Me yasa mutane ke da allergies?

Ko jikin mutum zai sami rashin lafiyan halayen lokacin saduwa da allergen ya dogara gaba ɗaya akan ko rundunar T cell da ke mamaye amsawar rigakafi a cikin jiki shine Th1 ko Th2 (nau'in 1 ko nau'in 2 mataimaki T).

Idan kwayoyin T sun mamaye Th1 (wanda aka bayyana a matsayin babban adadi da babban aiki na Th1), jiki ba zai shafi allergens ba, saboda aikin Th1 shine anti-virus, anti-bacteria and anti-tumor;idan kwayoyin T sun mamaye Th2, jiki zai dauki allergen a matsayin mai cutarwa mai cutarwa kuma ya tafi yaki da shi, wanda shine abin da ake kira "tsarin rashin lafiya".Mutanen da ke fama da allergies, ban da amsawar rigakafi da Th2 ke mamaye, yawanci suna tare da matsalar cewa Treg (kwayoyin T masu mulki) suna da rauni sosai.Treg wani yanki ne na ƙwayoyin T, wanda shine tsarin birki na tsarin rigakafi don kawo ƙarshen amsawar kumburi.Lokacin da ba zai iya aiki akai-akai ba, rashin lafiyar zai yi ƙarfi kuma ya daɗe.

Yiwuwar rigakafin rashin lafiyan

Abin farin ciki, dangantakar da ke tsakanin ƙarfin waɗannan rukunonin tantanin halitta T uku ba ta tsaya ba amma za a daidaita su tare da abubuwan motsa jiki na waje ko canje-canjen ilimin lissafi.Sabili da haka, wani abu mai aiki wanda zai iya hana Th2 ko ƙara Th1 da Treg sau da yawa ana la'akari da cewa yana da damar daidaita tsarin rashin lafiyar jiki da kuma rage halayen rashin lafiyan.

Rahoton da aka buga aBinciken Magungunan HalittuFarfesa Li Xiumin, Makarantar Pharmacy, Jami'ar Henan ta Magungunan Gargajiya ta Sin, da masu bincike daga cibiyoyin ilimi na Amurka da yawa, ciki har da Kwalejin Kiwon Lafiya ta New York da Cibiyar Asthma da Allergy ta Jami'ar Johns Hopkins, a cikin Maris 2022 sun nuna cewa daya daga cikin abubuwan guda dayaGanoderma lucidumtriterpenoids, ganoderic acid B, yana da abin da aka ambata a sama na rigakafin rashin lafiyan.

Sakamakon antiallergic na ganoderic acid B

Masu binciken sun fitar da ƙwayoyin rigakafi ciki har da ƙwayoyin T daga jinin marasa lafiya 10 masu fama da rashin lafiyan fuka, sannan kuma sun motsa su tare da allergens na marasa lafiya (ƙura, gashin cat, kyankya ko hogweed), kuma sun gano cewa idan ganoderic acid B (a wani abu). kashi na 40 μg/mL) sun yi aiki tare a cikin kwanaki 6 lokacin da ƙwayoyin rigakafi suka fallasa ga rashin lafiyar:

① Yawan Th1 da Treg zai karu, kuma adadin Th2 zai ragu;

② Cytokine IL-5 (interleukin 5) wanda Th2 ya ɓoye don haifar da halayen kumburi (rashin lafiya) za a rage ta 60% zuwa 70%;

③Cytokine IL-10 (interleukin 10), wanda aka ɓoye ta Treg don daidaita amsawar kumburi, zai ƙaru daga matakin lambobi ɗaya ko matakin lambobi goma zuwa 500-700 pg / mL;

④ Sirrin Interferon-gamma (IFN-γ), wanda ke taimakawa ga bambance-bambancen Th1 amma ba shi da kyau ga ci gaban Th2, yana da sauri, ta haka yana juyawa jagorancin amsawar rigakafi da wuri.

Karin bincike na tushen interferon-gamma da ganoderic acid B ya karu ya gano cewa interferon-gamma baya fitowa daga Th1 (ko da kuwa ko ganoderic acid B yana da hannu ko a'a, akwai ƙananan interferon-gamma da Th1 ya ɓoye) amma daga kisa T Kwayoyin da na halitta killer Kwayoyin (NK Kwayoyin).Wannan yana nuna cewa ganoderic acid B na iya tattara wasu ƙwayoyin rigakafi waɗanda ba su da alaƙa da halayen rashin lafiyan don shiga sahun ƙarfin maganin rashin lafiyan.

Bugu da ƙari, ƙungiyar bincike ta maye gurbin ganoderic acid B tare da steroid (10 μM dexamethasone) don lura da tasirinsa a kan ƙwayoyin rigakafi na marasa lafiya na asthmatic a fuskar allergens.A sakamakon haka, an rage adadin Th1, Th2 ko Treg da ƙaddamar da IL-5, IL-10 ko interferon-γ daga farkon zuwa ƙarshen gwajin.

A wasu kalmomi, tasirin anti-allergic na steroids ya fito ne daga gabaɗaya na hana amsawar rigakafi yayin da maganin rashin lafiyar ganoderic acid B shine kawai maganin rashin lafiyar jiki kuma baya rinjayar maganin rigakafi da ƙwayar cuta.

Saboda haka, ganoderic acid B ba wani steroid bane.Yana iya daidaita halayen rashin lafiyar jiki ba tare da lalata rigakafi na al'ada ba, wanda shine sifa mai mahimmanci.

Karin bayani: Ayyukan Jiki na Ganoderic Acid B

Ganoderic acid B yana daya daga cikinsu Ganoderma lucidumtriterpenoids (ɗayan kuma shine ganoderic acid A) wanda aka gano a cikin 1982, lokacin da asalinsa shine kawai “tushen ɗaciGanoderma lucidum'ya'yan itace".Daga baya, a karkashin binciken da masana kimiyya daga kasashe daban-daban suka yi, an gano cewa ganoderic acid B kuma yana da ayyukan da yawa na jiki, ciki har da:

Rage hawan jini / hana angiotensin mai canza enzyme (1986, 2015)

Hana hadawar cholesterol (1989)

Analgesia (1997)

➤Anti-AIDs/Hanyar da kwayar cutar HIV-1 (1998)

Anti-prostatic hypertrophy / Gasa tare da androgens don masu karɓa akan prostate (2010)

➤Anti-ciwon sukari/Hana ayyukan α-glucosidase (2013)

➤Anti-hanta ciwon daji/Kashe ƙwayoyin cutar kansar hantar ɗan adam da ke jure wa magunguna da yawa (2015)

➤Anti-Epstein-Barr cutar / hana nasopharyngeal carcinoma-haɗe da ɗan adam cutar cutar kwayar cutar (2017)

➤Anti- ciwon huhu / Rage mummunan rauni na huhu ta hanyar maganin antioxidant da anti-mai kumburi (2020)

➤Anti-allergy/Kayyade martanin rigakafi na ƙwayoyin T zuwa allergens (2022)

[Madogararsa] Changda Liu, et al.Modulation mai amfani dual mai dogaro da lokaci na interferon-γ, interleukin 5, da Treg cytokines a cikin ƙwayoyin asma masu haƙuri na gefen jini mononuclear ta ganoderic acid B. Phytother Res.2022 Maris;36 (3): 1231-1240.

KARSHE

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