Taa, ọtụtụ ndị mmadụ, mgbe ị na-ahọrọGanodermangwaahịa, na-ajụkarị, "Gịnị bụ ọdịnaya triterpene nke ngwaahịa gị?"O yiri ka ọdịnaya triterpene dị elu, ngwaahịa ahụ ka mma.Agbanyeghị, nke a ezighi ezi.

Ugbu a, usoro a na-ejikarị eme ihe nke ụlọ ọrụ ụlọ iji tụọ ọdịnaya nkeGanodermatriterpenes bụ usoro kemịkalụ.Usoro a nwere nsogbu na nkọwa na nnukwu njehie.Ya mere, ọkwa nke triterpene ọdịnaya enweghị ike igosi n'ụzọ ziri ezi mma mmanụ spore 

N'ezie, a na-ekpebi ogo ngwaahịa mmanụ spore site na ihe dị iche iche.chromatography mmiri na-arụ ọrụ dị elu nwere ike ịchọpụta nke ọma ọdịnaya nke "Ganoderic Acid A".Ọ bụrụ na ngwaahịa mmanụ spore nwere ike igosi n'ụzọ doro anya ọdịnaya nke "Ganoderic Acid A", ọ na-enye nkwa dị ukwuu maka ịdịmma ngwaahịa ahụ.Kedu ihe bụ Ganoderic Acid?Gịnị bụ ihe pụrụ iche mmetụta ya?Kedu ihe dị iche n'etiti ya na mkpokọta triterpenes?Taa, ka anyị mara ya.

Enwere ihe karịrị ụdị 300Ganodermatriterpene ogige.Kedu ndị ị maara?

Mbụ, ọ dị mkpa ịmara nke ahụGanodermaogige triterpene abụghị otu ihe, kama na-ezo aka na ihe ndị dị na yaGanodermanke nwere usoro triterpene.Ka ọ dị ugbu a, achọpụtala ihe karịrị ụdị 300, kesara naGanodermaahụ na-amị mkpụrụ naGanodermaspore ntụ ntụ.

Enwere ike kewaa ogige triterpene ndị a ka ọ bụrụ triterpenes na-anọpụ iche na triterpenes acidic.Triterpenes acidic gụnyere ụdị dị iche iche dị ka Ganoderic Acid A, Ganoderic Acid B, Ganoderic Acid F, wdg. N'agbanyeghị ma ọ bụ Ganoderic Acid A ma ọ bụ Ganoderic Acid B, ha abụọ bụ ndị ezinụlọ triterpene.Ha nke ọ bụla nwere usoro kemịkalụ dị iche iche na, n'ihi ya, nwere mmemme physiological dị iche iche.

N'ime ihe karịrị ụdị 300 nke ogige triterpene, Ganoderic Acid A bụ ugbu a kachasị nyocha na ọ bụ triterpene nke nwere ọtụtụ mmetụta achọpụtara.Ọ na-esitekarị na yaGanoderma lucidum, na ọ fọrọ nke nta ka ọ dịghị adị naGanoderma dị nro.

Ọzọ, ka anyị webata isi mmetụta nke Ganoderic Acid A nke egosipụtara n'ọtụtụ ebe na nyocha ọgwụ.

Mmetụta Ganoderic Acid A na mmerụ ahụ dị oke njọ

Na 2019, e bipụtara otu akụkọ na Journal of Nanjing University of Traditional Chinese Medicine.Ọmụmụ ihe ahụ guzobere otu nkịtị, otu ụdị, obere Ganoderic Acid A (20mg / kg), na otu Ganoderic Acid A (40mg / kg) dị elu.Ọ mụrụ mmetụta nke Ganoderic Acid A na ụmụ oke ndị a na-agbanye na D-Galactosamine (D-GaIN) na Lipopolysaccharides (LPS), yana ọrụ nchebe ya na usoro ndị metụtara ya megide mmerụ imeju nke D-GaIN / LPS kpatara na ụmụ oke.Ọmụmụ ihe ahụ chọpụtara na Ganoderic Acid A nwere mmetụta nchebe megide mmerụ imeju nke D-GaIN / LPS kpatara na ụmụ oke.A kwenyere na mmetụta a nwere ike jikọta na nhazi nke ụzọ akara NLRP3 / NF-KB.[1]

Mmetụta mgbochi tumor nke Ganoderic Acid A

Ịchọta ọgwụgwọ dị mma maka ọrịa meningiomas ọjọọ na-esiri ike ịgwọta na-abụkarị olileanya ndị dọkịta na ndị ọrịa.Ganodermana-adị irè mgbe niile n'igbochi etuto ahụ yana mgbake ịwa ahụ mgbe ọ gasịrị.

