Vim li cas tib neeg thiaj li ua xua?

Txawm hais tias tib neeg lub cev yuav muaj kev tsis haum tshuaj thaum ntsib ib qho kev ua xua nyob ntawm seb cov tub rog T cell uas muaj zog tiv thaiv kab mob hauv lub cev yog Th1 lossis Th2 (hom 1 lossis hom 2 pab T hlwb).

Yog tias T hlwb raug tswj hwm los ntawm Th1 (qhia tias muaj ntau thiab ua haujlwm siab ntawm Th1), lub cev yuav tsis cuam tshuam los ntawm kev ua xua, vim tias txoj haujlwm ntawm Th1 yog tshuaj tiv thaiv kab mob, tiv thaiv kab mob thiab tiv thaiv qog;Yog tias T hlwb raug tswj hwm los ntawm Th2, lub cev yuav suav tias yog cov tshuaj tsis haum tshuaj thiab mus ua rog nrog nws, uas yog lub npe hu ua "allergic Constitution".Cov neeg uas muaj kev fab tshuaj, ntxiv rau lub cev tiv thaiv kab mob uas tau tswj hwm los ntawm Th2, feem ntau yog nrog cov teeb meem uas Treg (txheej txheem T hlwb) tsis muaj zog heev.Treg yog lwm subset ntawm T hlwb, uas yog lub nres mechanism ntawm lub cev tiv thaiv kab mob los xaus cov inflammatory teb.Thaum nws tsis tuaj yeem ua haujlwm ib txwm, qhov kev tsis haum tshuaj yuav muaj zog thiab kav ntev dua.

Anti-allergic muaj peev xwm

Hmoov zoo, kev sib raug zoo ntawm lub zog ntawm peb lub T cell subsets tsis zoo li qub tab sis yuav raug kho nrog cov stimuli sab nraud lossis kev hloov ntawm lub cev.Yog li, cov khoom xyaw nquag uas tuaj yeem cuam tshuam Th2 lossis nce Th1 thiab Treg feem ntau suav hais tias muaj peev xwm los kho cov kev tsis haum tshuaj thiab txo cov kev tsis haum tshuaj.

Ib tsab ntawv ceeb toom luam tawm hauvKev tshawb fawb Phytotherapylos ntawm xibfwb Li Xiumin, Tsev Kawm Ntawv Pharmacy, Henan University of Traditional Chinese Medicine, thiab cov kws tshawb fawb los ntawm ntau lub tsev kawm ntawv Asmeskas, suav nrog New York Medical College thiab Johns Hopkins University Asthma thiab Allergy Center, thaum Lub Peb Hlis 2022 tau taw qhia tias yog ib qho ntawm cov khoom siv ntawmGanoderma lucidumtriterpenoids, ganoderic acid B, muaj cov lus hais saum toj no los tiv thaiv kev ua xua.

Antiallergic nyhuv ntawm ganoderic acid B

Cov kws tshawb fawb tau rho tawm cov kab mob tiv thaiv kab mob suav nrog T hlwb los ntawm cov ntshav ntawm 10 tus neeg mob ua xua mob hawb pob, thiab tom qab ntawd txhawb lawv nrog cov neeg mob tus kheej ua xua (plua plav, miv plaub hau, kab laum lossis hogweed), thiab pom tias yog ganoderic acid B (ntawm a koob tshuaj 40 μg / mL) ua ke thaum lub sij hawm 6-hnub thaum lub cev tiv thaiv kab mob raug rau cov allergen:

① Tus naj npawb ntawm Th1 thiab Treg yuav nce, thiab tus naj npawb ntawm Th2 yuav txo qis;

② Lub cytokine IL-5 (interleukin 5) secreted los ntawm Th2 mus induce inflammatory (allergic) cov tshuaj tiv thaiv yuav raug txo los ntawm 60% mus rau 70%;

③ Lub cytokine IL-10 (interleukin 10), uas yog secreted los ntawm Treg los tswj cov inflammatory teb, yuav nce los ntawm ib tug lej theem los yog kaum tus lej rau 500-700 pg / mL;

④ Kev tso tawm ntawm Interferon-gamma (IFN-γ), uas yog pab tau rau Th1 sib txawv tab sis tsis zoo rau txoj kev loj hlob ntawm Th2, yog sai dua, yog li thim rov qab cov kev taw qhia ntawm kev tiv thaiv kab mob thaum ntxov.

