Kutheni abantu benokwalana?

Ingaba umzimba womntu uya kuba ne-aleji xa udibana ne-allergen kuxhomekeke ngokupheleleyo ekubeni umkhosi we-T cell olawula ukuphendula kwamajoni omzimba yi-Th1 okanye i-Th2 (uhlobo loku-1 okanye uhlobo lwesi-2 lweeseli ze-T ezincedisayo).

Ukuba iiseli ze-T zilawulwa yi-Th1 (echazwe njengenani elikhulu kunye nomsebenzi ophezulu we-Th1), umzimba awuyi kuchaphazeleka yi-allergen, kuba umsebenzi we-Th1 u-anti-virus, i-anti-bacteria kunye ne-anti-tumor;ukuba iiseli ze-T zilawulwa yi-Th2, umzimba uya kujonga i-allergen njenge- dissident eyingozi kwaye uye ukulwa nayo, ebizwa ngokuba "ngumgaqo-siseko we-allergic".Abantu abane-allergies, ukongeza kwimpendulo yomzimba elawulwa yi-Th2, badla ngokukhatshwa nengxaki yokuba i-Treg (iiseli ze-T ezilawulayo) zibuthathaka kakhulu.I-Treg yenye i-subset yeeseli ze-T, eyona ndlela i-brake ye-immune system ukuphelisa impendulo yokuvuvukala.Xa ingakwazi ukusebenza ngokuqhelekileyo, i-allergies iya kuba namandla kwaye ihlale ixesha elide.

Anti-allergies kunokwenzeka

Ngethamsanqa, ubudlelwane phakathi kwamandla ezi zintathu ze-T cell subsets azimi kodwa ziya kulungelelaniswa ne-stimuli yangaphandle okanye utshintsho lwe-physiological.Ke ngoko, isithako esisebenzayo esinokuthi sithintele i-Th2 okanye inyuse i-Th1 kunye ne-Treg ihlala ithathwa njengenamandla okulungelelanisa umgaqo-siseko we-aleji kunye nokunciphisa ukusabela komzimba.

Ingxelo epapashwe kwiUphando lwePhytotherapynguNjingalwazi uLi Xiumin, iSikolo seKhemesti, iYunivesithi yaseHenan yezonyango zesiNtu zaseTshayina, kunye nabaphandi abasuka kumaziko emfundo aliqela aseMelika, kuquka iNew York Medical College kunye neJohns Hopkins University Asthma and Allergy Centre, ngoMatshi ka-2022 yachaza ukuba elinye lamacandelo onyango.I-Ganoderma lucidumi-triterpenoids, i-ganoderic acid B, ine-anti-allergies echazwe ngasentla.

Impembelelo ye-Antiallergic ye-ganoderic acid B

Abaphandi bakhupha iiseli zomzimba ezibandakanya iiseli ze-T egazini lezigulana ezili-10 ezine-asthma ye-allergies, kwaye emva koko bazivuselela kunye nezigulana (i-mite yothuli, iinwele zekati, i-cockroach okanye i-hogweed), kwaye bafumanisa ukuba i-ganoderic acid B idosi ye-40 μg / mL) isebenze kunye ngexesha leentsuku ze-6 xa iiseli ze-immune zavezwa kwi-allergen:

① Inani le-Th1 kunye ne-Treg liya kwanda, kwaye inani le-Th2 liya kuncipha;

② I-cytokine IL-5 (interleukin 5) efihliweyo yi-Th2 ukuze ibangele ukuvutha (i-allergies) ukusabela kuya kuncitshiswa nge-60% ukuya kwi-70%;

③I-cytokine IL-10 (interleukin 10), efihliweyo yi-Treg ukulawula impendulo yokuvuvukala, iya kunyuka ukusuka kwinqanaba ledijithi enye okanye inqanaba leedijithi ezilishumi ukuya kwi-500-700 pg / mL;

④ Imfihlo ye-Interferon-gamma (IFN-γ), eluncedo kwi-Th1 ukuhlukana kodwa engathandekiyo ekuphuhlisweni kwe-Th2, ngokukhawuleza, ngaloo ndlela ibuyisela ulwalathiso lwe-immune response.

