Ithimba eliholwa uSolwazi Yang Baoxue, umqondisi woMnyango Wezemithi, ePeking University School of Basic Medical Science, lishicilele amaphepha amabili ku-“Acta Pharmacologica Sinica” ekupheleni kuka-2019 nasekuqaleni kuka-2020, eqinisekisa ukuthi i-Ganoderic acid A, njenge- isithako esisebenzayo esikhulu seI-Ganoderma lucidum, inomthelela ekubambezelekeni kwe-renal fibrosis kanye nesifo sezinso se-polycystic.
I-Ganoderic A ibambezela ukuqhubeka kwe-renal fibrosis
Abacwaningi bahlinza ama-ureters ahlangene namagundane.Ngemva kwezinsuku ezingu-14, amagundane aqala ukulimala kwezinso kanye ne-fibrosis ngenxa yokuvinjelwa kokuphuma komchamo.Ngaleso sikhathi, i-urea nitrogen yegazi ephakeme (BUN) ne-creatinine (Cr) ibonise ukukhubazeka kokusebenza kwezinso.
Kodwa-ke, uma amagundane anikezwe umjovo we-intraperitoneal we-ganoderic acid ngethamo lansuku zonke lama-50 mg/kg ngokushesha ngemva kokuxhunywa kwe-ureter unilateral, izinga lokulimala kwamashubhu ezinso, i-renal fibrosis noma ukukhubazeka kokusebenza kwezinso ngemva kwezinsuku eziyi-14 lalingaphansi kakhulu kumagundane. ngaphandle kokuvikelwa kwe-Ganoderma.
I-ganoderic acid esetshenziswe ocwaningweni bekuyingxube equkethe okungenani izinhlobo ezihlukene zama-ganoderic acid, lapho iningi lawo bekuyi-ganoderic acid A (16.1%), i-ganoderic acid B (10.6%) kanye ne-ganoderic acid C2 (5.4%). .
Ukuhlolwa kwe-in vitro cell kubonise ukuthi i-ganoderic acid A (100μg/mL) ibe nomthelela omuhle kakhulu wokuvimbela i-renal fibrosis phakathi kokuthathu, ize ibe nomthelela ongcono kunengxube ye-ganoderic acid yasekuqaleni futhi yayingenawo umthelela onobuthi kumaseli ezinso.Ngakho-ke, abacwaningi bakholelwa ukuthi i-ganoderic acid A kufanele ibe umthombo oyinhloko womsebenziReishi amakhoweukubambezeleka kwe-renal fibrosis.
I-Ganoderic acid A ibambezela ukuqhubeka kwesifo sezinso se-polycystic
Ngokungafani ne-etiological factor ye-renal fibrosis, isifo sezinso se-polycystic sibangelwa ukuguqulwa kofuzo ku-chromosome.Amaphesenti angu-90 alesi sifo atholakala ngofuzo futhi ngokuvamile aqala cishe eminyakeni engamashumi amane.Ama-vesicle ezinso zesiguli azokhula abe makhudlwana njengoba isikhathi siqhubeka, okuzokhama futhi kucekele phansi izicubu ezivamile zezinso futhi kulimaze ukusebenza kwezinso.
Lapho sibhekene nalesi sifo esingenakulungiseka, ukubambezeleka ukuwohloka kokusebenza kwezinso sekube umgomo obaluleke kakhulu wokwelapha.Ithimba lika-Yang lishicilele umbiko ephephabhukwini lezokwelapha elibizwa nge-Kidney International ekupheleni kuka-2017, liqinisekisa ukuthi i-Ganoderma lucidum triterpenes inomphumela wokubambezela ukuqala kwesifo sezinso ze-polycystic kanye nokunciphisa i-syndrome ye-polycystic Kidney disease.
Nokho, kunezinhlobo eziningiLingzhiama-triterpenes.Iluphi uhlobo lwe-triterpene oludlala indima ebalulekile kulokhu?Ukuze bathole impendulo, bahlole ama-Ganoderma triterpenes ahlukahlukene okuhlanganisa i-ganoderic acid A, B, C2, D, F, G, T, DM kanye ne-ganoderenic acid A, B, D, F.
Ukuhlolwa kwe-in vitro kubonise ukuthi akukho neyodwa yama-triterpenes ayi-12 ethintekile ukusinda kwamangqamuzana ezinso, futhi ukuphepha kwakucishe kufinyelele ezingeni elifanayo, kodwa kwakukhona umehluko omkhulu ekuvimbeleni ukukhula kwama-vesicles ezinso, phakathi kwawo i-triterpene enomphumela omuhle kakhulu kwakuyi-ganoderic. acid A.
Kusukela ekuthuthukisweni kwe-renal fibrosis kuya ekuhlulekeni kwezinso, kungashiwo ukuthi kungumphumela wezimbangela ezihlukahlukene (ezifana nesifo sikashukela).
Ezigulini ezinesifo sezinso ze-polycystic, izinga lokwehla kokusebenza kwezinso lingase libe ngokushesha.Ngokwezibalo, cishe uhhafu weziguli ezinesifo sezinso i-polycystic zizowohloka zize zibe ukwehluleka kwezinso lapho sezineminyaka engama-60 ubudala, futhi kufanele zithole i-dialysis yezinso impilo yazo yonke.
Ithimba likaSolwazi u-Yang Baoxue liphumelele ukuhlolwa kwamaseli nezilwane ukuze lifakazele ukuthi i-ganoderic acid A, ingxenye ephezulu kakhulu ye-Ganoderma triterpenes, iyinkomba ye-Ganoderma lucidum yokuvikela izinso.
Yiqiniso, lokhu akusho ukuthi i-ganoderic acid A kuphela e-Ganoderma lucidum ingavikela izinso.Eqinisweni, ezinye izithako ziwusizo ngempela.Isibonelo, elinye iphepha elishicilelwe nguProfesa Yang Baoxue esihlokweni sokuvikelwa kwezinso liphinde labonisa ukuthi i-Ganoderma lucidum polysaccharide extract inganciphisa umonakalo we-oxidative otholwe izicubu zezinso ngokusebenzisa umphumela we-antioxidant.I-Ganoderma lucidum triterpenoids, equkethe izinhlanganisela ezihlukahlukene ze-triterpene ezifana ne-ganoderic i-asidi, i-ganoderenic acid ne-ganederol zisebenza ndawonye ukuze kubambezeleke i-renal fibrosis nesifo sezinso se-polycystic.
Ngaphezu kwalokho, isidingo sokuvikela izinso akukona nje ukuvikela izinso ngokwayo.Okunye okunjengokulawula ukungatheleleki, ukuthuthukisa ukuphakama okuthathu, ukulinganisa i-endocrine, ukuthoba izinzwa nokuthuthukisa ukulala ngokuqinisekile kuzosiza ukuvikelwa kwezinso, okungeke kubonakale kuphela nge-ganoderic acid A.
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Isikhathi sokuthumela: Apr-23-2020