Niaj hnub no, ntau tus neeg, thaum xaivGanodermacov khoom, feem ntau nug, "Dab tsi yog cov ntsiab lus triterpene ntawm koj cov khoom?"Nws zoo nkaus li tias qhov siab dua cov ntsiab lus triterpene, qhov khoom zoo dua.Txawm li cas los xij, qhov no tsis yog tag nrho.

Tam sim no, txoj kev siv los ntawm cov tuam txhab hauv tsev los ntsuas cov ntsiab lus ntawmGanodermatriterpenes yog ib txoj kev tshuaj.Txoj kev no muaj teeb meem nrog qhov tshwj xeeb thiab qhov yuam kev loj.Yog li ntawd, qib ntawm triterpene cov ntsiab lus tsis tuaj yeem yog qhov zoo ntawm cov roj spore 

Qhov tseeb, qhov zoo ntawm cov khoom siv roj spore yog txiav txim siab los ntawm ntau yam.Kev ua haujlwm siab ua kua chromatography tuaj yeem txheeb xyuas cov ntsiab lus ntawm "Ganoderic Acid A".Yog tias cov khoom siv roj ntsha tuaj yeem qhia meej cov ntsiab lus ntawm "Ganoderic Acid A", nws muab kev lees paub ntau dua ntawm cov khoom zoo.Ganoderic Acid A yog dab tsi?Nws cov teebmeem tshwj xeeb yog dab tsi?Dab tsi yog qhov txawv ntawm nws thiab tag nrho triterpenes?Hnub no, cia peb kawm paub.

Muaj ntau tshaj 300 homGanodermatriterpene compounds.Koj puas paub?

Ua ntej, nws tseem ceeb heev kom paub qhov ntawdGanodermatriterpene tebchaw tsis yog ib yam khoom, tab sis theej xa mus rau cov tshuaj hauvGanodermauas muaj cov qauv triterpene.Txog niaj hnub no, ntau tshaj 300 hom tau pom, faib rau hauvGanodermafruiting cev thiabGanodermaspore hmoov.

Cov tshuaj triterpene no tuaj yeem muab faib ua nruab nrab triterpenes thiab acidic triterpenes.Cov kua qaub triterpenes muaj ntau hom xws li Ganoderic Acid A, Ganoderic Acid B, Ganoderic Acid F, thiab lwm yam. Txawm hais tias nws yog Ganoderic Acid A lossis Ganoderic Acid B, lawv yog ob leeg ntawm tsev neeg triterpene.Lawv txhua tus muaj cov qauv tshuaj sib txawv thiab, vim li ntawd, muaj cov haujlwm sib txawv ntawm lub cev.

Ntawm ntau tshaj 300 hom triterpene tebchaw, Ganoderic Acid A tam sim no yog qhov kev tshawb fawb tshaj plaws thiab yog triterpene compound nrog ntau qhov kev tshawb pom.Nws feem ntau yog los ntawmGanoderma lucidum, thiab yuav luag tsis muaj nyob hauvGanoderma sinense.

Tom ntej no, cia peb qhia txog cov txiaj ntsig tseem ceeb ntawm Ganoderic Acid A uas tau pom dav dav hauv kev tshawb fawb tshuaj.

Cov nyhuv ntawm Ganoderic Acid A rau Mob Siab Mob

Hauv 2019, ib tsab xov xwm tau tshaj tawm hauv Phau Ntawv Xov Xwm ntawm Nanjing University of Traditional Chinese Medicine.Txoj kev tshawb no teeb tsa ib pab pawg, ib pawg qauv, ib pawg Ganoderic Acid A uas tsis tshua muaj (20mg / kg), thiab Ganoderic Acid A pawg (40mg / kg).Nws tau kawm txog cov teebmeem ntawm Ganoderic Acid A rau cov nas txhaj nrog D-Galactosamine (D-GaIN) thiab Lipopolysaccharides (LPS), thiab nws lub luag haujlwm tiv thaiv thiab cov txheej txheem cuam tshuam rau lub siab raug mob los ntawm D-GaIN / LPS hauv cov nas.Txoj kev tshawb nrhiav pom tias Ganoderic Acid A muaj kev tiv thaiv lub siab raug mob los ntawm D-GaIN / LPS hauv cov nas.Nws ntseeg tau tias qhov txiaj ntsig no yuav cuam tshuam nrog kev tswj hwm ntawm NLRP3 / NF-KB kev taw qhia txoj hauv kev.[1]

Anti-Tumor Effects ntawm Ganoderic Acid A

Nrhiav kev kho mob zoo tshaj plaws rau kev kho mob meningiomas nyuaj ib txwm yog kev cia siab ntawm cov kws kho mob thiab cov neeg mob.Ganodermaib txwm muaj txiaj ntsig zoo hauv inhibiting qog thiab tom qab phais mob rov qab.