⑤Uhlalutyo olongezelelweyo lomthombo we-interferon-gamma eyandiswe yi-ganoderic acid B yafumanisa ukuba i-interferon-gamma ayiveli kwi-Th1 (kungakhathaliseki ukuba i-ganoderic acid B ibandakanyeka okanye ayikho, kukho i-interferon-gamma encinci efihliweyo yi-Th1) kodwa ukusuka iiseli T umbulali kunye neeseli umbulali yendalo (iiseli NK).Oku kubonisa ukuba i-ganoderic acid B inokudibanisa ezinye iiseli zomzimba ezinganxulumananga kangako nealeji ukuba zijoyine amanqanaba achasene nokwaliwa amandla.

Ukongeza, iqela lophando liphinde latshintsha i-ganoderic acid B kunye ne-steroid (i-10 μM dexamethasone) ukujonga umphumo wayo kwiiseli zokuzivikela zezigulane ze-asthmatic ebusweni bezinto ezinokuthi zenzeke.Ngenxa yoko, inani le-Th1, i-Th2 okanye i-Treg kunye ne-concentration ye-IL-5, i-IL-10 okanye i-interferon-γ yancitshiswa ukususela ekuqaleni ukuya ekupheleni kovavanyo.

Ngamanye amazwi, isiphumo esichasene ne-allergies ye-steroids sivela kuxinzelelo olupheleleyo lwempendulo yomzimba ngelixa i-anti-allergies ye-ganoderic acid B ichasene ne-alergic kwaye ayichaphazeli ukuchasana nosulelo kunye ne-anti-tumor immunity.

Ngoko ke, i-ganoderic acid B ayikho enye i-steroid.Inokulawula ukuchasana nomzimba ngaphandle kokutshabalalisa i-immunity eqhelekileyo, eyona nto ibalulekileyo.

Isihlomelo: Umsebenzi wePhysiological of Ganoderic Acid B

Iasidi yeGanoderic B yenye ye I-Ganoderma lucidumi-triterpenoids (enye yi-ganoderic acid A) eyafunyanwa ngowe-1982, xa igama layo “yayingumthombo wobukrakra bomphefumlo.I-Ganoderma lucidumimizimba eneziqhamo”.Kamva, phantsi kophononongo lwe-relay yezazinzulu ezivela kumazwe ahlukeneyo, kwafunyaniswa ukuba i-ganoderic acid B inemisebenzi emininzi ye-physiological, kuquka:

➤Ukunciphisa uxinzelelo lwegazi/ukuthintela i-angiotensin-converting enzyme (1986, 2015)

➤Uthintelo lwe-cholesterol synthesis (1989)

➤I-Analgesia (1997)

➤Anti-AIDS/Uthintelo lwe-HIV-1 protease (1998)

➤Anti-prostatic hypertrophy/Ukukhuphisana neeandrogens zezamkeli kwidlala lengqula (2010)

➤Anti-diabetes/Uthintelo lomsebenzi we-α-glucosidase (2013)

➤Umhlaza wokuchasana nesibindi/Ukubulala iiseli zomhlaza wesibindi womntu onganyangekiyo ngamachiza (2015)

➤Intsholongwane ye-Anti-Epstein-Barr / inhibition ye-nasopharyngeal carcinoma-eyanyaniswa nomsebenzi we-herpes virus yomntu (2017)

➤Anti-nyumoniya / Ukunciphisa ukwenzakala okukrakra kwemiphunga nge-antioxidant kunye neziphumo zokuchasa ukudumba (2020)

➤I-Anti-allergies/Ukulawula ukusabela komzimba kwiiseli ze-T kwi-allergies (2022)

[Umthombo] Changda Liu, et al.Ixesha elixhomekeke kwi-double modulation enenzuzo ye-interferon-γ, i-interleukin 5, kunye ne-Treg cytokines kwisigulane se-asthma i-peripheral blood mononuclear cells nge-ganoderic acid B. Phytother Res.2022 Mar;36(3): 1231-1240.

ISIPHELO

★ Eli nqaku lipapashwe phantsi kogunyaziso olulodwa lombhali, kwaye ubunini balo bubo beGanoHerb.

★ Lo msebenzi ungasentla awunakuphinda uveliswe, ucatshulwe okanye usetyenziswe ngezinye iindlela ngaphandle kogunyaziso lweGanoHerb.

★ Ukuba umsebenzi ugunyazisiweyo ukuba usetyenziswe, kufuneka usetyenziswe ngaphakathi kwendawo yogunyaziso kwaye ubonise umthombo: GanoHerb.

★ Nakuphi na ukuphulwa kwengxelo engentla, i-GanoHerb iya kulandela uxanduva olusemthethweni olunxulumeneyo.

★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao waza waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.