Kungani abantu benokungezwani komzimba nezinto ezithile?

Ukuthi umzimba womuntu uzoba nokungezwani yini lapho uhlangana nengwadla kuncike ngokuphelele ekutheni ibutho le-T cell elilawula ukusabela kwamasosha omzimba emzimbeni yi-Th1 noma i-Th2 (uhlobo 1 noma thayipha u-2 wamaseli T asiza).

Uma amaseli e-T elawulwa yi-Th1 (evezwe njengenombolo enkulu nomsebenzi ophezulu we-Th1), umzimba ngeke uthinteke yizinto ezingezwani, ngoba umsebenzi we-Th1 u-anti-virus, anti-bacteria kanye ne-anti-tumor;uma amaseli e-T elawulwa yi-Th2, umzimba uzobheka i-allergen njenge-dissident eyingozi futhi ungene empini nayo, okubizwa ngokuthi "umthethosisekelo we-allergic".Abantu abane-allergies, ngaphezu kokuphendula kwamasosha omzimba okubuswa yi-Th2, ngokuvamile kuhambisana nenkinga yokuthi i-Treg (ama-T cell alawulayo) abuthaka kakhulu.I-Treg ingenye isethi engaphansi yama-T cell, okuyindlela yokubhuleka yamasosha omzimba ukuqeda impendulo yokuvuvukala.Uma ingakwazi ukusebenza ngokujwayelekile, ukungezwani komzimba kuzoba namandla futhi kuhlale isikhathi eside.

I-Anti-allergic kungenzeka

Ngenhlanhla, ubudlelwano phakathi kwamandla alawa ma-T cell subsets amathathu abushintshile kodwa buzolungiswa ngesisusa sangaphandle noma izinguquko zomzimba.Ngakho-ke, isithako esisebenzayo esingavimbela i-Th2 noma inyuse i-Th1 kanye ne-Treg ngokuvamile ibhekwa njengenamandla okulungisa ukwakheka kwe-allergic nokunciphisa ukungezwani komzimba.

Umbiko oshicilelwe kuUcwaningo lwePhytotherapynguSolwazi Li Xiumin, School of Pharmacy, Henan University of Traditional Chinese Medicine, kanye nabacwaningi abavela ezikhungweni zemfundo eziningana zaseMelika, okuhlanganisa iNew York Medical College kanye neJohns Hopkins University Asthma and Allergy Center, ngoMashi 2022 baveza ukuthi enye yezingxenye zeI-Ganoderma lucidumi-triterpenoids, i-ganoderic acid B, inamandla okubalulwe ngenhla okulwa nokungezwani nomzimba.

Umphumela we-Antiallergic we-ganoderic acid B

Abacwaningi bakhiphe amangqamuzana omzimba okuhlanganisa namaseli e-T egazini leziguli eziyi-10 ezinesifuba somoya esingezwani nomzimba, base bewavuselela ngezinto ezingezwani neziguli (uthuli lwezibungu, izinwele zekati, iphela noma i-hogweed), bathola ukuthi uma i-ganoderic acid B (i-allergies) umthamo we-40 μg/mL) usebenze ndawonye phakathi nenkathi yezinsuku eziyisi-6 lapho amaseli omzimba evezwa i-allergen:

①Inombolo ye-Th1 ne-Treg izokhula, futhi inombolo ye-Th2 izokwehla;

② I-cytokine IL-5 (interleukin 5) ekhishwe yi-Th2 ukuze ibangele ukungezwani (i-allergic) izokwehla ngo-60% kuya ku-70%;

③I-cytokine IL-10 (interleukin 10), ekhishwa yi-Treg ukuze ilawule impendulo yokuvuvukala, izokhuphuka isuka kuzinga ledijithi eyodwa noma ileveli yedijithi yamashumi iye ku-500-700 pg/mL;

④ Ukukhishwa kwe-Interferon-gamma (IFN-γ), okuwusizo ekuhlukaniseni i-Th1 kodwa okungekuhle ekuthuthukisweni kwe-Th2, kuyashesha, ngaleyo ndlela kubuyisela emuva indlela yokusabela kokuzivikela komzimba kusenesikhathi.

