Gulu lotsogozedwa ndi Pulofesa Yang Baoxue, director of the department of Pharmacology, Peking University School of Basic Medical Science, lidasindikiza mapepala awiri mu "Acta Pharmacologica Sinica" kumapeto kwa 2019 komanso koyambirira kwa 2020, kutsimikizira kuti Ganoderic acid A, monga chachikulu yogwira pophika waGanoderma lucidum, imakhudza kuchedwa kwa aimpso fibrosis ndi matenda a impso a polycystic.

Ganoderic A imalepheretsa kukula kwa renal fibrosis

Ofufuzawo adalumikiza unilateral ureters wa mbewa.Pambuyo pa masiku 14, mbewa zinayambitsa kuwonongeka kwa impso ndi fibrosis chifukwa cha kutsekeka kwa mkodzo.Pakadali pano, kuchuluka kwa urea nitrogen (BUN) ndi creatinine (Cr) kumawonetsa kuwonongeka kwa impso.

Komabe, ngati mbewa zinapatsidwa jakisoni wa intraperitoneal wa ganoderic acid pa mlingo watsiku ndi tsiku wa 50 mg/kg atangotha ​​​​unilateral ureteral ligation, kuchuluka kwa kuwonongeka kwa impso, fibrosis yaimpso kapena kuwonongeka kwaimpso pambuyo pa masiku 14 kunali kochepa kwambiri kuposa mbewa. popanda chitetezo cha Ganoderma.

Asidi a ganoderic omwe adagwiritsidwa ntchito poyesera anali osakaniza omwe ali ndi mitundu ingapo yamitundu yosiyanasiyana ya ma ganoderic acid, omwe ochuluka kwambiri anali ganoderic acid A (16.1%), ganoderic acid B (10.6%) ndi ganoderic acid C2 (5.4%). .

Kuyesa kwa ma cell a in vitro kunawonetsa kuti ganoderic acid A (100μg/mL) inali ndi zoletsa zabwino kwambiri pa aimpso fibrosis pakati pa atatuwo, idachita bwinoko kuposa kusakaniza koyambirira kwa ganoderic acid ndipo inalibe poizoni pama cell aimpso.Chifukwa chake, ofufuzawo adakhulupirira kuti ganoderic acid A iyenera kukhala gwero lalikulu la ntchitoReishi bowapakuchedwetsa renal fibrosis.

Ganoderic acid A imalepheretsa kukula kwa matenda a impso a polycystic

Mosiyana ndi etiological factor of renal fibrosis, matenda a impso a polycystic amayamba chifukwa cha kusintha kwa jini pa chromosome.Makumi asanu ndi anayi pa zana aliwonse a matendawa amatengera kwa makolo ndipo nthawi zambiri amayamba pafupifupi zaka makumi anayi.Ma vesicles a impso za wodwalayo amakula kwambiri pakapita nthawi, zomwe zidzafinya ndikuwononga minofu ya impso ndi kuwonongeka kwa impso.

Poyang'anizana ndi matendawa osasinthika, kuchedwetsa kuwonongeka kwa aimpso kwakhala cholinga chofunikira kwambiri chochizira.Gulu la a Yang linasindikiza lipoti mu magazini yachipatala yotchedwa Kidney International kumapeto kwa chaka cha 2017, kutsimikizira kuti Ganoderma lucidum triterpenes ili ndi zotsatira zochepetsera kuyambika kwa matenda a impso a polycystic komanso kuchepetsa matenda a polycystic Impso.

Komabe, pali mitundu yambiri yaLingzhitriterpenes.Ndi mtundu wanji wa triterpene womwe umagwira ntchito yofunika kwambiri pa izi?Kuti apeze yankho, adayesa mitundu yosiyanasiyana ya ma Ganoderma triterpenes kuphatikiza ganoderic acid A, B, C2, D, F, G, T, DM ndi ganoderenic acid A, B, D, F.

Kuyesa kwa m'galasi kunasonyeza kuti palibe 12 triterpenes yomwe inakhudza kupulumuka kwa maselo a impso, ndipo chitetezo chinali pafupifupi pamlingo womwewo, koma panali kusiyana kwakukulu pakuletsa kukula kwa ma vesicles a aimpso, omwe triterpene yokhala ndi zotsatira zabwino kwambiri inali ganoderic. asidi A.

Kuchokera pakukula kwa renal fibrosis mpaka kulephera kwaimpso, tinganene kuti ndi chifukwa cha zifukwa zosiyanasiyana (monga matenda a shuga).

Kwa odwala omwe ali ndi matenda a impso a polycystic, kuchepa kwa ntchito yaimpso kumatha kukhala kofulumira.Malinga ndi ziwerengero, pafupifupi theka la odwala omwe ali ndi matenda a impso a polycystic adzafika pofika zaka 60, ndipo ayenera kulandira dialysis ya impso moyo wawo wonse.

Gulu la Pulofesa Yang Baoxue ladutsa kuyesa kwa ma cell ndi nyama kutsimikizira kuti ganoderic acid A, gawo lalikulu kwambiri la Ganoderma triterpenes, ndi gawo la Ganoderma lucidum loteteza impso.

Inde, izi sizikutanthauza kuti ganoderic acid A mu Ganoderma lucidum yokha ingateteze impso.M'malo mwake, zosakaniza zina ndizothandiza.Mwachitsanzo, pepala lina lofalitsidwa ndi Pulofesa Yang Baoxue pa mutu wa chitetezo cha impso adanenanso kuti Ganoderma lucidum polysaccharide Tingafinye akhoza kuchepetsa kuwonongeka kwa okosijeni analandira ndi impso minofu kudzera antioxidant effect.Ganoderma lucidum triterpenoids, amene ali zosiyanasiyana triterpene mankhwala monga ganoderic asidi, ganoderenic acid ndi ganederol amagwira ntchito limodzi kuti achedwetse matenda a aimpso ndi matenda a impso a polycystic.

Komanso, kufunika koteteza impso sikungoteteza impso yokha.Zina monga kuwongolera chitetezo chamthupi, kukonza makwerero atatu, kusanja endocrine, kutonthoza minyewa komanso kugona bwino zimathandizira chitetezo cha impso, chomwe sichingachitike kokha kudzera mu ganoderic acid A.