Tawagar karkashin jagorancin Farfesa Yang Baoxue, darektan Sashen Kimiyyar Magunguna, Makarantar Kimiyyar Kiwon Lafiya ta Jami'ar Peking, ta buga takardu guda biyu a cikin "Acta Pharmacologica Sinica" a karshen 2019 da farkon 2020, yana mai tabbatar da cewa Ganoderic acid A, a matsayin babban aiki sashi naGanoderma lucidum, yana da tasiri akan jinkirta fibrosis na koda da polycystic koda cuta.

Ganoderic A ya jinkirta ci gaban fibrosis na renal

Masu binciken sun yi wa ƴaƴan berayen ureters tiyatar tiyata.Bayan kwanaki 14, berayen sun sami lalacewar tubules na koda da fibrosis na koda saboda toshewar fitsari.A halin yanzu, haɓakar urea nitrogen (BUN) da creatinine (Cr) sun nuna rashin aikin koda.

Duk da haka, idan an ba wa berayen allurar intraperitoneal na ganoderic acid a kashi na yau da kullun na 50 MG / kg nan da nan bayan haɗin urethra guda ɗaya, matakin lalacewar tubules na koda, fibrosis na koda ko rashin aikin koda bayan kwanaki 14 ya ragu sosai a cikin mice. ba tare da kariya ga Ganoderma ba.

Ganoderic acid da aka yi amfani da shi a cikin gwajin shine cakuda mai dauke da akalla dozin iri daban-daban na ganoderic acid, wanda mafi yawan su shine ganoderic acid A (16.1%), ganoderic acid B (10.6%) da ganoderic acid C2 (5.4%). .

Gwaje-gwajen sel a cikin vitro sun nuna cewa ganoderic acid A (100μg / mL) yana da tasirin hanawa mafi kyau akan fibrosis na renal a cikin ukun, har ma yana da tasiri mafi kyau fiye da cakuda ganoderic acid na asali kuma ba shi da wani tasiri mai guba akan ƙwayoyin koda.Saboda haka, masu bincike sun yi imanin cewa ganoderic acid A ya kamata ya zama babban tushen ayyukanReishi naman kazaa jinkirta fibrosis na renal.

Ganoderic acid A yana jinkirta ci gaban cututtukan koda na polycystic

Ba kamar abubuwan etiological na fibrosis na renal ba, cutar koda na polycystic yana haifar da maye gurbi a cikin kwayar halitta akan chromosome.Kashi 90 cikin 100 na cutar na gado ne kuma yawanci tana farawa ne kusan shekaru arba'in.Kwayoyin koda na majiyyaci za su yi girma yayin da lokaci ya ci gaba, wanda zai matse tare da lalata ƙwayoyin koda na yau da kullun tare da lalata aikin koda.

A cikin fuskantar wannan cutar da ba za a iya jurewa ba, jinkirta lalacewar aikin koda ya zama mafi mahimmancin manufar warkewa.Tawagar Yang ta buga wani rahoto a wata mujallar kiwon lafiya mai suna Kidney International a karshen shekarar 2017, inda ta tabbatar da cewa Ganoderma lucidum triterpenes na da tasirin jinkirta bullar cutar koda da kuma rage ciwon ciwon koda na polycystic.

Koyaya, akwai nau'ikan nau'ikanLingzhitriterpenes.Wane irin triterpene ne ke taka muhimmiyar rawa a cikin wannan?Don gano amsar, sun gwada Ganoderma triterpenes iri-iri ciki har da ganoderic acid A, B, C2, D, F, G, T, DM da ganoderenic acid A, B, D, F.

Gwaje-gwajen in vitro sun nuna cewa babu wani daga cikin 12 triterpenes da ya shafi rayuwar ƙwayoyin koda, kuma amincin ya kusan kusan daidai da matakin, amma akwai bambance-bambance masu mahimmanci wajen hana ci gaban ƙwayoyin koda, wanda triterpene tare da mafi kyawun sakamako shine ganoderic. acid A.

Tun daga tasowar fibrosis na koda zuwa gazawar koda, ana iya cewa ya samo asali ne daga dalilai iri-iri (kamar ciwon sukari).

Ga marasa lafiya da ciwon koda polycystic, yawan raguwar aikin koda na iya zama da sauri.Bisa kididdigar da aka yi, kusan rabin majinyata da ke fama da ciwon koda na polycystic za su tabarbare zuwa gazawar renal a kusa da shekaru 60, kuma dole ne su sami dialysis na koda har tsawon rayuwarsu.

Tawagar Farfesa Yang Baoxue ta wuce gwaje-gwajen tantanin halitta da na dabba don tabbatar da cewa ganoderic acid A, mafi girman kaso na Ganoderma triterpenes, wani yanki ne na Ganoderma lucidum don kare koda.

Tabbas, wannan ba shine kawai ganoderic acid A a cikin Ganoderma lucidum zai iya kare kodan ba.A gaskiya ma, sauran sinadaran tabbas suna da taimako.Alal misali, wata takarda da Farfesa Yang Baoxue ya buga game da batun kare koda kuma ya nuna cewa Ganoderma lucidum polysaccharide tsantsa zai iya rage lalacewar oxidative da ƙwayar koda ta samu ta hanyar maganin antioxidant.Ganoderma lucidum triterpenoids, wanda ya ƙunshi nau'o'in triterpene daban-daban kamar ganoderic. acid, ganoderenic acid da ganederol suna aiki tare don jinkirta fibrosis na koda da cututtukan koda na polycystic.

Abin da ya fi haka, buƙatar kare koda ba kawai don kare kanta ba ne.Sauran irin su daidaita rigakafi, inganta haɓaka uku, daidaita tsarin endocrin, kwantar da jijiyoyi da inganta barci tabbas zai taimaka kare koda, wanda ba za a iya samuwa ba kawai ta hanyar ganoderic acid A.