Kooxda uu hogaaminayo Professor Yang Baoxue, oo ah agaasimaha Waaxda Farmashiyaha, Dugsiga Jaamacadda Peking ee Sayniska Caafimaadka Aasaasiga ah, ayaa daabacay laba warqadood "Acta Pharmacologica Sinica" dhammaadka 2019 iyo horraantii 2020, iyagoo xaqiijinaya in Ganoderic acid A, uu yahay walaxda ugu muhiimsan ee firfircoon eeGanoderma lucidum, waxay saameyn ku leedahay dib u dhigista fibrosis kelyaha iyo cudurka kelyaha ee polycystic.

Ganoderic A ayaa dib u dhigtay horumarka fibrosis kelyaha

Cilmi-baadhayaashu waxay qalliin ku xidheen jiirarka kaadimareenka hal dhinac.14 maalmood ka dib, jiirarkii waxa soo gaaray dhaawac tubbada kelyaha iyo fibrosis kelyaha taasoo ay ugu wacan tahay soo saarista kaadida oo xirtay.Dhanka kale, kor u kaca nitrogen-ka dhiigga ee urea (BUN) iyo creatinine (Cr) ayaa muujiyay daciifnimada shaqada kelyaha.

Si kastaba ha noqotee, haddii jiirarka la siiyay cirbadeynta intraperitoneal ee ganoderic acid qiyaasta maalinlaha ah ee 50 mg / kg isla markiiba ka dib markii la gooyo kaadi-mareenka hal dhinac, heerka dhaawaca tubbada kelyaha, fibrosis kelyaha ama naafanimada shaqada kelyaha ka dib 14 maalmood ayaa aad uga yarayd jiirarka. iyada oo aan la ilaalin Ganoderma.

Ashitada ganoderic ee loo adeegsaday tijaabada ayaa ahayd isku dhaf ay ku jiraan ugu yaraan toban nooc oo kala duwan oo ah acids ganoderic, kuwaas oo ay ugu badan yihiin ganoderic acid A (16.1%), ganoderic acid B (10.6%) iyo ganoderic acid C2 (5.4%) .

Tijaabooyinka unugyada vitro waxay muujiyeen in ganoderic acid A (100μg / mL) ay saamaynta ugu fiican ku leedahay fibrosis kelyaha ee saddexda, xitaa waxay leedahay saameyn ka fiican marka loo eego isku dhafka asalka ah ee ganoderic acid oo aan wax saameyn ah ku yeelan unugyada kelyaha.Sidaa darteed, cilmi-baarayaashu waxay rumaysnaayeen in ganoderic acid A ay tahay inay noqoto isha ugu weyn ee waxqabadkalikaha Reishidib u dhigista fibrosis kelyaha.

Ganoderic acid A waxay dib u dhigtaa horumarka cudurka kelyaha ee polycystic

Si ka duwan qodobka etiological ee fibrosis kelyaha, cudurka kelyaha ee polycystic waxaa sababa isbeddel ku yimaadda hidde-sideyaasha koromosoomyada.Boqolkiiba 90 cudurka waa la iska dhaxlo oo badanaa wuxuu bilaabmaa da'da afartan jir.Xididdada kelyaha bukaanku way weynaan doonaan marka uu wakhtigu sii socdo, taas oo tuujin doonta oo burburisa unugyada caadiga ah ee kelyaha waxayna dhaawacaysaa shaqada kelyaha.

Marka la eego cudurkan aan dib loo celin karin, dib u dhigista sii xumaanshaha shaqada kelyaha ayaa noqotay hadafka ugu muhiimsan ee daaweynta.Kooxda Yang ayaa daabacday warbixin lagu daabacay joornaalka caafimaadka ee lagu magacaabo Kidney International dhamaadkii 2017, taas oo xaqiijisay in Ganoderma lucidum triterpenes ay saameyn ku leedahay dib u dhigista bilawga cudurka kelyaha ee polycystic iyo yaraynta cilladda cudurka kelyaha ee polycystic.

Si kastaba ha ahaatee, waxaa jira noocyo badan ooLingzhitriterpenes.Waa maxay nooca triterpene ee door muhiim ah ka ciyaara tan?Si loo ogaado jawaabta, waxay tijaabiyeen Ganoderma triterpenes kala duwan oo ay ku jiraan ganoderic acid A, B, C2, D, F, G, T, DM iyo ganoderenic acid A, B, D, F.

Tijaabooyinka vitro-ga ayaa muujiyay in midkoodna 12 triterpene uusan saameyn ku yeelan badbaadada unugyada kelyaha, nabadgelyaduna waxay ku dhowdahay heer isku mid ah, laakiin waxaa jiray kala duwanaansho weyn oo lagu xakameynayo koritaanka xididdada kelyaha, kuwaas oo triterpene leh saameynta ugu fiican ay ahayd ganoderic. acid A.

Laga soo bilaabo korriinka fibrosis ee kelyaha ilaa kelyaha oo fashilma, waxa la odhan karaa waa natiijada sababo kala duwan (sida sonkorowga).

Bukaanka qaba cudurka kelyaha ee polycystic, heerka hoos u dhaca shaqada kelyaha ayaa laga yaabaa inuu dhakhso badan yahay.Marka loo eego tirakoobyada, qiyaastii kala badh bukaannada qaba cudurka kelyaha polycystic waxay ka sii dari doonaan shaqada kelyaha ee da'da 60, waana inay qaataan sifeynta kelyaha inta ay nool yihiin.

Kooxda Professor Yang Baoxue ayaa ka gudubtay tijaabooyinka unugyada iyo xayawaanka si ay u caddeeyaan in ganoderic acid A, oo ah saamiga ugu sarreeya ee Ganoderma triterpenes, waa qayb index of Ganoderma lucidum ee ilaalinta kelyaha.

Dabcan, tani maaha in la yiraahdo kaliya ganoderic acid A ee Ganoderma lucidum ayaa ilaalin kara kelyaha.Dhab ahaantii, maaddooyinka kale ayaa hubaal ah inay caawiyaan.Tusaale ahaan, warqad kale oo uu daabacay Professor Yang Baoxue oo ku saabsan mawduuca ilaalinta kelyaha ayaa sidoo kale tilmaamay in laga soosaaray Ganoderma lucidum polysaccharide ay yareyn karto dhaawaca oksaydhka ah ee ay helaan unugyada kelyaha iyada oo loo marayo saameynta antioxidant. aashitada, ganoderenic acid iyo ganederol ayaa si wada jir ah uga wada shaqeeya dib u dhigista fibrosis kelyaha iyo cudurka kelyaha ee polycystic.

Waxa intaa dheer, baahida loo qabo in la ilaaliyo kelyaha maaha kaliya ilaalinta kelyaha lafteeda.Kuwa kale sida nidaaminta difaaca, hagaajinta seddexda sare, dheelitirka endocrine, dejinta neerfaha iyo hagaajinta hurdada ayaa hubaal ka caawin doonta ilaalinta kelyaha, taas oo aan lagu xaqiijin karin kaliya iyada oo loo marayo ganoderic acid A.