⑤ Kev tshuaj xyuas ntxiv ntawm qhov chaw ntawm interferon-gamma nce los ntawm ganoderic acid B pom tias interferon-gamma tsis tuaj ntawm Th1 (tsis hais seb ganoderic acid B koom nrog lossis tsis, muaj tsawg heev interferon-gamma secreted los ntawm Th1) tab sis los ntawm cov killer T cells thiab natural killer cells (NK cells).Qhov no qhia tau hais tias ganoderic acid B tuaj yeem txhawb nqa lwm lub cev tiv thaiv kab mob uas tsis muaj feem cuam tshuam nrog kev tsis haum tshuaj los koom nrog cov qib ntawm kev tiv thaiv kev ua xua.

Tsis tas li ntawd, pab pawg tshawb fawb kuj tau hloov ganoderic acid B nrog cov tshuaj steroid (10 μM dexamethasone) los soj ntsuam nws cov nyhuv ntawm lub cev tiv thaiv kab mob ntawm cov neeg mob hawb pob nyob rau hauv lub ntsej muag ntawm allergens.Yog li ntawd, tus naj npawb ntawm Th1, Th2 los yog Treg thiab cov concentration ntawm IL-5, IL-10 los yog interferon-γ raug txo los ntawm qhov pib mus rau qhov kawg ntawm qhov kev sim.

Hauv lwm lo lus, cov tshuaj tiv thaiv kev ua xua ntawm cov tshuaj steroids los ntawm kev tawm tsam tag nrho ntawm lub cev tiv thaiv kab mob thaum cov tshuaj tiv thaiv kev ua xua ntawm ganoderic acid B tsuas yog tiv thaiv kev ua xua thiab tsis cuam tshuam rau kev tiv thaiv kab mob thiab tiv thaiv qog noj ntshav.

Yog li, ganoderic acid B tsis yog lwm yam steroid.Nws tuaj yeem tswj kev ua xua yam tsis muaj kev puas tsuaj rau lub cev tiv thaiv kab mob, uas yog nws cov yam ntxwv tseem ceeb.

Daim ntawv ntxiv: Lub cev ua haujlwm ntawm Ganoderic Acid B

Ganoderic acid B yog ib qho ntawm cov tshuaj Ganoderma lucidumtriterpenoids (lwm yam yog ganoderic acid A) pom nyob rau hauv 1982, thaum nws tus kheej tsuas yog "qhov chaw ntawm iab ntawmGanoderma lucidumfruiting cev."Tom qab ntawd, nyob rau hauv kev tshawb nrhiav ntawm cov kws tshawb fawb los ntawm ntau lub teb chaws, nws tau pom tias ganoderic acid B kuj muaj ntau yam haujlwm ntawm lub cev, suav nrog:

➤ Txo cov ntshav siab / inhibiting angiotensin-hloov enzyme (1986, 2015)

➤ Inhibition of cholesterol synthesis (1989)

➤Analgesia (1997)

➤Anti-AIDS/Inhibition of HIV-1 protease (1998)

➤Anti-prostatic hypertrophy / Sib tw nrog androgens rau receptors ntawm prostate (2010)

➤Anti-diabetic/Inhibition of α-glucosidase kev ua (2013)

➤Anti-siab mob qog noj ntshav/Killing multidrug-resistant human mob cancer cells (2015)

➤Anti-Epstein-Barr virus / inhibition of nasopharyngeal carcinoma-associated human herpes virus activity (2017)

➤Anti-pneumonia / Alleviating mob ntsws raug mob los ntawm antioxidant thiab anti-inflammatory teebmeem (2020)

➤Anti-allergy/Regulating the immune response of T cells to allergens (2022)

[Source] Changda Liu, et al.Lub sij hawm-dependent dual beneficial modulation ntawm interferon-γ, interleukin 5, thiab Treg cytokines nyob rau hauv cov neeg mob hawb pob peripheral ntshav mononuclear hlwb los ntawm ganoderic acid B. Phytother Res.Peb Hlis 2022;36(3): 1231-1240.

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★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau, thiab nws cov tswv cuab yog GanoHerb.

★ Cov haujlwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis muaj kev tso cai ntawm GanoHerb.

★ Yog tias txoj haujlwm raug tso cai siv, nws yuav tsum tau siv nyob rau hauv qhov kev tso cai thiab qhia qhov chaw: GanoHerb.

★ Rau ib qho kev ua txhaum cai ntawm cov lus hais saum toj no, GanoHerb yuav ua raws li cov luag haujlwm raug cai.

★ Cov ntawv qub ntawm kab lus no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.