Pab neeg no coj los ntawm xibfwb Yang Baoxue, tus thawj coj ntawm Department of Pharmacology, Peking University School of Basic Medical Sciences, tau luam tawm ob daim ntawv nyob rau hauv "Acta Pharmacologica Sinica" thaum kawg ntawm 2019 thiab thaum ntxov 2020, lees paub tias Ganoderic acid A, raws li tus lub ntsiab active ingredient ntawmGanoderma lucidum, muaj cov txiaj ntsig ntawm kev ncua lub raum fibrosis thiab kab mob polycystic raum.
Ganoderic A retarded qhov kev loj hlob ntawm lub raum fibrosis
Cov kws tshawb fawb tau phais ligated unilateral ureters ntawm nas.Tom qab 14 hnub, cov nas tsim lub raum tubules puas thiab raum fibrosis vim thaiv cov zis tawm.Lub caij no, cov ntshav siab urea nitrogen (BUN) thiab creatinine (Cr) qhia txog kev ua haujlwm tsis zoo ntawm lub raum.
Txawm li cas los xij, yog tias cov nas tau txais kev txhaj tshuaj intraperitoneal ntawm ganoderic acid ntawm ib hnub koob tshuaj 50 mg / kg tam sim tom qab unilateral ureteral ligation, qib ntawm lub raum tubules puas, lub raum fibrosis lossis lub raum tsis ua haujlwm tom qab 14 hnub yog qhov tsawg dua cov nas. tsis muaj Ganoderma tiv thaiv.
Cov ganoderic acid siv nyob rau hauv qhov kev sim yog ib tug sib tov uas muaj tsawg kawg yog kaum ob ntau yam ntawm ganoderic acids, ntawm uas ntau tshaj yog ganoderic acid A (16.1%), ganoderic acid B (10.6%) thiab ganoderic acid C2 (5.4%). .
Kev sim hauv vitro cell tau pom tias ganoderic acid A (100μg / mL) muaj qhov cuam tshuam zoo tshaj plaws ntawm lub raum fibrosis ntawm peb, txawm tias muaj txiaj ntsig zoo dua li qub ganoderic acid sib tov thiab tsis muaj tshuaj lom rau lub raum hlwb.Yog li, cov kws tshawb fawb ntseeg tias ganoderic acid A yuav tsum yog lub hauv paus tseem ceeb ntawm kev ua haujlwm ntawmReishi ncebhauv kev ncua lub raum fibrosis.
Ganoderic acid A retards kev loj hlob ntawm polycystic raum kab mob
Tsis zoo li etiological yam ntawm lub raum fibrosis, kab mob polycystic raum yog tshwm sim los ntawm kev hloov pauv hauv cov noob ntawm chromosome.Cuaj caum feem pua ntawm cov kab mob no tau txais txiaj ntsig thiab feem ntau pib thaum muaj hnub nyoog plaub caug.Lub vesicles ntawm ob lub raum ntawm tus neeg mob yuav loj hlob zuj zus raws li lub sij hawm mus, uas yuav nyem thiab rhuav tshem lub raum cov ntaub so ntswg thiab puas raum kev ua haujlwm.
Nyob rau hauv lub ntsej muag ntawm tus kab mob no irreversible, ncua lub deterioration ntawm lub raum kev ua haujlwm tau dhau los ua lub hom phiaj tseem ceeb tshaj plaws ntawm kev kho mob.Yang pab neeg tau luam tawm ib tsab ntawv ceeb toom nyob rau hauv phau ntawv kho mob hu ua Raum International thaum kawg ntawm 2017, lees paub tias Ganoderma lucidum triterpenes muaj cov txiaj ntsig ntawm kev ncua qhov pib ntawm tus kab mob polycystic raum thiab txo cov kab mob polycystic raum kab mob.
Txawm li cas los xij, muaj ntau homLingzhitriterpenes muaj.Yam twg ntawm triterpene ua lub luag haujlwm tseem ceeb hauv qhov no?Txhawm rau kom paub cov lus teb, lawv tau sim ntau yam Ganoderma triterpenes suav nrog ganoderic acid A, B, C2, D, F, G, T, DM thiab ganoderenic acid A, B, D, F.