⑤Ukuhlaziywa okwengeziwe komthombo we-interferon-gamma okhuliswe nge-ganoderic acid B kutholwe ukuthi i-interferon-gamma ayiveli ku-Th1 (kungakhathaliseki ukuthi i-ganoderic acid B iyabandakanyeka noma cha, kukhona i-interferon-gamma encane kakhulu ekhishwa i-Th1) kodwa kusukela ku-Th1. amaseli T abulalayo namaseli abulalayo emvelo (NK cell).Lokhu kukhombisa ukuthi i-ganoderic acid B ingahlanganisa amanye amaseli omzimba angahlobene kangako nokungezwani komzimba ukuze ajoyine amandla alwa nokungezwani komzimba.

Ngaphezu kwalokho, ithimba labacwaningi liphinde lashintsha i-ganoderic acid B nge-steroid (10 μM dexamethasone) ukuze libone umphumela wayo kumangqamuzana okuzivikela omzimba eziguli eziphethwe yisifuba somoya lapho zibhekene nezinto ezingezwani nomzimba.Ngenxa yalokho, inani le-Th1, i-Th2 noma i-Treg kanye nokuhlushwa kwe-IL-5, IL-10 noma i-interferon-γ kuncishisiwe kusukela ekuqaleni kuze kube sekupheleni kokuhlolwa.

Ngamanye amazwi, umphumela we-anti-allergic we-steroids uvela ekucindezelweni okuphelele kokuphendula kwamasosha omzimba kuyilapho umphumela wokulwa nokungezwani komzimba we-ganoderic acid B umane nje uphikisana nokungezwani komzimba futhi awuthinti ukuzivikela kokutheleleka kanye ne-anti-tumor.

Ngakho-ke, i-ganoderic acid B ayiyona enye i-steroid.Ingakwazi ukulawula ukungezwani komzimba ngaphandle kokubhubhisa ukuzivikela okujwayelekile, okuyisici sayo esibalulekile.

Isithasiselo: Umsebenzi Womzimba we-Ganoderic Acid B

I-Ganoderic acid B ingenye ye I-Ganoderma lucidumi-triterpenoids (enye i-ganoderic acid A) eyatholwa ngo-1982, lapho ubunikazi bayo “bekuwumthombo womunyu weI-Ganoderma lucidumimizimba yezithelo”.Kamuva, ngaphansi kokuhlolwa kokudluliselwa kososayensi abavela emazweni ahlukahlukene, kwatholakala ukuthi i-ganoderic acid B nayo inemisebenzi eminingi yokuphila, kuhlanganise:

➤Ukunciphisa umfutho wegazi/ukuvimbela i-angiotensin-converting enzyme (1986, 2015)

➤Ukuvinjwa kwe-cholesterol synthesis (1989)

➤I-analgesia (1997)

➤Anti-AIDS/Ukuvinjelwa kwe-HIV-1 protease (1998)

➤Anti-prostatic hypertrophy/Ukuncintisana nama-androgens kuma-receptors ku-prostate (2010)

➤I-Anti-diabetes/Ukuvinjelwa komsebenzi we-α-glucosidase (2013)

➤Umdlavuza wesibindi/Ukubulala amaseli omdlavuza wesibindi womuntu amelana nezidakamizwa (2015)

➤Anti-Epstein-Barr virus / inhibition of nasopharyngeal carcinoma-associated human herpes virus umsebenzi (2017)

➤I-Anti-pneumonia / Ukunciphisa ukulimala okukhulu kwamaphaphu ngemiphumela elwa nokuvuvukala kanye ne-anti-inflammatory (2020)

➤I-Anti-allergies/Ukulawula ukusabela kwamasosha omzimba kuma-T cell kuma-allergies (2022)

[Umthombo] Changda Liu, et al.Ukuguquguquka okubili okuzuzisayo okuncike ngesikhathi kwe-interferon-γ, i-interleukin 5, ne-Treg cytokines esigulini esiphethwe yisifuba somoya amangqamuzana egazi e-mononuclear egazi nge-ganoderic acid B. Phytother Res.2022 Mar;36(3): 1231-1240.

PHELA

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★ Uma umsebenzi ugunyazwe ukusetshenziswa, kufanele usetshenziswe ngaphakathi kobubanzi bokugunyazwa futhi ubonise umthombo: GanoHerb.

★ Kunoma yikuphi ukwephulwa kwesitatimende esingenhla, i-GanoHerb izolandela izibopho ezingokomthetho ezihlobene.

★ Umbhalo wokuqala walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.