Sei vanhu vaine allergies?

Kuti muviri wemunhu uchange uine allergic reaction kana wasangana neallergency zvinoenderana zvachose nekuti mauto eT cell anotonga maitiro ekudzivirira zvirwere mumuviri iTh1 kana Th2 (mhando 1 kana Type 2 mubatsiri T masero).

Kana masero eT achitungamirirwa neTh1 (inoratidzwa senhamba huru uye basa rakakwirira reT1), muviri haungagadziriswi nemagetsi, nokuti basa reT1 ndiro anti-virus, anti-bacteria uye anti-tumor;kana masero eT achitongwa neTh2, muviri uchaona allergen seanopikisa anokuvadza uye anoenda kuhondo nawo, iyo inonzi "allergic constitution".Vanhu vane allergies, mukuwedzera kune immune system inotongwa neT2, inowanzoperekedzwa nedambudziko rekuti Treg (regulatory T masero) haana kusimba.Treg ndechimwe chikamu cheT masero, inova nzira yemabhureki eiyo immune system yekugumisa mhinduro yekuzvimba.Kana isingakwanise kushanda zvakajairika, iyo allergic reaction ichave yakasimba uye inogara kwenguva refu.

Anti-allergic mukana

Sezvineiwo, hukama pakati pesimba reaya matatu T cell subsets haana kumira asi anozogadziriswa nekunze kwekukurudzira kana shanduko yemuviri.Naizvozvo, chinhu chinoshanda chinogona kuvharidzira Th2 kana kuwedzera Th1 uye Treg inowanzoonekwa seine mukana wekugadzirisa allergic bumbiro uye kuderedza kusawirirana.

Chirevo chakaburitswa muPhytotherapy ResearchnaProfessor Li Xiumin, Chikoro cheFarmacy, Henan University of Traditional Chinese Medicine, uye vaongorori kubva kune akati wandei maAmerican zvikoro, kusanganisira New York Medical College uye Johns Hopkins University Asthma uye Allergy Center, muna Kurume 2022 yakaratidza kuti chimwe chezvikamu zveGanoderma lucidumtriterpenoids, ganoderic acid B, ine yataurwa pamusoro apa inorwisa-allergiki inogona.

Antiallergic mhedzisiro yeganoderic acid B

Vatsvagiri vacho vakaburitsa maseru edziviriro anosanganisira T masero kubva muropa revarwere gumi vane allergic asthma, uye ndokuvakurudzira nevanorwara zvavo (guruva mite, katsi bvudzi, mapete kana hogweed), uye vakawana kuti kana ganoderic acid B (panguva dose ye40 μg/mL) yakashanda pamwechete panguva yemazuva matanhatu apo maseru edziviriro akaiswa pachena kune allergen:

① Nhamba yeTh1 uye Treg ichawedzera, uye nhamba yeTh2 ichaderera;

② Iyo cytokine IL-5 (interleukin 5) yakavanzwa neTh2 kuti ikonzere kuzvimba (allergic) maitiro ichaderedzwa ne60% kusvika 70%;

③Iyo cytokine IL-10 (interleukin 10), iyo yakavanzwa neTreg kuti itonge mhinduro yekuzvimba, ichawedzera kubva padanho redhijiti rimwe chete kana gumi digit level kusvika 500-700 pg/mL;

④ Kuburitswa kweInterferon-gamma (IFN-γ), iyo inobatsira kumutsauko weT1 asi isingafadzi pakukura kweT2, inokurumidza, nekudaro ichidzosera kutungamira kwekudzivirira kwemuviri nekukurumidza.

⑤Kumwe kuongorora kwakabva interferon-gamma yakawedzera neganoderic acid B yakawana kuti interferon-gamma haibvi kuTh1 (zvisinei nokuti ganoderic acid B inobatanidzwa kana kwete, pane zvishoma interferon-gamma yakavanzwa neTh1) asi kubva mhondi T masero uye masero emuurayi echisikigo (NK masero).Izvi zvinoratidza kuti ganoderic acid B inogona kuunganidza mamwe maseru edziviriro asina hukama nealergic reactions kuti abatanidze mazinga e-anti-allergic force.

Pamusoro pezvo, timu yekutsvagisa yakatsivawo ganoderic acid B nesteroid (10 μM dexamethasone) kuti ione mhedzisiro yayo pamasero ekudzivirira evarwere vane asthmatic pamberi pezvinokanganisa.Somugumisiro, nhamba yeTh1, Th2 kana Treg uye kuiswa kweIL-5, IL-10 kana interferon-γ yakaderedzwa kubva pakutanga kusvika pakuguma kwekuedza.

Mune mamwe mazwi, iyo anti-allergic mhedzisiro ye steroids inobva pakudzvanywa kwese kwemaitiro ekudzivirira kwemuviri nepo anti-allergic mhedzisiro yeganoderic acid B inongori anti-allergic uye haina kukanganisa anti-utachiona uye anti-tumor immunity.

Nokudaro, ganoderic acid B haisi imwe steroid.Inogona kugadzirisa allergic reactions pasina kuparadza yakajairika immune, inova chinhu chayo chakakosha.

Appendikisi: Physiological Activity yeGanoderic Acid B

Ganoderic acid B ndeimwe yeadhi Ganoderma lucidumtriterpenoids (imwe yacho ganoderic acid A) yakawanikwa muna 1982, apo kuzivikanwa kwayo kwaingova chete “kunobva kuvavaGanoderma lucidummiviri inobereka michero”.Gare gare, pasi pekuferefetwa kwekuongorora kwevasayendisiti kubva kunyika dzakasiyana-siyana, zvakaonekwa kuti ganoderic acid B inewo mabasa akawanda ehupenyu, kusanganisira:

➤Kuderedza BP/kudzivisa angiotensin-inoshandura enzyme (1986, 2015)

➤Kuvharirwa kwecholesterol synthesis (1989)

➤Analgesia (1997)

➤Anti-AIDS/Inhibition yeHIV-1 protease (1998)

➤Anti-prostatic hypertrophy/ Kukwikwidzana neandrogens kune zvinogamuchira paprostate (2010)

➤Anti-diabetic/Inhibition yealpha-glucosidase chiitiko (2013)

➤Anti-chiropa cancer/Kuuraya maseru egomarara rechiropa asingarambi nemishonga (2015)

➤Anti-Epstein-Barr virus / inhibition yenasopharyngeal carcinoma-yakabatana nemunhu herpes virus chiitiko (2017)

➤Anti-pneumonia / Kuderedza kukuvara kwakanyanya kwemapapu kuburikidza ne antioxidant uye anti-kuzvimba mhedzisiro (2020)

➤Anti-allergies/Kudzora mhinduro yemuviri yemasero eT kune aleji (2022)

[Mabviro] Changda Liu, et al.Nguva-inotsamira kaviri inobatsira modulation ye interferon-γ, interleukin 5, uye Treg cytokines mune asthma murwere peripheral blood mononuclear masero neganoderic acid B. Phytother Res.2022 Mar;36(3): 1231-1240.

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