Hauv 2019, ib tsab ntawv tshaj tawm luam tawm hauv "Clinical and Translational Oncology" los ntawm pab pawg neeg mob hlwb thiab txha caj qaum ntawm Hollings Cancer Center (lub chaw mob qog noj ntshav tsim los ntawm National Cancer Institute of United States) tau taw qhia tias seb Ganoderic Acid A lossis Ganoderic Acid DM yog siv ib leeg, ob leeg tuaj yeem cuam tshuam qhov kev loj hlob ntawm malignant meningiomas thiab ua rau lub sijhawm muaj sia nyob ntawm cov qog nqaij hlav nas.Cov txheej txheem ntawm kev ua haujlwm yog cuam tshuam nrog kev rov ua haujlwm ntawm cov qog suppressor noob NDRG2.[2]

(Cov duab cov ntsiab lus yog muab los ntawm lub vev xaib raug cai)

Nyob rau hauv 2021, ib tsab xov xwm tau luam tawm nyob rau hauv Suav Journal of Clinical Pharmacology.Txoj kev tshawb no teeb tsa ib pab pawg sim siv 0.5mmol / L ntawm Ganoderic Acid A los cuam tshuam hauv nas glioma C6 hlwb.Nws tau pom tias thaj tsam ntawm cov qog nqaij hlav hauv pawg sim ntawm glioma nas yog me dua li ntawm pawg tswj hwm, thiab tus naj npawb ntawm CD31 lub hlwb qhia tau zoo tau txo qis dua piv rau pawg tswj hwm.Qhov xaus tau kos tias Ganoderic Acid A tuaj yeem cuam tshuam kev loj hlob ntawm nas glioma C6 hlwb hauv vitro, thiab tib lub sijhawm, nws tuaj yeem cuam tshuam kev loj hlob ntawm tus qauv glioma hauv nas los ntawm kev thaiv kev tsim cov hlab ntsha.[3]

Cov teebmeem ntawm Ganoderic Acid A ntawm lub paj hlwb

Hauv xyoo 2015, ib tsab xov xwm kev kawm tau tshaj tawm hauv Phau Tsom Faj ntawm Mudanjiang Medical University tau tshaj tawm tias los ntawm kev sim, nws tau pom tias 50μg / ml ntawm Ganoderic Acid A tuaj yeem ua rau kom muaj sia nyob ntawm hippocampal neurons, txhim kho SOD kev ua haujlwm ntawm epileptic-zoo li hippocampal neurons, thiab ua kom cov mitochondrial membrane muaj peev xwm.Nws tau pom tias Ganoderic Acid A tuaj yeem tiv thaiv qhov txawv txav ntawm hippocampal neurons los ntawm inhibiting cell oxidative puas thiab apoptosis.[4]

CovHinderCov teebmeem ntawm Ganoderic Acid A rau lub raum Fibrosis thiab Polycystic raum Kab Mob

Ib pab neeg coj los ntawm xibfwb Yang Baoxue, tus thawj coj ntawm Lub Tsev Haujlwm Saib Xyuas Tshuaj Kho Mob ntawm Peking University Tsev Kawm Ntawv ntawm Kev Tshawb Fawb Kev Kho Mob, tau tshaj tawm ob daim ntawv txuas ntxiv hauv "Acta Pharmacologica Sinica" thaum kawg ntawm 2019 thiab pib xyoo 2020. Cov ntaub ntawv tau lees paub qhov cuam tshuam. teebmeem ntawmGanodermantawm lub raum fibrosis thiab polycystic raum kab mob, nrog Ganoderic Acid A yog lub ntsiab zoo tivthaiv.[5]

Tsis tas li ntawd, Ganoderic Acid A tuaj yeem cuam tshuam kev tso tawm ntawm cov cellular histamine, txhim khu kev ua haujlwm ntawm ntau yam kabmob hauv lub plab zom mov, thiab muaj cov teebmeem xws li txo cov ntshav lipids, txo cov ntshav siab, tiv thaiv daim siab, thiab tswj lub siab ua haujlwm.[6]

Feem ntau, nws yog qhov zoo kom muaj cov ntsiab lus siab ntawmGanodermatriterpenes muaj.Ntxiv Ganoderic Acid A, paub txog nws cov txiaj ntsig zoo thiab muaj zog, yuav ua kom muaj txiaj ntsig zoo ntawm cov roj spore.

Cov ntaub ntawv:

1. Wei H., et al."Kev tiv thaiv cov nyhuv ntawm Ganoderic Acid A rau daim siab raug mob los ntawm D-galactosamine / lipopolysaccharide hauv cov nas," Journal of Nanjing University of Traditional Chinese Medicine, 2019, 35(4), p.432.

2. Wu Tingyao."Kev tshawb fawb tshiab: Cov kws tshawb fawb Asmeskas tau lees paub tias Ganoderic Acid A thiab DM tswj cov qog qog nqaij hlav NDRG2, inhibiting kev loj hlob ntawm meningiomas," GanoHerb Organic Ganoderma, 2020-6-12.

3.Yang Xin, Huang Qin, Pan Xiaomei."Inhibitory nyhuv ntawm Ganoderic Acid A ntawm kev loj hlob ntawm glioma nyob rau hauv nas," Suav Journal of Clinical Pharmacology, 2021, 37(8), p.997-998.

4. Wu Rongliang, Liu Junxing."Kev cuam tshuam ntawm Ganoderic Acid A rau kev mob vwm zoo li tso tawm hippocampal neurons," Phau ntawv Journal ntawm Mudanjiang Medical University, 2015, 36(2), p.8.

5. Wu Tingyao."Kev tshawb fawb tshiab: xibfwb Yang Baoxue pab neeg ntawm Peking University lees paub tias Ganoderic Acid A yog cov khoom tseem ceeb ntawm Ganoderma triterpenes rau kev tiv thaiv raum," GanoHerb Organic Ganoderma, 2020-4-16.

6. Wei H., et al."Kev tiv thaiv cov nyhuv ntawm Ganoderic Acid A rau daim siab raug mob los ntawm D-galactosamine / lipopolysaccharide hauv nas," Phau ntawv Journal ntawm Nanjing University of Traditional suav tshuaj, 2019, 35(4), p.433