Chikwata chinotungamirwa naProfessor Yang Baoxue, director weDhipatimendi rePharmacology, Peking University Chikoro cheBasic Medical Sayenzi, yakaburitsa mapepa maviri mu "Acta Pharmacologica Sinica" mukupera kwa2019 uye kutanga kwa2020, ichisimbisa kuti Ganoderic acid A, main active ingredient yeGanoderma lucidum, ine mhedzisiro yekunonoka renal fibrosis uye polycystic itsvo chirwere.
Ganoderic A inodzora kufambira mberi kwerenal fibrosis
Vatsvakurudzi vakavhiya unilateral ureters yemakonzo.Mushure memazuva gumi nemana, mbeva dzakagadzira kukuvara kweitsvo uye fibrosis nekuda kwekuvhara weti.Zvichakadaro, iyo yakakwira ropa urea nitrogen (BUN) uye creatinine (Cr) yakaratidza kukanganisa kweitsvo basa.
Nekudaro, kana mbeva dzakapihwa intraperitoneal jekiseni reganoderic acid pachiyero chezuva nezuva che50 mg/kg pakarepo mushure meunilateral ureteral ligation, dhigirii reitsvo tubules kukuvadzwa, renal fibrosis kana renal kusashanda zvakanaka mushure memazuva gumi nemana kwaive kushoma pane mbeva. pasina Ganoderma kudzivirira.
Iyo ganoderic asidhi yakashandiswa mukuyedza yaive musanganiswa une angangoita gumi nemaviri emhando dzakasiyana dzeanoderic acids, iyo yakawanda yaive ganoderic acid A (16.1%), ganoderic acid B (10.6%) uye ganoderic acid C2 (5.4%). .
In vitro cell kuyedza yakaratidza kuti ganoderic acid A (100μg/mL) yaive neyakanakisa inhibitory mhedzisiro parenal fibrosis pakati pevatatu, yakatove nemhedzisiro iri nani pane yekutanga ganoderic acid musanganiswa uye yakanga isina chepfu pamasero etsvo.Nokudaro, vatsvakurudzi vakatenda kuti ganoderic acid A inofanira kunge iri iyo huru yekuita basaReishi mushroommukunonoka renal fibrosis.
Ganoderic acid A inodzora kufambira mberi kwepolycystic itsvo chirwere
Kusiyana neiyo etiological factor ye renal fibrosis, chirwere chepolycystic itsvo chinokonzerwa nekushanduka kwejini pane chromosome.Zvikamu makumi mapfumbamwe kubva muzana zvehosha inogarwa nhaka uye kazhinji inotanga kusvika makore makumi mana.Ma vesicles eitsvo dzemurwere anokura nekufamba kwenguva, izvo zvinosvina nekuparadza zvakajairika itsvo tishu uye kukanganisa itsvo kushanda.
Mukutarisana nechirwere ichi chisingachinjiki, kunonoka kuparara kwebasa retsvo kwakava chinangwa chinonyanya kukosha chekurapa.Chikwata chaYang chakaburitsa mushumo mupepanhau rezvokurapa rinonzi Kidney International mukupera kwa2017, zvichisimbisa kuti Ganoderma lucidum triterpenes ine mhedzisiro yekunonotsa kutanga kwechirwere cheitsvo chepolycystic uye kuderedza chirwere chepolycystic Kidney chirwere.
Zvisinei, kune marudzi akawanda eLingzhitriterpenes.Ndeipi mhando ye triterpene inoita basa rakakosha mune izvi?Kuti vawane mhinduro, vakaedza akasiyana maGanoderma triterpenes anosanganisira ganoderic acid A, B, C2, D, F, G, T, DM uye ganoderenic acid A, B, D, F.
In vitro ongororo dzakaratidza kuti hapana kana imwe yegumi nemaviri triterpenes yakakanganisa kupona kwemasero eitsvo, uye kuchengetedzeka kwaive kwakada kusvika pamwero wakafanana, asi pakanga paine misiyano yakakura mukudzivisa kukura kwerenal vesicles, pakati peiyo triterpene ine yakanakisa mhedzisiro yaive ganoderic. asidhi A.
Kubva pakuvandudzwa kwerenal fibrosis kusvika kukundikana kwerenal, zvinogona kutaurwa kuti imhaka yezvikonzero zvakasiyana-siyana (zvakadai sechirwere cheshuga).
Kune varwere vane chirwere chepolycystic itsvo, chiyero chekuderera mukushanda kwetsvo chinogona kukurumidza.Maererano nenhamba, inenge hafu yevarwere vane polycystic chirwere cheitsvo vanozotadza kutadza kutadza kusvika pazera re60, uye vanofanirwa kugamuchira itsvo dialysis kweupenyu hwose.
Chikwata chaMuzvinafundo Yang Baoxue chakapfuura maseru nemhuka kuyedza kuratidza kuti ganoderic acid A, chikamu chepamusoro cheGanoderma triterpenes, indekisi chikamu cheGanoderma lucidum yekudzivirira itsvo.
Zvechokwadi, izvi hazvirevi kuti chete ganoderic acid A muGanoderma lucidum inogona kudzivirira itsvo.Chokwadi, zvimwe zvinhu zvinobatsira.Semuyenzaniso, rimwe bepa rakabudiswa naProfessor Yang Baoxue pamusoro penyaya yekuchengetedzwa kweitsvo zvakare rakaratidza kuti Ganoderma lucidum polysaccharide extract inogona kuderedza kukuvadzwa kweoxidative inogamuchirwa neitsvo tishu kuburikidza ne antioxidant effect.Ganoderma lucidum triterpenoids, iyo ine zvakasiyana-siyana zve triterpene compounds zvakadai seganoderic. acid, ganoderenic acid uye ganederol zvinoshanda pamwe chete kunonoka renal fibrosis uye polycystic itsvo chirwere.
Uyezve, kudiwa kwekudzivirira itsvo hakusi kwekudzivirira itsvo pachayo.Zvimwe zvakaita sekudzora kusadzivirirwa, kuvandudza matatu akakwira, kuenzanisa endocrine, kunyaradza tsinga uye kugadzirisa kurara zvichabatsira kuchengetedza itsvo, izvo zvisingagone kuitika chete kuburikidza neganoderic acid A.
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Nguva yekutumira: Kubvumbi-23-2020