ʻO ka hui i alakaʻi ʻia e Professor Yang Baoxue, ka luna o ke Keʻena ʻOihana Pharmacology, Ke Kula Nui ʻo Peking University of Basic Medical Science, i paʻi i ʻelua mau pepa ma ka "Acta Pharmacologica Sinica" ma ka hopena o 2019 a me ka 2020 mua, e hōʻoia ana i ka Ganoderic acid A, ʻo ia ka mea hooikaika nui oʻO Ganoderma lucidum, loaʻa ka hopena i ka hoʻopaneʻe ʻana i ka fibrosis renal a me ka maʻi maʻi maʻi polycystic.

Hoʻopaneʻe ʻo Ganoderic A i ka holomua o ka fibrosis renal

Ua hoʻopili ka poʻe noiʻi i nā ureters unilateral o nā ʻiole.Ma hope o 14 mau lā, ua hoʻomohala nā ʻiole i ka pōʻino o nā tubules kidney a me ka fibrosis kidney ma muli o ke kāohi ʻia ʻana o ka mimi.I kēia manawa, ʻo ka hoʻokiʻekiʻe ʻana o ke koko urea nitrogen (BUN) a me ka creatinine (Cr) i hōʻike ʻia i ka hōʻino ʻana o ka hana kīkī.

Eia nō naʻe, inā hāʻawi ʻia nā ʻiole i kahi injection intraperitoneal o ka waika ganoderic i kēlā me kēia lā o 50 mg/kg ma hope koke o ka ligation ureteral unilateral, ʻoi aku ka liʻiliʻi o ka hōʻino ʻana o nā tubules kidney, fibrosis renal a i ʻole nā ​​​​hana hana renal ma hope o 14 mau lā ma mua o nā ʻiole. me ka pale ole Ganoderma.

ʻO ka ʻakika ganoderic i hoʻohana ʻia i ka hoʻokolohua he hui ʻia i loaʻa ma kahi liʻiliʻi he ʻumikūmālua ʻano like ʻole o nā ʻakika ganoderic, a ʻo ka mea nui loa he ganoderic acid A (16.1%), ganoderic acid B (10.6%) a me ganoderic acid C2 (5.4%). .

Ua hōʻike ʻia nā hoʻokolohua in vitro cell i ka ganoderic acid A (100μg/mL) i ka hopena inhibitory maikaʻi loa i ka fibrosis renal ma waena o nā mea ʻekolu, ʻoi aku ka maikaʻi o ka hopena ma mua o ka hui ʻana o ka ganoderic acid kumu a ʻaʻohe hopena ʻona i nā cell renal.No laila, ua manaʻo ka poʻe noiʻi ʻo ka ganoderic acid A ke kumu nui o ka hanaʻO Reishi mushroomi ka lohi ʻana i ka fibrosis renal.

Hoʻopaneʻe ka Ganoderic acid A i ka piʻi ʻana o ka maʻi puʻupaʻa polycystic

ʻAʻole like me ka etiological kumu o ka renal fibrosis, polycystic kidney maʻi ma muli o ka mutation i loko o ka gene ma ka chromosome.He kanaiwa pākēneka o ka maʻi i hoʻoili ʻia a hoʻomaka ma kahi o ke kanahā makahiki.E ulu aʻe nā vesicle o nā puʻupaʻa o ka mea maʻi i ka wā e hele ai, kahi e ʻoki ai a hoʻopau i ka ʻiʻo maʻamau o ka puʻupaʻa a hōʻino i ka hana ʻāʻī.

I ke alo o kēia maʻi hiki ʻole ke hoʻololi ʻia, ʻo ka hoʻopaneʻe ʻana i ka deterioration o ka hana renal ua lilo i mea koʻikoʻi therapeutic pahuhopu.Ua paʻi ka hui o Yang i kahi hōʻike i loko o ka puke moʻolelo olakino i kapa ʻia ʻo Kidney International ma ka hopena o 2017, e hōʻoia ana i ka hopena o Ganoderma lucidum triterpenes i ka hoʻopaneʻe ʻana i ka hoʻomaka ʻana o ka maʻi polycystic kidney a me ka hoʻēmi ʻana i ka maʻi o ka maʻi polycystic Kidney.

