvavanyo, kwafunyaniswa ukuba i-50μg / ml ye-Ganoderic Acid A inokunyusa izinga lokusinda kwe-hippocampal neurons, ukuphucula umsebenzi we-SOD we-epileptic-like hippocampal neurons, kunye nokwandisa inwebu ye-mitochondrial enokwenzeka.Kwaboniswa ukuba i-Ganoderic Acid A inokukhusela ngokungaqhelekanga i-hippocampal neurons ngokuthintela umonakalo we-cell oxidative kunye ne-apoptosis.[4]

INqandaIimpembelelo zeGanoderic Acid A kwiRenal Fibrosis kunye nePolycystic Kidney Disease

Iqela elikhokelwa nguNjingalwazi uYang Baoxue, intloko yeSebe le-Pharmacology kwiYunivesithi yasePeking School of Basic Medical Sciences, lipapashe amaphepha amabini ngokulandelelana kwi-"Acta Pharmacologica Sinica" ekupheleni kuka-2019 nasekuqaleni kuka-2020. Amaphepha aqinisekisa ukuthintela. iziphumo zeI-Ganodermakwi-renal fibrosis kunye nesifo sezintso ze-polycystic, kunye ne-Ganoderic Acid A yeyona nto isebenzayo.[5]

Ukongezelela, i-Ganoderic Acid A inokuthintela ukukhululwa kwe-histamine yeselula, iphucula umsebenzi wezitho ezahlukahlukeneyo kwinkqubo yokugaya, kwaye ibe nemiphumo efana nokunciphisa i-lipids yegazi, ukunciphisa uxinzelelo lwegazi, ukukhusela isibindi, kunye nokulawula ukusebenza kwesibindi.[6]

Ngokubanzi, ngokuqinisekileyo kulungile ukuba nomxholo ophezuluI-Ganodermaiitriterpenes.Ukongeza i-Ganoderic Acid A, eyaziwa ngokuchaneka kwayo kunye neziphumo ezinamandla, kuya kuphucula kakhulu umgangatho we-oyile ye-spore.

IiReferensi:

1.Wei Hao, et al."Impembelelo ekhuselayo ye-Ganoderic Acid A kwingozi yesibindi eyenziwa yi-D-galactosamine / lipopolysaccharide kwiigundane," I-Journal ye-Nanjing University ye-Traditional Chinese Medicine, i-2019, i-35 (4), iphe.432.

2.Wu Tingyao."Uphando olutsha: Abaphengululi baseMerika baqinisekisa ukuba i-Ganoderic Acid A kunye ne-DM ilawula i-tumor suppressor gene NDRG2, inqanda ukukhula kwee-meningomas ezimbi," iGanoHerb Organic Ganoderma, i-2020-6-12.

3.Yang Xin, Huang Qin, Pan Xiaomei."Impembelelo ye-Inhibitory ye-Ganoderic Acid A ekukhuleni kwe-glioma kwiigundane," i-Chinese Journal ye-Clinical Pharmacology, i-2021, i-37 (8), i-p.997-998.

4.Wu Rongliang, uLiu Junxing."Impembelelo ye-Ganoderic Acid A kwi-epileptic-like discharge hippocampal neurons," I-Journal ye-Mudanjiang Medical University, i-2015, i-36 (2), p.8.

5.Wu Tingyao."Uphando olutsha: Iqela likaNjingalwazi uYang Baoxue kwiYunivesithi yasePeking iqinisekisa ukuba iGanoderic Acid A lelona candelo liphambili leGanoderma triterpenes kukhuseleko lwezintso," iGanoHerb Organic Ganoderma, 2020-4-16.

6.Wei Hao, et al."Impembelelo ekhuselayo ye-Ganoderic Acid A kwingozi yesibindi eyenziwa yi-D-galactosamine / lipopolysaccharide kwiimpuku," Ijenali yeYunivesithi yaseNanjing yeTraditional Chinese Medicine, 2019, 35 (4), p.433