Cov kev sim hauv vitro tau pom tias tsis muaj 12 triterpenes cuam tshuam rau kev muaj sia nyob ntawm lub raum hlwb, thiab kev nyab xeeb yuav luag nyob rau tib theem, tab sis muaj qhov sib txawv tseem ceeb hauv inhibiting kev loj hlob ntawm lub raum vesicles, ntawm cov triterpene nrog cov txiaj ntsig zoo tshaj plaws yog ganoderic. acid A.
Los ntawm kev txhim kho ntawm lub raum fibrosis mus rau lub raum tsis ua haujlwm, nws tuaj yeem hais tau tias nws yog qhov tshwm sim ntawm ntau yam ua rau (xws li ntshav qab zib).
Rau cov neeg mob uas muaj kab mob polycystic raum, qhov txo qis hauv lub raum ua haujlwm yuav nrawm dua.Raws li kev txheeb cais, kwv yees li ib nrab ntawm cov neeg mob uas muaj kab mob polycystic raum yuav ua rau lub raum tsis ua haujlwm thaum muaj hnub nyoog 60 xyoo, thiab lawv yuav tsum tau txais lub raum lim ntshav rau lub neej.
Xibfwb Yang Baoxue pab pawg tau dhau ntawm tes thiab tsiaj sim los ua pov thawj tias ganoderic acid A, feem ntau ntawm Ganoderma triterpenes, yog ib qho kev ntsuas ntawm Ganoderma lucidum rau kev tiv thaiv raum.
Tau kawg, qhov no tsis yog hais tias tsuas yog ganoderic acid A hauv Ganoderma lucidum tuaj yeem tiv thaiv lub raum.Qhov tseeb, lwm cov khoom xyaw yeej pab tau.Piv txwv li, lwm daim ntawv luam tawm los ntawm xibfwb Yang Baoxue ntawm lub ntsiab lus ntawm kev tiv thaiv raum kuj tau taw qhia tias Ganoderma lucidum polysaccharide extract tuaj yeem txo cov oxidative puas tau txais los ntawm lub raum cov ntaub so ntswg los ntawm cov nyhuv antioxidant.Ganoderma lucidum triterpenoids, uas muaj ntau yam triterpene tebchaw xws li ganoderic. acid, ganoderenic acid thiab ganederol ua hauj lwm ua ke kom ncua lub raum fibrosis thiab polycystic raum kab mob.
Dab tsi ntxiv, qhov yuav tsum tau tiv thaiv lub raum tsis yog los tiv thaiv lub raum xwb.Lwm yam xws li kev tswj hwm kev tiv thaiv kab mob, txhim kho peb qhov siab, ntsuas endocrine, soothing cov hlab ntsha thiab txhim kho kev pw tsaug zog yuav pab tau rau lub raum tiv thaiv, uas tsis tuaj yeem paub txog tsuas yog los ntawm ganoderic acid A.
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2. Meng J, et al.Ganoderic acid A yog cov khoom muaj txiaj ntsig zoo ntawm Ganoderma triterpenes hauv kev txhim kho lub raum cyst hauv lub raum kab mob polycystic.Acta Pharmacol Sin.2020 Lub ib hlis ntuj 7. doi: 10.1038/s41401-019-0329-2.
3. Su L, et al.Ganoderma triterpenes retard lub raum cyst txoj kev loj hlob los ntawm downregulating Ras/MAPK signaling thiab txhawb cell sib txawv.Raum Int.Kaum Ob Hlis 2017;92(6): 1404-1418.doi: 10.1016/j.kint.2017.04.013.
4. Zhong D, et al.Ganoderma lucidum polysaccharide peptide tiv thaiv lub raum ischemia reperfusion raug mob los ntawm counteracting oxidative stress.Sci Rep. 2015 Nov 25;5: 16910.doi: 10.1038/srep16910.
Post lub sij hawm: Apr-23-2020