Iqela elikhokelwa nguNjingalwazi u-Yang Baoxue, umlawuli weSebe le-Pharmacology, i-Peking University School of Basic Medical Sciences, lipapashe amaphepha amabini kwi "Acta Pharmacologica Sinica" ekupheleni kuka-2019 nasekuqaleni kuka-2020, eqinisekisa ukuba i-Ganoderic acid A, njenge eyona nto isebenzayo yeI-Ganoderma lucidum, kunempembelelo ekubambezelekeni kwe-renal fibrosis kunye nesifo sezintso ze-polycystic.
I-Ganoderic A ibambezele ukukhula kwe-renal fibrosis
Abaphandi batyanda ngokudibanisa i-ureters esecaleni kweempuku.Emva kweentsuku ze-14, iigundane zenze umonakalo we-kidney tubules kunye ne-fibrosis ngenxa yokukhutshwa komchamo.Ngeli xesha, i-urea nitrogen yegazi ephakamileyo (i-BUN) kunye ne-creatinine (Cr) ibonise ukukhubazeka kwezintso.
Nangona kunjalo, ukuba iimpuku zinikwe inaliti ye-intraperitoneal ye-ganoderic acid kwidosi yemihla ngemihla ye-50 mg / kg ngokukhawuleza emva kwe-unilateral ureteral ligation, iqondo lomonakalo we-tubules yezintso, i-renal fibrosis okanye ukukhubazeka komsebenzi wezintso emva kweentsuku ze-14 yayingaphantsi kakhulu kuneempuku. ngaphandle kokhuseleko lweGanoderma.
Iasidi ye-ganoderic esetyenzisiweyo kuvavanyo ibingumxube oqulathe ubuncinci ishumi elinesibini leentlobo ezahlukeneyo zeasidi ze-ganoderic, apho eyona ininzi yayiyi-ganoderic acid A (16.1%), i-ganoderic acid B (10.6%) kunye ne-ganoderic acid C2 (5.4%). .
Uvavanyo lweseli ye-in vitro lubonise ukuba i-ganoderic acid A (100μg/mL) ineyona mpembelelo ibalaseleyo yokuthintela kwi-renal fibrosis phakathi kwezi zintathu, yade yaba nefuthe elingcono kunomxube we-ganoderic acid wokuqala kwaye ayinayo ityhefu kwiiseli zezintso.Ke ngoko, abaphandi bakholelwa ukuba i-ganoderic acid A kufuneka ibe ngowona mthombo womsebenziReishi mushroomekubambezelekeni kwe-renal fibrosis.
I-asidi ye-Ganoderic A ibambezela ukuqhubeka kwesifo sezintso ze-polycystic
Ngokungafaniyo ne-etiological factor ye-renal fibrosis, isifo sezintso ze-polycystic sibangelwa kukuguqulwa kofuzo kwi-chromosome.Amashumi alithoba eepesenti esi sifo sizuzwa kwaye ngokuqhelekileyo siqala malunga namashumi amane eminyaka ubudala.I-vesicles yezintso zesigulane ziya kukhula zibe zikhulu njengoko ixesha lihamba, eliya kucudisa kwaye litshabalalise izicubu eziqhelekileyo zezintso kunye nokonakalisa ukusebenza kwezintso.
Ebusweni besi sifo esingenakuguqulwa, ukulibazisa ukuwohloka komsebenzi wezintso kube yeyona njongo ibalulekileyo yonyango.Iqela likaYang lipapashe ingxelo kwiphephancwadi lezonyango elibizwa ngokuba yi-Kidney International ekupheleni kwe-2017, eqinisekisa ukuba i-Ganoderma lucidum triterpenes inefuthe lokulibazisa ukuqala kwesifo sezintso ze-polycystic kunye nokunciphisa i-syndrome ye-polycystic Kidney disease.
Nangona kunjalo, kukho iintlobo ezininziLingzhiiitriterpenes.Loluphi uhlobo lwe-triterpene oludlala indima ephambili koku?Ukuze bafumane impendulo, bavavanya i-Ganoderma triterpenes eyahlukeneyo kuquka i-ganoderic acid A, B, C2, D, F, G, T, DM kunye ne-ganoderenic acid A, B, D, F.
Uvavanyo lwe-in vitro lubonise ukuba akukho nanye kwii-triterpenes ezili-12 ezichaphazela ukusinda kweeseli zezintso, kwaye ukhuseleko lwaluphantse lube kumgangatho ofanayo, kodwa kwakukho umahluko omkhulu ekuthinteleni ukukhula kwee-renal vesicles, phakathi kwayo i-triterpene enempembelelo engcono kakhulu yayiyi-ganoderic. acid A.
Ukususela ekuphuhlisweni kwe-renal fibrosis ukuya kwi-renal failure, kunokuthiwa yisiphumo sezizathu ezahlukeneyo (ezifana nesifo sikashukela).
Kwizigulane ezinesifo sezintso ze-polycystic, izinga lokuhla kokusebenza kwezintso linokukhawuleza.Ngokwezibalo, malunga nesiqingatha sezigulana ezinesifo sezintso ze-polycystic ziya kuchaphazeleka kukungaphumeleli kwezintso malunga neminyaka engama-60 ubudala, kwaye kufuneka bafumane i-dialysis yezintso ubomi babo bonke.
Iqela likaNjingalwazi uYang Baoxue liphumelele uvavanyo lweseli kunye nezilwanyana ukubonisa ukuba i-ganoderic acid A, eyona nxalenye iphezulu yeGanoderma triterpenes, yinxalenye yesalathiso seGanoderma lucidum yokukhusela izintso.
Kakade ke, oku akuthethi ukuba kuphela i-ganoderic acid A e-Ganoderma lucidum inokukhusela izintso.Enyanisweni, ezinye izithako ngokuqinisekileyo ziluncedo.Ngokomzekelo, elinye iphepha elipapashwe nguNjingalwazi uYang Baoxue ngesihloko sokukhuselwa kwezintso kwakhona kwabonisa ukuba i-Ganoderma lucidum polysaccharide extract inokunciphisa umonakalo owenziwe nge-oxidative ofunyenwe yi-kidney tissue ngokusebenzisa i-antioxidant effect.Ganoderma lucidum triterpenoids, equlethe iintlobo ezahlukeneyo ze-triterpene ezifana ne-ganoderic iasidi, i-ganoderenic acid kunye ne-ganederol zisebenza kunye ukulibazisa i-renal fibrosis kunye nesifo sezintso ze-polycystic.
Ngaphezu koko, imfuneko yokukhusela intso ayiphelelanga nje ekukhuseleni intso ngokwayo.Ezinye ezinjengokulawula ukhuselo lomzimba, ukuphucula iindawo ezithathu eziphakamileyo, ukulinganisa i-endocrine, ukuthomalalisa imithambo-luvo kunye nokuphucula ubuthongo kuya kunceda ukhuseleko lwezintso, olungenakuqondwa kuphela nge-ganoderic acid A.
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Ixesha lokuposa: Epreli-23-2020