N'afọ 2019, otu akụkọ bipụtara na "Clinical and Translational Oncology" nke ụbụrụ ụbụrụ na ndị otu mmemme akpụ azụ azụ na Hollings Cancer Center (ebe a na-ahụ maka ọrịa kansa nke National Cancer Institute nke United States họpụtara) rụtụrụ aka na ma Ganoderic Acid A ma ọ bụ Ganoderic. A na-eji Acid DM naanị ya, ha abụọ nwere ike igbochi uto nke meningiomas na-adịghị mma ma gbatịa oge ndụ nke ụmụ oke na-ebu akpụ.Usoro nke ime ihe metụtara mmeghari nke mkpụrụ ndụ tumor suppressor gene NDRG2.[2]

(A na-ewepụta ihe onyonyo site na webụsaịtị akwụkwọ akụkọ)

Na 2021, e bipụtara otu akụkọ na Chinese Journal of Clinical Pharmacology.Ọmụmụ ihe ahụ guzobere otu nnwale na-eji 0.5mmol/L nke Ganoderic Acid A iji tinye aka na mkpụrụ ndụ glioma C6 oke.Achọpụtara na mpaghara obe nke ụbụrụ n'ime ìgwè nnwale nke oke glioma dị ntakịrị karịa nke ndị na-ahụ maka njikwa, na ọnụ ọgụgụ nke CD31 mkpụrụ ndụ okwu dị mma belatara nke ukwuu ma e jiri ya tụnyere ndị na-achịkwa.Nkwubi okwu ahụ bụ na Ganoderic Acid A nwere ike igbochi mmụba nke mkpụrụ ndụ glioma C6 na vitro, ma n'otu oge ahụ, ọ nwere ike igbochi uto nke ụdị glioma na oke site na igbochi nhazi nke arịa ọbara tumor.[3]

Mmetụta Ganoderic Acid A na sistemụ akwara

N'afọ 2015, akwụkwọ akụkọ nke e bipụtara na Journal of Mudanjiang Medical University kọrọ na site na nyocha, achọpụtara na 50μg / ml nke Ganoderic Acid A nwere ike ịbawanye ọnụọgụ ndụ nke neurons hippocampal, kwalite ọrụ SOD nke epileptic-dị ka hippocampal neurons, ma mee ka akpụkpọ ahụ mitochondrial dịkwuo elu.E gosiputara na Ganoderic Acid A nwere ike ichebe neurons hippocampal na-agbapụta nke ọma site na igbochi mmebi oxidative cell na apoptosis.[4]

NkeigbochiMmetụta nke Ganoderic Acid A na Renal Fibrosis na Ọrịa Kidney Polycystic

Otu otu Prọfesọ Yang Baoxue, onye isi ngalaba nke Pharmacology na Schoollọ Akwụkwọ Mahadum Peking nke Basic Medical Sciences, bipụtara akwụkwọ abụọ n'usoro n'usoro na "Acta Pharmacologica Sinica" na njedebe nke 2019 na mmalite nke 2020. Akwụkwọ ndị ahụ kwadoro ihe mgbochi ahụ. mmetụta nkeGanodermana renal fibrosis na ọrịa akụrụ polycystic, yana Ganoderic Acid A bụ akụkụ kachasị dị irè.[5]

Na mgbakwunye, Ganoderic Acid A nwere ike igbochi ntọhapụ nke cellular histamine, kwalite ọrụ nke akụkụ dị iche iche na usoro nri nri, ma nwee mmetụta dị ka iwetulata lipids ọbara, ibelata ọbara mgbali, ichebe imeju, na ịhazi ọrụ imeju.[6]

N'ozuzu, ọ dị mma inwe nnukwu ọdịnaya nkeGanodermatriterpenes.Ịgbakwunye Ganoderic Acid A, mara maka mmetụta ya ziri ezi ma dị ike, ga-eme ka mma mmanụ spore dịkwuo mma.

Ntụaka:

1.Wei Hao, et al."Mmetụta nchebe nke Ganoderic Acid A na mmerụ imeju nke D-galactosamine / lipopolysaccharide kpatara na ụmụ oke," Journal of Nanjing University of Traditional Chinese Medicine, 2019, 35 (4), p.432.

2.Wu Tingyao."Nchọpụta ọhụrụ: Ndị ọkà mmụta America kwadoro na Ganoderic Acid A na DM na-achịkwa mkpụrụ ndụ ihe na-egbochi tumor NDRG2, na-egbochi uto nke meningiomas ọjọọ," GanoHerb Organic Ganoderma, 2020-6-12.

3.Yang Xin, Huang Qin, Pan Xiaomei."Mmetụta mgbochi nke Ganoderic Acid A na uto nke glioma na oke," Chinese Journal of Clinical Pharmacology, 2021, 37 (8), p.997-998.

4.Wu Rongliang, Liu Junxing."Mmetụta nke Ganoderic Acid A na epileptic-dị ka nkwụsị hippocampal neurons," Journal of Mudanjiang Medical University, 2015, 36 (2), p.8.

5.Wu Tingyao."Nchọpụta ọhụrụ: Prọfesọ Yang Baoxue's otu na Peking University kwadoro na Ganoderic Acid A bụ isi akụrụngwa nke Ganoderma triterpenes maka akụrụ nchebe," GanoHerb Organic Ganoderma, 2020-4-16.

6.Wei Hao, et al."Mmetụta nchebe nke Ganoderic Acid A na mmerụ imeju nke D-galactosamine / lipopolysaccharide kpatara na ụmụ oke," Journal of Nanjing University of Traditional Chinese Medicine, 2019, 35 (4), p.433