Iri tsinda riyobowe na Porofeseri Yang Baoxue, umuyobozi w’ishami rya farumasi, Ishuri rikuru ry’ubuvuzi bw’ibanze rya Peking, ryasohoye impapuro ebyiri muri “Acta Pharmacologica Sinica” mu mpera za 2019 no mu ntangiriro za 2020, zemeza ko aside Ganoderic A, nka Ibyingenzi byingenzi bigizeGanoderma lucidum, ifite ingaruka zo gutinza fibrosis yimpyiko nindwara yimpyiko.

Ganoderic A yadindije iterambere rya fibrosis yimpyiko

Abashakashatsi babaga uriteri imwe imwe yimbeba.Nyuma yiminsi 14, imbeba zagize impyiko zangirika hamwe na fibrosis yimpyiko kubera gusohoka kwinkari.Hagati aho, umuvuduko ukabije w'amaraso urea azote (BUN) na creinine (Cr) byerekanaga ko imikorere mibi y'impyiko idahwitse.

Ariko, niba imbeba zarahawe inshinge za intraperitoneal ya acide ganoderic ku gipimo cya buri munsi cya 50 mg / kg ako kanya nyuma yo guhuza ururetale imwe, urugero rwimpyiko zangirika, fibrosis yimpyiko cyangwa imikorere yimpyiko nyuma yiminsi 14 byari bike cyane ugereranije nimbeba nta kurinda Ganoderma.

Acide ya ganoderic yakoreshejwe mu bushakashatsi yari imvange irimo byibura amoko icumi ya acide ya ganoderic, muri yo menshi cyane yari acide ganoderic A (16.1%), aside ganoderic B (10,6%) na aside ganoderic C2 (5.4%) .

Mu bushakashatsi bwakozwe na vitro selile bwerekanye ko aside ganoderic A (100μg / mL) yagize ingaruka nziza zo kubuza fibrosis yimpyiko muri eshatu, ndetse ikaba yaranagize ingaruka nziza kuruta ivangwa rya acide ganoderic yambere kandi nta ngaruka z'ubumara zagize ku ngirabuzimafatizo.Abashakashatsi rero bemezaga ko aside ganoderic A igomba kuba isoko yingenzi yibikorwa byaReishi mushroommugutinda fibrosis yimpyiko.

Acide Ganoderic A idindiza iterambere ryindwara zimpyiko

Bitandukanye na etiologiya ya fibrosis yimpyiko, indwara yimpyiko polycystic iterwa no guhinduka kwa gene kuri chromosome.Mirongo cyenda ku ijana yindwara yarazwe kandi mubisanzwe itangira hafi imyaka mirongo ine.Imitsi y'impyiko z'umurwayi izagenda ikura uko ibihe bigenda bisimburana, bizanyunyuza kandi bisenye ingirangingo zisanzwe z'impyiko kandi byangiza imikorere y'impyiko.

Imbere yiyi ndwara idasubirwaho, gutinza kwangirika kwimikorere yimpyiko byabaye intego yingenzi yo kuvura.Itsinda rya Yang ryasohoye raporo mu kinyamakuru cy’ubuvuzi cyiswe Kidney International mu mpera za 2017, yemeza ko Ganoderma lucidum triterpène igira ingaruka zo gutinza itangira ry’indwara z’impyiko no kugabanya syndrome y’indwara y’impyiko.

Ariko, hariho ubwoko bwinshi bwaLingzhitriterpenes.Ni ubuhe bwoko bwa triterpene bugira uruhare runini muri ibi?Kugirango bamenye igisubizo, bapimye triterpene zitandukanye za Ganoderma zirimo aside ganoderic A, B, C2, D, F, G, T, DM na acide ganoderenic A, B, D, F.

Mu bushakashatsi bwa vitro bwerekanye ko nta na triterpène 12 yigeze igira ingaruka ku mibereho y’ingirangingo z’impyiko, kandi umutekano wari hafi ku rwego rumwe, ariko hari itandukaniro rikomeye mu kubuza imikurire y’imitsi y’impyiko, muri zo triterpene ifite ingaruka nziza ni ganoderic aside A.

Kuva mu mikurire ya fibrosis yimpyiko kugeza kunanirwa kwimpyiko, twavuga ko ari ibisubizo byimpamvu zitandukanye (nka diyabete).

Ku barwayi bafite impyiko za polycystic, umuvuduko wo kugabanuka kumikorere yimpyiko urashobora kwihuta.Nk’uko imibare ibigaragaza, hafi kimwe cya kabiri cy’abarwayi barwaye impyiko za polycystique bazagenda bangirika kubera kunanirwa kwimpyiko bafite imyaka 60, kandi bagomba kwakira dialyse yimpyiko ubuzima bwabo bwose.

Itsinda rya Porofeseri Yang Baoxue ryatsinze ubushakashatsi bw’ingirabuzimafatizo n’inyamaswa kugira ngo ryerekane ko aside ganoderic A, umubare munini wa Ganoderma triterpène, ari kimwe mu bice bigize Ganoderma lucidum yo kurinda impyiko.

Nibyo, ntabwo bivuze ko aside ganoderic A gusa muri Ganoderma lucidum ishobora kurinda impyiko.Mubyukuri, ibindi bikoresho rwose bifasha.Kurugero, urundi rupapuro rwasohowe na Porofeseri Yang Baoxue ku ngingo yo kurinda impyiko rwerekanye kandi ko Ganoderma lucidum polysaccharide ikuramo ishobora kugabanya kwangirika kwa okiside yakiriwe n’impyiko binyuze mu ngaruka za antioxydeant. aside, acide ganoderenic na ganederol bikorana kugirango bidindiza fibrosis yimpyiko nindwara yimpyiko.

Ikirenzeho, gukenera kurinda impyiko ntabwo ari ukurinda impyiko ubwayo.Ibindi nko kugenzura ubudahangarwa, kunoza uburebure butatu, kuringaniza endocrine, koroshya imitsi no kunoza ibitotsi rwose bizafasha kurinda impyiko, bidashobora kugerwaho gusa binyuze muri acide ganoderic A.