Eia naʻe, nui nā ʻano oLingzhitriterpenes.He aha ke ʻano o ka triterpene i hana nui i kēia?I mea e ʻike ai i ka pane, ua hoʻāʻo lākou i nā Ganoderma triterpenes me ka ganoderic acid A, B, C2, D, F, G, T, DM a me ganoderenic acid A, B, D, F.

Ua hōʻike ʻia nā hoʻokolohua in vitro ʻaʻohe o nā triterpenes 12 i hoʻopilikia i ke ola o nā pūnaewele puʻupaʻa, a ua aneane like ka palekana i ka pae like, akā aia nā ʻokoʻa koʻikoʻi i ka pale ʻana i ka ulu ʻana o nā vesicle renal, ma waena o ka triterpene me ka hopena maikaʻi loa he ganoderic. ʻakika A.

Mai ka hoʻomohala ʻana o ka fibrosis renal a hiki i ka hiki ʻole o ka renal, hiki ke ʻōlelo ʻia ʻo ia ka hopena o nā kumu like ʻole (e like me ka maʻi diabetes).

No nā poʻe maʻi me ka maʻi puʻupaʻa polycystic, ʻoi aku ka wikiwiki o ka emi ʻana o ka hana renal.Wahi a nā helu helu, ma kahi o ka hapalua o nā poʻe maʻi me ka maʻi maʻi polycystic kidney e hōʻemi ʻia i ka hiki ʻole o ka renal ma kahi o 60 mau makahiki, a pono lākou e loaʻa i ka dialysis kidney no ke ola.

Ua hala ka hui o Polofesa Yang Baoxue i nā hoʻokolohua cell a me nā holoholona e hōʻoia i ka ganoderic acid A, ka māhele kiʻekiʻe loa o Ganoderma triterpenes, he ʻāpana kuhikuhi o Ganoderma lucidum no ka pale ʻana i ka puʻupaʻa.

ʻOiaʻiʻo, ʻaʻole kēia e ʻōlelo ʻo ka ganoderic acid A wale nō i Ganoderma lucidum hiki ke pale i nā puʻupaʻa.ʻO kaʻoiaʻiʻo, he mea kōkua nā mea ʻē aʻe.Eia kekahi laʻana, kekahi pepa i paʻi ʻia e Professor Yang Baoxue e pili ana i ke kumuhana o ka pale ʻana i ka puʻupaʻa i hōʻike pū ʻia e hiki i ka Ganoderma lucidum polysaccharide extract ke hōʻemi i ka pōʻino oxidative i loaʻa mai i ka ʻiʻo kīkī ma o ka hopena antioxidant. ʻO ka waikawa, ka waikawa ganoderenic a me ka ganederol e hana pū ana e hoʻopaneʻe i ka fibrosis renal a me ka maʻi maʻi polycystic kidney.

ʻO ka mea ʻē aʻe, ʻo ka pono o ka pale ʻana i ka puʻupaʻa ʻaʻole wale no ka pale ʻana i ka puʻupaʻa ponoʻī.ʻO nā mea ʻē aʻe e like me ka hoʻoponopono ʻana i ka palekana, ka hoʻomaikaʻi ʻana i ʻekolu kiʻekiʻe, ke kaulike ʻana i ka endocrine, ka hōʻoluʻolu ʻana i nā aʻalolo a me ka hoʻomaikaʻi ʻana i ka hiamoe e kōkua maoli i ka pale ʻana i ke kīpē, ʻaʻole hiki ke ʻike ʻia ma o ka ganoderic acid A.